Shai Bel
@Mucus_Man
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The Bel Lab, boldly going where no one else bothers to. @ERC_Research funded lab. Former @LHooperLab postdoc. Opinions are my microbiota's. #NewPI
Here
Joined August 2017
๐จ๐จIโm excited to present our labโs new paper where we tried to provide a mechanistic explanation for the link between antibiotic use and risk of developing inflammatory bowel diseases (#IBD). A ๐งต/1.
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Please tell me I'm not the only one who sees "single cells" before realizing it's "jingle bells"
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PI and first author reading the reviews.
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"Single cell RNA seq of (insert organ name here) reveals heterogeneous cell population" Nature 2019 (every week).
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My son Adam wants to know how many โค๏ธ he can get for his drawing. Let's go!
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๐จ๐จIโm very excited (and terrified) to share our labโs first work (and my first as PI๐ฑ)!! We asked a seemingly fundamental question; how do mucus-secreting cells โknowโ how much mucus they need to secrete? Answering this taught us a lot about susceptibility to #IBD. A ๐งต /1.
Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress #bioRxiv.
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"This paper characterizes the first protein to be discovered in a meteorite." Yes, you read right. A protein found on a extraterrestrial meteorite!!! ๐ฎ๐ฑ.
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This paper is insane ๐คฏ for a few reasons. The first being they experimentally evolved a yeast into a multicellular organism. The second is that the review process took longer than the evolution process ๐คฆ๐ปโโ๏ธ.
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๐จ๐จI'm proud to present our lab's first peer-reviewed paper, out at @cellhostmicrobe๐ฅณ. We started out by asking a basic question about mucus secretion, and discovered something surprising about genetic risk to inflammatory bowel diseases (#IBD). A๐งต/1.
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This is a scary, yet amazing discovery. Cancer can arise without mutations following transient loss of epigenetic gene silencing.
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OMG guys, someone did a single-cell RNAseq and found NO difference between 2 populations!! I had no idea this technology was capable of that ๐ฑ.
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When the method section leads to a citation. Which leads to another citation. Which leads to a paper from the 70s that isn't online
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๐จ๐จOur MUCUS FACTORY is on the cover of @cellhostmicrobe!! Thank you Michael Grey for previewing our work and @AmirBErez for helping with the cover art.
Our March issue is now live โ with insights on mucus factories, fungal escape routes, superspreaders, and more
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Imagine never seeing a bird fly with your own eyes, and trying to describe how it flies based on this video, where the camera's frame rate is perfectly synchronized with the birds wings. This is doing science at the molecular scale.
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Celebrating the lab's first ACCEPTED manuscript by @MariaNaama_ & friends ๐ฅณ. More to follow soon!
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Never leave the centrifuge before it reaches full speed ๐ฌ.
Whatโs the best piece of advice that youโve ever received?.
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๐จ๐จI'm excited to share our new paper out now in @PLOSBiology! We found that Salmonella tricks us into killing its competitors, the gut microbiota, by inducing IL-1b production. This allows Salmonella to remodel the gut niche to it's advantage. A ๐งต/1.
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๐จ๐จI'm delighted to present our new work, where we aimed to understand why antibiotic use is a risk factor for development of inflammatory bowel diseases (IBD). Yes, MUCUS will be involved! A ๐งต/1.
Antibiotics damage the colonic mucus barrier in a microbiota-independent manner #biorxiv_immuno.
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Dear computational biologists/statisticians, I'm have a DESeq2 trust crisis and I hope someone can explain this to me: I ran DESeq2 on an RNAseq and got this volcano plot with a fantastic candidate gene (circled). A dream come true, right? /1
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25 years ago (May 21st), the greatest album of all time was released. How revolutionary was it? Absolutely nothing released before it sounded like it. Grunge was dead, britpop was dead, the lines between pop and rock were blurring. How influential was it? Almost everything /1
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This is fascinating!! The proteins in our cells are at the edge of their solubility and with age they simply can't stay soluble anymore and aggregate. Huge if true.
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Got a grant to study mucus glycosylations!! Finally starting to live up to my Twitter handle.
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๐ข๐ข๐ข๐จ๐จ๐จ. Me: I LOVE MUCUS!!!. The @ERC_Research:
๐ERC Starting Grant competition results are out!. Over โฌ619 million for the best ideas of young leading researchers - and the 1๏ธโฃst set of grants awarded under ๐ช๐บ@HorizonEU. Find out who, where and why ๐ . #EUfunded #FrontierResearch #ERCStG.
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Happy birthday Albert. Clearly you didn't submit too many grants.
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๐จ๐จ Gather โround children, itโs Bel lab story time! This one is called โtricking the tricksterโ. It tells the story of how we found a way to foil the evil plans of the master manipulator, Salmonella typhimurium. A ๐งต /1.
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๐จ๐จ I'm excited to announce that with the support of the @ERC_Research we will try to treat IBD with a boost of mucus!! A special thanks to @IldikoMe for supporting our efforts and advocating for IBD patients!.
๐ฃ Out now! First results of the 2024 ERC Proof of Concept call. 100 grants โ each worth โฌ150,000 โ will help ERC grantees to bridge the gap between the discoveries stemming from their frontier research and their practical application. More ๐
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"The authors must validate their findings with an in vivo model. Rejected"
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I really hope someone is taking this opportunity that millions of Americans are deworming themselves to study the effects on microbiome and gut immunity.
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Nature published negative results?? ๐ฑ What has the world come to?.
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I'm at a loss for words. I want to say how much Dr Beth Levine has inspired me, helped me, was kind to me, even though she barely knew me. Her passing is a huge loss of the scientific community, and for me personally. She will be sorely missed. @UTSWNews
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Walking through the posters trying to identify everyone you know from Twitter in real life .
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"My PI told me I just need to get this one last experiment done and then he'll send it to Nature".
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I'm happy to share that our paper on autophagy and mucus secretion was selected for the Cell Host Microbe Best of 2023!!! @MariaNaama_ @bo_schroeder ๐."We have selected 12 articles and reviews from among the most-accessed and most-cited articles from 2023.".
Read popular papers published in @CellHostMicrobe. Download the free Best of Cell Host & Microbe 2023.
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If you're wondering what it feels like waiting for a swarm of Iranian drones and missles heading your way, it's just like when the status goes to "pending editorial decision".
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Single watermelon seq reveals heterogeneous watermelon pepulation.
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Today is Purim (sort of a jewish Halloween) and a student in my lab came disguised as. ME ๐
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๐จNEVER IGNORE THE DATA.๐จ Here a story of how I did ignore it and lost big: A couple of years ago I was wrapping up my postdoc at the @LHooperLab. I was trying to establish a system where I isolate gfp-tagged ribosome from transgenic mice. /1.
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And here are the results ๐
How do we feel about Y axis not starting at 0?.
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ืืขืืื ืื ืืืื ืื ืืจืื ืื ืฉืื ืืจืืฆื ืฉื PCR.
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Western blots.
What are some of your favorite unexplained phenomenological observations in life sciences?.
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Screams into the void: EPITHELIAL CELLS ARE IMMUNE CELLS!! Don't @ me.
Freaky Friday in the gut: what happens when non-immune cells of the intestine perform immunological functions; and traditional immune cells exhibit non-immune functions in the gut? Check out this review from @ajithvasanthan @KylieReneeJames @adelynn_tang .
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Dear editor, I wrote you but you still ain't calling.I left my cell, my lab, and my home phone at the bottom.I sent two manuscripts back in autumn, you must not've got 'em.
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There's a saying in academia, that if you want to know what professors looked like when they were hired, you only need to look at their website. Well, not this one. Check out our new lab website and logo!! (built by Tagido Digital @GissinYonathan) .
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๐จ๐จ Our latest paper by @MariaNaama_ in @cellhostmicrobe was highlighted in @NatRevGastroHep ๐ฅณ.
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๐จWe made it to the ๐ฃbomb shelter in 10 seconds after the siren went off! A new family record! (we have 15 seconds according to safetly guidelines)
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No science without democracy. And no mucus either!!! 3 generations fighting for Israeli democracy ๐ช๐ป
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An excellent review linking cell biology to immunity. Good read.
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Please tell me I'm not the only one.
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1/Why is it so hard to understand that Hamas is a terror organization that has taken the citizens of Gaza hostages? No one is trying to collectively punish the people of Gaza. Israel is trying to remove the threat of Hamas from its own citizens AND from the Palestinians in Gaza.
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The Bel lab celebrating 4 years of fun (and some science) together ๐
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So it's not only that Israel didn't fire on that hospital, but the actual hospital building wasn't even hit?? Basically the entire world press ran with a completely fake story?! WTF?!.
And we now have footage of the (partially) burnt-out parking lot at the Ahli Hospital in Gaza. Overall damage to the structures in the complex appears to be limited, a clay-tiled awning adjacent to the parking lot is still mostly intact.
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๐จ๐จI'm excited to announce that we (Till Strowig @StrowigLab @Helmholtz_HZI, Amiram Ariel @UofHaifa and myself) were awarded a Research Cooperation Lower Saxony โ Israel grant from the @VolkswagenSt to study how interferons shape the gut microbiota and host physiology!! ๐ฅณ๐๐
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๐จ I'm thrilled to announce that @Winter_lab and I were awarded a 4-year @usisraelbsf grant to study immune responses to Salmonella infection๐ฅณ. I'm most excited about the chance to work with @Winter_lab, a great scientist and a great person who has been very supportive of me ๐
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What a treat to host @BarakRotblat and @OdedRechavi at @biumedicine! Thank you guys for making the trip. Had a great time ๐
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People, please stop saying that you "sacrificed mice" in your papers and talks. Most of us aren't Satanists and we don't sacrifice animals. We euthanize animals in research.
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We've taken the lead!!
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If I worked at a funding agency I'd start emails with: "I hope this email funds you well".
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The 1st PhD student to graduate from the lab @Mor_Zigdon gave the best fuยฉking defense lecture ever!! Congratulations Mor! ๐๐๐๐ฅ #proudPI
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Are you interested in how epithelial cells preserve homeostasis in the intestine, and what goes wrong when IBD develops? Of course you are!! Read all about it in this chapter @SoniaModilevsky, @MariaNaama_ and myself wrote ๐๐ผ.
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OMG, @VirusesImmunity recognized me from Twitter ๐ฑ๐ฑ๐ฑ๐ฑ๐ฑ. I feel like I just published ๐คฃ #NGI2020.
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๐จ๐จIn these difficult times we tried to put on our happy faces to celebrate @Mor_Zigdon's "accepted in principle" paper with our friends at @biumedicine ๐๐๐
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How cool is it to characterize a LIFEFORM UNKNOWN TO SCIENCE??!! .
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PI stepping out of the office to tell the lab they got funded.
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Back to popular demand, the Microbiome Israel Workshop!๐ฆ ๐งซ This lineup is unbelievable! All microbiomes included! @KorenLab @YissacharLab @SuezLab @EranElinav @finkel_omri @MoranYassour @YaelLitvak @amiyaal @Naama_GZ @EranBlacher @StraussmanR @LabMizrahi
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4 "not funded" in one week (3 of those in a single day). Happy birthday to me ๐ฃ
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Very few things feel as good as watching one's mentees succeed. Congratulations to @Mor_Zigdon for winning the best talk award and @SoniaModilevsky for winning the best poster award at the @biumedicine annual retreat ๐ค๐๐ป
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