Wei Xie
@xielablife
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Studies epigenetic reprogramming in early development. Professor, Life Science, Tsinghua Univ., Beijing B.S. Peking Univ.; M.S. & Ph.D. UCLA; Postdoc UCSD
Beijing, China
Joined December 2019
RT @biorxiv_genomic: De-novo DNA Methylation of Bivalent Promoters Induces Gene Activation through PRC2 Displacement
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Chromatin folks: don't miss GRC/GRS Genome Architecture in Cell Fate and Disease, June 15-20 2025 Ventura, CA. Registration deadline: Mar 18, 2025.
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@a_z_usa__ @NatureCellBio Congratulations Azusa! Beautiful work on Polycomb repression re-establishment!
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A legendary journey of a pioneer in the field of epigenetics. Thanks for sharing it.
I wrote a memoir for Michael Grunstein, a pioneer in histone biology and epigenetics, for @theNASciences. Read about his incredible personal journey and how his career unfolded.
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@VashKurdistani @theNASciences Thanks Siavash for writing this beautiful article about Michael and for sharing all these stories. A remarkable person and career.
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@longhua_guo @GCRLE1 @pewhealth @AFARorg @UMPhysiology Wow ... big congratulations Longhua! This is fantastic news!
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Marvelous work from Nicola Festuccia, Pablo Navarro and the team! Huge amount of work and beautiful/impressive mouse genetics. Glad that our Nr5a2 studies independently reached the same conclusion🤝🤝Congratulations!👏👏👏
After a massive team effort leaded by the incomparable @NicolaFestuccia I am really happy to share our freshly published @ScienceMagazine ms where we elevate Nr5a2 to the top of gene regulation in the morula. 🔥🔥🔥 Take a look at Nicola's description 👇!
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@pablonavarroLAB @NicolaFestuccia @ScienceMagazine Congratulations Nicola and Pablo! Really happy to see the paper is out now, which has been expanded tremendously from the preprint. Enormous amount of work and beautiful mouse genetics!
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@EddaGSchulz @AlexandraMMar @NatureGenet Thanks Edda and Alex! Really happy to see this nice N&V coming out.
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Thanks Edda and Alex for writing this beautiful and insightful N&V! @EddaGSchulz @AlexandraMMar and @NatureGenet Lots of interesting questions for early development and chromatin organization await to be answered and glad that we can contribute a small piece. Post your reply
Together with PhD student @AlexandraMMar we wrote a News&Views @NatureGenet about the new paper📜 from @xielablife. A stunning data set on the 3D chromatin structure of the X chromosome in early embryos reveals unexpected large-scale structures: 🐭🧬🔺🔺
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@Ella_Maru Thanks Ella. Excellent question. From the Hi-C heatmap (Fig. 5a), the changes of chromatin architecture in VE seem very limited. Differences are more apparent in MEF, as compartments appeared stronger, but more analyses are probably needed to confirm this.
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