Babak Razani, MD, PhD Laboratory
@RazaniLab
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Razani lab @ Center for Immunometabolism (https://t.co/4MwIEByzBT), Univ. of Pittsburgh studies macrophages, autophagy-lysosomes & nutrient signaling in metabolic d
Pittsburgh, PA
Joined January 2020
If you're interested in reading our @NatMetabolism paper on dietary #protein, #leucine, #mtor, #macrophage, and #heartdisease #atherosclerosis, here is the free link provided by the journal. Sharing here due to many requests. 👉
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@Polash_23 Good to hear from you Moydul. Congrats on your excellent paper getting accepted. I'll tweet about it when it's officially out.
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For the researchers of #autophagy, understanding the dynamics of autophagy (i.e. flux) is everything. Here is a must-read primer of the nuances and available tools from one of the true gurus @MizLabUT.
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Great paper by @LloydDHarvey & @chansteve73 lab at @PittVMI @PittDeptofMed in @ScienceMagazine identifying #endothelium NCOA7 as key regulator of #lysosome function, #oxysterol generation, & #PAH #pulmonaryhypertension. Marvelous translational effort.
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@ArdehaliHossein @heshamasadek @uarizona @sadayappanlab @J_Wertheim1 Congratulations Hossein on the new roles and to the stellar group you all are building in Tucson!
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Elegant & highly practical #PET imaging probe (CD45-PET) to monitor all sorts of #inflammation reported by lab of @m_rashidian1 & collaborators in @Nature. Why didn't we develop this years ago? Now excitement begins. How about #CVD #atherosclerosis uses?
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@KatsuFunai @LodhiLab @LarryDSpearsJr Anne Jensen-Urstad! Thanks for update Katsu. Always fun seeing old friends. Send our greetings to Anne and hope 2000s Semenkovich lab can have reunion at some point.
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Super start to 2025 by @MdSaifurRKhan1 of @RazaniLab @PittVMI with 2nd paper in same week! In clinical study with @ericapgun, Prof. Wheeler & colleagues, he used #metabolomics #biomarker data to profile progression of #gestationaldiabetes to #T2D #diabetes
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Check out new work by @MdSaifurRKhan1 of @RazaniLab @PittVMI & colleagues in @ScienceAdvances showing protective role of #sphingolipid #ceramide (via Ceramide Synthase, CERS2) in #insulin secretion, #T2D #diabetes. Nice combo of clinical & animal studies!
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Great to see our #protein #leucine #CVD work highlighted by @NatMetabolism as top most profiled paper in 2024! Happy new year & hopefully we bring you exciting data on #plantprotein soon! Shout out to @XiangyuZ0321 @RazaniLab & @PittDeptofMed @WashUDeptMed, other collaborators 🤝
Top altmetrics score 2024: #1🏆✨🥇🎇 B Mittendorfer, @RazaniLab (@PittTweet, @WUSTL) describe how dietary leucine drives deleterious macrophage #mTORC1 signaling and promote #cardiovascular disease in humans and mice 🐭👥
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RT @NatMetabolism: Top citations 2024: # 17🏆✨ #Bettina Mittendorfer, @RazaniLab (@washumedicine, @pitt_medicine) and co-authors describe a…
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Always great to see human studies on #thermogenesis. Study in @NatMetabolism by groups of Drs. @JorisHoeks & Lichtenbelt shows only 1 hour cold exposure with shivering provides #metabolic benefits. How about role of #brownfat & non-shivering thermogenesis?
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@hanrui_zhang Fantastic and impactful work @hanrui_zhang and lab. Looking forward to seeing it published soon.
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@Angela5239219 Hi Angela, thanks for your comment. Sure, whatever questions you have, I hope we can address - can also email me at brazani@pitt.edu.
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Cool paper by @LammingLab in @NatureAging showing that either #protein or #BCAA #isoleucine restriction can improve parameters of #aging, frailty. Very interesting contrast between our data linking #leucine to #CVD and theirs linking #isoleucine to #aging.
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@yvancharvet Nice work Laurent and kudos to your lab and colleagues for the excellent work in @NatureCVR. A great addition to the field.
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Always exciting when new critical components of #lipophagy (#autophagy of #lipids) are discovered. Kudos to work by Singh lab @autophagie1 in @MolecularCell on identifying VPS4A in hepatic lipophagy to ameliorate #MASLD. Wondering if same in #immune cells?
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