#newbegining
I'm very excited to announce my move
@GarvanInstitute
after ~3.5 years in Perth. It's time to move closer to my collaborative network in beautiful and bustling Sydney. I couldn't have imagined a better place for my science & intellectual quest than Garvan,
Embryonic tale of Tumorigenesis!!
Very excited to share our latest work in
@CellCellPress
on discovery of fetal-like cells in tumor microenvironment
Here is 'first-hand' glimpse of tumor time travel aka Oncofetal reprogramming of Tumor Ecosystem in HCC
Very elated to announce that I'll be starting my lab
@PerkinsComms
&
@CurtinUni
in Jan 2021. The Sharma lab will employ single cell genomics to study tumor evolution & ecosystem. I'm looking forward to working with motivated graduate students & post-docs. Plz RT & spread the word
Ever wondered why chemotherapy works for some patients but not for others? Well, we did, and discovered that tumors evolve differently under the selection pressure of same drug and ‘fate’ lies in the ‘fidelity of stem-cell hierarchy’.
Very humbled to receive
@CSL
Centenary fellowship to continue my work on
#oncofetal
ecosystem and work towards mRNA vaccines.. as a migrant who has crisscrossed from one country to another in pursuit of science this
@CSL
fellowship allows me to pursue my goals and provides long
On the path to a potential liver cancer vaccine: Dr Ankur Sharma has discovered how liver cancer cells grow in a similar way to the dividing cells of an embryo. A CSL Centenary Fellowship will support his next bold steps.
@PerkinsComms
@CurtinUni
We are recruiting postdoctoral fellows to work on
@nhmrc
funded project (3 years position) in the area of cancer immunotherapy and single-cell/spatial genomics. Candidates with experience in cancer, immunology, computational biology are strongly encouraged to apply. Plz RT
Singapore will be dearly missed.. Family, Friends & Mentors! A special thanks to
@FGinhoux
for being an inspirational mentor & friend.. A true science idol.. I have learnt a lot from SGP & community here.. Now ready for new beginnings
#Sharmalab
(After mandatory quarantine)..
We are hiring a Postdoctoral fellow to collaborate with us on Oncofetal ecosystem & tumor evolution
@SharmaaLab
Come work with us in beautiful Perth & work in the area of single cell genomics & spatial transcriptomics
@PerkinsComms
&
@CurtinUni
Plz RT!!
#NanoString
is pleased to announce the awardees of the Cancer Transcriptome Atlas Grant!
We received ~150 exciting & compelling grant submissions.
Congratulations to the winners: Prof. Tae Hyun Hwang, Drs. Randal Kaufman, Jessy Deshane, Ankur Sharma, & Anaelle Dumas.
#GeoMx
An atlas of cancer-associated T cells
- 21 Cancer types 🫀🫁
- 316 patients 👥
- 390,000 T cells 🧬
Another wonder pan-cancer atlas from Zemin Zhang and co.
Very excited and relieved to get first
@nhmrc
funding for our lab. And feeling solidarity for many great ideas missed out due to 9.5% success rate
Extremely thankful my team, CIs/AIs/mentors for guidance (Spl given this was my first attempt
@NHMRC
)
@PerkinsComms
@CurtinUni
#NHMRC
welcomes today's announcement by Minister for Health
@GregHuntMP
of $239 million to fund 248 innovative projects which will advance our understanding of a wide range of health and medical issues faced by Australians.
#NHMRCIdeas
👉
Very elated to announce the award of the MRFF EMCR grant
#TRACKERx
We will develop next-gen spatial omics-enabled diagnostic tests to detect early relapse in Liver cancer.
A global initiative b/w institutions across 🇦🇺🇸🇬🇬🇧🇮🇳
#Spaceisthenextfrontier
Here comes the first ever letter of award as PI. Got the NMRC-YIRG.. next let’s figure out how metastatic breast cancer cells evade immune system.
#onecellatatime
🔬💡 New insights from our
@NatureCancer
paper! We've uncovered a causal link between
#oncfetal
cells and post-surgery relapse in cancer patients. Our findings pave the way for adjunct immunotherapy treatments, offering hope to those at high risk.
Very excited to welcome
@rheapai1
as first PhD student.. She join us from
@astar_gis
🇸🇬 and will be working on Single cell genomics and immunotherapy response in solid tumors..
@PerkinsComms
@CurtinUni
Do you wonder from where resident tissue macrophages come? Their ontogeny & How do they evolve during development & aging? Then you’d like this beautiful in-depth
@ImmunityCP
review on ‘Time, Space & Origin of RTM’ from
@FGinhoux
@SvetoslavChaka1
& Camille
Have you wondered about recent reports of faecal–oral transmission in COVID-19? I’m sure it puzzle some of us. Here we present the scRNA-seq survey of human liver and report potential role of TROP2+ cells in COVID-19 associated liver dysfunction
Enjoying reading this beautiful review
@ImmunityCP
review from
@MartinGuilliams
&
@KC_DC_01
loved this figures! Time for some consensus on liver macrophage nomenclature.
Very grateful to be featured on the cover of
@CellStemCell
Thx
@j_saxe
for organizing this series & showcasing our
#newPI
resilience & optimism in these tough times. COVID has impacted us but
@SharmaaLab
@PerkinsComms
we are committed to building a stronger team to combat cancer
Over the past year, we've featured 71 early-career researchers who discussed their research and the COVID-19 pandemic's impact on their labs & lives. We mark the closing of this article series with interviews and essays from some of the participants.
Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages: Immunity
This beautiful study explores why Liver is a frequent site of breast cancer metastasis and identify the interplay between NK and aHSCs as a master switch of cancer dormancy and metastatic outgrowth.
Interested in working on single cell genomics and spatial transcriptomics? Wonder how fetal development and cancer are linked?
Come work with us.. we have opening for domestic (Australian) PhD students
@CurtinUni
@PerkinsComms
Very cool work in
@ImmunityCP
from Camille &
@FGinhoux
on heterogeneity of liver macrophages
-Identification of two distinct subset of Kupffer Cells in mouse liver
- CD206 high KC2 population control lipid metabolism in CD36 dependent manner
🧪🔍 Spatial methods provide a great tool to study cellular organization, but what if we could go further? In collab, with
@Quasarzafar
we Introduce
#Renoir
which adds a new dimension to understanding ligand-target interactions in spatial topologies! 🧬📍
In our new work we chart epigenome reconfiguration in human iPSC reprogramming, informing a new 'Transient Naive Treatment' (TNT) reprogramming strategy that corrects human iPSCs functionally and epigenetically. Read it here
@Nature
Very excited to welcome
@JenCurrenti
(first-post
@SharmaaLab
) Jen is T-cell Guru and she will lead the efforts on identifying T-cells in oncofetal niche, their interactions with myeloid cells and implications in immunotherapy response for HCC
#DEFINERx
#LCC
Introducing STOmics-GenX!! lead by
@JenCurrenti
In collaboration with
@LGMartelotto
@DrJasPlummer
@TheBgiGroup
we show that the removal of housekeeping genes from STOmics workflow could improve the detection of cell-type specific genes. More data, less $$
Very excited to announce that I will be joining
@asharmaiisc
as a PhD student in
@PerkinsComms
&
@CurtinUni
🥳. My journey started with
@asharmaiisc
3 years ago from an internship to a Research Officer and now a PhD student ☺️. Looking forward to my new life in Perth !! 😬
#adios2021
what a action packed year it was, so many professional and personal milestones.. new country, labs, publication, grant and a new human being in life 👨👩👧
Wishing y’all
#HappyNewYear2022
Excited to attend the inaugural
@ASCO
Breakthrough meeting on innovations in cancer at Bangkok 🇹🇭 and looking forward to present our work on single cell genomics! Also very thankful to organiser for selecting this work for Merit award!!
#ASCOBT19
Very interesting work on TME spatial architecture & clinical features in
@NatureGenet
- Imaging mass cytometry of 693 breast tumors linked to genomic & clinical data
- 10 recurrent TME structures associated with genomic signatures and survival outcomes
Very cool paper from
@dralexswarbrick
@sunnyz_wu
@GammyAL
& co
- A population of PD-L1+ macrophages that associate with high clinical grade and exhausted T cells in breast cancers
📢Alex will be speaking at
@ozsinglecells
tomorrow
Like always Reading/Listening Aviv is enlightening
“How come we are ever successful in drug discovery? And the answer is that biology is not random.
Yes, in principle, everything could interact with everything. But in practice, most of it does not.”
Landed in Brisbane and very eager to attend my first in-person
@ozsinglecells
meeting. All set to share some recent oncofetal ‘niche’ and spatial precision omics work from
@SharmaaLab
#ozsinglecell22
I really miss attending in-person talks, listening to interesting science, engaging in discussions and coming back with new ideas.. unfortunately webinars don’t have same impact..
#pandmiclife
A very comprehensive analysis of severe
#COVID19
by
@FGinhoux
& colleagues links immature neutrophil & non-classical monocyte pools with disease severity. Calprotectin could serve as much needed biomarker of disease severity!!
Very humbled to receive GIS Outstanding Clinical Partnership Award. Very grateful to our Clinical collaborators and
@rdasgupt
for providing opportunities to work on exciting projects.
End of year
@SharmaaLab
lunch.. grateful to work with this bunch of young scientists and looking forward to folks who are joining in early 2022.. very excited to kickstart DEFINERx and TRACKERx
#staytuned
My poster is up 😬 pls come visit my poster (poster
#23
) and we can have a chat on everything oncofetal, liver cancer or just Perth/PhD life in general 😆.. My first poster presentation, here we go !!
@SharmaaLab
@ozsinglecells
#ozsinglecell22
Very important paper from
@MacparlandSonya
@garybader1
and co.
A systematic comparison (much needed for the community) of scRNA-seq & sn-RNA-seq profiles of healthy human liver
Also macrophages are sensitive Celly! (see image and Fig6)
Since the beginning of the pandemic,
@CellStemCell
has featured the voices of early-career stem cell researchers to ensure the community got to meet them. Here's just one group of these inspiring young scientists
#ScienceThatInspires
Construction of a human cell landscape at single-cell level
- 60 tissues
- ~600,000 cells
- 102 cell types
- Cross species comparison
- stem and progenitor cell regulons lack lineage specificity
- regulons for differentiated cells more tightly wired
First week at
@PerkinsComms
and I truly loved each and every moment. Best part is to meet new colleagues and discuss ideas.. also beer is much better here..