Elias Orouji
@orouji
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Epigenomics Lead at Princess Margaret Genomics Centre @pmcancercentre @uhn | University of Texas MD Anderson Cancer Center @MDAndersonNews | DKFZ @dkfz alumnus
Toronto, Ontario
Joined April 2009
Excited to share our latest publication — "CAR-T cells in colorectal cancer: Pioneering new avenues in solid tumor immunotherapy". Journal of Clinical Oncology @JCO_ASCO PDF: w/ @ShaidaOuladan @McgillU | @UHN_Research @PMResearch_UHN @PMCancerCentre A comprehensive review of the application of CAR-T cell therapy in treating colorectal cancer. #CART #CellTherapy #ColorectalCancer @OncoAlert @OncoDaily
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RT @UHN_Research: Researchers at @PMResearch_UHN recently published a review on advancements in #CART #CellTherapy for #ColorectalCancer.…
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Spatial-Mux-seq -- Multiplexed spatial mapping of chromatin features, transcriptome and proteins in tissues @DengYanxiang @PennEpiInst
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RT @RonDePinho: Impressive results with "EC-FOLFOX6" in metastatic CRC w BRAF mutations. Encorafenib + cetuximab + FOLFOX6 vs SOC showed 60…
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Cell-Based Therapies in GI Cancers CAR-T Cells in Colorectal Cancer #GI25 #ASCODailyNews
New from#GI25 #ASCOEdBook: Cell-based therapies in GI cancers are promising. However, maintaining activity in the immunosuppressive tumor microenvironment must be addressed.
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CAR-T cells in colorectal cancer: Pioneering new avenues in solid tumor immunotherapy @JCO_ASCO @ASCO #GI25
#CART #CellTherapy #ColorectalCancer #Cancer #Immunotherapy
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Mapping cells through time and space with moscot
1/ Excited to see published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at
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Droplet-based high-throughput 3D genome structure mapping of single cells with simultaneous transcriptomics
Thrilled to introduce a new single-cell 3D genome analysis tool to our toolkit! Our high-throughput droplet Hi-C (dscHi-C) and dscHi-C-multiome methods use droplet microfluidics to generate tens of thousands of single-cell Hi-C profiles with high sensitivity in a single batch.
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RT @TitusBrinker: Our new paper is out @NatureComms! 🎉 An important effort led by Sarah Haggenmüller reveals substantial challenges in #mel…
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The next frontier: Chimeric Antigen Receptor-T Cells in Colorectal Cancer: Pioneering New Avenues in Solid Tumor Immunotherapy @JCO_ASCO
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RT @GillSharlene: Sharing this great @JCO_ASCO review of #CAR-T strategies in #colorectal cancer #CRCsm @orouji @UHN @ShaidaOuladan @mcgill…
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Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
Our paper describing the use of an ultrasensitive circulating tumour DNA detection assay to stratify #TRACERx patients with early-stage non-small cell lung cancer pre-operatively for clinical outcome is out today @NatureMedicine. Thread below 👇
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RT @romeerizwan: These results highlight the safety and potential efficacy of CAR NK cell therapy. Induced pluripotent stem-cell-derived CD…
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PERFF-seq (Programmable Enrichment via RNA FlowFISH by sequencing) Transcript-specific enrichment enables profiling of rare cell states via single-cell RNA sequencing @NatureGenet
PERFF-seq is out today in @NatureGenet! Our recent thread summarizes why we are excited about the prospects of programmable nucleic acid cytometry for studying rare cell states.
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RT @RonDePinho: Aged stem cells have reduced capacity to form tumors due to increased Nupr1 which upregulates Lipocalin which sequesters ir…
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Inhalable nanovesicles loaded with a STING agonist enhance CAR-T cell activity against solid tumors in the lung
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