Tony Wyss-Coray
@wysscoray
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Joined January 2017
Imagine we developed a drug to repair synapses and neurons and learned that the supply routes keeping neurons alive are broken in AD brains - it’s a possibility. Check out @andcyang ’s human brain vascular atlas and the related study from Heiman/Kellis
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Biologic & disease processes need to be viewed from an age perspective. How does your favorite gene change with age? check out Tabula Muris Senis and this App combining sc and bulkRNAseq across 10 ages in and
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excited to share an in-depth review of aging clocks or-more appropriate-methods to estimate biological age Congratulations to Jarod Rutledge and Hamilton @hammy_oh
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Aging is key to Neurodegeneration but the spatiotemporal contribution of genes to disease susceptibility (regional vulnerability) or progression is unknown. @Oliver__Hahn and team captured gene expression changes across brain regions and mouse lifespan
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Congratulations to David Gate and all our fantastic collaborators!.An immune-cell signature marks the brain in Alzheimer’s disease
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I'm thrilled and humbled to direct the Phil and Penny Knight Initiative for Brain Resilience at the Stanford Wu Tsai Neuro and work towards eradicating age-related cognitive decline and dementia. Thanks for the amazing gift and to all who made it happen.
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Very excited to share work of Andrew Yang, supported by a fantastic team and productive collaborations with @mjameslab and @CarolynBertozzi: .Brain blood vessels soak up blood proteins defying barrier stigma. Thanks for a wonderful review by Rich Daneman!!
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Exercise is in your blood – I’m so happy for Zuri DeMiguel to get this amazing study out against all odds. With tremendous help from Nathalie Khoury, Mike Betley, Benoit Lehallier @blehall &collaborators Kaci Fairchild &Tom Rando
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We find granzyme positive CD8 T cells next to degenerating neurons in hippocampi of Alzheimer’s patients. A smoking gun and a dead body but more work will be needed to prove that that gun killed the neuron. More here and here
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How can we slow aging or rejuvenate brains and other organs without having biomarkers to test interventions? @JarodRutledge1 and @hammy_oh may have a solution Congrats and thanks to these superstars and to all for this massive effort!
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and here is our simple web browser developed by Patricia Losada to look up the expression of your favorite gene in the human brain vasculature and in AD.
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Excited to share Zurine DeMiguel’s study from our lab showing plasma from exercised mice transferred into sedentary ones, reduces brain inflammation and improves cognitive function! The complement and coagulation systems seem to have a key role in this:
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Great collaboration with @carolynbertozzi, Michael Bassik, and Ludwig Aigner lead to this cool discovery by Julia Marschallinger suggesting lipid droplets in microglia may have a critical role in aging and neurodegeneration
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We have little molecular data how complex brains age across regions. Check out study from @Oliver__Hahn with app to query how your favorite gene changes region specific. Major implication for risk and resilience to cognitive decline and degeneration
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Check out our latest manuscript on BioRxiv describing aging of the mouse at the transcriptome level in 17 tissues from 1-30 months
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Excited to share Benoit Lehallier’s plasma proteome of aging paper which is out in Nature Medicine today
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What Alzheimer noted as fat saccules in glia may have been lipid droplets. They can be induced by Abeta in microglia leading them to release factors that damage neurons. ApoE4 makes things worse Congrats @Michael_S_Haney @robipalo and fantastic team
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Can’t believe we just moved into the amazing new Neuroscience/ChEM-H building designed by Ennead Architects. Super excited to share a large open lab with @BrunetLab and @kaltschmidt_lab
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Congratulations to Andrew Yang and Fabian Kern @fabiankern13 for generating a transcriptomic map of the Covid brain. Great collaboration with Andreas Keller at Saarland Univ shows broad activation of brain cells and signs of immune and neuronal dysfunction.
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Excited that this is in print now! congratulations again to shared authors Michelle Chen, Andrew Yang, and @HanadieYousef!.Brain Endothelial Cells Are Exquisite Sensors of Age-Related Circulatory Cues
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thrilled to share @jvpluv study showing soluble CD22 from oligos in humans impairs microglia and blocking this interaction benefits iPSC derived Niemann-Pick C-induced microglia. Awesome collaboration with @BlurtonJonesLab @CarolynBertozzi @PascaStanford
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Check out Benoit Lehallier’s paper describing waves of aging in the human plasma proteome - the first major wave at age 34! - based on >4,300 people and 2,900 proteins at
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Congratulations to Julia Marschallinger and her team and thanks to wonderful collaborators Mike Bassik, @CarolynBertozzi and Ludwig Aigner for characterizing lipid droplets in microglia. Excited to see what people think!
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At the bottom of the paper it says “data available upon request”. The corresponding author only answers after the 3rd email with “sorry, we are already working on that. ” no data for you or anybody? Should we make a website to shame such people?.
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via @Stanford. Congratulations Carolyn @CarolynBertozzi and looking forward to continue great collaborations.
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Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological… wow, look at this Kaplan-Meier plot OR table from a landmark AD Genetics Consortium study led by Eric Reiman.
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how about predicting your age based on plasma proteins? or if you are interested in how you favorite protein changes we age, Patrica Moran Losada made an app:.
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Congrats @andcyang RyanVest @fabiankern13 to human brain vascular map & role in AD in collaboration with @SiegenthalerLab and Andreas Keller Discovered 2 types of pericytes, one differentially lost in AD, PV fibroblast types & tie AD GWAS to vasculature
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Wow! check this out! Super aging mostly fraudulent? "Supercentenarians and the oldest-old are concentrated into regions with no birth certificates and short lifespans"
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Also, check out the Shiny app developed by Patricia Moran Losada to query age-related changes of >2,000 proteins
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Beautiful arguments. Ask nature - learn - be humble. Don’t impose your answers on nature. Critique of the Hypothesis, and a Defense of the Question, as a Framework for Experimentation
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The 50 Most Influential People in Health Care of 2018 | surprised but honored
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Congratulations to @JarodRutledge1 for discovering DDC as a possible CSF and urine biomarker for Parkinson’s disease check out many other interesting proteins. Thanks to @blehall and collaborators in this wonderful collaboration with the @pddoc lab.
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Also, if you ever wondered how a gene may change with age in any of the major tissues or cells of a mammal check here with these amazing browsers: And
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Neurodegenerative gene’s function is not all about those bases
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wanted to acknowledge and thank @StephenQuake and @Nick_Schaum who started this crazy project >5 years ago and recruited 16 Stanford labs to make this happen. Congrats @robipalo for this analysis of blood rejuvenation. Got to love his “Picasso plots”
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Following up on our Tabula Muris we present now Tabula Muris Senis in close collaboration wit Steve Quake and the Biohub on BioRxiv
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here is the correct link to explore changes of some 3,000 plasma proteins with age
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19th Bay Area Aging Meeting BAAM starring now. 700 registered participants
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Brilliant in vivo CRISPR screen of the HSC lineage from @Michael_S_Haney and @awilkinsongroup on identifying new transcriptional regulators of hematopoiesis. Exciting that age-related decrease in SAGA complex is rescued with young blood during parabiosis.
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John’ Pluvinage’s @jvpluv thorough review on systemic factors as mediators of brain homeostasis, aging and neurodegeneration is out
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Excited to get started on studying the role of the brain vasculature on cognitive aging and proud to share with fellow awardees Rusty Gage and Mukesh Jain and their teams!.
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Blocking protein curbs memory loss in old mice Congratulations to Hanadie Yousef and thanks to the entire team!!.
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Congratulations Kang! Thrilled to be working with you as we develop the Knight Initiative for Brain Resilience.
We've got big news: @Stanford has named Kang Shen as the next director of the Wu Tsai Neurosciences Institute! Together we will continue our mission to advance our understanding of the #mind and #brain in health and disease. Read more:
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We are looking for an associate director for the new Knight Initiative for Brain Resilience who helps us develop a transformative program to eradicate age-related cognitive decline and dementia. Let’s Just do it!.
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Just received the honor with my fellow awardees Rusty Gage and Mukesh Jain.
Congratulations to three pioneering awardees of the first @American_Heart Paul G. Allen Brain Health grants! #AHA18
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Check out our latest collaboration with Steve Quake and Michelle Chen in his lab at
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Wow. A whopping benefit of plasmapheresis and albumin in moderate Alzheimer in Phase 2b/3 trial. Note albumin fraction contains many other proteins
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proud to see see Liz Kirby and Eva Czirr, former fellows in the lab, both mentioned in this article. Way to go girls!. ‘He was exceptional. He lived and lived and lived.’ Scientists are proud of their old mice. via @WSJ.
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There is a Kickstarter campaign underway for a documentary on Ben Barres life. There are only 7 days to go and about 7K left to raise for the project to be viable. Ben was a true inspiration for me as well. Please donate.
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Important finding to consider as we use AAV.
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Congratulations to @WernigLab to their intriguing study linking microglia to neurodegeneration and providing evidence for therapeutic potential of microglia replacement in a model of rapidly progressive prosaposin deficiency lipid storage disorder
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congratulations to @JarodRutledge1 and @blehall for describing new fluid biomarker AADC for Parkinson's disease in great collaboration with Kathleen Poston @pddoc.
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check out our Tabula Muris single cell atlas of the young mouse
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Four distinct trajectories of tau deposition identified in Alzheimer's disease
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Congratulations Carolyn! Honored to be able to collaborate with you!.
Congratulations to ChEM-H co-director @CarolynBertozzi, recipient of the 2020 Chemistry for the Future Solvay Prize for the invention of #bioorthogonal chemistry: @StanfordUChem @HHMINEWS
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Congratulations @CarolynBertozzi !!!.Special report: Twenty extraordinary women blazing trails in biopharma R&D — Covid-19 and beyond -
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Aged blood inhibits hippocampal neurogenesis and activates microglia through VCAM1 at the blood-brain barrier
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Peter Davies, Beloved Giant of Alzheimer’s Disease Research dies at 72
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Congrats Hanadie Yousef to this fine protocol! Much more to come by using it- stay tuned. .
Here's another #neuroscience #protocol from our latest issue: Papain-based Single Cell Isolation of Primary Murine Brain Endothelial Cells Using Flow Cytometry, from @wysscoray @Stanford_ChEMH More neuroscience here #methods #opensciece #flowcytometry
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@DMSabatini happened with our paper in Nat Neurosci last week when self- declared troll Leonid Schneider tweeted about an obvious erroneous duplication of an image to discredit our work. I thanked him and immediately notified the journal editor to fix the mistake. Definitely nerve wrecking.
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Congratulations David Gate for winning a Junior Faculty award at ADPD Conference in Lisbon
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Getting Between Fibrin and Complement Receptor Cools Inflammation | ALZFORUM
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Congrats Malene! Great to have you in NorCal😀.
📢 time! Dr. Malene Hansen is joining Buck as our new Chief Scientific Officer! Buck CEO Eric Verdin sums it up: “She is an extraordinary scientist with the background, vision, and skills to enhance our leadership position and to accelerate our mission"
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Protein isolated from human cord blood has antiaging effects on memory in mice
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Congrats again to outgoing scholar Kyle Brewer and to incoming Tal Iram! very proud of you and the lab garnering the second of these awards in a row!.
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I love this comparison. We evolve. I’m typing this on a device that is more complex than what brought the first humans to the moon 🌝.
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Plasma proteomics reveals tissue-specific cell death and mediators of cell-cell interactions in severe COVID-19 patients
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Congratulations Sam!.
Excited to share first preprint from my postdoc work in Stevens lab: “Single Cell Sequencing Reveals Glial Specific Responses to Tissue Processing & Enzymatic Dissociation in Mice and Humans” a thread below #singlecell #microglia #methodsmatter 1/n.
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check out Joe Castellano’s paper which came out in Nature today. Congrats Joe!
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Awesome experience as we witnessed the total eclipse a few miles southeast of Madras, OR
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Investigational drugs didn’t slow memory loss, cognitive decline in rare, inherited Alzheimer’s, initial analysis indicates via @wustlmed.
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@DGateLab Congratulations again, David! I’m so glad it worked out under these most challenging of circumstances 👍.
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Trillions Upon Trillions of Viruses Fall From the Sky Each Day
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Are preprints the future of biology? A survival guide for scientists
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@RickBagshaw @DMSabatini Rick, it would be nice if it were simply a note to point out a mistake (which should obviously be done) but unfortunately, the tweets that alerted me speak otherwise (see attached).
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Great thanks effort to democratize software. Thanks.
A comprehensive analysis of the usability and archival stability of omics computational tools and resources #bioRxiv.
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