Yelena Y. Janjigian MD
@YJanjigianMD
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Chief, Gastrointestinal Oncology at Memorial Sloan Kettering Cancer Center
New York, NY
Joined September 2017
Checkmate 649 published! @sloan_kettering ✅ @KoheiShitara #ASCO21 @ASCO Leading Phase III studies is fun! Thank you to all the patients and caregivers, to my amazing colleagues and @bmsnews @ScienceAtBMS
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Checkmate 649 Two- year update published on line today in Nature. Open Access coming soon @KoheiShitara @Nature @mvicaracal @MSKCancerCenter @MSK_DeptOfMed @OncoAlert
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I love seeing my work in the same issue with papers about quantum physics and volcanic ash! My family of ‘hard’ scientists finally impressed. I ❤️@Nature @mvicaracal @MyriamChalabi #Science #cancer
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Notes from a 7th grader’s science class! My daughter is learning about #immunesystem and #Immunology #WomenInSTEM I am so proud. #nyc #doe the future of science @sloan_kettering
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My mom called to inform me she discovered me on @Twitter -- studied every single tweet & response from others 'the whole night' with lots of feedback. PSA: my mama is watching your every move now. .
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3 years from the phase II abstract @OncoAlert @ASCO #GI19 to publication of interim Phase III. Thank you to collaborators @KoheiShitara @TaberneroJosep & @mvicaracal @Nature for easy pub process.
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Prodige24 adjuvant mFOLFIRINOX vs Gem in resected panc 5 year follow up. mFOLFIRINOX is better and completing all chemo survival is important. 5 year OS 43% @myESMO @OncoAlert #ESMO2021
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Excited to share the news!! Nivolumab FDA approved in 1st Line gastric cancer! Not restricted by CPS. Thankful to all our pts who participated in CM649. @KoheiShitara @sloan_kettering @OncoAlert
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Celebrating with my amazing research team! We changed SOC again @sloan_kettering Twice in one month. #gastriccancer @RWilliams_MSK @RyanMoyMDPhD @FDAOncology approval
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Gastrointestinal Oncology Service @sloan_kettering is hiring. Are you passionate about translational research, clinical investigation and want to be on the team that brings hope and new treatments to cancer patients worldwide? Please DM me if interested and RT. @OncoAlert.
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Excited to finally share that Keynote 811 survival data in first line HER2+ gastroesophageal cancer will be presented at @myESMO @MSKCancerCenter @MSK_DeptOfMed .
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Memorable night at @ASCO #asco22 10th annual Giants in Cancer Reception honoring the new inductees, including our own Luis Diaz @MSKCancerCenter who is being recognized in the Translational Science category. Thank you @OncLive @AndreaCercek
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Congrats Charlie Rudin our new Cancer Center Deputy Director! So bright & kind. We met 15 yrs ago; I was 8 mos pregnant, doing my 1st talk @asco & looking for a job! Charlie was the discussant, his positivity & support settled my nerves & gave a needed . confidence boost
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#woman at a window. Manifesting for the next scientific meeting to be in #italy. Perhaps a pan tumor #ERBB2 #HER2 @PTarantinoMD @ScaltritiLab @Daniela_Molena @sandrapdangelo
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My daughter made a diorama of Rosalind Franklin hidden behind a curtain while Wilkins, Watson & Crick get Noble Prize. Never too early to learn about discovery &scientific credit. Franklin’s contribution to the discovery of the double helix of 🧬 was crucial.She got a raw deal.
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With super stars ⭐️⭐️ In #NYC @MSKCancerCenter waking up to messages & congrats calls from all over 🌎 on how absolutely amazing our GI Oncology group is 🥰@MSK_DeptOfMed privileged to have @ldiaz1971 @AndreaCercek @LumishMelissa as colleagues plus 43 gifted GI MDs. #teamwork
Very proud of our study published in @NEJM. 100% clinical complete response with dostarlimab alone in mismatch repair-deficient locally advanced #RectalCancer. No radiation or surgery! @ASCO #ASCO22 @MSKCancerCenter
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In TMB high tumors treated w/ ICB, improved OS was associated mainly with POLE muts and with defective DNA mismatch repair, not overall mutational burden. @sloan_kettering @BenjcRousseau @MikeFooteMD @ldiaz1 @OncoAlert @SteveMaronMD @CYOC_MSK
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Voted - 🇺🇸! Made time in between research meetings & right after I picked up oseltamivir at the pharmacy for kid #2 who is home from school w influenza. Please #vote our future and freedom depends on it. @MSKCancerCenter @MSK_DeptOfMed
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To my colleague and gifted physician @GABOUALFA Happy 20 year service anniversary with Memorial Sloan-Kettering Cancer Center. Heres to many more discoveries and breakthroughs on GI Oncology service. @sloan_kettering
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Our new CEO is a physician scientist and a pancreatic cancer surgeon. MSK is constantly evolving. I am thrilled for our patients and our scientific community @MSKCancerCenter
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Excellent argument against preop chemo for MSI-H localized gastric cancer by @LizzySmyth1. “We can cure many MSI H gastric ca w surgery alone.”@IGCCHouston @MansfieldPaul @ILSONDavid @FlorianLordick
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Exploring the beautiful Saint-Émilion region with my love❤️❤️Little R&R after a busy @myESMO #ESMO22. @janjim01 🌤☀️🌞l'équilibre travail-vie #worklifebalance
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I got to spend the week with this excellent team of residents rounding @sloan_kettering. Up next they get to round with DOM Chair. Thank you for covering the service this weekend Deb Schrag @debschrag. @MSK_MedChiefs @MSKEducation
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Practice changing study by @MSKCancerCenter @MSK_DeptOfMed Chair @debschrag & colleagues. @OncoAlert
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MSK’s own Luis Diaz, MD will be #POTUS right hand man on the cancer advisory board! @sloan_kettering @LDiaz1 @OncoAlert Expect strong leadership and innovation. President Biden Appoints Members to National Cancer Advisory Board
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Many improvements in #gastric cancer therapies from 2017 to 2023. Great to be back in Japan 🇯🇵 with @KoheiShitara at Japanese Society of Medical Oncology meeting. Looking forward to many more years of productive collaborations between our groups. @MSKCancerCenter
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$BMY announces positive Phase 3 trial results in first-line gastric and esophageal #cancers
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Google reminded me what life was like 2 years ago. @ASCO 40k attendees- crowded halls. Glad I have pics to back up my old lady stories of the pre pandemic(s) scientific meetings to the generations trained in virtual space. “When I was your age. ” Surreal.
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How do we Target #KRAS in Colorectal Cancer? Read this piece in @nejm & learn from one of @MSKCancerCenter brightest physician-scientists @RonaYaeger
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We have a two year position for early career investigator focused on gastroesophageal cancer. Details below .
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The sheer joy on these faces! Picture taken the day we heard the great news from @ConquerCancerFd @MSKCancerCenter that @LumishMelissa got a YIA & @SteveMaronMD a CDA. #ASCO22. Being a mentor is the best job I have!
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#ESMO23 ❤️Perfect for us! @myESMO @sara_lonardi1 @MyriamChalabi @ChiaraCrem1 @JenSeligmann @FilippoPietran4
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Dr. Balogun @FiyinfoluB congratulations 🎈🎊🎉 on your well deserved Award for Patient Recognition. Your patients adore& respect you and your GI Oncology family is so proud of you! @MSK_DeptOfMed @MSKCancerCenter @ILSONDavid @ldiaz1971 @AndreaCercek
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The next chapter in #her2positive EG cancer. The RP2D dose T-DXd 6.4 mg/kg + Cap 1000 mg/m2 BID. 43% ORR in Chemo and traz refractory disease. Up next 1st line TDXd/cape/pembro @ASCO @OncoAlert @JeeyunM @sloan_kettering @YJanjigianMD
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Speaking about clinical trial development in my native language #russian @ASCO, #Russian Society of Clinical Oncology (RUSSCO) & RakFond -as faculty at the RakFond-ASCO Clinical Trial Workshop for Young Investigators in Moscow, Russia. I am a bit nervous! @sloan_kettering.
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Congratulations 🎈 Steve! Dave was my CDA mentor and I am yours. That makes Dave Solit your mentoring grandfather. Make us proud. @SteveMaronMD @DSolit @ConquerCancerFd @MSKCancerCenter @MSK_DeptOfMed
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In pts w endometrial ca (dMMR & pMMR) pembrolizumab +chemotherapy resulted in significantly longer PFS than with chemotherapy alone 74% vs 38% progression free @ 12 mos. Congrats Dr. Carol Aghajanian & team!
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Very cool paper and important reminder that we can learn a lot from well designed correlates of a ‘negative’ clinical trial. @Nature
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Esophageal and Gastric @NCCN guideline includes use of PD-1 inhibitor first line metastatic, CPS>5 and HER2 negative @OncoAlert
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Dinner conversation w my 13 year old daughter. Mama, which is the most powerful white blood cell?#medtwitter how would you answer? #Immunology.
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I enjoyed meeting Japan’s brightest early career investigators at #jsmo2023 and giving my feedback on work in progress and shared challenges in the quickly evolving field of #gastric cancer research. @MSK_DeptOfMed
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Endometria ca:The median OS ⬆️ with lenvatinib+ pembro than with chemo (pMMR: 17.4 vs. 12 mos; HR for death, 0.68; 95% CI, 0.56 to 0.84; P<0.001; overall: 18.3 vs. 11.4 mos; HR, 0.62; 95% CI, 0.51 to 0.75; P<0.001). @NEJM @sloan_kettering
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An unforgettable experience to return to Paris after the challenges of the past 2 years. Thank you @myESMO #esmo2021.
Now #ESMO21 : Results of the CheckMate-649 study of Nivolumab + Ipilimumab or Chemotherapy vs. Chemotherapy alone in advanced gastric and esophageal cancer!! @myESMO @OncoAlert @YJanjigianMD @sloan_kettering
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The future is bright for #HER2 gastric ca pts. @LumishMelissa used 89Zr-trastuzumab PET to identify HER2 heterogeneity in gastric ca pts. Innovative work @sloan_kettering recognized by #ASCO21 Merit Award 🥇 @OncoAlert @LewisLabMSKCC @ConquerCancerFd
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@MSKCancerCenter changed the paradigm in #MSI-H #rectal CA @MSK_DeptOfMed @AndreaCercek presenting 12 mos update of @NEJM data @ plenary w Dr. Baba. With 💯😉 enthusiasm from the audience. 👏🇯🇵🇺🇸🌸🌸🌸@ASCO
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Two days of intense focus on gastric cancer w/added bonus of spending time with my friend Dr. Vivian Strong @IGCCHouston @MansfieldPaul @MSKCancerCenter Photo credit to Sr. Murray Brennan (a famous photographer)
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Mira que guapas (majas dicen acá en España) y felices 😁 —the best part of academic medicine is making friends and learning new languages. #WCGIC2022.
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Happy Holidays from our work family @sloan_kettering @MSK_DeptOfMed to yours. #GIOncology @SteveMaronMD @ImaneDika @MikeFooteMD @debschrag @MSK_GeriOnc @KarunaMDPhD Share your pics- how are you keeping your team together?
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Proud of my love ❤️. A compassionate physician, superb educator& role model to @nyugrossman colleagues. Expert in Point of Care Ultrasound #POCUS honored today by his colleagues with this prestigious award. @BellevueHosp patients so fortunate to have your care
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The brilliant @KarunaMDPhD of @MSKCancerCenter @MSK_DeptOfMed sharing her work using #CRC organoid models to discover new treatments to stop 🛑 tumor metastasis. #SU2C @SU2C
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Congratulations Dr. Abou-Alfa @GABOUALFA. Adding yet another ⭐️FDA ⭐️approval to the long list of your accomplishments. Your dedication to your patients and the mission of @MSKCancerCenter @MSK_DeptOfMed is exceptional. 👏👏👏@OncoAlert
The FDA has approved a combination of #immunotherapy drugs (durvalumab plus the experimental drug tremelimumab) for people with unresectable liver cancer — based on a clinical led by MSK gastrointestinal medical oncologist Ghassan Abou-Alfa.
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20 (69%, 95% CI 49–85) of 29 patients had an objective response
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He did! First day as an attending under his belt. Congratulations @Sam_Cytryn ! It gets easier after today 😉@MSKCancerCenter @MSK_DeptOfMed looking forward to opening more GEC studies in #Westchester.
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Targeting the "undruggable" targets in colorectal cancer #KRASG12C #CRC @MSKCancerCenter @MSK_DeptOfMed @RonaYaeger & @KlempnerSam @FDAOncology @OncoAlert
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I am riding @Cycle4Survival on May 13 2022.@MSKCancerCenter to raise funds for analysis of microbiome/tumor/blood samples from esophagus & stomach cancer pts who developed cancer at a young age. Please support our team #STGI!
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Important interview @nytimes with Dr. Mendelsohn, co-Director of @sloan_kettering Center for Young Onset Colorectal Cancer @manjuggm @CYOC_MSK
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Congrats @RyanMoyMDPhD -4 yrs of fellowship flew by @sloan_kettering. So productive ⭐️⭐️⭐️ K08🙌 and many papers -I am proud of the medical oncologist you’ve become. @columbiacancer is lucky to get you.@SohailTavazoie
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Promising Phase 2 data from Fight study in FGFR2 IHC+ GC. Pts w/ IHC 2-3+ 10% over expression w/ greater benefit. looking forward to seeing additional biomarker data including ctDNA and tumor NGS and need Phase III confirmation. @OncoAlert
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Expresso and croissant with @DocCatenacci @myESMO #ESMO2021 what can be more nourishing before the plenary this afternoon?
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Our mission @MSKCancerCenter is to end cancer for life. Making sure oncologists are aware of our exciting new breakthroughs is critical to improving outcomes for gastric and esophageal cancer patients.
Join us now for the next session at today's #OncologyCongress! Yelena Janjigian, MD (@YJanjigianMD) of @MSKCancerCenter is covering the evolving treatment landscape for gastric & GEJ cancers: #gastriccancer
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Prevalence of Germline Alterations on Targeted Tumor-Normal Sequencing of EG Cancer | Esophageal Cancer @JAMANetworkOpen @sloan_kettering The study supports germline testing in patients with gastric cancer and early-onset EG cancer.
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Trastuzumab Deruxtecan in Previously Treated HER2-Positive Gastric Cancer @NEJM @ASCO @KoheiShitara
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On my way to #TimesSquare. To do my talk in #Immunotherapy in GI tumors. Lots to cover! @gotoPER @donnashort @DrChoueiri @CharuAggarwalMD
Looking forward to this conference with practical tips on application of IO in clinic and management of tough clinical cases! Still not too late to join! @DrChoueiri @MattGalsky @RobertFerrisMD @YJanjigianMD Drs. Sznol, Weber and Emens!.#GoToICIC #gotoPER @donnashort.
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@KoheiShitara visit to @sloan_kettering 2 years ago. The world 🌎 felt so small and well connected. Collaborations and ideas came so naturally—including a positive global Phase 3 CM649 study. These friendships and global connections are key!
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The 13th Annual meeting of the Chinese GI OncologyGroup(CGOG). Wonderful to be back in beautiful Beijing to build collaborations with bright minds from all over China. Touring Peking university cancer hospital today! @MSKCancerCenter @MSK_DeptOfMed
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In Destiny-Gastric03TDxd+5FU/pembro study 85% HER2+ tumors are also PDL1+ -further confirming the importance of dual anti PD1/HER2 blockade. Notably 20% of tumors tested HER2+ at local hospital were HER2- centrally-- highlighting the #EGcancer heterogeneity. @OncoAlert
In this video, @YJanjigianMD, @MSKCancerCenter, discusses findings from a preliminary biomarker analysis of the ongoing DESTINY-Gastric03 trial. @ESMOWorldGI @myESMO #WCGIC2022. Watch the video:
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No benefit w/ Avelumab Maintainence strategy in 1st line #gasticcancer. The OS curves cross at 9 mos. almost identical to 1st Pembro data. @ASCO #GI20 @OncoAlert
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The spirits are high at work today @MSKCancerCenter @MSK_DeptOfMed Team #STGI will ride today to raise funds for @Cycle4Survival rare cancers! Come cheer us on tonight @Equinox on 61st! @CowzerDarren @ImaneDika @MikeFooteMD @lori_janjigian
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Another night of hugs and awards. This time focusing on the future of our mentees! @Sam_Cytryn @MSK_DeptOfMed @ConquerCancerFd @ASCO @MSKCancerCenter @DSG_MD YIAs and IDEA mentees.
Many many congratulations-@ferguskeane2 @YJanjigianMD (Chief & mentor) @DrSamuelCytryn - very talented MSK oncology Fellows - Conquer Cancer Young Investigator and Merit awards!@MSK_DeptOfMed @MSKCancerCenter @CentralParkWMD
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Thrilled to support & celebrate the 2024 @ASCO @ConquerCancerFd YIA and IDEA awardees in GI onc! Honored to work with these talented physician-scientists @MSKCancerCenter Creating a supportive environment for them to thrive is what it's all about. #ASCO24 #GIOncology
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Thank you @NYCHealthSystem @BellevueHosp for vaccinating my girls! Feeling relieved and proud. My daughters felt strongly about getting vaccinated ASAP and asked me & @janjim01 to take them. #bellevuestrong #Vaccine #covid19
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~7% EG adeno are EGFR amplified. Difficult subset to study b/c EGFR MABs flopped in unselected Phase IIIs. Dr. Maron & team showed clinical benefit with EGFR inhibition in pts w/ EGFR amp EG ca. @SteveMaronMD @JCO_ASCO @MSKCancerCenter @MSK_DeptOfMed .
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A breakthrough for esophagus and stomach cancer patients Top 5 of #Science advances by @sloan_kettering in 2021 #WomenInSTEM @ECActionNetwork @DeGregorioFF @NoStomach4Cancr @StomachCancer_.
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Today’s Spotlight on @sloan_kettering #PancreaticCancer dream team. Dr. Balogun @FiyinfoluB and the superb care coordinator Afua Awuah. Extra ⭐️⭐️⭐️ for the stylish attire. #Wednesdayvibe
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On my way to Debbie’s Dream Foundation 10th Annual Gala to accept the 2019 Tree of Life Medical Award! I am honored and humbled by the work that is being done by the Foundation to help pts, raise awareness and funds to #stopcancer #stomachcancer.@StomachCancer_ @sloan_kettering.
On May 4, 2019, Debbie's Dream Foundation will celebrate a decade of supporting patients, caregivers, and families and raising awareness and funds for stomach cancer research at our 10th Annual Dream Makers Gala. Come.
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Thank you @sloan_kettering GI oncology advanced practice providers 💜❤️💜 National #APP week!
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Spending quality time @AACR #AACR22 #nola with the newest faculty joining @MSKCancerCenter @MSK_DeptOfMed GI Oncology group! Welcome to the #STGI family. @MikeFooteMD @BenjcRousseau. The future is bright ⭐️⭐️⭐️⭐️
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Zanidatamab (ZW25) monotherapy, & in combo w/ taxol or 5fu based therapy in HER2+ GC. 33% ORR monotherapy is promising! Watch out for diarrhea, it's been an issue IMO. Love ❤️ the renaissance of #ERBB2 gastric cancer field. The more options the better for our pts. @OncoAlert
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Check out our recent commentary in @Cancer_Cell @wolchokj @sloan_kettering @CharlotteAriyan Eradicating micrometastases with immunecheckpoint blockade: Strike while the iron is hot.
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Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRASG12C Mutation. Congratulations @RielyMD and many others @MSKCancerCenter @MSK_DeptOfMed Looking forward to publication of #CRC data @RonaYaeger
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Congrats Dr. Makker @sloan_kettering Well done 🤩 pembrolizumab+ lenvatinib Significantly Improved PFS and OS vs. Chemotherapy in Patients With Advanced Endometrial Cancer Following Prior Platinum-Based Chemotherapy in Phase 3 Study
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With the #pianorecital behind me I can finally focus on my @ASCO #GI20 talk! Biomarkers to Guide Surveillance and Adjuvant Therapy of Early-Stage Disease. See u in SF @Daniela_Molena @KlempnerSam
My piano teacher today: ‘ah. I can see that you submitted your grant’. R01 is in! The off target effect of scientific research. Get out of your comfort zone. #metronome
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Excited to have HER2 PET trial completed and published. Preclinical work began a decade ago with @LewisLabMSKCC & supported by @DeptofDefense & @ConquerCancerFd Kudos to @LumishMelissa @SteveMaronMD organizing & publishing this story. @MSKCancerCenter @MSK_DeptOfMed.
Our latest. lead by @YJanjigianMD. Noninvasive Assessment of Human Epidermal Growth Factor Receptor 2 (HER2) in Esophagogastric Cancer Using 89Zr-Trastuzumab PET: A Pilot Study
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So nice to share the podium at #ASCO24 with my colleague and friend @VickyMakker. Feels like just yesterday we were fellows together! @MSK_DeptOfMed @MSKCancerCenter
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#California dreaming ☀️☀️☀️about the next steps with upcoming projects & collaborations. Thankful for the opportunity to do this with @SU2C #SU2C @MSKCancerCenter @MSK_DeptOfMed
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@MSKCancerCenter we use PDL-1 PET to help direct next generation of immunotherapy clinical trials in gastroesophageal cancer to help more patients. Great paper by @Sam_Cytryn in collaboration w/ Lewis lab @LewisLabMSKCC @MSK_DeptOfMed
Can we measure programmed-death ligand 1 status in gastroesophageal cancer with PET? #NuclearMedicine #GastricAdenocarcinoma #PETscan @MSKCancerCenter @Sam_Cytryn @YJanjigianMD
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#NursesWeek #NursesDay2020 #ThankYouNurses @sloan_kettering #Throwback to pre #COVID19. we ❤️❤️❤️❤️ our nurses. Their strength, professionalism and expertise continue to inspire!
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GI oncology @GreatDebatesCME going strong for 20+yrs. Save the date for March 22-23 2025 #GDGI date in NYC!
Look at this amazing group for @GreatDebatesCME #GDUGI Day 1. PHENOMENAL speakers. 🙏🙏 🤩@YJanjigianMD @rachnatshroff @HKennecke @smitha42 @MallaMidhun @smitha42 @KristenCiombor @RyanMoyMDPhD @DrJZell ❤️ this group!!! #cancer #canceresearch
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Come to NYC on January 26 and join our @MSKCancerCenter @MSK_DeptOfMed GI Oncology crew in a LIVE session with FREE registration. All star line up @EileenMOReilly @GABOUALFA @MikeFooteMD and more! @OncLiveSOSS @OncLive @donnashort
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Mission accomplished!! Memorable night with @MSKCancerCenter @Cycle4Survival riding together for a common cause. Thank you to all the riders and supporters ❤️@RyanMoyMDPhD @SteveMaronMD @ImaneDika @W_Park_MD @MikeFooteMD
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Great experience working with @TheLancet team and my colleagues @KoheiShitara @BMS_ImmunOnc_US publishing this data @OncoAlert @sloan_kettering.
#Nivolumab plus chemotherapy shows superior OS, PFS benefit, and acceptable safety profile—compared to chemotherapy alone—in previously untreated advanced gastric, gastro-oesophageal junction, or oesophageal adenocarcinoma. 🔗 by @YJanjigianMD et al.
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In Japan Phase 2 DESTINY-Gastric01 Trial of DS-8201 Versus Chemotherapy Met Primary Endpoint!!!⭐️⭐️⭐️.Biggest deal in HER2+ #gastriccancer. US study is on the way @sloan_kettering .
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Exciting early data in 11 pts 61% ORR in heavily pretreated gastric cancer w claudin 18.2 CAR-T CT041. Over half of claudin 18.2 expression high are in non -signet ring tumors. No grade 5 events. Is PFS 5.6 mos really worth the trouble -hope we can do better in earlier lines?
Chanel 4 @myESMO #ESMO21 @LizzySmyth1 chairing Upper GI Oral session tune in to check out Claudin 18.2 @CARsgen_Ther Car-T data in gastric cancer.
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