Namuli et al. study genetic modifiers of Huntington's disease as therapeutic targets. Their analysis of diverse human genetic evidence highlights cross-repeat expansion disorder relevance and prioritizes PMS1 for future research. @GalenWright @um_research

Carmel commented on ‘Intraspinal microstimulation of the ventral horn has therapeutically relevant cross-modal effects on nociception’, by Bandres et al. Read the commentary here 👉🏻 @jasoncarmel

Gentreau et al. report that statin use is linked to higher white matter hyperintensity volumes and lower grey matter volumes, indicative of the brain’s ageing process. Grey matter alterations were partially explained by reduced cholesterol. Read at:

Sansone et al. report that glioblastoma MGMT promoter methylation percentage correlates with cortical localization but not specific anatomical regions, shedding light on tumor biology. Read at:

Gomes et al. report that corticotropin-releasing hormone (CRH) is a promising biomarker for Lewy body disease and parkinsonian disorders. CRH levels were linked to cognitive decline and inflammation, offering new insights into disease mechanisms. Read at:

Luo et al. report differential changes in olfactory bulb and olfactory-eloquent areas in early Parkinson's, using advanced fMRI. Findings highlight potential biomarkers for early diagnosis and treatment. Read at:

Gong et al. report that cerebral white matter myelination, measured via advanced MRI, predicts better preservation of processing speed with age. Their findings highlight myelin’s key role in cognitive efficiency. Read at:

Falci et al. report that dorsal root entry zone microcoagulation relieves below-level neuropathic pain and alters brain network connectivity in spinal cord injury patients. Their findings suggest a role of the SNS in relaying below-level pain. Read at:

Landles et al. report that full-length mutant huntingtin protein levels decrease with CAG repeat expansion, while pathogenic HTT1a levels increase. These findings have critical implications for Huntington’s disease therapies and bioassays. Read at:

Muehlberg et al. report that dopamine availability in the sensorimotor putamen modulates motor learning, beyond its role in movement execution, highlighting cortico-striatal plasticity as a key mechanism. Read at:

Uguen et al. report loss-of-function PLAT variants as the cause of a recessive disorder with hydrocephalus, Dandy-Walker malformation, and intellectual disability. Their findings implicate disrupted plasminogen pathways in these disorders. Read at:

Köcher et al. report that concussion severity impacts zebrafish larvae escape behavior through opposing effects: habituation deficits at lower forces and fatigue at higher forces. Insights could advance concussion research. Read at:

Lin et al. report structural covariance alterations in periventricular leukomalacia that disrupt motor grey matter networks. Preterm infants show greater damage, with thalamic volume linked to motor skills. Read at:

Bureau et al. report early mitochondrial changes in the retina and optic nerve in hereditary optic neuropathy mouse models, with Opa1 and Nd6 mutations showing distinct patterns. These findings may inform pre-symptomatic therapies. Read at:

Di Stadio et al. commented on ‘Beyond the cochlea: exploring the multifaceted nature of hearing loss in primary mitochondrial diseases’, by Koohi et al. Read the commentary here 👉🏻

Gregory et al. report that alternatively activated macrophages are associated with faster growth rates in vestibular schwannoma, highlighting the need for new therapeutic targets that modulate the tumour immune micro-environment. Read at: @gracegregory_

Fischer et al. report that interdisciplinary management of cognitive impairment in people with HIV is crucial in improving care. Novel technology, including telerehab and serious video games, shows promise for improving quality of life. Read at:

Rahimi et al. report that dimethyl itaconate alleviates pain in rats during the formalin test, reducing NGFI-A/B and pro-inflammatory cytokines while increasing IL-10 expression in the spinal cord. Read at:

Leipp et al. report the potential of GFAP, a biomarker of astrogliosis, in early Alzheimer’s diagnosis and disease monitoring. Plasma GFAP outperforms CSF in diagnostics, aiding early detection and differentiation from other dementias. Read at:

Keegan et al. highlight the importance of spinal cord evaluation in multiple sclerosis, linking advanced imaging techniques to clinical outcomes and progression markers like atrophy. Collaboration and innovation are key to improving care. Read at: