💡 Dr. Jianmei Leavenworth and scientists at @UABNews report that CD4+ T cells are required for durable tumor control in syngeneic murine models of #glioblastoma multiforme after treatment with an oncolytic #herpes simplex virus. 🧠 @NatureComms |

🔬 Drs. Stanislav Dikiy, Alexander Rudensky, and team members at @scrippsresearch identify core features of the terminal differentiation of effector Treg cells in non-lymphoid tissues and their function. 👉 @NatImmunol |

🦠 Researchers showed that #macrophages actively take up human heavy-chain ferritin in vitro via macrophage scavenger receptor 1. 👓 Learn more at @NatureComms! |

@DrRahulKumarPhD It's our pleasure! Congratulations to the team. 🤗

🔎 Dr. Anna Pasetto's team at @karolinskainst evaluated T cell responses in patients with advanced #hepatocellular carcinoma to understand whether reactive T cell populations could be identified despite the #immunosuppressive environment. 👉 @Gut_BMJ |

🐭 Investigators with @DrRahulKumarPhD at @UCSF observed in hypoxia-exposed mice an increase in resident interstitial #macrophages, which expanded through proliferation and expressed the #monocyte recruitment ligand CCL2. 👉 @jclinicalinvest |

As the definitive NK meeting, the 10th Innate Killer Summit will reveal long-anticipated clinical data, applications to autoimmune diseases, and more! Unlock the 2025 agenda: Register using an exclusive discount 55658StemCell10 to receive 10% off your pass!

🧪 To address whether epithelial cell-derived extracellular vesicles (EVs) can be modified to acquire the capacity to induce an #immune response, scientists at @MDAndersonNews engineered 293T EVs to harbor immunomodulatory molecules. 📖 @acsnano |

💊 A #dendritic cell-independent, next-generation intraperitoneal #immunotherapy was described that activated peritoneal cavity B cell subsets for intraperitoneal anti-tumor immunity via exogenous #antigen presentation. 📑

🎯 Scientists demonstrated a decisive role for ETV7 in driving CD8+T cell terminal exhaustion and revealed that ETV7 may be a promising target and biomarker for improving the efficacy of cancer #immunotherapy. 👉 @NatureCancer |

🥼 Dr. Peter Eggenhuizen's team at @MonashUni investigated whether #Tregs engineered to express glomerular basement membrane-T cell receptors specific for α3(IV)NC1135- 145 better suppress #autoimmunity. 👉 @Kidney_Int |

🥜 Dr. Jeppe Madura Larsen and team members at @DTUtweet investigated the humoral, regulatory, and sublingual tissue #immune response to prophylactic sublingual immunotherapy administration of a single purified peanut #allergen in Brown Norway rats. 🔗

💊 Lipid-metabolically remodeled T cells with delayed senescence increase efficacy in tumor microenvironment, highlighting a novel strategy for solid tumor #immunotherapy. 👓 Learn more at @jitcancer! |

🔎 Dr. Mark Davis' team at @Stanford analyzed the contributions of CD4+ Tregs expressing FOXP3 and CD8+ Tregs expressing killer cell immunoglobulin-like receptors to the control of autoreactive T and B #lymphocytes. 👉 @NatImmunol |

🚦 In this study, researchers investigated the mechanism by which GP73 regulates T-cell-mediated #antitumor immunity within the tumor microenvironment. 👓 Check it out at @jitcancer! |

📢 Drs. Pilar Martín and Francisco Sánchez-Madrid at @CNIC_CARDIO discuss the contribution of T cells to myocardial injury and remodeling, focusing on specific #immune receptors that have a critical role in regulating immune tolerance. @jclinicalinvest |

💉 Scientists uncover a function of STING in regulating JAK1/STAT activation downstream of IFN-I stimulation and provide a new insight for future design and clinical application of STING agonists for #cancer therapy. 🔓 @jclinicalinvest |

🔎 This study identifies a potential mechanism responsible for altered #Treg function in the context of immune #aging, and also implicates SOAT2 as a potential target for tumor #immunotherapy. 🔓 @NatureComms |

🔬 Drs. Florian Kühnel lead @MHH_life researchers in demonstrated that membrane-associated T cell engagers expressing oncolytic #viruses are powerful T cell activating tools suitable for local #immunotherapy of a broad range of tumors. 🔓 @EmboMolMed |

📉 Sphingobacterium multivorum diminished the therapeutic efficacy of αPD-1 mAb, which was associated with increased #Treg infiltration and decrese CD8+ T cell infiltration. Learn more! 🔗