FRPharmS (Consultant).Lead Clinician Paediatric Infection (SPAIIN). Clinical Lead U of Liverpool. Actual job: Football/Gymnastic chauffeur for 3 sports mad boys
Check out this simple, safe & pragmatic guide for managing DDI’s with paxlovid on
@covidDDIs
. Thanks
@kndhill
. Tools like this & Liverpool website/app mean that non specialists can manage DDI to ensure the most amount of patient benefit & access to a 1st line drug
This has made my day! A massive first for me, I have been so lucky to work with the most amazing group of people in Glasgow, my amazing Hep/HIV colleagues all over the country & the fabulous team at U of Liverpool.
New website for COVID-19!
As some HIV or HBV/HCV drugs are being trialled against COVID-19, we have produced drug interaction information for these drugs and other experimental agents. Please check the website regularly for updates as new drugs are added.
Over 120 Molnupiravir Rxs written over last 2 wks (including Christmas Day!) by us
@alisonboyle_1
@laskeyj
@Kimberley_P23
Amazing effort from GGC at implementing this pathway quicker than anything I’ve been involved in & a huge team effort. Every last person went above & beyond.
I haven’t been a consistent
@rpharms
member in the past but I’ve been so pleased with the help & support through my Consultant accreditation & have met some great people. This letter was very, very appreciated amidst the current chaos.
@RPSScotland
@clareupnorth
@CarruthersA89
A brilliant poster & 🧵from Kirsteen, pharmacists are key for paxlovid. Removing all amber & red interactions would result in only 40% of patients getting paxlovid, using pharmacists to manage interactions increased this to 71% increasing access to a more efficacious treatment.
As a pharmacist that works in HIV & COVID, thought I’d share some work I’ve been doing preparing for Paxlovid! Looked at all our eligible patients on Covid OP pathway for the first 3 weeks and if we could have safely given them Paxlovid. 👇🧵
@FionaMarra
@covidDDIs
@UKCPAPIN
Spent time this a.m helping my friend in her community pharmacy, a crazy amount of pressure they are under! I’m hearing lots about drs &nurses being moved to help, come on pharmacy there are many non urgent roles that can take a back seat to help out colleagues on the front line
Lucas started his pro youth journey last night with rangers with a celebration night of his achievements. He is living his best life & so much organisation & planning went into such a brilliant night. He is one lucky boy
@RFC_Youth
@ZebJacobs
@max_ashmore
@stcadocsprimary
In the home straight of having COVID with the kids & grateful to have the most amazing family & friends who made doorstop drop offs feel like Christmas day for us. Me & my new antibodies are looking forward to getting back to work 🦠💪
Happy National Technician day to these 2 champions (and all our team) Wine for morning tea! Alison & I couldn’t cope without you, our heroes ❤️
@NHSGGCPharmacy
@alisonboyle_1
Our full University of Liverpool drug interactions website is now live as we move from PDF tables to full clickable commentaries amazing team & project to be part of
@daveback01
@alisonboyle_1
@justinchiong
& Catia, Saye, Sara, Katie & Jasmine
#dreamteam
Our COVID interaction site now has twitter
@covidDDIs
Over 400 co-med interactions with remdesivir,favipirivir,lopinavir/r, darunavir/c,chloroquine, nitazoxanide &ribavirin. Coming soon hydroxychloroquine & toculizumab. Swallowing advice on all available.
This study is very small & in no way conclusive yet that this combination works, also used together this combo have additive QTc concern & require highly specialist input. Possibly his most dangerous tweet yet
HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine. The FDA has moved mountains - Thank You! Hopefully they will BOTH (H works better with A, International Journal of Antimicrobial Agents).....
👩🏿⚕️It was a pleasure to chair the
@rpharms
Women in Pharmacy reception in Parliament today!
It was inspiring to talk to so many women leaders who are making a real difference in their communities and who had so many great ideas for the future of the sector.
2nd vaccine ✅
@NHSLouisaJordan
10 weeks from first. Such an amazingly slick operation, in and out in minutes. Unbelievable organisation for such a huge site. Well done
@NHSGGC
Congratulations to Joshua (S1) who performed excellently at the Scottish Mens Artistic Gymnastics National Grades - winning two🥇two🥈and one🥉Joshua dedicates many hours to his training and is achieving great success 👏🌟
#celebratingsuccess
#gymnastics
@stninianshigh
Fab company, nice food & drink made by somebody else, lots of laughs & stumbling distance home. If Carlsberg made Friday nights... although maybe indoor next time so I don’t need 3 jackets & a blanket 👵🏼
@laskeyj
@KateStock3
@robb_fiona
cheers ladies 🥂
The legend retires. Dr Ray Fox leaves the building. Great night
@rcpsglasgow
celebrating a phenomenal contribution to HIV & HCV. Thinking of the thousands of prescriptions we’ve written, countless MDTs & great social events with the best team. You will be greatly missed 👏👏
Paxlovid (nirmatrelvir/ritonavir) granted FDA EUA today for use in Covid-19. Better data than molnupiravir but significant contraindicated or dose modification/monitoring of co-meds. Watch this space for full DDI recommendations managing this prescribing.
Slightly misleading headline as
@NHSScotland
completed treatment of children 12-18 in 2018 and children 3-11 in 2020 with few individual cases left nationally.
Children in England are set to be the first in the world to be offered a cure for Hepatitis C.
The world-first treatment will help the NHS in achieving its goal to eliminate Hepatitis C in England ahead of the 2030 target, set by
@WHO
. ➡️
I loved joining this team for a mini secondment to enhanced surveillance for COP26. A super talented & welcoming team, carrying out an incredible amount of work around the clock.
Released today by
@P_H_S_Official
a preliminary report on Surveillance of the impact of
#COP26
on COVID-19 infections in Scotland
Read the full report here
PANORAMIC finally out 🦠 Conclusion: molnupiravir did not reduce already low hospitalisations/deaths among higher risk, vaccinated adults with COVID-19 in the community, but resulted in faster time to recovery, and reduced viral detection and load.
New oral COVID-19 therapies showing significant promise. No DDI of concern with molnupiravir (added to ) but paxlovid is a ritonavir boosted combination. Only 5 day duration but potent enzyme inhibition is immediate & drug interactions will be problematic.
The imminent anti-Covid pills, which have considerable promise to help us prevail over the pandemic
Summary
@heidiledford
@nature
Added a Table row to account for the cytochrome interactions with common drugs for the Pfizer drug combo (due to ritonavir)
Paxlovid DDIs are live on
@covidDDIs
! Hopefully our information will allow for safe prescribing of ritonavir in the community for Covid-19. Thanks FDA for this gift 2 days before Christmas 🤪 but grateful to be part of the best team
@daveback01
@alisonboyle_1
Catia, Saye, Sara
Drug interactions for Paxlovid now on
@covidDDIs
. An incredible effort from the team who only received the DDI information in the labels on December 23rd and worked over Christmas to finalise all the commentaries.
Street party ✔️ bag pipes ✔️ kids outside playing football til 11pm talking about when they will be playing for Scotland ✔️ imagine the party if we won…
#proud
🥳🥳🥳🏴🏴🏴🏴🏴🏴🏴
@ScotlandNT
First morning cycle to work, 11 miles (should have been 10 but I wasn’t paying attention at end and took a detour!)
@laskeyj
not too bad, not looking forward to the uphill home though...
@HamiltonMusical
the best musical ever. Fact. My date tonight to the capital had the best night, pretty sure all 47 songs were sung (quietly) by him word perfect 🥰 Go go go if you get the chance. He even got to meet the man himself…
@clareupnorth
@rpharms
@PharmaSupport
Managed it too! 1.5 degrees in Balgray Loch so I’m a lightweight & needed the wetsuit. Still pretty cold 🥶 my 10 year old joined me. Exhilarating! Happy New Year 🥳
Fantastic practical presentation from
@FionaMarra
on
#Paxlovid
drug interactions at
#antiviralPK
workshop.
Take home: Inhibition interactions are more important than induction interactions & many Co meds can be safely stopped for short term treatment
#IDtwitter
#COVID19
Following on from yesterday, that’s a wind up now for gymnastic comp season for Josh. Scotland squad camp & a silver medal to finish off 3 days in Durham. Proud mum 😮💨🥈🏴🔥
It’s so lovely to back & chairing the Liverpool symposium on prescribing in complex patients. Packed auditorium of real life humans! 3 excellent cases on patients marginalised from clinical trials.
#hivglasgow
@hivinteractions
My bit in The Times, now outside the paywall.
Where safe and appropriate, Covid vaccination should be prioritised for the terminally ill, so they can spend time meaningfully with loved ones.
To support, pls RT - and better yet, cc your local MP
#PalliativeCare
Undetectable = untransmittable.
When a person living w/HIV is taking effective antiretroviral therapy, the viral load becomes so low that it is undetectable. A person with an undetectable viral load has no chance of passing on HIV. Read more:
#AIDS2018
It’s EASL abstract submission night and true to form it will come to the 11pm deadline. Tonight’s curveball is I am filling in author declarations on my phone in the stadium at Accies v Livingston in -4 degrees 🥶🥶 (11 goals though for Zac 🎉) 1 hour to go…
HCV treatment in
@NHSGGC
doesn't happen without the amazing work of our pharmacy technicians, Cecilia, Janice and Elaine
@NHSGGCPharmacy
- happy pharmacy technician day!
Delighted to kick off this evening by chairing the first session of the Liverpool Course with
@daveback01
& presenting some quick fire cases with Prof Khoo. Great attendance, great content, great speakers
@hivinteractions
well done again 👏 session 2 just kicking off
"This course is not to be missed," says our Program Chairs Dr. David Back & Dr. Saye Khoo.
Read their invitation below on how this year's
#LiverpoolCourse
addresses improving patient care in the context of
#clinicalpharmacology
education.
Learn more>>
1/ A previous report of 1099 hospitalised
#COVID19
patients from 52 hospitals in China now published in
@NEJM
The median age=47y, 16% of hospitalised pts had severe disease, 5% were admitted to ICU, 3% had ARDS, 2.3% required ventilation & 1.4% died.
@clareupnorth
Agree. As a pharmacist ‘off license’ and ‘no data’ can be hard to swallow but knowing that my own parents and many others will be vaccinated sooner is a no brainier. I’ve also had a good read of the data available on how the vaccines work & feel it’s the right decision.
Lopinavir/r no benefit in very sick patients, what about addition of chloroquine or hydroxychloroquine as is being used in many many countries? Data needed urgently
All ready for the
#liverpoolcourse
in Lithuania - a half day workshop of mini lectures, cases&interactive discussion all about improving patient outcomes through better management of DDIs. from UoL staff and ID clinicians across Eastern Europe
@Virology_Edu
@livuninews
@livuniITM
We've updated to highlight our full range of resources, including educational videos and printable charts about HCV prescribing. Here's the new page and one of our new treatment selectors, showing interactions between DAAs and anticonvulsants.
Useful algorithm from
@MayoClinic
on managing QTc risk in patients starting on experimental therapies of hydroxychloroquine, chloroquine, lopinavir/r or azithromycin for COVID. Link in comments
Have a look at these 3⃣ useful
#COVID19
data collection & resources:
✅A COVID-19 drug interactions website▶️
✅A ‘data dashboard’ to monitor COVID-19 case statistics in PLWH▶️
✅
@LEOSS_CoV_2
open register▶️
Looking forward to presenting at this tomorrow with some fabulous speakers. The Liverpool Masterclass in Antiviral Pharmacology
#LMAP2020
has over 500 people registered so far from round the globe. Still time to register👇
We are hosting a free online workshop on Wednesday 11th November 2020: Liverpool Masterclass in Antiviral Pharmacology
#LMAP2020
. For more info and to register:
*must see talk* take 1hr out of your day to watch these hugely important sessions by global experts on COVID 19 at CROI2020 delivered last night
@alisonboyle_1
@katjc1
@NHSGGCPharmacy
I believe this is the link to study Trump is talking about. *SIX* patients received both hydroxychloroquine & azithromycin & overall study population not seriously ill. MUCH more data needed
Saturday night. 10pm. Kicking off
#hivglasgow
by presenting a complex patient as part of this brilliant multi drug resistance symposium with many of the greats
@drlaurajwaters
@GerettiAnna
, Saye, Jonathan et al. Did I say it was 10pm? Hardcore