Sethi_Lab
@LabSethi
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Dedicated physicians & scientists determined to improve outcomes in patients with gastrointestinal cancers through basic and translational research @DanaFarber
Boston, MA
Joined November 2020
A collaborative effort to engineer a dual knock-in reporter system to simultaneously broadcast aberrant stem cell and differentiation activity in colorectal cancer for discovery science. @JunQiLab @fonlikk @paulthekid_ @zxli_phd
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RT @srikosuri: It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendr…
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RT @ItaiYanai: Postdocs need a place to learn and practice the scientific creative process. Tomorrow we start the "Postdoc Night Science" c…
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RT @HenryYin19: As a PI, most of my lab skills have deteriorated. I barely know how to do anything in the lab, but I'm pretty good at mult…
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RT @whitefishlab: Hey everyone - we are hosting an EpiCancer conference at @Ludwig_Cancer Oxford. Focused on non-genetic mechanisms of tumo…
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RT @m_rashidian1: 1. Excited to share our paper published in @Nature today, introducing CD45-PET as a robust approach for noninvasively im…
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Highly recommend. They should open it to PIs next time :)
What is Night Science? It’s the creative part of the process, where we come up with the ideas that will be tested later in Day Science mode. It’s like being in another world that is hard to explain, but you know it when you get there. Join us on Tuesday at the Harvard Workshop!
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Highly recommend attending!
Boston friends! Come next week to my two hour workshop on the creative scientific process. And thank you Ann for organising it 🙏
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RT @arjunrajlab: Reposting my offer for 1-1 mentoring for anyone… email me and we'll find a time! Especially happy to talk with those from…
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Beautiful work! Figure 7 is insightful. TME changes in response to tumor regression can be bystander events. To show CD8+ T-cell depletion partially hinders anti-tumor effect of KrasG12V targeting points to a function contribution. I am curious about the increase in M1-like cells
Ready, set, degrade! So proud to share our work in @jclinicalinvest, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link: 🧵
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Incredibly grateful to the team leading this collaborative study: @fonlikk @zxli_phd @paulthekid_ Akhouri Kishore Raghawan @JamesClearyMD @JunQiLab
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Using genetic screens, we nominate DAPK3 as a functional mediator of CRC differentiation following HDAC1/2 inhibition. These findings highlight the importance of chemically targetable histone modifications in controlling cellular states with therapeutic potential.
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Genome-wide profiling assays revealed that H3K27ac and H3K9ac associated with open chromatin and upregulation of differentiation genes. Inhibiting EP300, a principle writer of H3K27ac, reversed CRC differentiation mediated by HDAC1/2 inhibition.
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After confirming this finding across different CRC models, we profiled histone post-translational modifications, identifying 3 marks with the greatest abundance following HDAC1/2 inhibition.
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Could not agree more! We need to support the entire spectrum of science, fundamental to translational. Funding basic science is critical as our predictive power for translation is limited.
One of the most surprising lessons for me in 30 years in science is how it's essentially impossible to predict what major scientific breakthroughs will emerge or where they'll emerge from. But how we fund science is mostly based on the assumption that we can make such predictions
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RT @BullmanLab: 🚨 We’re hiring! 🚨 Join the Bullman Lab at MD Anderson’s James P. Allison Institute as a Postdoctoral Fellow! ☀️ 📍Houston, T…
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RT @DFCI_CancerBio: Dana-Farber Cancer Institute Awards Richard and Nancy Lubin Its Highest ... via @YouTube. The L…
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