Furlan-Magaril_lab
@FurlanLab
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We study chromatin conformation regulating transcriptional dynamics in mature cells
IFC-UNAM, Mexico City
Joined January 2019
Paper alert!! We share a cost-effective protocol to obtain clean and viable cell suspensions from breast tumor biopsies to perform scRNAseq and Hi-C! Congratulations to Aura Stephenson @AuraGussinye9 and everyone involved! @IFC_UNAM
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RT @IFC_UNAM: Esta semana, asiste o sigue en vivo la transmisión de nuestro seminario institucional. Presenta el Dr. Armando Tovar, quien p…
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RT @AMathelier: We're #hiring a postdoc to study epigenetic imprinting during adipogenesis. Cool interdisciplinary project to analyze ChIP…
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RT @orouji: Multiscale footprints reveal the organization of cis-regulatory elements @JD_Buenrostro lab https://t.…
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RT @YinShenLab: Join us for GRC/GRS: Genome Architecture in Cell Fate and Disease this June in Ventura, CA!
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RT @BrancoLab: We are hiring! 3-year BBSRC-funded postdoc position available. TEs, epigenetics, pregnancy: if you love one or more of these…
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RT @HelmholtzMunich: Ancient Viral DNA Shapes Early Embryo Development Researchers at #HelmholtzMunich & @LMU_Muenchen have uncovered the…
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RT @xielablife: Chromatin folks: don't miss GRC/GRS Genome Architecture in Cell Fate and Disease, June 15-20 2025 Ventura, CA. Registration…
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RT @CEpigenomics: Our agenda has been finalized for Spatial Epigenomics Virtual Day Wednesday, Jan. 29. Join us for this compelling series…
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RT @ngaboreden: Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhance…
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@Ella_Maru @kari_jacome However, CTCF DNA binding motif is far more conserved at highly accessible boundaries compared to less accessible boundaries. We hypothesized that this might mean more stable CTCF binding.
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@Ella_Maru @kari_jacome Thank you :) Yes! Highly accessible boundaries have on average more CTCF, however when comparing high and low accesible boundaries with the same number of CTCFs, highly accessible boundaries are anyhow more robust.
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We explored protein occupancy at boundaries. Ctcf, cohesin and REST bind together and ZNF316 and EMSY bind together as two independent modules at boundaries.
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We found that the most accesible boundaries are more occupied by proteins, and are more robust insulating chromatin contacts compared to less accessible boundaries.
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We experimentally classified boundaries based on chromatin accessibility by introducing a digestion time course.
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