Satoshi Yoshiji
@SatoshiYoshiji
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Assistant Prof & PI @mcgillu using human genetics & multi-omcs for drug discovery | Endocrinologist | PhD @mcgillu & KyotoU | Visiting scholar @broadinstitute
McGill Univ, Montréal, QC
Joined March 2021
📣 We are hiring! Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada! ✅Fully Funded Positions • 2 MSc Students • 1 PhD Student • 1 Postdoc ✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine ✅Location: 740 Dr. Penfield, Downtown Montreal ✅Our Research: 1. Human genetics & multi-omics for drug discovery. 2. Building and analyzing a new multi-ancestry multi-omics biobank of 12,500 people. 3. Using genomics & proteomics to dissect cardiometabolic disease heterogeneity. Check out our recent Nature Genetics paper to learn more. Interested? Let's talk!
📣Excited to share our paper in @NatureGenet! Do plasma proteins mediate obesity’s effect on CAD risk? →Using two-step proteome-wide MR, domain-aware MR, epigenomics & scRNA-seq, we prioritized endotrophin as a mediator & potential therapeutic target A 🧵
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RT @SeriKitada: Fully funded roles at McGill to study cardiometabolic diseases & advance precision medicine via human genetics & multi-omic…
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@somijemmacho @pnatarajanmd @NorrinaA @DaichiShimbo @chiragjp @genetisaur @HyeonChangKim1 @dmljmd @mchonig @broadinstitute @CGM_MGH @mghcvrc @patrick_ellinor So well deserved!! Congratulations!🎉
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Thank you, @hammy_oh! Great question. The variance in C-terminal COL6A3 and endotrophin levels is not explained exclusively by BMI (no circulating protein is). Importantly, BMI and BFP (another proxy for obesity used in the study) are continuous traits, and obesity is not binary (BMI of 30, 40, and 50 represent different levels of obesity). So yes, endotrophin levels vary even in individuals without obesity due to BMI and other factors. Step 2 MR (C-terminal COL6A3/endotrophin → CAD) does not depend exclusively on obesity. The analysis suggests that endotrophin is causal for CAD in the general population, highlighting broader implications. A useful analogy can be blood glucose levels. Obesity may increase glucose levels and the risk of type 2 diabetes, but the glucose-to-diabetes association is not exclusively dependent on obesity.
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RT @lab_tanaka: I am happy to share our new article published in Genome Research. This project proposed a new deep learning approach to inf…
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RT @skoyamamd: We are excited to share our latest work, "Genetic Predisposition to Low-Density Lipoprotein Cholesterol and Incident Type 2…
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RT @chenyangsu: @SatoshiYoshiji's lab is hiring! Working with Satoshi as a PhD student has been so valuable to me. His mentorship and sup…
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RT @TianyuanLu1: My amazing friend and colleague @SatoshiYoshiji at my alma mater is recruiting. Great people, Great place, Great opportuni…
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📣採用情報: マギル大学Human Genetics学部の吉治研究室では、大規模ヒトゲノム・オミックスを活用した創薬標的同定・個別化医療推進の研究を行っており、以下のポジションを募集しています！ • 2 MSc, 1 PhD, 1 Post-doc 日本からは、京都大学・マギル大学ゲノム国際連携専攻 (共同学位課程)で、当ラボへの留学も可能です。 年約240万円の経済支援＋マギル側授業料免除があり、負担を抑えて留学可能です。 研究内容: • 大規模ヒトゲノム＆マルチオミクスによる創薬ターゲット探索 • 新たなmulti-ancestry, multi-omicsバイオバンクの構築・解析 • ゲノミクス＆プロテオミクスを用いた心血管代謝疾患の多様性解析 マギル大学は東海岸のモントリオール・カナダにあり、QS大学ランキングでトップ30に位置し、特にライフサイエンス、ゲノム領域に強い大学です。 詳細は元ポストをご参照ください↓
📣 We are hiring! Join Yoshiji Lab at McGill University Dept of Human Genetics in Montreal, Canada! ✅Fully Funded Positions • 2 MSc Students • 1 PhD Student • 1 Postdoc ✅Goal: Using human genetics and multi-omics for drug target discovery and precision medicine ✅Location: 740 Dr. Penfield, Downtown Montreal ✅Our Research: 1. Human genetics & multi-omics for drug discovery. 2. Building and analyzing a new multi-ancestry multi-omics biobank of 12,500 people. 3. Using genomics & proteomics to dissect cardiometabolic disease heterogeneity. Check out our recent Nature Genetics paper to learn more. Interested? Let's talk!
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RT @DanielJDrucker: New data illustrating how circulating proteins mediate the effects of obesity on cardiometabolic diseases prioritizing…
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RT @chenyangsu: Check out our work just published in Nature Genetics! @NatureGenet Led by @SatoshiYoshiji at @mcgillu
#AcademicTwitter 👇
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