Danielle Beckman
@DaniBeckman
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Ph.D. in Neuroscience 🇧🇷 Researcher at the @CNPRCresearch 🇺🇲 Working with high-resolution microscopy 🔬 #NeuroCovid is real.
California
Joined May 2009
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Pinned Tweet
This video that covers our work showing how SARS-CoV-2 spreads in the brain and can cause
#LongCovid
is from almost 2 years ago. Unbelievable to see so little progress was made in this area...
#CovidIsNotOver
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@TheCinesthetic
Requiem for a Dream and everyone's descent into madness, especially Sara Goldfarb.
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I've been noting and showing brain injury after COVID-19 for 3+ years.
Signed,
A P.h.D brain pathology microscopist
I’ve been noting this for 3+ years.
Signed,
A board certified brain injury doctor
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So, I am redoing my annual BSL-3 facility training, and this is how we have to dress to work with
#SARSCoV2
in the Lab. I am investigating the same strain that is circulating everywhere, Omicron variants KP.2 and KP.3. What do you think? 🙇
#biohazardous
#BSL3
#Covid
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I spent another day in the microscope taking photos of dozens of healthy brains infected with
#SARSCov2
(monkey and human), only to come to Twitter and see all the 'specialists' denying it is real. People who have never used a microscope before. This world is a dystopia.
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"But SARS-CoV-2 doesn't even infect the brain, how can you want to work with that?"
My dude. My job is literally spending the whole day taking pictures of SARS-CoV-2 in the brain. I literally see this crap every day, all the time; it says hi to me, and I say back hi to it every
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COVID-19 will never be like the Flu. Never.
At least not for the brain.
I would love to be wrong; please prove me wrong with evidence and real science!
It is quite simple.
#SARSCoV2
can access the brain using several different mechanisms that Influenza cannot.
A: Viral
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Let's celebrate all athletes who are still masking? I want to start with the super badass Raven Saunders. Raven is chasing an Olympic gold medal at the Paris Games after earning silver in Tokyo. A mask and long nails did not disrupt their qualification for the Olympics in June💅
Australian Olympic medal chances will be better 4 protecting athletes from inconvenient airborne infectious diseases like Cvd, with good quality respirators
Well done to the Australian Olympic medical team 👏
can we pls put you in charge of nat PH when you return from Paris?
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Charging $42,250 for an HIV drug that can be sold for $40 a year and still make 30% profit is criminal. This drug has outstanding results in preventing
#HIV
transmission.
People at the
#AIDS2024
conference protesting today.
A new drug described as “the closest we have ever been to an HIV vaccine” could be sold for $40 a year and still make 30% profit, but is currently being sold by pharma companies for $42,250. Absolutely criminal.
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Imagine being a badass scientist, MIT Physics, Forbes 30u30, and having millions of followers on multiple social media communicating about sciences. Just married, full of hopes and dreams. Suddenly, this is everyday life for you. This is the reality of
@thephysicsgirl
and so many
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Not 👏Brain 👏Fog👏
This is a photo of a neuron exploding with
#SARSCoV2
.
This is Brain Damage.
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It is
#COVID19
that is leaving people with neurological problems. It is not the vaccine.
SARS-CoV-2 spike mRNA vaccine does not contain the intact virus. Only active virus infecting the brain can replicate inside the neuron, as shown in the image below. It is crystal clear.
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Not now alien bacteria, not now...👽
Bacteria on the International Space Station have mutated into opportunistic pathogens never seen on Earth: several strains of a multi-drug-resistant bacterium known as Enterobacter bugandensis
read more:
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I can start with an uncomfortable question: Why is a 'respiratory virus' replicating inside the large intestine 676 days post-COVID-19 infection?
#LongCovid
New research shows COVID’s impact is more prolonged than previously thought, with signs of inflammation and traces of virus detectable years after infection.
The results raise uncomfortable questions about long-term health implications that we are only beginning to understand.
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Have you seen the blood-brain barrier (BBB) before?
Astrocytes (🟢) surround most of the blood vessels in the brain (🔴red blood cells). They help separate everything that comes with the blood from the rest of the central nervous system.
BBB dysfunction is linked to early
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As a neuroscientist, I know I will end up looking at brains infected with
#H5N1
soon. How do I know that? The story of the last months summarized chronologically in 4 papers:
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Many people tend to forget that this is why Steve Jobs died. He rejected potentially life-saving surgery in favor of alternative treatments like acupuncture, dietary supplements, and juices. Though he ultimately embraced the surgery, there was not enough time to save him.
In a study of 1 901 815 cancer patients, those who chose alternative medicine had a 2-fold greater risk of death compared with patients who had no alternative medicine use.
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Definitely not just a cold
#SARSCoV2
GUESS WHAT?! A new study has shown SARS-CoV-2 infection is DISTINCT from common respiratory viruses!
Unequivocally, COVID is NOT "just a cold."
These findings are HUGELY significant, for multiple reasons! Here's a breakdown of the study (written for a general audience)...
1/16
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Many people have no idea how these things work.
For example, right now, as a Brazilian, I can't accept invitations to speak at conferences in Europe because my visa to work in the U.S. has expired.
I am not illegal; I have a work contract with the University of California until
This is a reminder that international scientists face various hurdles and citizenship in some countries is worse than others. I had 2 students miss 4-6 weeks this year JUST to renew their visas (India and China).
(have to admit that global south was confusing, coming from NZ)
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Keep saying that to friends. Even if you don't mask regularly, please mask inside airplanes.
A systematic review of airplane flights and Covid infections: duration of flight correlated with infection risk, long flights> 6 hours markedly increased risk (25X) and mask use blocked them
h/t
@linseymarr
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I just wish public health leaders and politicians would read this study, which includes data from 800,000 adults in England.
We are getting cognitively slower even when the infection is "All resolved."
#LongCovid
outcomes are even worse.
#CovidIsNotOver
So, repeat Covid infections really are making us dumb and dumber.
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Leaky blood-brain barrier in long-COVID associated brain fog
This study confirms everything I have seen in the microscope over the last few years.
They use a technique called dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), an imaging technique that can measure
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I apologize to everyone who used to follow me before, especially the ones here for microscopy photos. But I can't and won't stop talking about viruses. If you love neurons and brains like I do, and your job is to look at this daily, you would also be heartbroken. 🔬💔
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The spread of misinformation about
#COVID
has been so strong that, in 2024, the Olympic committee still thinks hand sanitizers will help with that.
This is the result of public leaders following institutional medicine and not science & engineering.
#AIRBORNE
Health officials in France admit a large COVID outbreak at the Olympics is possible but they’re not worried & recommend the following:
“Face masks are not required inside the Olympic Village but hand sanitizer is available in its clinics and restaurants.”
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Not sure who made these, but they are great and available to download here:
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More than 4 years of pandemic and so much research, it is unacceptable for a leader to test positive for
#COVID
(with symptoms) to casually enter an airplane without a mask. Anti-science is everywhere, and I am exhausted.
Video by Qingyan Chen, air quality expert at Purdue Uni.
here's live video of Biden boarding a plane to leave Vegas after self-isolate after testing positive for covid
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Out today in
@ScienceMagazine
"In patients with long COVID, the complement system no longer returns to its basal state but remains activated and, thus, also damages healthy body cells.
Patients with active Long Covid disease also had elevated blood levels, indicating damage to
Our work on
#LongCovid
🩸 is now out in
@ScienceMagazine
!
We found increased complement activation and markers of thromboinflammation in patients with active Long Covid.
1/
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I have been sick with
#COVID19
for 10 days now. I was able to avoid this disease since its beginning, but it finally got me, as it did with so many people around the world. I never thought that this disease was not severe. I lost my grandmother to it in 2021; she had an extensive
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Because she wants to. Why is this even in the news? Leave people wearing their masks alone.
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This makes me angry beyond words. We are a generation to be known for letting the older just die. These people survived wars but did not survive our daily irresponsible decisions. My grandma survived being a Jew in Poland during WW2 and started a new life in Brazil, but she did
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My last post about being sick with
#COVID19
attracted much attention, good and bad. For those who wished me well, thank you very much! I have already recovered my sense of smell and taste and am improving from Covid symptoms every day.
For the denialists who took precious time
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Good science takes time. The paper below took 2 years under review to be published. Reliable evidence of
#LongCovid
will just keep coming. Medical doctors and scientists need to keep up with the literature. It is our duty.
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New data about
#LongCovid
comes every single day from the most important scientific journals in the world. Yet mainstream media don’t discuss it. Why is that?
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Let's call it a respiratory virus, what can possibly go wrong?
Everything.
Covid is systemic.
#neuroCovid
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One thing about
#neuroCovid
(acute and
#LongCovid
) is that it can happen regardless your COVID case is mild or not. Scratchy throat, stuffy runny nose, and mild cough are respiratory symptoms that do not correlate with neurological ones. Once the virus enters the brain (it can
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Marc Veldhoen
@Marc_Veld
blocks me, unblocks me just to share my post, and then blocks me again. Stop being a coward, Marc; at least learn how to discuss science like a grown-up.
The image is not from an unknown source; it is mine, and it is published. It is not an in vitro
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How I published 1 first-author paper during 2.5 years of my post-doc:
- I collected all my data and learned how to become a scientist.
- I read like a normal human being.
- I write like a normal human being.
Seems to be paying off.
How I published 13 first-author papers during my 2.5 year post-doc:
- All the data were already collected
- 5 papers were literature reviews
- I read incredibly fast
- I write even faster
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Please listen to
@PutrinoLab
:
1 - There is no such thing as mild Covid-19.
2 - We still don't know the long-term consequences of a Covid-19 infection.
3 - We still don't understand what is
#LongCovid
.
4 - We still don't know why some people don't recover.
@LongCovidSOS
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This is a common misconception. I agree that detecting viral particles in the brain does not mean acute infection. However, what
#SARSCoV2
does is not only infect the brain, but it actually replicates inside the neurons. Few viruses replicate inside neurons; they usually infect
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Good morning! Another day, another chance to get closer to cure
#LongCovid
. Happy Friday and let's go to work! 🔬💪💪
And of course I'm wearing
@BerlinBuyers
😎
#YallMasking
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You guys can think I'm crazy, but my boss, who is also the president elected of the Society for Neuroscience
@SfNtweets
, has a wall in his house just with images of neurons infected with COVID and neuroinflammation.
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Finland has zero cases of
#H5N1
and is vaccinating their farmworkers. In the U.S, farmworkers are getting infected every day now and no vaccines so far. Will we only start bothering when rich people gets infected?
You don’t send farm workers in to cull H5N1 infected birds without goggles and masks. Period. If it’s too hot to wear those protections, it’s too hot to cull. We need vaccines to be made available to farmworkers. We have to stop gambling with peoples’ lives.
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The paper below was published in 2006, way before
#SARSCoV2
. It is a detailed analysis of how different coronaviruses enter the brain and induce different types of inflammatory and immunological damage.
We know exactly what happens in the brain during the acute and chronic
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Reminder that to enter human cells,
#SARSCoV2
binds to ACE2 receptor, which is highly present in ALL blood vessels in the body due to its most important function: regulating vascular tone.
#Covid
is a vascular disease and this is the damage it can do to the brain and heart.
A reminder that not only is Covid not a cold or the flu, it is vascular. It affects every organ of your body, including the brain. There is no treatment or cure for long Covid organ damage.
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I'm still on a mental health break from this place. For the xenophobic and misogynistic haters and COVID minimizers, I'm also still fully supported by the Uni of California, and our research in
#Neurocovid
is stronger than ever. Grants and papers coming. More news on that soon!
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An unwelcome guest: a photo of
#SARSCoV2
infected cells arriving in the brain. This indicates neuroinflammation and blood-brain barrier disruption. The staining is for SARS-Cov-2 nucleocapsid protein (pink color), astrocytes (yellow), and nuclei of all cells (blue).
#neuroCovid
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This was me at 7 years old when I was diagnosed with social anxiety disorder. I was never able to play or interact with other children normally. I had and still have serious difficulties talking about myself and sharing my thoughts. A couple of months ago, I started posting here
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There is just SO MUCH misinformation about how Normal Aging vs. Neurodegenerative Diseases can affect the brain. Let's start with the basics: neurons don't die with normal aging; they lose synapses (the connection between neurons). Behavioral changes are progressive, subtle, and
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Do viral pathogens increase the risk of neurodegenerative disease?
Recent analysis of more than 400.000
patients across different biobanks point to several straightforward conclusions:
- Increased risk of developing neurodegenerative diseases persists up to 15 years after a
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We are witnessing firsthand one of the oldest and best schools in Public Health and Epidemiology acknowledging for the first time some very important information here.
Thank you, Yale School of Public Health
@YaleSPH
for sharing this.
#LongCovid
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Every
#COVID
infection is a risk for the brain because:
1- Ace2 receptor (entry receptor for SARS-Cov-2 in cells) is highly expressed in all blood vessels, including cerebral ones.
2- The virus arriving in the brain will cause a mess. Even if you don't look at infected cells,
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And, in complete honesty, I strongly suggest engineers should keep telling us all how to manage PPE and outbreaks in hospitals.
#COVID
The religious devotion to surgical masks protecting against all ills flows from ignorance about high levels of air delivery required by code in CDN health facilities.
It’s a core defence vs outbreaks, and it’s an engineered system.
And works even when N95 are not worn.
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Two neurons having a conversation, surrounded by some busy microglia doing their job: maintaining neuronal networks and helping with injury, repair, and pruning! The brain is beautiful! 🧠🔬
#neuroscience
#Microscopy
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To everyone suffering with
#LongCovid
, you are not crazy. There is a reason why you are sick and science is advancing a lot every single day.
A new study just published shows that altered markers in the blood and tongue after COVID infection can disrupt how we perceive
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I have been seeing the same.
#COVID19
is a serious vascular disease.
Brain fog in Long COVID linked to damaged blood vessels—a key insight shedding light on this complex condition. Understanding the root cause is crucial for targeted treatments. Let's support research efforts and spread awareness!
#ubuffalo
#longcovid
#covid19
#covid
#longhaulers
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Sarah
@sarah_buckel
, another person affected with severe
#LongCovid
, opted to end her life and applied for assisted suicide.
I feel so helpless and heartbroken. Too many are suffering from a disease that most people choose not to think about. It is just the flu, they say.
These
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A confocal microscopy image of Your Majesty, the neuron, the king of the brain jungle 🧠🔬! This one is the classical pyramidal cell, the most common neuronal type in the mammalian cerebral cortex. In blue, staining for PSD95, a major protein in excitatory synapses that helps
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Myelin and Covid
I often post high-magnification photos, so sometimes it is hard (even for me in the microscope) to have an idea of the big picture of the damage that a microorganism like
#SARSCoV2
can cause in the brain.
The photos below are a comparison of the same region in
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I don't think most people understand how bad this is. The mutation PB2-M631L detected before in cattle and birds, and now in a human infected with
#H5N1
, increases the virus capability to replicate inside human cells. Every single infection creates a new opportunity for the virus
You do get that this is bad, right? And that once again public health agencies and officials are just watching it happen?
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"Recovery from infection will provide lasting protection against"
Reality: After the third COVID infection, patients have a 40% chance of developing
#LongCOVID
.
Data from the
@StatCan_eng
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This is how Covid-19 can increase the risk of Alzheimer's disease.
Alzheimer's starts in the entorhinal cortex (Ento), which is also part of the Primary Olfactory Cortex. It is basically the first region of the brain to receive the virus after infection, and it happens within
I missed this when it came out. "it is likely that SARS-CoV-2 eventually reaches the same temporal and frontal cortical fields that are affected in AD, with yet unknown consequences." Not reassuring.
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This is what a lot of the people in charge get it wrong (epidemiologists and public health leaders).
Scientists who are actually directly studying
#SARSCov2
persistency (me and many others) are seeing the same results. There is a reason why
#LongCovid
is so prevalent.
I know a "T-cell expert" trying to sell herd immunity for COVID-19 since 2020 who is having a hard day today.🙈🙈
"Collectively, our data are consistent with a model in which persistence of SARS-CoV- 2 results in chronic tissue-based inflammation, T cell activation, and perhaps
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How it feels to work in a BSL3. Now, complain again about wearing an N95 respirator. We are being exposed to the same virus.
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What's the biggest difference between a neuron from a young vs. an aged primate? It is not the length of the axon and dendrites, but the number of spines available to make contact and connections with other surrounding neurons! 3D recon. made with
@ImarisSoftware
#neuroscience
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Important study published today investigating why some people develop
#LongCovid
The most striking finding is a massive disconnect between the humoral (B-cell) and cellular immune (T-cell) response in Long COVID patients.
In summary, these two systems should work together to
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#Neurocovid
, here we go again. I share here only peer-reviewed studies from reputable journals. But the data won't stop coming.
Biomarkers for neuronal damage after Covid infection: even mild or asymptomatic
#SARSCoV2
infection leads to reflections of neuron (Nfl marker) and
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Only 45 people were tested for
#H5N1
over the past 3 months across the whole U.S.
"We're flying blind": CDC has 1 million bird flu tests ready, but experts see repeat of COVID missteps.
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✅ Go to Portland to talk about brain dysfunction in Alzheimer.
✅ Sneak in some
#neuroCovid
slides to my presentation.
✅ Leaving Portland without brain dysfunction myself.
#MaskUp
😎😷
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7 human coronaviruses known to humankind
3 caused the last pandemics.
All 7 are found inside the brain. But there is nothing to worry about—it is just a common cold!
Minimizers, shouting: "There are four known human coronaviruses that all cause common colds!"
Minimizers, mumbling under their breath: *"And three, specifically the three most recent, that are deadly."*
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Please. Do you want a hard photo? A few years ago we had to open mass graves to bury everyone who died of
#COVID
in the middle of one of the most developed cities on the planet. In the 21st century. And in your government.
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Do people realize that the retina is actually brain tissue, a piece of the central nervous system in a peripheric location?
In the already confirmed olfactory path,
#SARSCoV2
has to open some doors to reach the brain. The retina is a door open all the way.
Source:
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Got 3 more Job rejections just in the last few hours, for applications that took me months to put together. I want to study 🧠viral persistence and autoimmunity. I will not give up on having my Neurovirology Lab one day. But man, I wish Academia could be a little less hard.
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Just wanted to add that my brother and I got heavily bullied at school because we were both too nerd, shy, and reserved. Many years later, I regret nothing, still love being a nerd. And nerds are ruling the world. 🤓
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Back again looking at some neurogenesis in the developmental brain! Newborn neurons in 🟣 (dcx marker) are slowly starting to mature and express markers of fully developed neurons (🔵, map2 marker). Astrocytes in🟠(Gfap marker) and microglia in🔴(Iba1 marker) are also present!
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Brain abnormalities in survivors of COVID-19 after 2-year recovery: a functional MRI study
- A 2-year follow-up imaging study indicating ongoing alterations in the putamen, temporal lobe, and superior parietal gyrus.
- Cognitive failure, general fatigue, and neurological
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I know a "T-cell expert" trying to sell herd immunity for COVID-19 since 2020 who is having a hard day today.🙈🙈
"Collectively, our data are consistent with a model in which persistence of SARS-CoV- 2 results in chronic tissue-based inflammation, T cell activation, and perhaps
Up to 2 years after Covid, persistent virus and T cell activation in multiple tissues, especially high in gut
#LongCovid
@ScienceTM
@MichaelPelusoMD
and colleagues
@UCSF
@UCSFMedicine
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Many Olympians have to give up their careers and their dreams because of
#LongCovid
Imagine winning the Olympic gold and being unable to get off the couch soon after.
"Hello everyone, unfortunately I have to announce today that I will not be able to take part in the Olympic Games in Paris. I suffer from a so-called post-infectious syndrome caused by a viral infection... the cause of this syndrome is unclear... in February of this year I
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If you have to watch one single video in your life about Myalgic Encephalomyelitis (
#MECFS
), please watch the one below by
@jenbrea
. Since the pandemic started, the number of people suffering like this has skyrocketed. The time to inform ourselves is now.
#LongCovid
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I will keep repeating, even if nobody pays attention. We don't want to test what
#H5N1
does to the brain. Influenza viruses are usually not neutropic, but we know this is not true for H5N1. Back in 2009 we already knew they are particularly bad for dopaminergic neurons.
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President Biden is dropping the Presidential race while infected with
#Covid
for the third time.
Whoever replaces him MUST address the risks of multiple Covid infections and
#LongCovid
.
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@Marc_Veld
Marc, we understand your disappointment because your 2021 hypothesis about post-pandemic immunity failed. I am so sorry, but this is common in science and real life. Now, move on and stop attacking scientists and patients on Twitter who are pointing out that you failed.
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I hate being alarmist, but I am also not consuming any milk in the near future. I am very aware of what Influenza can do it the brain.
#H5N1
#AvianFlu
@jgoodmansunset
Personally, I’ve spent 27 years studying H5N1 viruses. So, I’m going to wait for data I hope is coming soon from both FDA (pasteurization) & USDA (genomic data & raw milk handling). Minor inconvenience to pause my milk consumption while waiting for data. Delayed transparency
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I will keep repeating that: Olfactory and cognitive systems overlap in the brain.
The virus goes directly into specific brain regions --> brain scan shows volume abnormalities in the same regions ---> patients show cognitive decline and other behavioral alterations
#neuroCovid
"In our cohort, all survivors experienced one episode of the original
#COVID
strain infection."
The occurrence of cognitive impairment among older COVID-19 survivors was:
10.2% at 6 months
12.5% at 1 year
19.1% at 2.5 years post-infection.
Still don't believe in
#LongCovid
?
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Exercising after COVID infection will increase your risk of
#LongCovid
. Long Covid patients also present extensive mitochondrial dysfunction and several muscle abnormalities that are worsened after physical exercise.
@ACSMNews
is not okay that you invite speakers that are
A Long Thread 🧵…
Astounded to sit in a session at the
@ACSM
conference where high profile researchers/medical professionals are advocating for the role of GET and CBT in treating
#LongCOVID
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What can we do to prevent
#dementia
?
Science shows us that modifying 12 major risk factors might prevent or delay up to 40% of dementias.
These factors are: less education (7%), hypertension (2%), hearing impairment (8%), smoking (5%), depression (4%), physical inactivity (2%),
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Let me rephrase this:
Scientists used store-bought milk to characterize the complete genetic sequence of
#H5N1
, because
@USDA
and
@CDCgov
aren't doing anything.
#BIRDFLU
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We already know Covid-19 is making us more stupid, we just need to start applying the same tests for young people now.
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Neuroscientists have known for decades that the
#H5N1
virus is not a common influenza for the brain. The paper below is from 2009. The news would be politics listening to scientists.
Bird flu has been invading the brains of mammals. Here’s why
"To break inside a cell, flu viruses exploit a protein called sialic acid on the cell’s surface..studies have shown that parts of the human brain..are covered in birdlike sialic acid proteins.
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According to a new study, we could have avoided at least 271,000 to 447,000 deaths in the U.S. with better COVID-19 restrictions.
There are no words for this. 🤬
#COVID
No f***ing kidding.
🤬
"Stricter Covid mask rules could’ve saved hundreds of thousands of lives, new study finds"
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So
#neuroCovid
is real. It is very much real, and I wish it wasn't. I really wish I did not need to look at how fast viruses destroy neurons. I would just go back to try to help in the Alzheimer's fight. Go back to see neurons slowly dying, not this insanity we are seeing now.
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"It's just the flu." 🙄
Acute respiratory infections in children are still common, but they never died as much as they do now.
Analyzing 235,829 children and adolescents hospitalized from February 2020 to February 2023 in Brazil, the authors of this study showed that
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A super important study published today. They looked at 10 million people in Japan and 12 million in South Korea.
The long-term risk of neuropsychiatric events following COVID-19 was higher than the risk in both the general population and those with another respiratory
A huge study of
#LongCovid
in South Korea and Japan
shows a pronounced increase of Guillain-Barré syndrome, cognitive deficit, insomnia, anxiety disorder, encephalitis, ischemic stroke and mood disorder. Reduced by vaccination
@NatureHumBehav
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