Gaetano Gargiulo & ggargiul.bsky.social
@ggargiul_2020
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Scientist, cancer researcher, group leader @MDC_Berlin, studying brain & lung tumors and synthetic genetics, occasionally cooking and supporting Inter FC
Berlin
Joined December 2020
Our paper is finally out! We established causal links between clinically relevant covariates and the most aggressive brain tumor state, the mesenchymal glioblastoma. Our technology is generally applicable to complex phenotypes! Thanks to the team/funders!
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RT @catgyoung: Distilling the potential impact of science based on a title is so dangerous. Some of the biggest biomedical breakthroughs c…
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the synthetic locus control region for this study was designed using
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RT @GuccioneLab: Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder @Sleemmzz…
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RT @Sleemmzz: Big thanks to @GuccioneLab @Nickbar36316207 @lab_marine @ggargiul_2020 @owen_sansom for the fantastic collaboration, and to…
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RT @eportacangen: It took 3 years, 4 rounds of reviews, 96 VISIUM samples, 10 cancer types, and 1 clinical trial, but it's finally out: Th…
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Looking forward to reading it!
Interested in a novel crosstalk between astrocytes and T cells in the microenvironment of brain tumors? Our recent publication explores it to improve immunotherapies in the CNS. Fantastic work by @NeiblaPriego @RenacerBrainMet @CNIOStopCancer
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So cool @adrianbracken & team, I am reading it as I tweet :)
Please see 🧵by @evan_healy4 about our new paper exploring the role of PRC1 and PRC2 in non-dividing cells 👇
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A good weekend read!
Finally published!! Thanks to all patients for the generous donation of tumor samples 🙏 and to the amazing members of my lab & collaborators who made this work possible @brainhekate @bryanwgranger @LeoGarMont @Varelasamantha1 @MichaelKogan20 @StefanoBerto83 @bowersbrainsurg
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Timely! “replacement of just 0.001% of training tokens with medical misinformation[…]likely to propagate medical errors.[…]corrupted models match the performance of their corruption-free counterparts[…]we propose a harm mitigation strategy that captures 91.9%of” crap (NFW :)).
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The science of pasta cacio e pepe 🇮🇹👨🍳 "Finally, we present a scientifically optimized recipe based on our findings, enabling a consistently flawless execution of this classic dish." Applied science at its best, with real-world impact
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Couldn’t agree more! - we provide evidence that also the other side of the dosage matters!
Increased KRAS mutant allele dosage is an important negative prognostic feature that will need to be integrated into clinical practice as we move into the era of 🎯 RAS-directed therapeutics for PDAC. 🔸️ Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival 🔸️
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Congrats Maria @castro2355_mg that’s a challenge worth taking!
Very proud to see our immune-mediated gene therapy strategy for malignant brain cancer #GBM published @TheLancetOncol thank you Pedro Lowenstein for not giving up in spite of all the “almost” insurmountable challenges! To our patients, always!
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Like 🌵 storing water in a drought? Congrats @MAF_Dawson & team for uncovering a cool buffering mechanism: nuclear speckles storing export-ready mRNAs to cope with sudden transcriptional inhibition. And please say to Ewa, we were in the same “trailer” during our postdocs @ NKI :)
Why can a human tolerate a drug that globally inhibits transcription? Why do transcription inhibitors not cure cancer? Our first paper of 2025 may help explain (some) of this! So very proud of @DrTobiasW & Ewa Michalak who led the work!
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You’re off to a great start Peter @BrainSurgn1989! This is going to the be my first deep dive of the year!
Read our latest #research on glioblastoma origins and growth, injury-reprogramming to neural crest-like identity, led by Akram Hamed from my lab, with @lincolndstein,@MarioniLab,@BenSimons_Lab, published with @SpringerNature in @nature,
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Thanks Chris!
A very important and exciting / must-read study 👇
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