Valerie Chew
@Valeriechew29
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PI, Cancer immunology lab, liver cancer @Singhealth . Assoc Prof @DukeNUS
Singapore
Joined April 2018
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Have been waiting for this for a long time and finally I've made it to Assoc Prof! Thanks to all the people who make this possible. Special thanks to
@dukenus
who provided me the opportunity to grow and shine and putting such a nice ceremony to celebrate this milestone!
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Dictionary of immune response to cytokines. On the way to build a full immune dictionary bits by bits with single cell data!
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Woman power in liver cancer research!
#GirlPower
#EASL
#LiverCancerSummit
@LorenzaRimassa
@analleo
@ma5RN
@SherrieBhoori
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Wow! WGS data from 13,880 solid tumors spanning 33 cancer types, integrating genomic data with real-world treatment and outcome data!
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Our most recent study showing key biomarkers for response and irAEs to anti-PD-1 treated HCC patients. We also discovered combination immunotherapy with anti-PD-1 + anti-TNF2 that enhances response without increasing irAEs.
#HCC
#immunotherapy
@ILCAnews
@SgSI35993969
🆕Article in press❕
Uncoupling immune trajectories of response and adverse events from anti-PD-1 immunotherapy in
#hepatocellularcarcinoma
🔓
#OpenAcces
at👉
#HCC
@Valeriechew29
#LiverTwitter
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Interesting study published in jhep! Spp1 is important in forming tumour immune barrier dampening response to immunotherapy.
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Very proud of my team member, Aldo Prawira, being awarded with the top basic science poster at
#ilca23
.
#hcc
#nash
#spatialtranscriptomics
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1
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Nice first day sessions at
#EASL
#LiverCancerSummit
2024 in
#Rotterdam
. Just delivered my first ever state of the art talk and enjoyed the discussion with fellow colleagues tremendously!
@valerie_paradis
@valerievilgrain
@TimGreten
@Zucmanrossi
@ma5RN
@masatoshikudo
.
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Congratulations to my PhD student for her successful PhD thesis defense today! I'm so proud of Yun Hua Lee for her hard work and dedication studying the rare immune subsets in HCC. She graduates with 5 papers (4 research articles n 1 review) published. Well done!
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Impressive result from Keynote 189: Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer by Prof Marina Garassino in Best of Asco (BASCO) 2019 Singapore.
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Fresh out. Our study on hypoxia-induced immunosuppression by Treg and cDC2 interaction in HCC. Another important consideration in immunotherapeutic design for highly hypoxic HCC.
#hepatology
#HCC
#hypoxia
#cancerimmunology
#ILCA
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For all the amazing women I know from work and personal life. Last one is my most amazing mum! U r beautiful, wonderful, amazing. Happy international women's day
#IWD2024
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We are so grateful for the Forbeck cancer forum on liver cancer that brings together experts in the field to discuss the future of HCC therapy. It was such an intimate meeting deep dive into the science n clinical knowledge of HCC
#livercancer
#forbeckforum
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Honoured to speak on the immunology of radiotherapy in HCC at such a big meeting co-organised by Asian Oceanian Congress of Neuroradiology, Singapore Congress of Radiology and Interventional Radiology Education Singapore. Opening address by our Minister of State for Health!
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Ending the
#sgsi2024
with a fun
#speakerdinner
to thank our distinguished speakers traveling from far and near to give their excellent talks.
@junsionglow_
@StJohnLab
@FGinhoux
@Lab_AmitSinghal
@BaptisteJanela
@chrisruedl
@SgSI_Immunology
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Great
#apple2024
faculty dinner at
#honolulu
#Hawaii
#Battleship
#MissouriMemorial
. Thank u arranging for this meaningful n historical location for our dinner
@GABOUALFA
. Happy to see my friends and colleagues again!
@docamitgs
@StephenLChan1
@ChiunHsu
@changhoon_yoo
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Showing my overseas guests the delicious Singapore delicacy hainanese chicken rice!
@CancerInflam
@cw_lab
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I was so honoured to be sharing a taxi ride to airport today after
#apasl2023
with Prof
@WRayKimMD
. I was so embarrassed for not knowing how big a superstar he is in hepatology. Yet he was so very kind and humble. We shared a great conversation and certainly hope to meet again!
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A timely single-cell analysis on neutrophils in liver cancer!
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Poster session day 1
#ilca23
with
@valerie_paradis
and Prof Young Nyun Park! It's most fun to be meeting old friends at ILCA meeting to catch up over science!
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Key 5 key aspects of AI algorithm for liver cancer: Extractable, Accurate, Reproducible, Portable and Interpretable; by
@AshleySpannMD
.
#ILC2022
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Begin my journey serving as advisory board for the prestigious
@NatRevGastroHep
. Hoping to bring more relevant and important topics on gastro and hepatology for the journal.
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What an eventful
#ilca23
with more intimate interaction with friends and colleagues working on liver cancer. Great leadership from
@Zucmanrossi
Tim Mayer and
@augustoNYC
for putting up an excellent program this year. Look forward to see u all next year at ilca 2024.
#teamsg
#hcc
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This year,
#ILCA23
honors Prof. Valerie Vilgrain for her remarkable contributions to liver cancer research as a female radiologist-an inspiration to young researchers, especially women!
#WomenInSTEM
We're proud to honour the outstanding radiologist Valérie Vilgrain with the Nelson Fausto Award 2023 and 4 exceptional individuals with the Junior Investigator Awards. 🏆
Thank you all for your remarkable contributions to advancing
#livercancer
research.
Follow
#ILCA23
for
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Thank u for bringing me to beautiful
#Kyoto
for
#apasl2024
. It's lovely weather these two days with great friends and colleagues in and out of the meeting. Always happy to speak about
#tumourmicroenvironment
#immunelandscape
of
#hcc
as it is my passion!
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Really honoured to receive this award, nicely bubble wrapped n shipped to my office this morning.
#Gilead
#liverdisease
#gileadresearchscholars
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Anti-TIGIT antibody improves PD-L1 blockade through myeloid and Treg cells
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Fresh online: our study shows the peak of immune evasion at intermediate-stage of HCC, offering insights into strategic timepoint therapeutic intervention.
@SgSI35993969
@ILCAnews
0
5
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Fascinating tumour slices as a patient derived tumour tissue model for drug testing including for immunotherapy!
@shilpachokshi
#EASL
#LiverCancerSummit
2024
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Delighted to share the research highlight I have been invited to write on the study published in Cell Research by Prof Liang Wu and Jian Zhou's team, using spatial transcriptomic analysis to decode the biology of the invasive tumor margin in liver cancer.
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Ending
#2023
with Swot analysis n a fun board game with my team. So proud of the team I built, who see more strengths n opportunities than weaknesses n threats. May
#2024
bring more success and great discoveries to our team!
#bye2023
#happy2024
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Truly state of the art talk on liver transplantation for HCC by
@sapisochin
#EASL
#LiverCancerSummit
. Provoking us to really rethink about LT with a fresh perspective!
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Great fun with our immunologists from around the world discussing science together in the past 2 days. Always great to end with some beers n music!
@SgSI35993969
@NicoleLaGruta1
@YUmmunology
@FGinhoux
@Lab_AmitSinghal
@CancerInflam
@StJohnLab
@laura_rivino
@GuptaR_lab
#sgsi2022
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5
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Really fun debates this afternoon on basic science: liquid vs tissues biomarkers Me vs
@TimGreten
and on clinical: atezo bev vs durva tremb as first choice immunotherapy. Katie Kelly vs Richard Finn.
#debates
#ilca23
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Fresh out in 2021 our discovery on intratumoural immune heterogeneity as hallmark of tumour evolution. A fruitful cross-disciplinary collaboration for our regional liver Cancer program.
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Is pathologist going to be endangered species? Thought provoking first talk sharing important perspectives on AI-based Pathology on diagnosis and prognosis of liver cancer by
@Caldera60373705
.
#ILC2022
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The last lab outing of 2022 with afternoon beers and nice team building session learning more about each other's personalities, strengths and weaknesses. We look forward to a greater 2024! Merry Xmas from VC lab to all of u!
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Feels really great to be at University Malaya for a one day HCC masterclass sharing our insights in the management of HCC.
#HCC
#immunotherapy
#tumourmicroenvironment
#um
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Clinical science session focusing treatment for cholangiocarcinoma (CCA) and biliary tract carcinoma (BTA).
@chiarabraconi
@DrAngelaLamarca
@sapisochin
@LorenzaRimassa
@StephenLChan1
important areas requiring more research!
#ILC2022
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Ending my journey to
#apple2024
with nice
#americansteak
dinner with dear
#friends
n
#colleagues
followed by a nice stroll on beautiful
#waikikibeach
, taking in the
#breathtaking
#beauty
of
#fullmoon
night with gentle
#breeze
.
#mahalo
#Hawaii
thank u for the
#aloha
experience
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Great fun at
#apasl2023
discussing about liver cancer with my fellow colleagues
@StephenLChan1
@liverwei
. Even more fun catching up with our Taiwanese hosts, who turns the gala dinner into a karaoke singing session!
#hcc
#immunotherapy
. Hope I didn't sing off-tune!
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Impressive location for
#bsi23
speakers dinner at magnificent and beautiful City Hall Belfast. Great food with conversation on immunology and beyond with my fellow immunologists. Big shout out to
@SgSI35993969
#sgsi
representatives
@StJohnLab
@laura_rivino
in BSI!
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Presidential address and Award ceremony acknowledging the great achievement in liver cancer by
@bruixj
. And congratulations to 4 young basic and clinical scientists for their excellent work in oral/ poster presentations
@BenniRuf
@LewinskaMonika
@FulgenziClaudia
@allaire_manon
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Happy hours bring the people together!
@StJohnLab
@Lab_AmitSinghal
@finkkkatja
@gascoigne_nick
@NicoleLaGruta1
@GuptaR_lab
@SgSI35993969
#sgsi2022
#sgsi
#immunology
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Welcoming our president of sgsi
@FGinhoux
to our happy hours!
@Anto_Berto
@SgSI35993969
@laura_rivino
#sgsi2022
#sgsi
#immunology
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It was such great fun chairing Day 2
#ILC2022
debate session with
@JuliusChapiro
. Great energy from the LIRARDS team Claude Sirlin
@maximeronot
. Really set a new standards for good debate! Great insights from the mouse model team Tom Bird
@SRebouissou
as well!
@ILCAnews
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4
19
Huge crowd of 1400 at the opening ceremony of
#bsi23
. Excellent keynote talk from
@RonaldGermain
on immune imaging, such colourful and animated 3D and multi-photon imaging as usual. Looking forward to represent
@SgSI35993969
to talk abt cancer immunol!
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Day 2 morning sessions on biliary tract cancer & cholangiocarcinoma
#cca
#btc
#apple2024
@petergalle
followed by state of the art lecture
#soa
from Prof Zhou Jian, new president of
#apple
Chinese guidelines on management of HCC (CNLC)!
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Best oral and poster presentation awards. Congratulations to my team member Aldo Prawira again and thank u
#ilca23
for giving this opportunity for us to showcase and discuss our work with the experts in the field!
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Speaking at
#apvic2024
with my fellow colleagues
@asharmaiisc
@Lab_AmitSinghal
. Great meeting in wonderful Melbourne deep dive into immunology!
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1
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Day 1 general session on
#hccsurveillance
with ILCA-Apple
@docamitgs
@StephenLChan1
followed by
#eastmeetswest
experience on
#locoregional
therapy
#tace
#tare
and
#radiation
. Lunch session by
@changhoon_yoo
sums up key points for first line systemic therapy.
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Great day 2 morning sessions on spatial omics in HCC at
#ilca23
with experts from the field
@XinWang77
Prof Irene Ng and Prof Qiang Gao. Indeed, it's the dawn of spatial omics analysis in HCC and it's definitely timely to discuss this cutting edge technology in HCC research.
#hcc
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I have certainly not done enough to deserve this covid resilience medal but I really appreciate the effort of acknowledging our healthcare team for their commitment and hard work in fighting covid. They are our true heroes!
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The first in person SgSI & SIgN young immunologist Symposium a great success! Thank u all the Co organisers, speaker and participants of the event!
@SgSI35993969
@astar_SIgN
#immunology
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3
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Very proud to be among the expert panelists for the APASL webinar this evening with Masatoshi Kudo and Stephen Lam Chan!
@StephenLChan1
#hcc
#immunotherapy
#systemictherapy
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4
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Early morning meeting for my first keynote talk for the Japan Society of Hepatology. Excellent program this morning with interesting talks and discussion!
#hcc
#tumourmicroenvironment
#immunotherapy
#cancerimmunology
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Nice work on macrophages engineering in reshaping tme and preventing liver mets
In vivo macrophage engineering reshapes the tumor microenvironment leading to eradication of liver metastases
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Great work from
@TimGreten
discovering CD29+ Treg as the Treg population expanded upon ICI and potentially link to treatment resistance.
#GUTImage
by
@bengreen_MD
et al on
"Immunosuppressive CD29+ Treg accumulation in the liver in mice on checkpoint inhibitor therapy" via
@BenniRuf
@TimGreten
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A nice evening discussing on
#precision
#oncology
#molecular
profiling for targeted cancer therapy with
#oncologists
@danieltanmd
and colleagues!
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It's complicated with hcc treatment these days but we always have excellent guidance and experience sharing from our experts
#EASL
#LiverCancerSummit
@sangrobruno
@LorenzaRimassa
@petergalle
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2
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Concluded day 1 morning session for
#sgsi2024
with great talks on
#immunometabolism
from our local and overseas speakers! Also introduction of Stereoseq FFPE from our platinum sponsor
@ST_Omics
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Day 2 morning session of
#EASL
#LiverCancerSummit
2024 focusing on really important topics on AI and liq biomarkers for liver cancer. Great talks from
@Caldera60373705
@maximeronot
@ArndtVogel
@Fla_doc
!
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Review from our team summarising the recent findings from multi- and high-dimensional immune-profiling in the field of Cancer immunology.
New
#JITC
article: High-dimensional immune-profiling in cancer: implications for immunotherapy
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"It is better to light a candle than to curse the darkness". I like that! In time for the candle lights Xmas season. New data from scrna seq resolved pancreas biology!
The 6th
#TopGUTPaper2023
from
#June2023
by
@CephasScience
et al on
“It is better to light a candle than to curse the darkness: single-cell transcriptomics sheds new light on pancreas...” via
Podcast:
@delgiornokathy
@VanderbiltU
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Potential antigen presenting capability of neutrophils from Gao Qiang and Fan Jia's team.
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Pm session 2 concluded with trained immunity in the context of infectious diseases.
@SgSI35993969
@bert_le
@sylviealonzo
@MazDivangahi
@FGinhoux
@Lab_AmitSinghal
@StJohnLab
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Great
#sgsi
#bsi
session in
#bsi23
on advances in cancer immunotherapy. Thank u for bringing us as
@SgSI35993969
representatives. We are really grateful for the opportunity to show our work to
#bsi
community and have certainly learnt a lot from all the excellent talks!
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Back to Sg with exciting line up of meetings after meetings. First up with
#imcore
& Prof Ira Mellman discussing collaborative potentials with Sg followed by sg liver cancer consortium
#SLCC
then
#GiHep
Conference!
#excitingjuly
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#ILC2022
so excited with the biggest in person meeting so far since the pandemic (am I the only one wearing mask here?) Exciting science discussions and networking with my peers.
@CancerInflam
#easl
#hcc
#nash
#tumourimmunology
#immunotherapy
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Learning from the master himself Prof Bruno Sangro on tips for a good abstract for successful publication!
#ILC2022
#MASTERCLASS
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The key role of intratumoral immune triads between antigen-presenting cells and antigen-specific CD4+ and CD8+ T cells for effective immunotherapy.
Intratumoral immune triads are required for immunotherapy-mediated elimination of solid tumors
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Celebrating the great mentor n leader from Duke-Nus, Prof Patrick Casey!
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Fascinating talks on Sars-cov2 infections. Boosters or not? T cells or B cells immune response? Prof Ravi Gupta
@Anto_Berto
@SgSI35993969
#sgsi2022
#sgsi
#immunology
#COVID19
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Please join us for our in person 12th Singapore Society for Immunology (SgSI) Annual Symposium in Duke NUS, Singapore on 10-11 Nov 2022. We have a line up of international distinguished speakers including Mathias Heikenwälder
@CancerInflam
@MEBirnbaum
and
@NicoleLaGruta1
We are happy to share an update on our sponsors and speakers for the upcoming 12th SgSI Annual Symposium. Register your interest here:
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Happy to be part of the team with
@DasguptaRam
A team of scientists prestigious NRF Singapore grant to uncover the fundamental mechanisms of liver disease progression from fatty liver disease to fibrosis/cirrhosis (liver scarring), and eventually, liver cancer.
Read more:
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Happy to be on board!
Joining our board of Associate Editors for
#BiosciRep
is
@Valeriechew29
. She leads and develops projects in cancer immunology at
@SingHealthSG
Find out more about
#BiosciRep
:
#WomenInScience
#WomenInSTEM
@WomenScienceDay
#BiosciencesForAll
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Support to
#mothers
in
#science
! Once at a conference, as a poster judge I can totally empathise with a mother trying to balance between presenting poster n caring for her young baby. BTW the baby is simply so cute! Science is a long journey, don't forget to also live ur life!
Three scientist mothers call for a change in how conference childcare costs are reimbursed, drawing on their personal experiences
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Sea of posters. Think I'm n=1 Singapore representative again?
#ILC2022
#hcc
#tumourimmunology
#immunotherapy
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Presenting the preprint of our study using
#scrnaseq
&
#spatialtranscriptomics
to understand immune dynamics and interaction between
#treg
#caf
in driving resistance to
#immunotherapy
in steatotic liver disease
#sld
related
#hcc
Single-cell and spatial atlas of steatotic liver-related hepatocellular carcinoma
#biorxiv_immuno
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13
Arriving at
#Melbourne
#Australia
for
#apvic2024
discussing about
#Vaccines
#immunology
#immunotherapy
with fellow colleagues
@YUmmunology
@Lab_AmitSinghal
@asharmaiisc
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With my fellow women in science. My pillars of support and strong advocates. My buddies for serious business and fun!
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Concluded the first half of day 1 talking about cancer immunology with heavy focus on Nash and hcc.
@CancerInflam
@SgSI35993969
#sgsi2022
#immunology
#oncoimmunology
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Recent publication from our team showing CD38 as exhaustion marker on resident memory T cells in HCC.
#CD38
#tcell
#trm
#exhaustion
#hcc
New Research: CD38 marks the exhausted CD8+ tissue-resident memory T cells in hepatocellular carcinoma: Introduction
Despite recent advances in immunotherapy for hepatocellular carcinoma (HCC), the overall modest response rate underscores…
#immunology
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When in hawaii, of course we gonna do the hawaiian dance!
@richardfinn
is definitely going be the best dancer of the night!
#apple2024
#aloha
#hawaiiandance
@GABOUALFA
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1
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Boarding the redeye flight to Amsterdam and can't wait to be at
#EASL
#LiverCancerSummit
2024 real soon! Very honoured and excited to be the state of the art
#soa
speaker on the first day!
The EASL
#LiverCancerSummit
is just around the corner, starting in FIVE DAYS! It's an exciting time for doctors, researchers, and professionals focused on liver tumour study and treatment. This event brings you the latest in research, innovations, and networking opportunities in
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Talking about immune landscape of HBV related HCC on the Sunday afternoon with my friends in Taiwan Digestive Disease Week
#TDDW
2021
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