Sho Suzuki (he/him)
@ShoSuzuki20
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Assistant Professor at School of Biological Sciences, Nanyang Technological University, Singapore. NRF fellow, Postdoc@Cornell, PhD@Tokyo Tech
Joined December 2019
2月から、シンガポール南洋理工大学で研究室を立ち上げることになりました。これまでの研究を発展させ、オルガネラ接触部位のエンドリソソーム経路における生理的意義とその分子メカニズムを追求します。ポスドクや大学院生を募集していますので、興味のある方はぜひご連絡ください！.
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📷 New Preprint! ER supplies membrane to endosomes for ESCRT-mediated sorting. (1/7)
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今回は、このNRF fellowship採択により、この機会が得られました。非常に手厚い魅力的な制度です。現在も募集しているので、興味のある方はぜひご応募ください。.
シンガポールは若手研究者招聘のため、15年前からNRF fellowshipを提供している. ・5年間、合計~3億円の研究費（自身の給料は含まず）.・受賞者自身が、国内の大学/研究所から所属を選択.・テニュアトラックPIとして研究室を運営.・毎年10名程度が受賞.・毎年2月末~3月頭〆切.
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I'm absolutely blown away by this incredible research! SNARE insertion into an autophagosome, temporally regulated by PI4P, can be reconstituted in vitro. Huge congratulations to @SaoShinoda, our Weill Institute star @MasaakiU5, and all the team! 🌟.
Syntaxin 17 recruitment to mature autophagosomes is temporally regulated by PI4P accumulation #biorxiv_cellbio.
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I am excited to share my postdoc work as a preprint. Mvp1/Snx8 mediates retromer-independent recycling.
A PX-BAR protein Mvp1/SNX8 and a dynamin-like GTPase Vps1 drive endosomal recycling #biorxiv_cellbio.
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My boss, Scott Emr, will give the Shaw prize lecture on 10/29(10/28 in the US). I think this will be his first zoom lecture.
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Fantastic work from @MizLabUT!.
Online Now: Ubiquitination of phosphatidylethanolamine in organellar membranes
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❗️Cluster hiring❗️.NTU SBS is hiring for THREE tenured/tenure-track positions! Come be my colleague and please help RT!. 1.Drug Discovery or Pharmacology: 2.Fungal or Plant Biology: 3.Cryo ET:
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It was a truly fantastic experience to attend in MMB meeting. For me, it was my first time giving a presentation to over 200 audiences. It was a big honor. I hope I can attend the in-person Gordon conference near future. Thank you for organizing this fantastic meeting.
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This is a really cool paper. New lipid transfer proteins for endosome-to-Golgi traffic.
SHIP164 is a Chorein Motif Containing Lipid Transport Protein that Controls Membrane Dynamics and Traffic at the Endosome-Golgi . #biorxiv_cellbio.
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This is a truly awesome paper! Beautiful genetic screening have revealed a fundamental question in apoptosis.
Online Now: Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane
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Merry Christmas from my home fish tank! (Zebra fishes expressing GFP, mCherry, or BFP etc. from Walmart)
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Suzuki lab will soon recruit at all levels—postdocs, Ph.D. students, and technicians. If you’re passionate about membrane biology, feel free to DM me!.
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Congrats Scott!.
Our heartfelt congratulations to the Shaw Laureates 2021 and thank you for their great contribution in their areas of expertise.
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Good words, Jeff!.
Wise words from Emr &co (@Cornell):."contact sites are useless without proteins that facilitate some sort of transfer, sensing, or communication between the membranes. Some tethering function is likely inherent in the biology of many of these facilitators".
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私の所属するシンガポール南洋理工大学、School of Biological Sciencesでは、CryoETを専門とするTenure trackのAssistant/Associate ProfessorもしくはTenured Professorを募集しています。大学や学部についてご質問がある方は、お気軽にお問い合わせください。.
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Suzuki's lab will further explore the role of ER in endosomal function. I will recruit at all levels soon—postdocs, Ph.D. students, and technicians. If you’re passionate about membrane biology, feel free to DM me! (8/8).
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Great work, Lu! Congratulations!.
Zhu et al @CornellMBG show that Rcr1 & Rcr2, two adaptors for the E3 ligase Rsp5, are sorted to distinct locations. Exomer sorts Rcr1 to the plasma membrane and the upregulation of Rcr1 via the Calcineurin signaling pathway maintains cell integrity
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Atg9 is a scramblase! Beautiful studies revealed the most surprising finding in the autophagy field. Congrats Matoba-san and Noda-san!.
"Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion" by Kazuaki Matoba, Nobuo N Noda et al. , Nature Structural & Molecular Biology 26 Oct. 2020.
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This is super beautiful.
色んなことがあっても、染色体が凝集して分配されるのを観ると心が癒されるよね。この植物(African Blood Lily)における体細胞分裂の動画は本当に美しいし、生命の神秘を感じる。.ref:
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Congrats! @MasaakiU5!.
Congratulations to our newest postdoc, @MasaakiU5, for being awarded an HFSP Postdoctoral Fellowship! @weillinstitute @CornellChem
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来年度からの給料をボスと交渉するにあたり、今年のNIHの給与水準を調べたところ、ずいぶんと上がっているのに、びっくりした。
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Fantastic review! Absolutely recommend it! 🙌.
How do #organelles acquire #membrane #lipids? Our review in @AnnualReviews of Cell and Developmental Biology defines a family of bridge-like lipid transport proteins that control membrane area and so much more! Check out the ahead of print version now. @YaleCellBio @AGuillenSaman.
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This is cool!.
Chemically induced dimerization is great, but what could we do with chemically induced trimerization?! Find out here! Chemically inducible trimerization tools based on split FRB or FKBP with full-length FKBP or FRB, respectively.
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Takeshi Noda, who was a postdoc in Emr lab and a PhD student in Ohsumi lab, discovered yeast mTOR downregulates autophagy. This is a really good news article.
Yoshinori Ohsumi, Takeshi Noda and colleagues at the National Institute for Basic Biology in Japan discovered that the Tor protein controls the breakdown process of autophagy in yeast cells. @Spieringmj writes about their classic paper in @jbiolchem:
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Great paper is out! Ubiquitin and it’s binding protein cause LLPS leading to the formation of proteasome droplet.
Stress- and ubiquitylation-dependent phase separation of the proteasome:
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This is amazing.
This is #ChikungunyaVirus imaged by cryo-electron microscopy 🔬The level of detail we can now get blows me away 😱 Want to know why I love science? LOOK HOW AMAZING IT IS. You can very clearly see the E2 protein crossing the lipid bilayer 👨🏼🔬. Ref on sub tweet. #virology #scicomm
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@My_Liberty_ コーネル大学で研究員を6年やっているものです。この度は誠におめでとうございます。学部からの入学がいかに大変か、本当に尊敬します。色々な声を目にしましたが、アメリカ、特に大学卒の人たちは多様性を重んじ、他者を尊敬します。.
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Beautiful work! Congrats Shawn!.
The VINE complex is a VPS9-domain GEF-containing SNX-BAR coat involved in endosomal sorting #biorxiv_cellbio.
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I think this one of the best review for mechanistic insight of autophagy (especially yeast people). Great work! Also, thanks for citating my PhD work! Hahaha. .
Angelina's (@Ansa_Lina) and Martin's review summarising the "Mechanisms of Autophagy in Stress Response" .@ELS_CellBiology is now available for free download:.
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南洋理工大学、鈴木研究室では、エンドソーム機能における小胞体の役割をさらに追及していきます。博士研究員、大学院生を募集していますので、興味のある方はぜひご連絡ください。(8/8)
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ポスドクをはじめた2015年と比較すると、1年目の給与が7000ドル/年近く上昇している。添付が2015年。
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The beautiful work, led by @MakinoShiho and Yoshinori Ohsumi, demonstrates selective mRNA degradation through autophagy, which definitely contributes to cellular remodeling in response to environmental cues. Congratulations!.
The Ohsumi lab shows yeast preferentially target specific mRNAs for autophagic degradation #autophagy @RIKEN_CPR.
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Great paper from Ming improves knowledge of vacuole membrane degradation.
TORC1 regulates vacuole membrane composition through ubiquitin- and ESCRT-dependent microautophagy
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Congrats to my previous labmate, Yui Tomioka, for her outstanding JCB paper, revealing the mechanim of selective degradation of the NPC complex via autophagy.
TORC1 inactivation stimulates autophagy of nucleoporin and nuclear pore complexes | Journal of Cell Biology | Rockefeller University Press
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This is really cool.
A selective autophagy pathway for phase separated endocytic protein deposits #biorxiv_cellbio.
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This is very interesting for me. Snx4 makes a complex with Snx5(Vps17) and Snx17 for Stx17 recycling from the autophagosomal membrane.
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@KaoriYamada01 @minesoh 出典は忘れてしまいましたが、古いバージョンに近いレシピだと思います。精製が甘いポリクロには劇的な改善が見られ、名前と共にラボで流行ってます。笑.
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This study developed extremely pH- and hydrolase- resistant Green fluorescent protein, which is pretty useful in various ways.
Online now! a signal-retaining #autophagy indicator, localized to #mitochondria (mito-SRAI) is able to quantitatively measure mitophagy and was applied to screen for chemical inducers of mitophagy and in a #mouse model of #Parkinsons disease. @RIKEN_CBS
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This is prety useful resource! The game-changer has just shown up.
Endogenous tagging + 3D live-cell imaging + mass-spec interactome = an open-source map of the human proteome. So excited for our first release, wonderful collaboration with @labs_mann @loicaroyer & many other colleagues. @OpenCellCZB
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This is a really really good news. I have been waiting for a long time. Now, my family can be fully vaccinated!!.
Great news!!. Pfizer vaccine for children under 5 may be available in U.S. by end-Feb - report
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Congrats, Rick! Beautiful story!.
It's out! Twitterless Rick Hooy solves a #CryoET structure of clathrin-independent, adaptor protein complex that is hijacked during HIV infection. Thanks to Yui and Snow along with @DanTudorica3 for bringing this story together. Thread below: 1/9
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This is really cool!.
Happy to finally share this work!! Proteasomes cluster at the ER, apparently by phase separation. We propose that these clustered proteasomes perform ERAD. They directly engage a specialized patch of the ER membrane and are surrounded by a cloud of Cdc48.
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近所のスーパーで手に入るお出汁。これを使って、作ったときだけ、2才の娘がYummyという。たまたま何だろうか。
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Beautiful!.
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