FrattaLab
@FrattaLab
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FrattaLab @UCLIoN working on #RNA biology of #ALS and #SBMA and #Kennedy's disease
Joined November 2019
@AberdareNic this will take some time and is not going to impact what is due to go to clinical trials now, but hopefully the following generation of therapies.
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Great perspective from Yi Zeng and Aaron Gitler. Wonderful collaborations and long journey with @ClaireLePichon and @ule_lab. And funding to start and now continue the work from UCL NgTP/@SRausingTrust @The_MRC @mndassoc @MNDoddie5 @TheCrick
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RT @arianna_tucci: #RepeatExpansionDisorders are up to three times more common than current estimates. Underdiagnosis or reduced penetrance…
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@BrielmaierL @PeteHarley95 @jbneuro we definitely look forward to independent confirmation. same ASOs can be used by anybody for all such experiments.
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RT @OscarWilkins16: We're looking for someone with a creative mindset and excellent modern molecular biology skills (DNA manipulation, Illu…
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RT @MasudHusain: Why small mindedness is having big consequences @Brain1878 I live under its shadow. I suspect most of you do too. It is t…
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RT @RueppLab: Do you love #RNA and #neuroscience? Are you looking for a #postdocposition on #ALS and gene therapy? Join @RueppLab @UKDRI @K…
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This work was led by @SamBryce_Smith and a joint effort with @mariasecrier and many others. Parallel efforts from the Gitler and La Spada labs also identify the link between TDP-43 and 3'UTR changes and out now:
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TDP-43 loss causes mis-splicing in ALS/FTD. We now show it also induces widespread cryptic 3'UTRs. This increases RNA stability, translation and function of ELK1 and other TFs. Also provides novel targets for biomarker and therapeutics development.
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RT @isaacs_adrian: Really excited about our latest preprint, where we uncovered a neuroprotective role for neuronal polyunsaturated fatty a…
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See the full thread from brilliant first author @OscarWilkins16 Exceptional collaborators on this, including @ClaireLePichon @ule_lab @MaxZYJChien Jo Wlaschin @UCLIoN @TheCrick
New BioRxiv paper on using cryptic splicing to unlock precision gene therapy activation for ALS, FTD & other TDP-opathies! Key contributions @MaxZYJChien Josette Wlaschin +many others from @ClaireLePichon @ule_lab @FrattaLab labs and more. A thread 🧵 1/13
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Want to deliver gene therapies broadly, but activate them only in diseased neurons? TDP-REG "hacks" TDP cryptic mis-splicing to drive expression only WHEN and WHERE needed! Less toxicity, wider therapeutic window, new options for sporadic ALS therapies.
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RT @PataniLab: Our latest @NeuroCellPress reveals widespread mislocalisation of proteins & mRNAs in ALS. This is partly reversed by VCP ATP…
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RT @isaacs_adrian: Check out our new preprint on generation and characterisation of C9orf72 polyGR and polyPR knock-in mice. A huge effort…
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