@JoannaMasel
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[email protected] https://t.co/25SPoxQbES… Use https://t.co/6z9pMRUBaa or https://t.co/8t56aqiECT
Tucson, AZ
Joined May 2018
I'm hiring a postdoc! To use substitution models to understand protein evolution and/or improve phylogenetic methods.
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Our latest preprint finds that a shortage of beneficial mutations does more to drive small populations extinct than mutational meltdown does. Explainers elsewhere @MawassWalid @JosephMatheson2 @Uliseshmc @JeremyJBerg
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We have a new version of this preprint now up. It was depressing to add discussion of lack of testing for H5N1, in new developments while the manuscript was in review.
Our latest preprint finds that mass testing could control a future pandemic, even without contact tracing, avoiding both lockdowns and mass infection. Appendix covers logistics, achievable with sufficient investment/preparation. Let's do better next time.
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@3rdreviewer We found that Ne predicts amino acid usage in vertebrates We used a different and we think better Ne metric.
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Our latest paper is up at @eLife. @disordermodel @phylowheeler @JennyJames91 @geo_hano. Explainers at other two sites.
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@Coooo110 Saturation means that a dynamic process has converged on its equilibrium state. A rapid process will rapidly arrive at an equilibrium.
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I'm hiring a postdoc, for bioinformatics work on amino acid substitution models. I think they are key for understanding biophysics of selection on proteins, mutation patterns, and ancient life, as well as improving phylogenetic methods.
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RT @PaulSaxMD: Olgotrelvir significantly shortened symptom duration in Covid compared to placebo (8.5 vs 11.0 days) -- something that Paxlo…
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RT @famulare_mike: Close reporting on H5N1. Why do I think this article is worth promoting? It’s for the industry—…
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@dbweissman @SamurSciCop @vsbuffalo @jgschraiber You also get interference from unlinked mutations when Ud>1 (and Ud>2.5 eg for humans) even with complete outcrossing. And this messes up rescaling, see
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Our latest preprint explains why fitness can be defined in so many ways, and which version(s) you should use for what. See threads in other places for explainers @geeklhem @pierrickbourrat
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Our latest paper on background selection is out at @GenomeBiolEvol. Thread explainers at other 2 sites. Briefly: the 1-locus model of independent sites is dead when the deleterious mutation rate exceeds 1. @JosephMatheson2
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@DavidEnard @TwelveSharp We have a better Ne proxy, in an improved, coming-soon revision to we will detail its (non-)relationship with gBGC. Calculation code is at
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RT @SiddhantPus: Episode 3 of The Purpose Podcast is out now In this one, @JoannaMasel talks about a trend that stretches all the way back…
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@HarmitMalik @ArlinStoltzfus @WeismanCara There is a problem with over annotation of de novo genes, but some are real. Eg see our
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RT @wc_ratcliff: Hey, we have a new paper out proposing a new hypothesis to explain why bacteria and archaea have never evolved "complex" m…
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RT @amandalws: Interesting and important article on how Apple and Google contributed to the failure of a promising startup: "In [the] futur…
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