Isabelle Foote
@IsabelleFFoote
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Postdoc @IBG_CUBoulder | Prevention Co-Lead @DEMONNetworkUK | Interests: dementia prevention, multivariate genetics & ⬇️ health inequality
Boulder, CO
Joined January 2019
Check out our new preprint on the genetic architecture of #frailty! In this work we apply Genomic SEM to 30 frailty deficits to perform the first GWAS of the latent genetic profile of frailty, which uncovers 408 genomic risk loci! 1/8
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RT @FrancescaRoFa: Our study out today in @TheLancet Healthy Longevity advocates for young adulthood as a key, yet overlooked, stage for de…
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RT @Anna_Furtjes: 🧠🧬New preprint! Lifetime brain atrophy GWAS (N = 43,110). A thread Lifetime brain atrophy estimated from a single MRI:…
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RT @David_D_Ward: In almost 30,000 participants of 4 cohort studies over 20+ years of follow-up, we found that #frailty was a strong risk f…
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8/8 Thanks to the💫team: @JonnyPFlint, @Anna_Furtjes, @doctormullin, John Fisk, Tobias Karakach, @RutenGroup, Nick Martin, @MichelleKLupton, @DrDJLlewellyn, @Janice_Ranson, @SimonRCox, @drmluciano, @Krockdoc & Andrew Grotzinger!!
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2/8 We use GWAS sumstats for 30 frailty traits to perform genomic factor analysis, which produces a bifactor model that includes a General Factor of genetic overlap across all the frailty traits, plus 6 novel factors of genetic overlap between specific subsets of deficits..
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@drruthdobson @phazha_bothongo @ben_m_jacobs Congratulations Ben!!!! 😍😍🤩🤩 hope you are celebrating well!!!
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RT @ChiesaScott: 📢New advance article published today in @Brain1878. Using a lifecourse Mendelian Randomization approach in @uk_biobank &…
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RT @charl_marshall: NEW! 🚨 from @preventiveneur1 @sam_ereira @adeelrazi We describe a technique to predict who will get dementia up to 9 ye…
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RT @MarioniGroup: Marginal linear regression gives >11k EWAS hits for BMI. Joint and conditional BayesR gives 27! Methods matter in this pr…
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RT @jacksonthorp: Our review of the genetics of substance use disorders is out now in @molpsychiatry
@zac_gerring, @DerksEske, Jorien Treu…
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RT @ABATED_Study: We are currently recruiting focus group members for the DIADEM study here at @preventiveneur1. This study will evaluate d…
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RT @David_D_Ward: In our new preprint, we measured frailty trajectories in the years preceding dementia to better understand the direction…
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