UK Dementia Research Institute
@UKDRI
Followers
14K
Following
4K
Media
2K
Statuses
8K
The UK’s leading research institute transforming the lives of people affected by neurodegenerative conditions. Principal funder: @The_MRC
United Kingdom
Joined January 2017
⭐️The UK DRI exists to transform the lives of people affected by or at risk of neurodegenerative conditions.⭐️. Our vision is ‘healthy brain🧠ageing for all’. Our research will transform lives. We are the UK DRI. @The_MRC @alzheimerssoc @AlzResearchUK @lifearc1 @TheBHF
0
11
37
This week we welcomed the legendary Rory Cellan-Jones (@ruskin147), to the living lab at our UK DRI Care Research & Technology Centre🙌. Rory wrote about his experience in a brilliant blog post, which you can read here👉
0
27
296
It is our pleasure to announce that Prof Siddharthan Chandran has been selected as the new Director of the UK DRI 👏🎉 🧠 👏 🎉 🧠 . Prof Chandran is a world-leading clinician-scientist, renowned for his pioneering work in MND & neurodegeneration research👉
5
51
220
Image 2 of 4: Eruption of Etna's Embers . Human neurons grow in a device (bottom), and the 'wires', which carry the electrical impulses, travel through tiny grooves to get to the other side (top). This chaotic network of the wires gives the effect of a volcanic eruption. 4/6
2
33
186
We are delighted to announce that Prof Mina Ryten has been appointed as the new Director of the UK DRI Centre at Cambridge University, and Van Geest Professor! 🎉👏🧠🧬🎉👏🧠🧬. Read more👉
9
22
133
CONGRATULATIONS to geneticist Prof John Hardy (UK DRI at UCL) on the announcement of his knighthood in the New Year honours! 🎉🥳. Read more 👉
1
22
130
HUGE congratulations to @TSpiresJones (Group Leader, UK DRI at Edinburgh) who will become the next President-Elect for @BritishNeuro! .👏🥳👏🎉👏🧠. Read more about the announcement & Tara's manifesto 👉
13
14
122
Exciting news today as new drug lecanemab is reported to have slowed cognitive decline by 27% in people with early-stage Alzheimer's disease, in a large, phase 3 clinical trial. Read more in our latest news story👉
0
30
104
New year, new labs! So exciting to move into our shiny, newly-refurbished space @UCL Cruciform building! Within these walls we will help #conquerdementia
4
30
91
Terrific news today as results from phase 3 trial of #Alzheimers drug donanemab presented at #AAIC23 confirm the drug significantly reduced amyloid in the brain & slowed disease progression👏 🧠 . UK DRI researchers comment on the encouraging results🙌 👉
3
26
90
We're thrilled to announce 4 new UK DRI Emerging Leaders: @SophieMorse20, @jojacksonhere, Dr Emma Clayton & Dr Philip Weston👏 🎉 🥳 . The initiative supports exceptional ECRs on their journey to independence. Find out more about our new Emerging Leaders👉
3
14
91
Huge congrats to @TSpiresJones (UK DRI at Edinburgh) who has been elected as a Fellow of the @acmedsci today!👏. Prof Spires-Jones is one of 58 exceptional scientists recognised for their remarkable contributions to advancing biomedical & health sciences👉
4
16
85
"I am truly excited to lead our brilliant team of researchers and collaborators in pushing the boundaries of science and unlocking vital understanding.". New UK DRI at Cambridge Director Prof Mina Ryten in @CambridgeIndy ⬇️ .
1
14
82
Absolutely delighted for Prof Giovanna Mallucci (Centre Director, UK DRI at Cambridge) who has been awarded the prestigious 2021 Potamkin Prize for Research in Pick's, Alzheimer's and Related Diseases 🎉👏🧠🥳. Read more about the announcement👉
3
16
84
We urgently need to accelerate progress in dementia research and develop new treatments. We've joined other leaders in the field to call on the government to take action now 👇
3
34
79
Image 2 of 5: Brain defenders. A mouse brain magnified 100x to show individual cells. The red and green colours highlight immune cells of the brain gathering around amyloid plaques - the protein deposits found in Alzheimer's. 4/7
2
12
79
🚨Breaking 🚨FDA approves Aduhelm (aducanumab) for the treatment of Alzheimer's disease. Significant milestone as the first disease-modifying drug for the condition .
2
42
86
Image 5 of 5: Lava lamps. TAF15 (pictured in red) is a mutant protein involved in neurodegenerative disease. Here the TAF15 protein forms bubbles (green) filled with RNA, that assemble around the cell nucleus (blue). 7/7
4
15
81
Congratulations to UK DRI researchers Prof Karen Duff and Prof Siddharthan Chandran, who have who have been elected as Fellows of the @acmedsci for their outstanding research into neurodegenerative diseases! 🎉. Read more 👉 #AMSFellows2022
2
20
82
Congratulations to the UK DRI's @TSpiresJones for receiving the Inge Grundke-Iqbal Award from @alzassociation at #AAIC24! 👏 . This award is presented to the senior author of the most impactful study published in Alzheimer’s research in the past 2 years👉
2
11
75
We're delighted to announce 3 new UK DRI Emerging Leaders: @M_Malpetti, @AnnaMallach, & @val_jaramillo! 🎉 🙌 👏 . The initiative supports exceptional ECRs on their journey to setting up an independent lab. Find out more about our new Emerging Leaders👉
5
12
79
Lab-grown brain organoids hint at potential treatment options for motor neurone disease and frontotemporal dementia 🧠. 📰 New @NatureNeuro article out today from Cambridge researchers including UK DRI Group Leader Dr Gabriel Balmus👉
2
24
80
Congratulations to UK DRI Director, Prof Bart De Strooper, for his election to the Academy of Medical Sciences Fellowship! 🎉. ➡️
1
16
77
We’re over the moon that the @Brain_Prize has been awarded to our Director Bart De Strooper and our Professor John Hardy @UCLBrainScience – congratulations to all four winners on this outstanding recognition! #brainprize
2
39
75
Exciting research by Prof Bart De Strooper has discovered how neurons die in #Alzheimers🧠. The study reveals new insight into the mechanism by which neurons initiate a form of cell death known as necroptosis, when exposed to amyloid plaques & tau tangles👉
0
34
79
Huge congrats to @DrPujaM, the winner of our Science Imaging Competition 2023, for her amazing image 'Eruption of Etna's Embers' 🥳🎉👏. Neurons grow in a device (bottom), & 'wires' carrying the electrical impulses travel through tiny grooves to get to the other side (top). 🧵1/6
1
11
78
THRILLED to announce a major cell model initiative for Alzheimer’s 🧠. Led by Prof Julie Williams & UK DRI at Cardiff 🏴 - iPSC Platform to Model Alzheimer’s Disease Risk (IPMAR) - aims to become one of the largest cellular model resources available 🔬. 👉
2
24
72
We're delighted to welcome a new Group Leader to the UK DRI at King's!🎉👏🥳. Dr Andrea Serio (@The_SERIOus_Dr) aims to tackle motor neuron disease (MND) from a unique angle, applying principals from his background in bioengineering👉 @KingsIoPPN
4
8
75
🗣️Announcing our new £2M initiative - Multi-‘omics Atlas Project (MAP)🧠- led by UK DRI at Imperial. This human brain atlas will use an unprecedented range of techniques to examine tissue from across the course of Alzheimer's disease. 📰Read more➡️
1
30
69
We're proud to announce & congratulate our 6 #UKDRI centres: @Cambridge_Uni @cardiffuni @EdinburghUni @imperialcollege @KingsCollegeLon @ucl
0
64
69
Huge congratulations to the brilliant Dr Soyon Hong (@soyonhonglab, UK DRI at UCL) - awarded this year's 'David Hague Early Career Investigator of the Year' at #ARUK2023 by Caroline van den Brul MBE👏🧠🎉🏆. Read more & watch our new film with Dr Hong👉
3
7
69
Brilliant podcast with @axl_montagne (UK DRI at Edinburgh), discussing his research into the role of blood brain barrier dysfunction in the diseases that cause dementia. Check it out ⬇️ .@foundmyfitness .
4
20
71
We have a new Research Fellow position open in the lab of Prof Karen Duff (Centre Director, UK DRI at UCL). Ideally suited for a newly qualified postdoc interested in understanding the role of abnormal tau protein in neurodegenerative disease. 🗓️ 5 Feb 👉
1
49
67
We're delighted today to announce our new 'Emerging Leaders' programme - an initiative to support research fellows on their journey to independence! 🎉🧠. Find out more about programme & first UK DRI Emerging Leaders👉 (1/4)
2
18
68
Hi everyone, it’s Lizzie, @e_a_english 👋. Today, I’m taking over @UKDRI Twitter for #InternationalWomensDay #IWD2023! 👩🔬. Stay tuned to @UKDRI & #UKDRIxWiNUK throughout the day to learn about inspiring women in dementia research & inequities in our field.
3
11
69
Exciting news today as results from phase 3 trial of #Alzheimers drug lecanemab presented at #CTAD22 confirm the drug reduced amyloid in the brain & slowed cognitive decline👏. UK DRI researchers comment on the news, hailed as 'the beginning of the end'🙌👉
2
20
66
And that's a wrap! Thank you to everyone who joined us for #Connectome2022 over the last few days👏. It was brilliant to catch up with you all on our 5th anniversary - here's to the next five!. Full vid👉
0
36
70
Image 3 of 4: Pirates of the Caribbrain: The Curse of the Plaque Pearl . A protein called complement receptor 1 (CR1) is found on microglia and astrocytes (red) and amyloid-beta plaques (green/yellow) in the Alzheimer's disease brain. 5/6
1
13
68
Important new research led by Prof Siddharthan Chandran & Prof Josef Priller (UK DRI at Edinburgh) reveals insight into why motor neurons degenerate in MND🧠. Microglia, the brain's immune cells, show impaired waste clearance & build up of toxic proteins👉
2
12
66
We're in Brighton for the next few days for our annual conference, Connectome 🥳 🧠 🙌 . Researchers from across all UK DRI centres are coming together for a packed programme of exciting science! Stay tuned for updates. #Connectome2023
0
13
66
Encouraging news today as a second Alzheimer's drug, donanemab, has been shown to slow cognitive decline in a phase 3 trial👏. More in the @Independent👉
0
25
67
Huge congrats to Dr Sarah Marzi (@sj_marzi) who will be joining the UK DRI at King's as a new Group Leader this September!🥳🎉👏. Dr Marzi will apply her background in epigenetics to tackle amyotrophic lateral sclerosis (ALS)👉 @KingsIoPPN
5
6
62
🎉 Big congratulations to Dr Soyon Hong, Dr Tim Bartels & Prof Adrian Isaacs (UK DRI at UCL), who have each been awarded a Collaborative Pairs Pilot Projects award by @ChanZuckerberg, as part of a world-wide call 🌍. Read more about the projects ➡️
3
8
62
Amazing people make progress in #Alzheimers research possible, & this week we're proud to feature them. @ClionaFarrell_ (UK DRI at @ucl, funded by @alzheimerssoc) aims to investigate Alzheimer's in people with Down's syndrome. #WorldAlzheimersMonth #FillingTheGaps
2
26
56
VERY excited to be hosting our first research & careers mini-conference for secondary school students! 🎉🥳. Brilliant chance to go behind the scenes & hear from academics/clinicians about their work on the brain 🧠. 🗓️ 15-16 Sept 👉
3
27
60
Fantastic interview with Prof Julie Williams (UK DRI at Cardiff Centre Director) on @BBCRadio4's #TheLifeScientific this morning!. Prof Williams spoke to @jimalkhalili about her work at the forefront of #Alzheimers research🧠. Listen here⬇️.
5
14
58
It's #InternationalDayOfWomenAndGirlsInScience! #IDWGS2021 🎉. A special thanks to everyone taking on the challenge of #dementia in labs, offices, clinics. around the world! 🙌. To celebrate, we'll be sharing some highlights from the last year ⬇️
1
23
56
Today marks the start of World Alzheimer’s Month!🧠. Throughout Sept, we’ll be shining a spotlight on our dementia researchers and initiatives across the Institute.Stay up to date via our blog👉 & subscribe to our new e-newsletter👉
1
26
58
Huge congratulations to Prof Sarah Tabrizi (UK DRI at UCL) who has received the 2022 Osler Medal and the Huntington’s Disease Society of America (HDSA) 2022 Outstanding Research in Huntington’s Disease Award 🎉👏👉
1
11
57
Congratulations to Prof Paul Matthews (Centre Director, UK DRI at Imperial) who has been appointed the new Director of @RosFrankInst!. Huge thanks to Prof Matthews for his hard work & commitment to UK DRI, & we look forward to continuing to work together👉
3
4
56
After 6 years as UK DRI Director, Prof Bart De Strooper is stepping down to focus full-time on his research. His lab will remain within the UK DRI, where he will continue his world-leading work on understanding the fundamental mechanisms of Alzheimer’s👉
0
15
54
Positive peer pressure: new @CellReports study reveals how neurons & astrocytes cooperate to maintain a healthy homeostatic state in microglia . From the team at UK DRI at Edinburgh, led by Dr Jing Qiu & Prof Giles Hardingham . Read the full story👉
0
16
57
Congratulations to Prof Joanna Wardlaw CBE (Group Leader, UK DRI at Edinburgh) who has been awarded this year's @BritishNeuro 'Outstanding Contribution to Neuroscience Award'! 🧠 🎉👏. More about Prof Wardlaw's research👉
Huge CONGRATULATIONS to this year's #BNAPrizes winners👏✨🥳.Outstanding Contribution to Neuroscience 2021: Professor Joanna Wardlaw.Public Engagement of Neuroscience 2021: The BrainBus team.Awarded live at the #BNAFestiveSymposium!.Full info here:
0
9
54
Super interesting study, led by @w_mcewan (UK DRI at Cambridge) reveals new insight into the mechanisms underlying an experimental antibody therapy for Alzheimer's🧠. The findings could pave the way for safer and more effective immunotherapy drugs👏👉
0
19
52
Today, on #WorldAlzheimersDay, UK DRI acknowledges all those impacted by the disease & other causes of dementia. Our 600+ researchers are working hard to uncover the causes of #dementia and identify promising treatments. Prof Bart De Strooper reflects 👉
1
35
56
We’re excited to announce our first Grand Challenge to improve early diagnosis of #Alzheimers. Led by @marcaurelbusche (UK DRI at UCL), the highly collaborative project will develop a biomarker that accurately detects the earliest signs of disease👉 1/4🧵
3
23
50
A new study by @w_mcewan & @_sophiesanford reveals that type-I interferons, a part of the innate immune response, may increase the build up of misfolded toxic tau protein in Alzheimer’s🧠 . The research could provide a new avenue for disease therapeutics👉
0
14
53
We're excited to welcome a new Group Leader to the UK DRI at Edinburgh!🎉👏. Dr Philip Hasel (@HaselPhilip) is researching the function of a specific type of astrocyte only found at the brain border, in health and disease. Find out more about his work👉
1
7
55
Image 1 of 4: Axon Hurricane . Long projections known as axons extend away from the cell bodies of neurons that are derived from stem cells. The axons naturally form a right-turning hurricane-like shape. 3/6
1
1
53
Team led by Prof Bart De Strooper (UK DRI Director) & Dr Mark Fiers @CBD_VIB, have used pioneering spatial transcriptomics to probe brain cells in the direct vicinity of amyloid plaques in Alzheimer’s. 📰New @CellCellPress publication out today.➡️
2
19
54
The UK DRI Biomarker Factory, led by Prof Henrik Zetterberg and Dr Amanda Heslegrave (@ajh1269) supports the development of new fluid biomarker tests, leading the way for simple blood tests for neurodegenerative conditions. Take a tour of the factory👉
1
17
52
Huge congratulations to Prof Sarah Tabrizi (UK DRI at UCL), Prof Bill Wisden & Prof Paul Elliott (both UK DRI at Imperial), who have been elected as Fellows of the @royalsociety today in recognition of their invaluable contributions to science!👏🥳👉
0
14
51
Huge congratulations to @_sophiesanford, who has today been awarded the @BritishNeuro Award for Public Engagement of Neuroscience, for her work pioneering Making it Brain - a free, online careers event for students👏🎉. Read more👉
0
6
51
Interesting new research led by @TSpiresJones (UK DRI at Edinburgh) has revealed fresh insight into how misfolded tau spreads through the #Alzheimers brain, via synapses🧠. Scientists say the study could hold the key to stopping the disease progressing👉
0
14
45
🔔 Our Director, Prof Siddharthan Chandran, was invited to discuss our work in dementia and neurodegenerative conditions this week with the House of Commons Science, Innovation and Technology Committee. The Select Committee was investigating how UK science and research is
0
19
53
“This is the beginning of the end for dementia,” said Prof Nick Fox, as we officially opened our hub at UCL. Thanks to our funders @The_MRC @alzheimerssoc @ARUKnews and everyone who has helped bring promise to the millions of people affected by dementia.
1
24
47
This week, we're celebrating the brilliant scientists who make progress in #Alzheimers research possible🧠 🙌 . Meet @mathieubourdenx (@duff_lab, UK DRI at @ucl), whose research aims to understand how the brain ages. #WorldAlzheimersMonth #FillingTheGaps #PostdocAppreciationWeek
0
20
48
🎉👏 Congratulations to Professor Karen Duff (Centre Director, UK DRI at UCL) on picking up the 2020 'Outstanding Contribution to Neuroscience' award from @BritishNeuro! 👏🎉.
🎄Live at #BNAFestiveSymposium: We’re delighted to announce our 'Outstanding Contribution to Neuroscience' 2020 BNA prize…👏👏Congratulations to Karen Duff, @UKDRI .@miltenyibiotec @Scientifica_Int
4
5
47
Fantastic to hear from our first keynote speaker @wysscoray (@Stanford) at #Connectome2023 today!. A fascinating talk on his incredible work looking at how circulatory blood factors modulate brain structure & function, & factors from young organisms can rejuvenate old brains🧠
0
7
50
Motor neurone disease could be treated by boosting energy in nerve cells. New research just out from a team at UK DRI at @EdinburghUni supported by @The_MRC @mndassoc @mndresearch #ALS #MND @DrArpan100. Read more 👇.
2
23
45
SO EXCITED to be in sunny Brighton today at the #BYOB2023 Brain Science Fair teaching families about neuroscience! 🧑🔬. We've got jelly brain dissection & toxic protein Tetris from the team at UK DRI at Cambridge 🧠 . Last entry to the Brighthelm Centre 2pm!
1
7
49
We're thrilled that the Scottish Government are investing £400,000 over the next three years in our @EdinburghUni centre to develop new treatments for Motor Neurone Disease (MND). #scotland #mnd.
0
26
45
We're OVER THE MOON our founding funders @alzheimerssoc and @ARUKnews are together Charity of the Year for the #LondonMarathon 2019! Join us to overthrow old attitudes and fund research here at the @UKDRI to lead the charge towards cures. @DementiaRev
0
25
48
HUGE congratulations to Dr Wioleta Zelek (UK DRI at Cardiff) & Dr Aitana Sogorb-Esteve (UK DRI at UCL) recipients of prestigious Race Against Dementia fellowships & our latest UK DRI Emerging Leaders🎉. #WorldAlzheimersDay2021 . Learn about their projects👉
4
14
44
"We’re at the end of the beginning of our misunderstanding of the disease, & we’re at the beginning of being able to end it.". 🗣️Interview out today with Centre Dir. at UK DRI at UCL, Prof Karen Duff, discussing tau, selective vulnerability & trials. 👉
0
15
43
The UK Dementia Research Institute (UK DRI): Five years of innovation in discovery science🧠🧪🔬. 📽️ Who we are👉.📖 What we do & how we do it👉 📩 Sign up for our monthly newsletter👉
1
18
43
Image 5 of 5: AstrocytER . The endoplasmic reticulum (ER), a network of membranes through which proteins and other molecules move, is stained within astrocytes, the star shaped supporting brain cells. 7/7
0
4
49
Congratulations to Dr Sam Barnes & Dr Soyon Hong (@soyonhonglab), who were awarded funding in the 4th round of our Cross-Centre Postdoctoral Awards!👏🎉. Their project will investigate the role of microglia in #Alzheimers👉
4
5
47
New Alzheimer's drug donanemab has hit headlines today as it was reported to slow cognitive decline by 35% in a phase 3 trial🧠🙌. UK DRI researchers comment on the momentous news👉
0
9
44
🖥️Fantastic opportunity to catch Prof Sir David Klenerman (UK DRI at Cambridge) - all welcome! 🙌. "Detecting and Characterising the Protein Aggregates Formed in Neurodegenerative Diseases". Webinar hosted by @KingsIoPPN . 🗓️28 April ⏰12pm BST➡️
0
33
48
Brilliant presentation from @DrArpan100 at #BNA2023 on the innovative @mndsmart and ongoing exciting developments taking place. An ambitious initiative with huge potential to change lives!
1
11
47
"I hope my work helps us to start unravelling some of the mechanisms that lead to Alzheimer's disease". @nlconnor_robson is an @AlzResearchUK fellow & Emerging Leader at the UK DRI at Cardiff, where she is researching the genetics of late-onset #Alzheimers🧠⬇️ . #WorldBrainDay
2
11
47
Congratulations to Dr Kat Bowles 👏(@bowles_lab, UK DRI at Edinburgh) who has been awarded a Tauopathy Challenge Workshop Prize from @RCFNeuro, in partnership with @CurePSP & the Aging Mind Foundation 🧠. 👉
5
7
43
A team led by @nir_grossman (UK DRI at Imperial) have developed a new technology that, for the first time, allows structures deep inside the brain to be electrically stimulated without surgery. It's now being trialled as a treatment for Alzheimer's👉
1
15
47
Head injuries may worsen cognitive decline decades later. People who experienced head injuries in their 50s or earlier score lower than expected on cognitive tests at age 70, according to a new study co-led by Prof Nick Fox (Group Leader, UK DRI at UCL). 👉
0
21
45
Excellent workshop led by @e_a_english from @WomeninNeuroUK at #ARUKConf24!. Important discussion about the leaky pipeline in dementia research, and an open and honest panel discussion and Q&A👏👏. #WiNUKxARUK
1
8
45
Great talk from Prof Bart de Strooper at 'Unravelling Dementia Together' at the British Embassy in Brussels today👏. Basic research is crucial to cure dementia, & international collaboration is pivotal to solve this global issue🤝
0
10
46
🗣️ "Now is the time to pull together, not pull apart”. UK DRI Director, Prof Bart De Strooper, on a new alliance between top research institutes from around Europe - CURE-ND 🧠. 🇩🇪@DZNE_de .🇫🇷@ParisBrainInst.🇧🇪@MissionLucidity.🇬🇧@UKDRI. Read more 👉
0
9
42
Since its launch in 2017, the UK DRI has made important progress in overcoming dementia. Now, we are thrilled to announce major funding that will set us on track for success in our next phase👉1/2
2
11
42