Rajesh Sannapureddi
@RR_Sannapureddi
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Research Scholar @iiserbhopal Alumnus @nitrourkela #JNVKadapa #IISER Bhopal Interested in #Science #Technology
Bhopal
Joined August 2020
RT @bwajtweeting: G-T mismatches are notorious within a duplex 🧬... but what would a ribose sugar do to it? Check out a recent work of ours…
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@PuDuan143907 We have taken NOE-based distances and Residual dipolar couplings (RDCs) for structure refinement. I would say NOEs and RDCs are readouts.
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@PuDuan143907 X-ray crystallography structures show a pattern of P1 being most planar and followed by P2, P3. However solution NMR structures deviates from this trend, potentially caused by poor estimation of distances and low proton associated nucleic acids.
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@NesreenElathram @global_nmr @bwajtweeting MYC based promoter sequences have ability form G-quadruplexes and form parallel topology. In literature , these are well studied G-quadruplexes.
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@NesreenElathram @global_nmr @bwajtweeting Thanks Nesreen, 2D 15N-1H data shown here is for QAD and QAAD samples. G9 is in a plane-3 (P3) tetrad, that is close to appended duplex in these samples, as small changes in stacking caused by duplex potentially results in such change.
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RT @arunrichardc: Nanoscale/PCCP special issue: @bwajtweeting and coworkers present their work on how 5-formylcytosine weakens the G-C pair…
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More details about the work can be found
Conformational Plasticity of Parallel G-Quadruplex─Implications on Duplex–Quadruplex Motifs | Journal of the American Chemical Society @iiserbhopal #Plasticity #Conformation #GQuadruplex @Duplex #Motifs #DNA
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RT @J_A_C_S: Conformational Plasticity of Parallel G-Quadruplex─Implications on Duplex–Quadruplex Motifs | Journal of the American Chemical…
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RT @bwajtweeting: Do read our work on multi-pronged approach (structure survey, #NMR measurements and #MD) that unravels "Conformational Pl…
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RT @bwajtweeting: #JRF position open at the #BioNMR lab @iiserbhopal @chm_iiserb Project focuses on mapping conformational properties of #D…
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RT @bwajtweeting: How does #5formylcytosine modify conformational characteristics of duplex #DNA? Find out more in our recent work. Congrat…
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@moxie9028 @bwajtweeting @iiserbhopal @serbonline Thanks, @moxie9028 . These quadruplex-duplex structures are being used in DNA engineering, catalysis, and drug-targeting.
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RT @ThevoiceDeepraj: Thrilled to present a poster titled "Mapping Molecular Interactions of G-Quadruplex Structure" at the #GlobalnmrTC2022…
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