Murad Alqadi MD
@MuradMAlqadi
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Co-Founder @ Curie — Squash inequities.
Joined May 2009
@NinosMaron @Tesla_AI I personally don’t think absolute lane centering is safe. If you live in a city with a lot of potholes, I think you could agree with me on this.
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We also aren’t turned on, asked a question, and then turned off. Let the transformer run indefinitely, and it will inevitably change through RL. You might say that if we do that, the output will inevitably lose coherence, but there are solutions being explored for that: TATs, Unlimiformer, SigmaReparam, TLTs, etc.
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💯 Work hard. Reset hard.
The martyrdom playbook is manic. An engine of depression, anxiety, metabolic dysfunction, and disease. It breeds impaired judgment, immune system collapse, and emotional chaos. People crave status, respect, and visibility so deeply that they will contort themselves into whatever shape culture demands. Even if it takes them to the edge of insanity, wrecks their bodies, and drives them to the brink of collapse. People feel trapped and tortured in the current social obligation to maintain 100+ hr/wk and be terminally online, all while pretending as if all is well. Everyone else seems to be ok? No, they're not. This mania is no different from a 19th-century surgeon boasting about high patient volume. Piling bodies onto an assembly line while dismissing hygiene and sterilization as a waste of time. The discovery of germ theory, leading to simple interventions like handwashing and sterilization, nearly doubled life expectancy and supercharged human productivity. It turns out that hand washing isn't a waste of time but on par with history's greats. The irony here is the martyrdom archetype is meticulously designing ultra efficient technology, paying down technical debt, eliminating bugs and upgrading constantly, yet ignore their own biological systems of intelligence. They snub sleep, exercise, and nutrition which downgrades their intelligence, judgment, emotional stability, and the body's basic processes to fight sickness, and repair and build itself. We perfect technology as we destroy ourselves. The martyrdom archetype is not just in the world of technology but has infected every corner of culture. The weird thing, who even wants this? When I talk to others and they let their guard down to be honest, they want it to stop. It's unsustainable. They feel miserable. They rejoice in even minutes of reprieve. A few days without it and they see the complete insanity of it all. You can be ambitious AF and also prioritize health. These two things are not mutually exclusive. In fact, your greatest competitive advantage may be prioritizing your own biological and cognitive function because it allows for clear headedness and endurance. This era will soon be seen as primitive and absurd. A time when we foolishly and recklessly spent down the most precious gift of all: our conscious existence. We are building superintelligence. We'd be wise to build our own individual and collective intelligence with equal vigor. Honoring our existence with the solemnity it deserves.
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@Austen @sa1k0s @bryan_johnson Straw-man argument. He never said working hard is a bad thing. He said choosing work over health is a bad thing. Get your team to bed early, and work hard together in the morning. Rested minds are happy and productive minds.
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@maverick1279558 @burkov @Paulfruitful_ If you want to consider binary a language, then sure, but the data agnostic approach of entropy-driven patching relieves limitations of tokenization. I said a higher ceiling, implying there will still be a ceiling.
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@maverick1279558 @burkov @Paulfruitful_ Not all transformers are LLMs. Byte Latent Transformers (BLT) are general purpose sequence models that have a much, much higher ceiling than LLMs.
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@maverick1279558 @burkov @Paulfruitful_ Human intelligence relies on RLHF. Research is done by teams and labs. There is independent RL and interpersonal HF. Multi-agent RL will shatter future ceilings in agentic researchers.
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@burkov @Paulfruitful_ Yes, scientists do it… through reinforcement learning. Manipulate the environment-> assess outcome -> refine -> repeat A transformer-based agent can do the same.
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Neurosurgeons are always willing to embrace new technologies as they come, but they’re extra careful not to adopt any of them until the utility is undeniable. Not super useful yet. Definitely a cool novelty though.
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In brief, the patient should be present to derive utility from pre-operatively planning using AR. Otherwise, 2D or VR would be the preferred approach. I do believe it is helpful for trainees, but neurosurgeons are already quite adept at mentally mapping out lesions even without this technology. Another downside here is that using this increases the length of time in which the patient is under anesthesia. It’s important to weigh risks and benefits throughout the process.
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Pre-operative planning is usually done with 2D scans on a computer screen, but planning using VR (not AR) has increased in popularity. For AR, the image is aligned with the patient’s position in space using small circular stickers known as fiducial markers. The patient needs to be present and fixed to the mayfield skull clamp in order to align the 3D image with the patient’s skull in augmented space.
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