Courtney Hanna
@cw_hanna
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Sir Henry Dale Fellow/Group Leader, Centre for Trophoblast Research, University of Cambridge, interested in trophoblast, epigenetics and developmental biology
University of Cambridge
Joined November 2020
@Ella_Maru @CellStemCell @GeorgiaL38395 @Vicensella @Loke_CTR @Cam_Repro @PDN_Cambridge Thanks for your question! We haven't tested whether DNMT3L can prevent their loss, as this would require over-expression during or immediately after derivation of a new hTSC line. What we do see is that DNMT3L expression cannot recover imprinted methylation in hTSCs once lost.
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Compared to early human trophoblast, hTSCs lack DNMT3Lexpression, which is necessary for PMDs in mouse trophoblast. When we ectopically express DNMT3L in hTSCs, we find placental PMDs are restored, supporting a conserved role for DNMT3L in de novo methylation in trophoblast.
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Using single-cell RNA-seq + PBAT, we characterised the molecular profiles of NSN and SN GV oocytes, which show highly distinct chromatin structures (example below). A great collaboration!
Our study characterizing oocyte stages during early development in mice is out now We present a classifier to stratify oocytes into NSN and SN stages, and highlight why it is important to take this into account for downstream functional studies
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RT @ATvardovskiy: Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains https:…
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Happy to see this was published yesterday! It was great working on this with Shankar and @ShifaanT. And thank you to the great editorial team at @NatRevMCB.
Now Online: Origin, fate and function of extraembryonic tissues during mammalian development
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RT @LabRowe: We have put together an exceptional scientific programme for the @GenSocUK #Epigenetics2025 meeting to be held in Belfast. Are…
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RT @RalphSGrand: It is challenging to study the ability of transcription factors to engage their motifs in the cell. We tried to address th…
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RT @sangerinstitute: The inner lining of the uterus, the endometrium, has been mapped during multiple phases of the menstrual cycle 🔎 Rese…
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RT @bart_theeuwes: I’m really excited to share our research, which exploits an ESC model, chimeric embryo experiments and single-cell multi…
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