Ankur Sharma
@asharmaiisc
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Laboratory Head @GarvanInstitute | @CSL Centenary Fellow | OncoFetal Ecosystem | #SingleCell #SpatialTranscriptomics #LiverCancer #Immunotherapy #Vaccines
Sydney, New South Wales
Joined September 2009
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Pinned Tweet
#newbegining
I'm very excited to announce my move
@GarvanInstitute
after ~3.5 years in Perth. It's time to move closer to my collaborative network in beautiful and bustling Sydney. I couldn't have imagined a better place for my science & intellectual quest than Garvan,
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Embryonic tale of Tumorigenesis!!
Very excited to share our latest work in
@CellCellPress
on discovery of fetal-like cells in tumor microenvironment
Here is 'first-hand' glimpse of tumor time travel aka Oncofetal reprogramming of Tumor Ecosystem in HCC
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Very elated to announce that I'll be starting my lab
@PerkinsComms
&
@CurtinUni
in Jan 2021. The Sharma lab will employ single cell genomics to study tumor evolution & ecosystem. I'm looking forward to working with motivated graduate students & post-docs. Plz RT & spread the word
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slide-DNA-seq 🔥
Spatially resolved DNA sequencing: A much needed revolution in spatial genomics 🧬
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Ever wondered why chemotherapy works for some patients but not for others? Well, we did, and discovered that tumors evolve differently under the selection pressure of same drug and ‘fate’ lies in the ‘fidelity of stem-cell hierarchy’.
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Stem cells remember: Very cool work from Elaine Fuchs and team on epigenetic memory of stem cells
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Very humbled to receive
@CSL
Centenary fellowship to continue my work on
#oncofetal
ecosystem and work towards mRNA vaccines.. as a migrant who has crisscrossed from one country to another in pursuit of science this
@CSL
fellowship allows me to pursue my goals and provides long
On the path to a potential liver cancer vaccine: Dr Ankur Sharma has discovered how liver cancer cells grow in a similar way to the dividing cells of an embryo. A CSL Centenary Fellowship will support his next bold steps.
@PerkinsComms
@CurtinUni
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We are recruiting postdoctoral fellows to work on
@nhmrc
funded project (3 years position) in the area of cancer immunotherapy and single-cell/spatial genomics. Candidates with experience in cancer, immunology, computational biology are strongly encouraged to apply. Plz RT
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Singapore will be dearly missed.. Family, Friends & Mentors! A special thanks to
@FGinhoux
for being an inspirational mentor & friend.. A true science idol.. I have learnt a lot from SGP & community here.. Now ready for new beginnings
#Sharmalab
(After mandatory quarantine)..
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We are hiring a Postdoctoral fellow to collaborate with us on Oncofetal ecosystem & tumor evolution
@SharmaaLab
Come work with us in beautiful Perth & work in the area of single cell genomics & spatial transcriptomics
@PerkinsComms
&
@CurtinUni
Plz RT!!
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Very proud to share our
@NatureRevCancer
article on oncofetal reprogramming. Here we discussed classical & new concepts of oncofetal reprogramming, their implications in cancer development & progression. Always fun to work with
@FGinhoux
@CurtinUni
@PerkinsComms
@astar_research
NEW content online! Oncofetal reprogramming in tumour development and progression
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Happy to receive Cancer Transcriptiome Atlas Grant from
@nanostringtech
this will help us in understanding the spatial heterogeneity of tumor ecosystem
#spaceisnextfrontier
#SingleCell
#NanoString
is pleased to announce the awardees of the Cancer Transcriptome Atlas Grant!
We received ~150 exciting & compelling grant submissions.
Congratulations to the winners: Prof. Tae Hyun Hwang, Drs. Randal Kaufman, Jessy Deshane, Ankur Sharma, & Anaelle Dumas.
#GeoMx
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An atlas of cancer-associated T cells
- 21 Cancer types 🫀🫁
- 316 patients 👥
- 390,000 T cells 🧬
Another wonder pan-cancer atlas from Zemin Zhang and co.
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.
@SharmaaLab
retreat to celebrate 1-year anniversary, accepted publication and grant submission
#dreamteam
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Very excited and relieved to get first
@nhmrc
funding for our lab. And feeling solidarity for many great ideas missed out due to 9.5% success rate
Extremely thankful my team, CIs/AIs/mentors for guidance (Spl given this was my first attempt
@NHMRC
)
@PerkinsComms
@CurtinUni
#NHMRC
welcomes today's announcement by Minister for Health
@GregHuntMP
of $239 million to fund 248 innovative projects which will advance our understanding of a wide range of health and medical issues faced by Australians.
#NHMRCIdeas
👉
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Christmas came early for
@SharmaaLab
@PerkinsComms
Unboxing the one and only
#xenium
@10xGenomics
stay tuned for Xciting spatial biology in clinical trial space ⚕️🧬
#spaceisthenextfrontier
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Visium is an art and I’m blessed to work with these artists!! Adding normal and tumor on same capture area.. increasing output and saving $$$
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- Benchmarking of 16 integration methods using 45 paired & 32 simulated datasets
- Tangram, gimVI & SpaGE top-performing methods for predicting spatial distribution
- Cell2location, SpatialDWLS & RCTD top-performing methods for cell type deconvolution
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Very elated to announce the award of the MRFF EMCR grant
#TRACKERx
We will develop next-gen spatial omics-enabled diagnostic tests to detect early relapse in Liver cancer.
A global initiative b/w institutions across 🇦🇺🇸🇬🇬🇧🇮🇳
#Spaceisthenextfrontier
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Here comes the first ever letter of award as PI. Got the NMRC-YIRG.. next let’s figure out how metastatic breast cancer cells evade immune system.
#onecellatatime
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*These authors contributed equally to this work
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MNP-VERSE: An integrated atlas of
178,651 MNPs from 13 tissues across 41 datasets
- Identification of immunosuppressive TAM in tumor periphery
Very happy to collab on this tour de force by
@FGinhoux
@cadutertre
@KevinMulder19
@amto94
@wanting_kong
& co.
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🔬💡 New insights from our
@NatureCancer
paper! We've uncovered a causal link between
#oncfetal
cells and post-surgery relapse in cancer patients. Our findings pave the way for adjunct immunotherapy treatments, offering hope to those at high risk.
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Very excited to welcome
@rheapai1
as first PhD student.. She join us from
@astar_gis
🇸🇬 and will be working on Single cell genomics and immunotherapy response in solid tumors..
@PerkinsComms
@CurtinUni
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Do you wonder from where resident tissue macrophages come? Their ontogeny & How do they evolve during development & aging? Then you’d like this beautiful in-depth
@ImmunityCP
review on ‘Time, Space & Origin of RTM’ from
@FGinhoux
@SvetoslavChaka1
& Camille
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Have you wondered about recent reports of faecal–oral transmission in COVID-19? I’m sure it puzzle some of us. Here we present the scRNA-seq survey of human liver and report potential role of TROP2+ cells in COVID-19 associated liver dysfunction
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Another beautiful paper from Zemin Zhang and colleagues: A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
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Enjoying reading this beautiful review
@ImmunityCP
review from
@MartinGuilliams
&
@KC_DC_01
loved this figures! Time for some consensus on liver macrophage nomenclature.
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Very grateful to be featured on the cover of
@CellStemCell
Thx
@j_saxe
for organizing this series & showcasing our
#newPI
resilience & optimism in these tough times. COVID has impacted us but
@SharmaaLab
@PerkinsComms
we are committed to building a stronger team to combat cancer
Over the past year, we've featured 71 early-career researchers who discussed their research and the COVID-19 pandemic's impact on their labs & lives. We mark the closing of this article series with interviews and essays from some of the participants.
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Thankful to this bunch
@SharmaaLab
who have decided to work with me.. what a fun ride 2022 was.. we posted first preprint from our nascent lab.. and many more to come
#staytuned
#endofyearlunch
#oncofetal
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Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages: Immunity
0
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Very grateful to
@j_saxe
@CellStemCell
for highlighting the
#NewPIs
research and their resilience during
#COVID__19
from
#lockdowns
to border closures!
Happy to featured with
@Marta_Shahbazi
@ProfSamiraMusah
@Jeevisha_Bajaj
Giacomo Donati & Weiqi Zhang
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This beautiful study explores why Liver is a frequent site of breast cancer metastasis and identify the interplay between NK and aHSCs as a master switch of cancer dormancy and metastatic outgrowth.
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Interested in working on single cell genomics and spatial transcriptomics? Wonder how fetal development and cancer are linked?
Come work with us.. we have opening for domestic (Australian) PhD students
@CurtinUni
@PerkinsComms
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Congratulations to
@SharmaaLab
PhD student
@rheapai1
for securing LCC PhD top-up scholarship!! Watch out for some fascinating stories from this rising star in coming years
@PerkinsComms
@CurtinUni
#livercancer
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Congratulations
@armish1910
for securing her first grant
@RaineFoundation
as independent PI
@telethonkids
#justthebegining
#microbiome
#newPI
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Very cool work in
@ImmunityCP
from Camille &
@FGinhoux
on heterogeneity of liver macrophages
-Identification of two distinct subset of Kupffer Cells in mouse liver
- CD206 high KC2 population control lipid metabolism in CD36 dependent manner
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Celebrating 2 year’s anniversary of
@SharmaaLab
with this bunch of great scientists.. very eager to share an exciting ‘embargoed’ information.. we are hiring.. come work with us
@PerkinsComms
@CurtinUni
#livercancer
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PI life is mostly about replying to emails and meetings and in between (if you get time) trying to get some work done..
#NoteToSelf
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Pro-Code: When CRISPR genomics meets spatial transcriptomics
Very innovative work from
@MaximeDhainaut
@Brown_lab1
@MiriamMerad
& co.
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🧪🔍 Spatial methods provide a great tool to study cellular organization, but what if we could go further? In collab, with
@Quasarzafar
we Introduce
#Renoir
which adds a new dimension to understanding ligand-target interactions in spatial topologies! 🧬📍
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Know your hashing!
Cell lines:
- Ab works better for cells
- Lipid for nuclei
Tissues:
- Ab works better for spleen and lung
- Lipid for brain
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Loved reading this behind the paper from
@ry_lister
& Jose Polo
#powerofcollaboration
In our new work we chart epigenome reconfiguration in human iPSC reprogramming, informing a new 'Transient Naive Treatment' (TNT) reprogramming strategy that corrects human iPSCs functionally and epigenetically. Read it here
@Nature
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Best days are when you receive ‘We are delighted to accept for publication the manuscript..’ in your inbox and Starbucks on your table..
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Very excited to welcome
@JenCurrenti
(first-post
@SharmaaLab
) Jen is T-cell Guru and she will lead the efforts on identifying T-cells in oncofetal niche, their interactions with myeloid cells and implications in immunotherapy response for HCC
#DEFINERx
#LCC
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Introducing STOmics-GenX!! lead by
@JenCurrenti
In collaboration with
@LGMartelotto
@DrJasPlummer
@TheBgiGroup
we show that the removal of housekeeping genes from STOmics workflow could improve the detection of cell-type specific genes. More data, less $$
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Looking forward to our continued association from 🇸🇬 to 🇦🇺 I couldn’t have asked for a better PhD student to start my journey!!
Very excited to announce that I will be joining
@asharmaiisc
as a PhD student in
@PerkinsComms
&
@CurtinUni
🥳. My journey started with
@asharmaiisc
3 years ago from an internship to a Research Officer and now a PhD student ☺️. Looking forward to my new life in Perth !! 😬
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#adios2021
what a action packed year it was, so many professional and personal milestones.. new country, labs, publication, grant and a new human being in life 👨👩👧
Wishing y’all
#HappyNewYear2022
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Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin
@CellCellPress
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RIBOmap- Method to mapping translating RNAs in cells and tissues
Spatial translatomics!!
@ScienceMagazine
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Exercise exercise specifically drives Kupffer cells toward an anti-inflammatory phenotype with trained immunity via metabolic reprogramming 🏃♀️🚴♀️
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EMBO has removed the 40-year age limit from the eligibility criteria for the Young Investigator Programme.
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Looking forward to co-organising Multiomics2022 with
@aruthak
and colleagues
In 2022 all roads leads to Brisbane
@ozsinglecells
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Very interesting work on TME spatial architecture & clinical features in
@NatureGenet
- Imaging mass cytometry of 693 breast tumors linked to genomic & clinical data
- 10 recurrent TME structures associated with genomic signatures and survival outcomes
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10
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Very proud of
@Justine_SJW
@ReginaWongg
and
@rheapai1
for compiling this review article on ‘Single‐Cell RNA Sequencing for Precision Oncology’
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One of the most rewarding part of
#newPI
life is to see evolution of your nascent lab.. it was exciting week in the lab with
@NatureRevCancer
article and three presentation from extraordinary scientist
@JenCurrenti
@ersgupta
@rheapai1
in the lab here to more
#oncofetal
research
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Very cool paper from
@dralexswarbrick
@sunnyz_wu
@GammyAL
& co
- A population of PD-L1+ macrophages that associate with high clinical grade and exhausted T cells in breast cancers
📢Alex will be speaking at
@ozsinglecells
tomorrow
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Very nice work on spatial transcriptomics in primary liver cancer
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New review from
@SharmaaLab
@JenCurrenti
et al., in
@PPPublishing
on
Immunosuppressive mechanisms of
#oncofetal
reprogramming in the tumor microenvironment and it’s implications in immunotherapy response.
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Like always Reading/Listening Aviv is enlightening
“How come we are ever successful in drug discovery? And the answer is that biology is not random.
Yes, in principle, everything could interact with everything. But in practice, most of it does not.”
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Landed in Brisbane and very eager to attend my first in-person
@ozsinglecells
meeting. All set to share some recent oncofetal ‘niche’ and spatial precision omics work from
@SharmaaLab
#ozsinglecell22
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I really miss attending in-person talks, listening to interesting science, engaging in discussions and coming back with new ideas.. unfortunately webinars don’t have same impact..
#pandmiclife
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Started enjoying cycling as weekend sport and love the landscape along the Swan!!
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Very humbled to receive GIS Outstanding Clinical Partnership Award. Very grateful to our Clinical collaborators and
@rdasgupt
for providing opportunities to work on exciting projects.
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End of year
@SharmaaLab
lunch.. grateful to work with this bunch of young scientists and looking forward to folks who are joining in early 2022.. very excited to kickstart DEFINERx and TRACKERx
#staytuned
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Blessed to work with this bunch of extremely talented scientists
@SharmaaLab
(missing
@ersgupta
@CosterKhyriem
)
@TheASMR1
#galadinner
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5
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A good day for
@SharmaaLab
! First postdoc in lab
@JenCurrenti
for MACA Ride ECR award for IO work and in collaboration with
@JNilsson_lab
we will embark on a new spatial biology project
#Immunotherapy
thanks to MACA Riders for support to
@PerkinsComms
researchers
#WorldCancerDay
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scifi-RNA-seq: combines preindexing of whole transcriptomes with droplet-based scRNA-seq
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Why I back the Uniform Civil Code & think Liberals must. My piece for
@washingtonpost
as
#TripleTalaq
hearings begin
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5
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Have you wondered whether allergies can be transferred from mother to fetus? Amazing work from
@FGinhoux
& colleagues (
@StJohnLab
@RashaAM11
) in
@ScienceMagazine
demonstrate 'vertical transmission' of maternal allergy via fetal mast cells
#OntogenyMatters
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Rhea is a rising star!! Go visit her poster and get to know more about her PhD project
#ozsinglecell22
My poster is up 😬 pls come visit my poster (poster
#23
) and we can have a chat on everything oncofetal, liver cancer or just Perth/PhD life in general 😆.. My first poster presentation, here we go !!
@SharmaaLab
@ozsinglecells
#ozsinglecell22
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Very important paper from
@MacparlandSonya
@garybader1
and co.
A systematic comparison (much needed for the community) of scRNA-seq & sn-RNA-seq profiles of healthy human liver
Also macrophages are sensitive Celly! (see image and Fig6)
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PhD scholarship in
@SharmaaLab
on Spatial context of oncofetal ecosystem in HCC.
Come work with cutting-edge tech with young team of researches & clinical partners.
#SpaceIsTheNextFrontier
@CurtinUni
@PerkinsComms
(EOI closes 18th Aug)
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Moving to a new place & setting up lab is certainly most exciting phase of academic life. Though ongoing
#pandemic
#TravelRestrictions
have made it lil challenging for
#ECRs
but our resilience is stronger than ever! Thanks to
@CellStemCell
@CellPressNews
for
#ScienceThatInspires
Since the beginning of the pandemic,
@CellStemCell
has featured the voices of early-career stem cell researchers to ensure the community got to meet them. Here's just one group of these inspiring young scientists
#ScienceThatInspires
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Here we go! Draft program of
@ozsinglecells
Perth hybrid meeting
@PerkinsComms
From mapping immune cells to tumor ecosystems and Microbes!
Talks by
@MiriamMerad
@FGinhoux
@dralexswarbrick
@armish1910
@JulioSaezRod
@10xGenomics
@nanostringtech
#gowest
#Networks
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Construction of a human cell landscape at single-cell level
- 60 tissues
- ~600,000 cells
- 102 cell types
- Cross species comparison
- stem and progenitor cell regulons lack lineage specificity
- regulons for differentiated cells more tightly wired
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8
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Excited to welcome
@CosterKhyriem
as a computational PhD student in our lab. Costa has been a long term collaborator with
@FGinhoux
@armish1910
@jerry760
@astar_research
In
@SharmaaLab
he will continue to work on joint projects with
@armish1910
&
@FGinhoux
#Oncofetal
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First week at
@PerkinsComms
and I truly loved each and every moment. Best part is to meet new colleagues and discuss ideas.. also beer is much better here..
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