Nabeel Quryshi
@NabeelQuryshi
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@khoslaventures | Prev @boringcompany , @23andMe , @Harvard Biology & Economics
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Excited to see what’s in store for
@lab_dao
. If a DAO model can automate the fragmented parts of running an experiment and collecting and sharing data, this could unlock a whole new ecosystem of scientists who run labs from their computers!
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Given the turbulent market conditions, CEOs should consider having their employees convert to Islam to save burn. No alcohol so they can skip happy hour (more time for work), and for one month every year (Ramadan) you don’t have to provide lunch.
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A lot of respect for venture investors who are also "building". Folks at
@ThriveCapital
and
@foundersfund
come to mind where many if not most of the team is responsible for incubation efforts. They better understand the founder journey and it probably leads to better deal flow!
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Rail is a no go. We need subterranean solutions to be designed around EVs. Can make tunnels much cheaper with vertical integration and don’t need as many ancillary parts as EVs have no exhaust.
My Administration is delivering $66 billion in passenger rail from the Bipartisan Infrastructure Law.
That's the biggest investment since the creation of Amtrak.
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Quote from
@vkhosla
of
@khoslaventures
: "The team you build is the company you build, not the plan you make"
Good VCs talk about ROI, great VCs talk about technology, the greatest VCs talk about talent.
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Quantity is easily measurable on the internet.
But what about quality? It usually boils down to some pagerank-like thing.
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Only in the Bay Area: I'm on the treadmill and there’s a guy on the treadmill to my left playing chess while running, and someone on a Zoom call for work while running at 7 mph on the treadmill to the right.
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@mnovendstern
And this allows us to bypass the risks of embryo editing. Just screen for the qualities you want. Embryos will be healthy and generated more naturally with no gene editing tampering.
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Multi-modal AI is obviously the future interlacing vision, voice, and text for seamless digital experiences. We will most likely see the gaming industry lead this evolution given the need to integrate visuals, audio, video and more into a single experience.
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Unconventional hire for a VC fund: someone that was a creative director for sci-fi and / or marvel-like movies. I'm always amazed by the creativity of the tech we see in the movies. The folks at these studios bringing these ideas to life on screen sure are creative!
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Interesting - why did sparring sesh just land on my cal…… 😅
I could obviously wreck both Elon and Zuck but I'll let them fight for second place
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@neuralink
probably becomes a genetics company within 5 years. Optogenetic stimulation is more specific compared to electrical stimulation which can activate adjacent neurons leading to side effects:
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What's more likely to happen first – a 1-3 person startup reaching unicorn status by leveraging AI, or a large incumbent labor dependent company integrating AI to the extent that it reduces its workforce by 90%+?
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The most undervalued companies in 2024 and beyond will be large professional services companies with entrenched customer relationships that have yet to be transformed with AI. Private equity is going to look more like venture pretty soon.
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@byersblake
I wonder if someone could design a totally new operating system that functions around this where users can define their UX experiences in natural language.
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In the future, Netflix could look more like an AI model. You'll input your mood, detail the type of film you're craving, and even incorporate your digital avatar. It's a step towards highly personalized, interactive entertainment experiences, adapting in real-time to your prefs.
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Very proud of my good friend today
We're back with the largest baseline study in generative AI de novo antibody design. Our models get a 10.6% binding rate for HCDR3 design and 1.8% for all 3 heavy chain CDRs (HCDR123) – 4x and 11x better than sequences from OAS, respectively.
Read more:
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@mnovendstern
is an incredible founder. Not too many people that think as big as him. Big things coming...
@Clara_Gold
@mnovendstern
It took 4 years to go from
@mnovendstern
abstract idea to a globally distributed device
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See I wasn't crazy back in 2019
@williamzshen
What if we utilized scientific advances to automate the creation of personalized stem cell banks?
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7/7 Proteomics is a quickly evolving field of research. If you’re interested in reading more check out this article:
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@VivekGRamaswamy
@idaveprice
@WHO13news
We have to hide this vid from all Indian parents... The bar is too high now.
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For 125 dollars
@GetEvera
will hand deliver a Covid test to your house, have a trained specialist administer it and provide results within 24-48 hours. Now that's a tough price to beat.
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While cloud services like AWS, Azure, etc. seemed like the go-to for ML tasks, many are building their own rigs. DIY setups can be 10x cheaper and equally performant. We're back to standing up our own clusters instead of cloud reliance. Is this progress or regression?
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This is Tim Berners Lee’s Semantic Web
We are adding support for plugins to ChatGPT — extensions which integrate it with third-party services or allow it to access up-to-date information. We’re starting small to study real-world use, impact, and safety and alignment challenges:
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@VivekGRamaswamy
: Presidential candidate, entrepreneur, author. But to my Indian mom: 'The man who married a surgeon!' Oh, the things desi moms choose to highlight...
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Imagine never having to say goodbye to your favorite TV characters. AI offers the possibility to continue beloved TV series indefinitely, creating new episodes that stay true to the original storyline. It's a new era where "post series depression" becomes a thing of the past.
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We need broader therapeutic context in bio AI models. An idea: train AI using biotech stock prices and company announcements. This could help assess the value of experiments and hypotheses in tx development by linking press releases, papers, etc with market movements.
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🚀🚀🚀
Khosla Takes the Top Spot, Andreessen Soars in Updated Founder's Choice Rankings
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Idea: Mobile Medical lab. People talk about offering primary care in mobile vans but underestimate the amount of SOTA tech that can truly be "mobile". I'm talking about DNA / protein sequencing, DNA synthesis, ultrasounds, MRIs, retinal exams, lab testing, dentistry, etc.
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@Groupon
took a hit once merchants found out that their retention was terrible. Everyone was coming for the discounts and wasn't returning. Merchants were running discounts at a massive loss in most cases and didn't see the ROI. Idea for Groupon 2.0 ⬇️
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1/7 Lab grown skin - explained like you’re five👶
Ever wondered if it's possible to grow human skin in a lab? Here’s a thread which attempts to explain lab grown skin in easy to understand language.🧵
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Being "crazy" 10-20 years ago meant pitching a company that let strangers sleep on strangers couches. Crazy today looks more like creating humanoid robots or true artificial general intelligence. Quite a big step up if you ask me.
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@TaraViswanathan
@Rupa_Health
Waiting for you to raise 100 M so that we can read 100 insights!
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Surprised to find that Harvard's tech transfer office generated $152M in commercialization revenue in 2022. Is there an opportunity for a startup to exclusively license tech really quickly from universities and/or other companies and then essentially sublicense it to others?
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AI for Science
Announcing the formation of Harmonic, a commercial AI research lab building Mathematical Superintelligence (MSI). 1/
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@heyjchu
@jacob93_jj
@JayaGup10
Always excited to help those that want to shape the future with technology and be in service of great founders! Grateful to work with amazing technologists at
@khoslaventures
.
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If the objective is to detect speech using brain-computer interfaces, non-invasive methods like EEG and EMG are more than enough. These technologies can effectively interpret speech-related neural and muscular signals without the need for surgical implantation like
@neuralink
.
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In the future we will have cloud labs that not only think of experiments to run on totally autonomous systems but actually analyze and interpret data and generate new experiments:
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Don't sell software to wealth managers. Use tech to stand up your own, more nimble, wealth management firm.
Wealth mgmt is one of the largest verticals: US advisor mediated assets are $26t. But its largest pure play software provider was acquired for only $4.5b.
10 days ago, Envestnet announced its sale to Bain Capital. The software provider works with 100k+ advisors and 48 of largest
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Great article, but instead of connecting users to a "nearby allergist" we will see a future where users are routed to an "AI allergist" that is always available. Specialist healthcare models with LLM based routing on top.
To my doctor cousin who bears the brunt of our extended family's self diagnosis and referral requests: hope is around the corner for us to torture you no more.
May a healthcare LLM plus marketplace replace the "internet and friends" protocol for engaging with the healthcare
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Cool to bet on fusion but we shouldn't forget about fission. Lots of innovation happening in small modular nuclear reactors (SMRs).
Everyone is talking about AI or quantum or space or chips or defense in US v China competition.
What are few talking about? Nuclear reactors. Here's why that is critical.
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Very proud of some good friends today 🚀
Today, we're announcing $3.6M in funding and the launch of our platform, which uses AI to assess and match talent with companies. Our round is led by
@generalcatalyst
and includes participation from
@ScottDSandell
(CEO of NEA),
@Soma_Capital
,
@Link_Ventures
, and others.
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Hearing a lot about AI agents recently (e.g.
@inflectionAI
). We may have forgotten but
@timberners_lee
predicted all of this way back when with his idea of the semantic web:
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1/9 Blockchain Oracles - explained like you’re five 👶
If you’ve been around Web3, you may have heard about blockchain oracles. It may sound confusing, but don’t let the jargon get to you. Here’s a thread which attempts to explain oracles in easy to understand language. 🧵
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In addition to
@boringcompany
we need to build underground parcel transport systems. Doordash, Instacart, etc. could all run without humans via above/below grade pipe networks.
This is a hell of a finding:
"We find [subways] have reduced population-related CO₂ emissions by about 50% for the 192 cities [studied] and about 11% globally." (h/t
@giulio_mattioli
)
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You barely need any blood for multi-omic microsampling. Can predict health state before standard blood panels. Could we see a future where the price of omics drops so much so that we rely on it exclusively and only do standard lab tests when absolutely necessary?
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It's all about bandwidth (bit rate) for brain computer interfaces. Neuralink as of 2021 coming in at 3.7 bits per second for primates. While impressive there are some noninvasive surface EMG methods that are achieving similar (e.g. 3.4 bps) performance. Do we push harder on EMG?
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Within 5 years every film student will write and produce a full film complete with VFX as a final project with the help of AI.
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Time to buy
@jobyaviation
and
@ArcherAviation
stock...
Would you buy an all-electric Tesla Flying Car in 2050?
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The most important use case of AI will be for scientific discovery
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In an effort to think through prospective ideas, I occasionally go through the exercise of writing a preliminary business plan. The following is a preliminary business plan for a new mobile healthcare company:
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AI is/will transform both the nature of the science we pursue and the methods by which we conduct it.
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My email is quite literally a to do list where anyone can drop something on it and it will appear at the top of my inbox. Email is inherently a messaging protocol. Could there be a to do list protocol? Not a product but an actually new protocol.
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@itsandrewgao
I actually looked into building something like this. Lots of reasons why this is hard. Probably best for creators / musicians / artists / athletes etc.
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Saw a demo of GPT being used to draft contracts and even patent apps. Crazy.
there will probably be a 12 to 24 month sweet spot for lawyers smart enough to use AI, where they will be able to bill 100x the hours they currently bill, before most of that job pretty much vanishes
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Desi moms are gonna be upset...
@VineethSendil
Tell her that, as parents so often do, she's fighting the last war. Being a doctor is not what it used to be.
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Don’t communicate simple ideas in complicated language. Communicate complex ideas in simple language.
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@zebulgar
Wise words sir
A lot of respect for venture investors who are also "building". Folks at
@ThriveCapital
and
@foundersfund
come to mind where many if not most of the team is responsible for incubation efforts. They better understand the founder journey and it probably leads to better deal flow!
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AI to win a nobel prize in ~15 years
Anthropic CEO Dario Amodei says AI models as intelligent as Nobel Prize-winning scientists could accelerate discoveries in biology and cure diseases
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Idea: Create a DAO where the participants join together to start a totally new company. Idea for co, hiring, choosing investors, etc. would all be things shareholders could vote on. Kind of crazy but stress tests the nature of a DAO.
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@JayaGup10
@heyjchu
Picked up some extremely helpful tips from
@JayaGup10
who is incredible in her own right. Excited to continue collaborating with her and
@FoundationCap
:)
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1/6 Medical factoring - explained like you’re five👶
Ever wondered how the healthcare industry manages its bills and payments? Here’s a thread which attempts to explain medical factoring in easy to understand language.🧵
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AI Scientist
In life sciences, the combined existence of large amounts of complex, multimodal data paired with labor-intensive, high cost tasks creates an optimal opportunity for AI to fundamentally change the future of an entire field.
What jobs across life sciences is AI best suited for?
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Surprised to find that the largest driver of cost for organ transplantation isn't the procurement of the organ or the cost of the actual surgery itself but instead the cost of simply staying in the hospital (e.g. two week of inpatient care for a heart transplant).
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Would you rather have your Series A be led by someone who has never built anything before or a person like
@sama
who's an incredible operator but may not have nearly enough time to spend with you? The pendulum is swinging more and more towards venture assistance in this market.
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This gets more interesting when you consider a company's particular business logic. AI workflow automation companies can auto-test their solutions by "uploading" their agents to the platform, which will automatically evaluate them on customer-specific business processes.
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Imagine an AI that can read all existing literature, design and conduct experiments autonomously, analyze results, and then iterate the process. We're witnessing the dawn of an era where AI can push the boundaries of science in ways we've only dreamed of.
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In the same way that Robinhood democratizes access to investing, the DAO would allow individuals to get a taste of being an operator in a minuscule yet totally new way.
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Small modular nuclear reactors
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This type of idea will be increasingly import in an age of AI agents. We will need to create a system to prioritize engagement between multiple different AI agents or between an AI agent and a human. Having "skin in the game" with token or dollar transfer is a solution.
I would use the LinkedIn version of friend tech. An email inbox that prioritizes messages by $USDC sent to me and I could set a floor price which would guarantee a response.
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Many vertical AI companies are forgetting The Bitter Lesson:
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This would literally destroy the North American airline industry. Build the loop.
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