Charu Aggarwal, MD, MPH, FASCO
@CharuAggarwalMD
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Leslye M. Heisler Professor of Lung Cancer Excellence @PennMedicine | AD @PC31 | #CCC Chair @ASCO | Tweets my own | COI: https://t.co/ghKU8KhBvl
Philadelphia, PA
Joined June 2018
Effective July 1, you can call me PROFESSOR Aggarwal!🌟🌟🌟 . Thrilled to have been promoted @Penn. I could not have done it without the incredible mentorship and collegiality of my colleagues @PennMedicine @PennCancer (and worldwide). Special thanks to all the letter-writers and
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Humbled and honored to be appointed Section Chief for Lung/HN cancer @PennMedicine @PennCancer! Grateful for all the mentorship and support, and excited for what the future has in store with exceptional colleagues @CoreyLangerMD @MMarmarelis @LovaSunMD @AditiSinghMD @CCiunci
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I don’t get to update my profile often, so this is FUN!! . Thrilled to be joining the @PennPrecisMed team as Associate Director to advance the footprint of #PrecisionMedicine across @PennMedicine . @PennCancer @PennMDForum .@david_b_roth2 @kevinbmahoney @jonepstein1
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Promoted to Associate Professor @PennMedicine @PennCancer! . So amazing to hear+see the news in my office with a congratulatory message from @lynn_schuchter and colleagues in the division of hem onc! Grateful for my mentors, advisors, family and letter writers. #Yay!!!!
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Hi, I’m a medical oncologist. You might know me from my greatest hits “Sugar doesn’t feed cancer” “Vitamin C doesn’t cure cancer” And the chart topping “Palliative therapy doesn’t mean giving up. ”.
Hi, I’m a senior engineer. You might know me from my greatest hits “but *why* is it null?” “There is greater honor in deleting code than in writing more” And the chart-topping “let’s just walk over to them and ask”.
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So honored to receive the “Woman Disruptor of the Year Award” today- thank you @HemOncToday for the wonderful recognition! .@PennCancer @PennMedicine @PennMDForum @ShikhaJainMD @marklewismd @WimedicineOrg
Breaking barriers & shattering ceilings is what the Woman Disruptor of the Year is doing 💁♀️.The award, presented with @WimedicineOrg, goes to @CharuAggarwalMD! 🏆.Dr. Aggarwal is leading & setting the tone for successful careers with meaningful advancements. Congrats! 🎉
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Tonight I was appointed the inaugural chair holder of the Leslye Heisler endowed professorship @Penn @PennCancer to support research in #LungCancer. I am incredibly honored, humbled & grateful to the Heisler Family for this gift, and for everyone who has supported me. #CureCancer
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Few words of wisdom from Dr. Fauci regarding cancer care and #cancer screening during the #COVID19 pandemic @PennMedicine @PennCancer
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Ready to #ConquerCancer - headed to Chicago! #ASCO22 @ConquerCancerFd @ASCO @PennMedicine @PC3Innovation @PennPrecisMed
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Prioritizing speaking opportunities as a parent of young kids is super hard, especially in academic medicine. But, these are the moments that are worth it! We have a Swim Champion in the family! 🙌🏽.Won’t miss this for the world! #ProudMom #WorkLifeBalance @WeAreWLO @WomeninOnc
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5-year outcomes with first line pembrolizumab c/w chemo in patients with #NSCLC PDL1>50% published in @ASCO_pubs #JCO .✴️Median OS doubled (26.3 vs 13.4)!.✴️5 year OS rate 31.9% vs 16.3%!!.✴️Benefit seen despite 66% crossover!!!.@MartinReck2 @JulieBrahmer @LealTiciana #LCSM
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Thrilled to be leading efforts across @PennMedicine to advance the footprint of #PrecisionMedicine and lead efforts in Precision Oncology Innovation @PC3Innovation @PennPrecisMed @PennCancer. Humbled, and stoked for what the future has in store! @HemOncWomenDocs.
We congratulate PC3I Faculty @CharuAggarwalMD on her appointment as Director of PC3I’s Program in Precision Oncology Innovation. 🔍Learn more about Dr. Aggarwal: .➕Follow us to hear more about our work in #precisiononcology #innovation.
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Are you even going to #ASCO23 if you don’t have a #PlaneSelfie? ✈️ . Ready to #ConquerCancer @ASCO! See you all in Chicago! @ASCOPres
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My husband and I continue our #COVID19 journey with some de-stressing moves. As we close out the Easter weekend, sharing some levity before we all return to work tomorrow. #COVID19 #Oncologists .@ASCO @drdonsdizon
My husband like me, is an oncologist. Like our colleagues, we are anxious & grieving. But we’re learning new ways to de-stress. With one foot in front of another, we will show up, and take care of our pts when they need us most. A little levity in the time of #COVID19.@ASCO
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So honored to have received #FASCO today, and be able to share it with so many dear colleagues and friends. It’s an honor to serve @ASCO in its mission! . @PennCancer @PennMedicine @PennMDForum @OncoAlert
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#ASCO22 was amazing, but nothing, nothing beats time at the pool with my kids! Happy Saturday Morning! Hello weekend! @ASCO @HemOncWomenDocs
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Beautiful, eloquent and poised discussion of #LAURA by @LeciaSequist emphasizing the importance of PFS benefit in this population, preventing morbidity from CNS Mets while balancing the issue of cost, QoL and biomarkers 👏🏽🫁.@ASCO #ASCO24 @OncoAlert
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We know that #ComprehensiveMolecularGenotyping is essential in patients with advanced #NSCLC - but do we know if availability of results impacts #Survival? .In a real world cohort study, we asked this question.@MMarmarelis - out now in @JCOPO_ASCO @ASCO .👉🏽
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It's publication Friday! Excited to share the results of @PennCancer study on role of serial monitoring of #ctDNA #NGS as a biomarker of response in pts receiving pembrolizumab based therapy for 1L met #NSCLC published in @ASCO_pubs #JCOPO #LCSM .
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There are many gaps associated with #Biomarker Testing in #NSCLC. Striking to see that using commercial and medicare claims data, approximately 64% of potentially eligible pts do not get personalized therapy! . @JCOPO_ASCO .
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SO excited to co-chair @PennCancer’s #COVID19 and Cancer Conference, with Dr. Fauci as our guest speaker!!. I am honored and humbled to lead a Q&A session with Dr. Fauci with Dr. Vonderheide, in what promises to be an amazing evening. Woohoo!.
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Congratulations to @jillfeldman4 for being awarded the patient advocate award this year @ASCO #ASCO24 - we are so lucky to have your wisdom, candor and friendship! .@EGFRResisters #LCSM @OncoAlert
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A group of my closest pelo-oncers convinced me to get this shirt. Can’t say I don’t love it! 🚴 🏃🏾♀️ 💜.#WomenInOnc @onepeloton
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Roses are red, violets are blue,.I submitted my @ASCO abstracts, have you. #ASCO23 #ValentinesDay #Oncology
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Overheard this conversation b/w my girls this morning:.3 yo: I want to be a doctor when I grow up, just like mama. 5 yo: I don’t know, I want to be a mama when I grow up, just like mama. I like both options! I guess I’m doing something right! #parenting #WomenInmedicine.
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En route to @myESMO #ESMO23! Looking forward to an exciting meeting with an impactful scientific agenda with practice changing implications in #LungCancer. Can’t wait to connect with friends! Madrid, see you in 7 short hours! 🇪🇸
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Thankful and incredibly grateful to have received the #CovidVaccine today @PennMedicine #COVID19 .#Igottheshot
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Nothing more brutal than a manuscript rejected after *third* round of extensive revisions. Nothing. 😒 .Happy Monday #MedTwitter.
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Our paper exploring the value of plasma tumor mutation burden (#TMB) as a biomarker in #NSCLC pts receiving #pembrolizumab based therapy, including chemo-immunotherapy came out online @CCR_AACR today. Why this may be important?.(1/6).@EricaCarpenter1.
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5 year update of PACIFIC data being presented @ASCO #ASCO21. Using consolidation #Immunotherapy, with one year of duevalumab, substantial % of pts are alive at 5 years 42.9% vs. 33.4% #LCSM
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My amazing AA made a folder for #ASCO22 including an annotated map of the conference hall and the exhibit booths! 😮 So grateful to have a rockstar supportive team who understands the craziness of @ASCO AM w/o even being there! @PC3Innovation @PennPrecisMed @HemOncWomenDocs
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Today, I kneeled in silence with other members of @PennMedicine @PennCancer @Penn in support of #BlackLivesMatter #WhiteCoatsForBlackLives
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Let’s take a minute. Have we seen anything like this in NSCLC before? mPFS NR at 5 years? 👏🏽👏🏽👏🏽👏🏽. These curves are very impressive, and should urge us to think about management of AEs and optimize 1L Tx for ALK+ NSCLC. @ASCO #ASCO24 @ALKPositiveinc @OncoAlert @bensolomon1.
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#ASCO24 News Planning with @ASCO Cancer Communications Committee today! . Thanks to this group of volunteers for the incredible effort to create a fantastic press program for the AM. Lucky to have had @elmayermd, immediate past chair guide me in this role of CCC Chair and look
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#TumorBoardTuesday .Why is it important to #test? .- Survival has increased tremendously!.- We have a real chance to offer personalized therapy to our patients!.- lower toxicity! .#LCSM #LungCancer #BiomarkerTesting
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.@HosseinBorghaei was celebrated today amongst friends and family @FoxChaseCancer as he became the inaugural Gloria and Edmund Dunn chair in Thoracic Oncology. I was honored to be invited to celebrate and humbled to call him my friend. Congratulations Hoss!
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KRAS inhibitors are finally here!. ➡ Not one, but 4 other drugs are in clinical trials, w/ others being developed. ➡ There is an impact of co-MT, including STK11/KEAP.➡ Future lies in combination therapies, in trials now.#WCLC20 @IASLC @kRasKickers
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This! #Election2020 .Historic results. First woman Vice President, first woman of color, first president elect with >70mil votes! .#TimeToHeal #Timetocelebrate
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Final OS analysis of J-ALEX.Alectinib vs Crizotinib. ✴️ No significant OS difference.BUT .✴️ Majority of patients crossed over to alectinib (~78%). @ALKLungCancer @alk_fusion @ASCO #ASCO21 @OncoAlert
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I am reviewing #ASCO21 @ASCO top abstracts across categories in #NSCLC. Next up, #Immunotherapy #LCSM. Links here 👇.9000 - 9001 - 9016 - 8511 - .8512 -
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Plasma based genotyping can increase detection of molecular alterations in patients with #NSCLC - and we are building upon this observation ( .Working w/ Drs. Jeff Thompson and @EricaCarpenter1, we are continuing to move the front door. (1/6).
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#ASCO23 @ASCO #LCSM CSS .Combination chemotherapy with #gefintib #osimertinib . ✨ started with G—>changed to O.✨ N=501, ex19 del or L858R.✨ mPFS 18mo, p=0.005.✨ O arm mPFS 25.2 mo.✨ OS NOT better!! . @EGFRResisters @OncoAlert @LungCancerRx
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Let’s take a minute. Have we seen anything like this in NSCLC before? mPFS NR at 5 years? 👏🏽👏🏽👏🏽👏🏽. These curves are very impressive, and should urge us to think about management of AEs and optimize 1L Tx for ALK+ NSCLC. @ASCO #ASCO24 @ALKPositiveinc @OncoAlert @bensolomon1.
Not to steal the thunder from the oral session today, but this is the CROWN PFS curve, more or less flat between 2-5 years and still 60% progression free at 5 years! #ASCO24 #LCSM. Is it worth the side effects of lorlatinib to turn ALK+ NSCLC into CML?
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Thrilled to see "Aumolertinib in EGFR-Mutant Lung Cancer: Will the Promise of Cost Disruption Ease Access?" in print. We discuss implications for clinical trial design, and cost, and access - with the brilliant @oncology_bg out in @JCO_ASCM #LCSM.
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Sexual Harassment in Oncology. For anyone who thinks this doesn't happen in medicine, I urge you to look at this study from @IshwariaMD @DrMarkham @DrSGraff @JuliaLClose @luvpooh101 @reshmajagsi et al, detailing the incidence (70%!!!!) and outcomes #ASCO21 .@HemOncWomenDocs
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Voting for the @ASCO Election is now open. I am honored and humbled to be running as one of the candidates for the Nominating Committee, alongside many talented friends and colleagues. Visit to learn more about the candidates and place your votes!.
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#ASCO23 @ASCO.KN671 - 1st IA: Periop ChemoIO + Adj IO. Dual endpts EFS/OS.N=797–>397 in P. ✨~40% completed adj tx .✨1/3rd split across PDL1 levels.✨EFS HR=0.58, mEFS NR w P.✨OS HR=0.73. @OncoAlert @ASCOPost
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Molecular Testing in Early Stage NSCLC .@JAMAOnc @JackWestMD and I discuss that it is most appropriate to get comprehensive NGS in early stage NSCLC where systemic therapy is indicated. #LCSM #BiomarkerTesting.
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Humbled to have been part of the @ASCO Nominating Committee process with @ASCO leaders as we gear up for the annual ASCO Election! Another successful day at #ASCOHQ . @ASCOPres @lynn_schuchter @DrEricWiner @cardismith @rachnatshroff @montypal @KimmieNgMD @NehaVapiwala Drs. Eric
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Probably the best infographic GIF I have seen on the #COVID19 epidemic. We must all do our part #HandWashing #Containment #FlattenTheCurve .
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Meta-analysis of AEs post #Immunotherapy w aPD-1/PDL-1 ~ 20k pts, 66% w/ at least 1 AE, 14% >= G3 AE. Sobering reminder that even though overall irAE #pneumonitis was 2.7%, and >= G3 was only 0.67%, it was the cause of death for 28% of the cases! #OncoAlert #LCSM @JAMAOnc.
Comprehensive meta-analysis of 125 trials treating w anti-PD-1 & anti-PD-L1 inhibitors across a broad range of cancers reveals patterns of observed toxicities & significant differences among different checkpoint inhibitors #immunotherapy.
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“I can’t be your mentor without occasionally being your tormentor” - another gem from @TedLasso .Happy Weekend, everyone! #Believe @MedLasso @TheRealDoctorT @ETSshow.
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We are so proud to be part of “House of Lynn” @ASCOPres @ASCO #ASCO24.Grateful to have fantastic leadership in the house @AngieDemichele @PennCancer @PennMedicine @PennMDForum @OncoAlert @PC3Innovation
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I’m a doctor. I’m worried. For my patients. For my family. For my friends. For nurses. For dozens of health care workers. For myself. @Philadelphia: Do your part .#SocialDistancing #StayatHome .@PennMedicine #COVID19 #LCSM.
"My advice is that universally people should assume that they could be carrying the virus." Dean J. Larry Jameson, MD, PhD, spoke with @phillymag on why #socialdistancing is so important. Stay home to keep yourself and others safe.
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Getting ready for @IASLC #WCLC19!.Which data are you most excited to see? I’ll start (in no particular order):.- tTMB in KN21, KN189.- Neg predictor MT in plasma for response to IO (MYSTIC).- plasma TMB in chemoIO .- CASPIAN: durva+EP in SCLC.- FLAURA 3 .#OncoAlert #LCSM
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Hang in there everyone!! #InThisTogether .#StayHome #WashYourHands.#COVID19 . @theweeknd inspiration for the #Weekend
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Those who cannot learn from history are doomed to repeat it. Yet those who *do* study history are doomed to standby helplessly while everyone else repeats it. We must learn from 1918, and from Italy.#InItTogether .#SocialDistancing #COVID19
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Lung Plenary #LAURA Osi in Stage III unresectable #NSCLC - amazing results and will definitely affirm my practice to deliver targeted tx for pts w/ EGFR Mutation @EGFRResisters .mPFS 39.1 vs. 5.6 months, HR 0.16.Well done, @RamalingamMD and investigators @ASCO #ASCO24
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Wonderful to catch up with friends and gearing up for a great #ASCO23 with fantastic leadership @ASCOPres @lynn_schuchter @AngieDemichele @tomleblancMD @SoniSmithMD @ASCO
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FDA Approves New Pembrolizumab Dosing Schedule, this is really impactful in the #COVID19 era, and will help us minimize exposure for patients with #NSCLC #LCSM @OncoAlert .
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It’s only been half a clinic day, but so far ALL my patients for this morning have been fully vaccinated. 💪🏽👏🏽#COVDID19 #Hope #VaccinesWork.
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Thrilled that our RCT #TESTING is enrolling! .Funded by @theNCI, this trial will answer an important question about the introduction of "early liquid bx" in NSCLC and patient education via Telehealth #BiomarkerTesting #LCSM #NCT05790460.@kate_rendle
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New report of Exon 16–Skipping HER2 as a mechanism of resistance in #EGFR L858R/T790M+ #NSCLC post-osimertinib; very important to remember to obtain molecular sequencing at the time of PD.@JTOonline #LCSM .
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Leaving @myesmo @IASLC #Prague with a full heart- so amazing to see old friends & new and hear advances in #LungCancer! #ELCC24 .@danieltanmd @AnneTsao2 @JhanelleGray @ReckampK @JoeChangMD @PC3Innovation @PennCancer
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#Biomarker Testing for #NSCLC. ➡️ Only a third to half of pts getting tested for EGFR/ALK/BRAF/ROS .➡️ Only 50% tested within 30 days of new dx.➡️ Median test to treatment ~ 16 days. While there seems to be a trend towards improvement, we NEED to do better!.#LCSM .@IASLC #WCLC20
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Honored and humbled to be accepted into the @ASCO Leadership Development Program ‘19-‘20. Looking forward to a year of learning from the best, and to connect with friends, mentors and colleagues who have been previous #asco_ldp participants! @PennCancer.
Congrats @VamsiVelcheti @DrSGraff @PGrivasMDPhD et al on joining the @ASCO Leadership Development Program. Its a great learning experience!.((Use #asco_ldp to connect w prior (and future) participants! )).
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#ADRIATIC - new standard of care in #SCLC, where we have not seen an advance in >2 decades. Truly historic data with use of immunotherapy consolidation #LungPlenary @DavidRSpigel @LaurenByersMD .@ASCO #ASCO24 @OncoAlert
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Before we all continue to pile on #ADAURA, can someone tell me % of patients who received Immunotherapy upon progression on IM-010 or KN-91. See figure. I will remind you that immunotherapy alone or in combination is THE SOC for 1L Metastatic NSCLC. How come we don't see that
Hey @JackWestMD, did you already see p25 of the #ADAURA supplementary appendix? Curious of your thoughts given 88% of pts in the placebo arm who developed progression and were fit enough to get more tx got a TKI. #ASCO23
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Going Live for #TTLC22 in less than 5! Tune in to our Immunotherapy Session live now! @IASLC #LCSM.@LeciaSequist @DrRoyHerbstYale @RamalingamMD @HwakeleeMD
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Bad scans are hard for oncologists too.
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So proud of @PennMedicine Internal Medicine Housestaff. They are compassionate, caring, deliberate and kind in the face of uncertainty. Presenting to you #Ninjas of inpatient oncology @PennCancer. Humbled to work with each one of them @PennMDForum. #InThisTogether .#COVID19
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Thrilled to serve as a Meeting Co-Chair alongside @LeciaSequist @RamalingamMD @DrRoyHerbstYale and Dr. Bunn. Looking forward to reinvigorating the #SantaMonica Meeting #TTLC22 .back to in person (🤞🏽). @IASLC #LCSM @KristinRicheim1 . Save the date(s) 👇🏽.
@IASLC #TTLC22 Meeting Chairs invite you to Save the Date for this dynamic meeting (Feb 23-26). Presenters will summarize data on relevant targets for new therapies & preclinical/early clinical data for ea. of the drugs directed against these targets #LCSM
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So much GREAT science being presented @ASCO #ASCO23. Check out @OncoAlert @imedverse @ASCOPost @HemOncToday for updates!. #LCSM
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I am hopeful for a better future for my fellow Americans, my patients and my family. I voted today to make my voice heard. Have you? #MakeAmericaKindAgain #VOTE
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#OncoAlert phase III KN48 data just presented at #ASCO19 Pembro Improves OS against EXTREME with or w/o chemo, in pts w/ PD-L1 CPS>1. RR higher when added w/ chemo, but so is toxicity. Emerging clear standard to go with P, PC—> I have reservations given high tox #HNCSM
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I was shocked to read the @TheCancerLetter piece today. Heard from many colleagues that this behavior was known in the field and went on for years. Years. Check out this abstract on findings of sexual harassment of oncologists @ASCO #ASCO21. We need to do better.
.@theNASEM “Iceberg” provides the critical framework around which we reconcile our perceptions and understanding of #sexualharassment. The egregious cases make the news but we’re here to address that COMPLICIT OCEAN that keeps this ENTIRE ICEBERG afloat.
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Fantastic women in oncology session @IASLC #WCLC22.Missed a pic w/ @karenkellymd.So good to connect with women leaders! @HwakeleeMD @NarjustFlorezMD @clarissamathias @ElaineShumMD @RachelSanbornMD @NaglaAKarimMD
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T4. In the future, we will be using liquid biopsy across the spectrum of #LungCancer management including screening #LCSM
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Celebrating the success of #TTLC23 in a different way! Cheers! @IASLC .@LeciaSequist @JoelNealMD #LCSM
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You know your patients KNOW you, when they bring you homemade snacks to get through the day! .I am always humbled by my patient’s generosity #LCSM @PennMedicine @PennMDForum @PennCancer
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#ASCO23 @ASCO.#CHRYSALIS.✨N=108, Med f/u 10.2 mo.✨101 evaluate.✨ORR 30%, mDOR 10.8 months.✨ mPFS 5.7 months.✨ ORR 61% vs 14% in MET IHC+/-. @EGFRResisters @OncoAlert @BenjaminBesseMD @Jbauml
#ASCO23 @ASCO .👇🏽Today at Opening #LCSM CSS .#CHRYSALIS. Important Question: METIHC or FISH in Progression on Osimertinib in #EGFRMT #NSCLC . @BenjaminBesseMD @Jbauml .@OncoAlert @HemOncToday @LungCancerRx.
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Kicking off #WCLC22 with @IASLC president @HwakeleeMD Karen Kelly in #Vienna #LCSM @LeciaSequist @KHigginsMD @triparnasen @ChristianRolfo @danieltanmd
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I LOVE daylight saving time Sunday morning. Said NO one.
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Plasma based NGS testing is now considered standard of care for testing of molecular mutations in #NSCLC. Terrific start to the day #LiquidBiopsy20 @drgandara discusses approvals of current assays including @GuardantHealth and @FoundationOne #LCSM @IASLC
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