Josh Goldberg Lab 🇮🇱💔🎗️
@GoldbergLab
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Usually: Parkinson's & cellular physiology of basal ganglia, combining ephys, adv. imaging & mathematical modeling. Now: overthrowing our fascist gov’t
Jerusalem, Israel
Joined August 2018
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חובההההההה
לצפות בראיון הזה
אחד מכתבי האישום כנגד וההספדים על מדינת ישראל שראויים להיזכר להיחקק בראש של כל ישראלי
עינב צנגאוקר אמא של מתן שחטוף בעזה אתמול בלילה בצאתה מאיכילוב בסרטון שאסור לפספס, אין מילים הלב נשרף 💔
@netanyahu
אני לא יודע אם יקח חודש רבעון או חס ושלום יותר כדי שתעוף מהחיים שלנו, אבל אני יודע בידיעה מוחלטת שלנצח תיזכר כמי שניסה להחריב את ישראל ושאת העונש שלך על הרוע,
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what has
@mbeisen
done for the Palestinian cause? What do you know about our sympathy for the Palestinians? How many Palestinian students do you have? I currently have 3. Many of us Israeli academics boycotting Eisen, have been active against Israeli occupation for many years &..
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Just got the call from the Rector - I've been promoted to associate professor! There are so many people to thank. Rachel and the kids - the loves of my life - you've been a part of this journey from the start. Then: mentors colleagues and students. Toda!
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Happy to share our
@NatureComms
on acetylcholine waves in the striatum and a mathematical theory of how they may be intertwined with dopamine waves first described by
@arifahamid
thanks to
@NicTritsch
and
@Gasarpong
for in vivo data
@MatityahuLior
for 2plsm data and Naomi Gilin
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α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms
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This stressful time is a really appropriate time to visit my fabulous grad student, Nadine’s, family in the beautiful village of Jatt. I met her parents and younger bro. We even tried to talk a bit about
#Parkinsons
#meant2livetogether
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This is huge!! The Sayeret Matkal team that stormed the Entebbe terminal in 1976 under the command of Yoni Netanyahu in a Letter to Bibi “Your brother sacrificed himself for the country, you are sacrificing the country for your own interest”
פרסמנו ב8: מכתבם של לוחמי צוות אמנון, הצוות הראשון של לוחמי סיירת מטכל שפרצו לטרמינל באנטבה, ״עם מרצדס, בלי רולקס״, חייליו ואוהביו של מפקד סיירת מטכל יוני נתניהו זל. ״הילד שלך כינה אותנו טרוריסטים״ כתבו לאחיו של יוני זל, ראש הממשלה בינימין נתניהו. ״אתה ביבי מקריב את המדינה״.
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A new adventure in these troubled times... beginning a short sabbatical at Northwestern University Feinberg School of Medicine, Department of Neuroscience at the Surmeier Lab.
@NorthwesternU
@NUFeinbergMed
@Neuroscience_NU
@Hujimed
@MedNeuroHUJI
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Paper
#2
accepted to eLife in 2022 (a year with many 2s). Both on striatal cholinergic interneurons:
#1
focused on their nicotinic control of SPNs, and now
#2
on how their dendritic nonlinearities help dissociate cortical and thalamic inputs. Two eLife, Two eLife, Le’Chaim!🥂
Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons
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Helping plant tubers in a Kibbutz near Gaza with the one and only
@SilberbergGilad
and his buddy Avital
(w mortar booming in the background)
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our latest pre-print: Striatal Neurons Are Recruited Dynamically Into Collective Representations of Self-Initiated and Learned Actions in Freely-Moving Mice
@SSRN
@cellpressnews
Sneak Peek
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So, yes, it is a callous, myopic and knee-jerk reaction by
@mbeisen
that is totally uninformed and is an in insult to our values, integrity and intellect. Hamas are responsible for Palestinian suffering in Gaza. many of the fleeing Gazans say it themselves
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First lab outing since Covid. Much to celebrate (right to left):
@LTiroshi
is off to
@DanielDombeck
; Lior has a preprint on
@biorxivpreprint
; Nadine and Osnat finishing MSc; Yara finished Med School (!!!) & I was tenured a while back.
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so I’ve switched from flora to fauna. Today I’m escorting Palestinian shepherds in the West Bank. A settlement can be seen on the top of the hill in the background. It is relaxing to watch sheep graze! Esp. during such hard times
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support Palestinian self determination. Hamas' brutal massacre, rape and abduction is an entirely different matter. As
@POTUS
said we have a duty to respond. Israel will provide a humanitarian corridor. Who is gunning down Palestinians who are trying to use it today?
#HamasisIsis
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נלכדתי בעין המצלמה
אין על
@Microsoft
ישראל
שתרמה
#xboxone
לנער על הרצף מהעוטף שבמעלה החמישה
קוראים לו ג'וש. הוא התנדב לאסוף מהמשרדים שלנו מכשיר xbox שאלתרתי מהרגע להרגע עבור ילד עם צרכים מיוחדים שפונה מקיבוצי העוטף לירושלים ושהיה חייב מכשיר. "ראיתי שהרחוב שלכם נקרא על שם אלן טיורינג", הוא אומר לי בעיניים נוצצות בזמן שאני מוסר לו את החבילה. "זה מגניב, אני חוקר מוח ואני
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See our new preprint analyzing dendritic dynamics in cholinergic interneurons w/ optogenetics+2P imaging & how they affect proximal vs. distal inputs. W/
@BergmanHagai
we show for the 1st time that TANs 'pause' from internally generated events in sleep
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My talented postdoc
@kuhwa911
worked out how mutant
@alpha_synuclein
in intact brainstem neurons slows their electrical activity. Cool electrophysiological mechanism causing nonmotor symptoms that presage
#Parkinsons
by decades. Future
#biomarker
? . Pls RT
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Our contribution to flurry of mss on
#dopamine
and
#acetylcholine
in the
#striatum
. We provide novel data on cholinergic waves and propose a mathematical model for
#dopamine
waves described recently by
@arifahamid
Looking forward to discussing at
@dopaminesociety
@MatityahuLior
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@RaffaellaTonini
@SilberbergGilad
@a_schrag
Charo Moratalla
@fgeorges007bnst
Gilberto Fisone and we were just awarded a huge EU Consortium grant to study non motor symptoms of
#Parkinsons
disease . Yippee!!! Fun, and excting and with the Best Colleagues Ever
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Two of our
@HebrewU
students were arrested by undercover police after a non-violent protest. We are waiting for them outside
@israelpolice
station
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Delivering homemade sandwiches to troops and found frightened dogs (because of the booms) that were left behind by evacuees. Taking them with us. And to top it off, met a nursing student of ours
@hujimed
now a combat paramedic
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Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons
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our first lab meeting since 10.7 - some shared their stories and their emotions and then we buckled down to talk shop which is what Israeli scientist (of all ethnicities and political leanings - represented in our team) need to do.
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היסטוריה באוניברסיטת חיפה: פרופ' מונא מארון התמנתה לסגנית הנשיא ודיקנית למחקר ופיתוח. מברוק
@MounaMaroun
ותודה ל
@haitham_amal
על העדעון …
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What’s wrong with the striatal cholinergic interneurons in Parkinson’s disease? Focus on intrinsic excitability
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@LTiroshi
submitted her dissertation. 1st
@GoldbergLab
PhD! This brilliant scientist is moving to greener pastures w/
@DanielDombeck
. She will be missed in more ways than I can tell (or realize yet). Parting is such sweet sorrow. photo:
#IBAGS2019
#SaintJeandeLuz
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Heroic work by
@kuhwa911
(it took 5 yrs!) showing that
@alpha_synuclein
drives a channelopathy in vagal motoneurons (due to shrinkage) that reduces vagal output and may explain prodromal constipation in
#Parkinsons
. It’s finally out… (no pun intended)
@ANDPDProject1
@ScienceofPD
α-Synuclein–induced Kv4 channelopathy in mouse vagal motoneurons drives nonmotor parkinsonian symptoms
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A great week! a paper accepted and today a
@usisraelbsf
grant awarded for another great four years of collaboration with
@lab_plotkin
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הייתי הערב בכנס של #שמאלאמוני
שמעתי את הרבניות דינה בר שלום ולא שקדיאל ואת
@NitzanShilony
החריפה ועוד כהנה וכהנה וידידנו
@freyisrael1
מתעד
מודה דמעות זלגו על פניי יותר מפעם אחת
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Today we trimmed Tomato plants to prepare them for pickin’ in a village near Gaza left to right: yours truly, Rachel and Michal & Kobi Cohen-Hattab
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protesting at the knesset today against our new fascist parliament/ government. Tomorrow escort my son who’s enlisting to an infantry division to protect this crazy country
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Waiting outside courtroom hearing for Prof. Amit Danieli and Matanel Tschekhnovski (sp?) who were randomly and violently arrested in last night’s demonstration in Jerusalem
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These young scientists deserve a hand of applause for all the hard work:
@MatityahuLior
@meitalshm
@YviJohansson
and Jeff Malgady from
@lab_plotkin
A round of GIN&Tonic on me 🍸
A tonic nicotinic brake controls spike timing in striatal spiny projection neurons
Our new collaboration with
@GoldbergLab
and
@SilberbergGilad
is out on eLife! Thanks
@usisraelbsf
!!!
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this is me
@GoldbergLab
אנחנו בכניסה לשגרירות האמריקאית בירושלים בקריאה נשיא ארצות הברית, באמצעות השגריר, להציל את הדמוקרטיה הישראלית.
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This out yesterday... more on waves to follow hopefully soon
Activity patterns in the neuropil of striatal cholinergic interneurons in freely moving mice represent their collective spiking dynamics
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מסיע חיילים בכל הארץ ומצאתי פנינה ביסוד המעלה
פו בככר
הנה שגיא שהאכיל אותי מעדנים
מומלץ!
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This was quite a journey, thanks
@LTiroshi
for all the hard work and deep insights! Happy Hanukkah 🕎
I’m thrilled to share that our latest research, unveiling the unreliability of striatal neural responses through a unique application of sparse labeling, has been officially published!
@SfNJournals
@Yara_Atamna
@GoldbergLab
@Hujimed
Key findings 🧵
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just another striatal patching and optogenetics day at the lab
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Another great ms by
@StephCragg
: Targeted activation of cholinergic interneurons accounts for the modulation of dopamine by striatal nicotinic receptors
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בהצלחה לד״ר מחאג׳נה עם צער רב על העוול שנגרם לו בהדסה (פה עם עוגה מרולדין שנתתי לו ביום שהוחזר לעבודה)
יום חמישי, 30 במרץ, 2023
לאחר שהחזיר אותו לעבודתו.. דוקטור אחמד מחאג'נה מתפטר מעבודתו בבית החולים הדסה.
הרופא אחמד מחאג'נה הגיש את התפטרותו מבית החולים הדסה לאחר שהנהלת בית החולים פיטרה אותו והחזירה אותו לתפקיד מאוחר יותר בטענה שהציע חתיכת ממתק לילד פלסטיני בבית החולים, >>>>
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Dopamine Deficiency Reduces Striatal Cholinergic Interneuron Function in Models of Parkinson’s Disease
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ווי
@lirishavit
תודה ששיתפת ! 💔😔
לאחרונה התקיים מפגש של אהרון ברק עם נציגי משפחות החטופים במטה המשפחות
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For all DA enthusiasts out there this is the coffee for you
@mohebial
@StephCragg
@VidaConference
@SilberbergGilad
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Osnat Oz and Nadine Waited submitted their MSc theses, on
#cholinergic
#interneurons
and brain stem Ca2+ currents, respectively. Congrats! It was great working with you, and best of luck! What a great way to start a fresh new year!
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If you are a
#scientist
from
#Ukraine
(faculty/student) the
@HebrewU
is inviting you to spend up to 4 months (dorms plus >2000 USD/mo stipend). If you work on basal ganglia, Parkinson's, ephys/imagining, pls DM or contact me. joshua.goldberg2
@mail
.huji.ac.il
@Hujimed
🇺🇦🔬🇮🇱
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I have a patch clamping joke but it sucks
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@FeralHeather
@bita137
Who are you calling right wing? me?! who are you calling genocidal? Israel?! Shame on you, your rhetoric and your misrepresentations! And do your fact checking for example about what institution
@OdedRechavi
is proudly associated with.
@TelAvivUni
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on our way to APPD meeting at
@TelAvivUni
to hear
@SpillantiniLab
and other great speakers
@AvrahamLab
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Cherry tomatoes 🍅 🍒 today (mortar in the background)
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Coincidence of cholinergic pauses, dopaminergic activation and depolarization drives synaptic plasticity in the…
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as a scientist we always aim to pick the low hanging fruit 🍋 (near the Gaza strip) with jet fighters above
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Therefore for
@mbeisen
to portray it as if his ousting has do to his recent post is disingenuous - only further indicating that he is incompatible with being an EIC of anything
I did not mean to insinuate anything other than what has appeared in
@eLife
board’s statement “his approach to leadership, communication and social media has at key times been detrimental to the cohesion of the community we are trying to build and hence to eLife’s mission.”
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check out our new lab website (parts still under construction)
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Striatal neurons are recruited dynamically into collective representations of self-initiated and learned actions in freely-moving mice
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Another important finding in this paper (Fig 3) that is not obvious from its title is that we show that action potentials from an individual striatal cholinergic interneuron cause local dopamine release i.e., w/o requiring synchrony
@StephCragg
@JoeyCheers
@XOanAxon
@KhaliqLab
Happy to share our
@NatureComms
on acetylcholine waves in the striatum and a mathematical theory of how they may be intertwined with dopamine waves first described by
@arifahamid
thanks to
@NicTritsch
and
@Gasarpong
for in vivo data
@MatityahuLior
for 2plsm data and Naomi Gilin
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Lab outing to pick eggplants near the Gaza strip. We even heard a siren (and dropped to the floor) and then a boom (probably a mortar falling or an iron dome intercept)
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so is cutting fetuses out of their mother’s wombs, and cutting both their heads off, and cutting children’s off legs. so cut the BS !shutting down enemy comms is a perfectly useful and necessary move to help the maneuvering forces.
#HAMASisISIS
have stashes of fuel to power up
Cutting off all communication to a population of 2.2 million is unacceptable. Journalists, medical professionals, humanitarian efforts, and innocents are all endangered.
I do not know how such an act can be defended. The United States has historically denounced this practice.
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I am speaking at The 30th Annual Meeting of the Israel Society for Neuroscience (ISFN). Please check out my talk if you're attending the event! - via
#Whova
event app
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removing dead tomato vines in a greenhouse that went to waste because the Farmer, Tal Maman, was killed in action as a member of the emergency squad (כיתת כוננות) defending his moshav
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Highly selective brain-to-gut communication via genetically defined vagus neurons: Neuron
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check this out!
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Was there ever a military force that delivered medical supplies and baby food to a fortification of a the one and same enemy that slaughtered its babies and raped maimed kidnapped and murdered its women men and elderly?! (courtesy of ארץ ג׳האד on telegram)
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Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons
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Thanks
@SilberbergGilad
for the giving me a taste of Kayaking too .
#ibags2023
was a great success both scientifically and socially in the never-ending Swedish Sun
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Thank you for what you wrote. However, we no longer have trust in ex-
@mbeisen
because of the likelihood of an implicit bias against, and after this present fiasco, likelihood for retaliation against Israeli authors. If he has any decency/courage, he has to step down or be let go.
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On october 7th Israeli women were murdered, kidnapped and raped. All in the name of "freedom fighting".
RAPE IS RAPE!
We call all women rights organizations, all feminists, all women, from all over - Don't stay silent. Stand with Israeli women.
@ZerMoran
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חייבים לבער את התופעה הזאת אהל עוד יותר לעצור את הרציחות של פלסטינאים בגדה בידי מתנחלים חמושים!
החמאס היהודי מסית לרצח תינוקות.
@IL_police
הפרטים אצלי אם אתם מחליטים להזיז את התחת לפני שדתיים ירצחו שוב תינוקות.
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גם אני פתחתי היום שיעור עם אמירה אישית על הבעייתיות של הרפורמה הזאת לציבור הסטודנטים של מקצועות הרפואה ועל הפגיעה הצפויה באקדמיה. קורס שלי - אני מביע את דעותיי ללא מורא.
בניגוד לנהלים
שיעור באוניברסיטה העברית על חיידקים - המרצה מדבר נגד הרפורמה המשפטית
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I’m not showing you the calcium imaging that goes with this rat race 😜
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Please register to our upcoming seminar on brain disease on Sept 12-13 2023 featuring great speakers
@MarinLab
@StephCragg
@bush_professor
@AvrahamLab
@inna_slutsky
@GUmschweif
@anat_kahan
@RevahLab
@ChaimPutterman
@haitham_amal
@MarcoAsaf
@shira_knafo
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watching superbowl LV with folks 1:50 am (everyone is vaccinated)
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I'm humbled...
One of our partners,
@GoldbergLab
, gave a presentation in Bordeaux last week! Dr Goldberg is one of many highly-esteemed academics in our consortium. Stay tuned for more information on the EU funded AND-PD project in the coming weeks!
@EU_H2020
@ParkinsonsUK
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This is one of my favorite and most elegant projects.
hurray to Lior Tiroshi for an incredible combination of theoretical and incredible finesse.
Population dynamics and entrainment of basal ganglia pacemakers are shaped by their dendritic arbors
#biorxiv_neursci
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We got it! Thanks and congrats to my partners: Jeff Wickens
@OISTedu
and Lin Tian (
@LinTianLab
). Looking forward to an exciting collaboration and cool science!
We are happy to announce the winners of the 2019 HFSP Research Grants, Postdoctoral Fellowships and Career Development Awards. Congratulations to all new awardees! For the lists of awards and press releases see:
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Am seeking postdocs to do cool electrophysiology and two photon imaging on anxiety and depression in Parkinson's disease. Also check out
@RaffaellaTonini
@SilberbergGilad
@FisoneL
@MoratallasLab
@fgeorges007bnst
members of same EU consortium grant
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Closure in 5 hours - some fun in the (December) sun and Mediterranean sea breeze
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@HaimTraitel
אני נמס ממך, אח יקר. בייחוד כי יש לי בן בגדסר נחל שהתחיל בדיוק במקביל אליך טירונית. מסור שכויח עצום לאחותך. ולהורים : ״תפארת זקנים בני בנים ותפארת בנים אבותם״.
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דיברת חד ולעניין. מרשים ומרגש
לא זוכרת כבר הרבה שנים הפגנה גדולה כל כך. מי שחשבו שיצליחו לרסק את הדמוקרטיה ולשנות את פני ישראל בלי מאבק יבינו שהם טועים טעות מרה.
הערב הארץ היתה מלאה בתקווה גדולה.
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I got inoculated for Covid-19 !(walked in 15 min before they close the clinic assuming they’d have extra doses that might go to waste- i was right)
בא״ה אמ״ה שהחיינו וקיימנו והגיענו לזמן הזה Go
@pfizer
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Yes! 2nd paper currently being revised for
@eLife
🤞
#PeerReview
from
@eLife
of 👉🏿 Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons
#biorxiv_neursci
#reviewedpreprint
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Me and my Cody James hat (that
@IamVoldabort
helped me buy) on a pickup truck in the town of Dekel near the Gaza strip & picking tomatoes with Prof. Kobi Cohen -Hattab, chair of Land of Israel studies department at
@Bar_ilan
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