Targeted temperature management is recommended for patients after cardiac arrest, but the supporting evidence is of low certainty. In an open-label trial with blinded assessment of outcomes, we ran...

Mask wearing and social distancing for Covid-19 has all but cut influenza cases in New Zealand this year, with only six flu isolates detected in this country from April to August.  Professor Michael...

Whether prehospital administration of tranexamic acid increases the likelihood of survival with a favorable functional outcome among patients with major trauma and suspected trauma-induced coagulop...

The effect of delivering nutrition at different calorie levels during critical illness is uncertain, and patients typically receive less than the recommended amount. We conducted a multicenter, dou...

Intensive care unit (ICU)–acquired weakness often develops in patients who are undergoing invasive mechanical ventilation. Early active mobilization may mitigate ICU-acquired weakness, increase sur...

We found that tranexamic acid did not reduce death from gastrointestinal bleeding. On the basis of our results, tranexamic acid should not be used for the treatment of gastrointestinal bleeding...

Intravenous fluids are recommended for the treatment of patients who are in septic shock, but higher fluid volumes have been associated with harm in patients who are in the intensive care unit (ICU...

OPINION: If New Zealand respects the rules, we can be spared the worst of the pandemic. It's that simple.

Studies that have evaluated the use of intravenous vitamin C in adults with sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown mixed results with respect to t...

Ignore calls to end lockdown early, as that puts tens of thousands of Kiwi lives at stake, expert says.

Intensive care unit (ICU)–acquired weakness often develops in patients who are undergoing invasive mechanical ventilation. Early active mobilization may mitigate ICU-acquired weakness, increase sur...

Patients who are undergoing mechanical ventilation in the intensive care unit (ICU) often receive a high fraction of inspired oxygen (Fio2) and have a high arterial oxygen tension. The conservative...

Oxygen therapy is a key component of supportive care for patients who have hypoxemic respiratory failure and are being treated in the intensive care unit (ICU). Yet, although oxygen can be lifesavi...

Health experts have been surprised by a lower number of deaths throughout the country over the lockdown period.

Let’s start by considering what our pretest probability should be regarding whether hypothermia is beneficial after cardiac arrest.  Every enzyme in

The comparative efficacy and safety of balanced crystalloid solutions and saline for fluid therapy in critically ill adults remain uncertain. We systematically reviewed randomized clinical trials (...

This cluster randomized trial compares the effects of proton pump inhibitors (PPIs) vs histamine-2 receptor blockers (H2RBs) on 90-day mortality among patients requiring invasive mechanical ventila...

Whether conservative management is an acceptable alternative to interventional management for uncomplicated, moderate-to-large primary spontaneous pneumothorax is unknown. In this open-label, multi...

Acute kidney injury is common in critically ill patients, many of whom receive renal-replacement therapy. However, the most effective timing for the initiation of such therapy remains uncertain. We...

This quasi-experimental cohort study examines the association of intravenous radiocontrast exposure with kidney injury in patients undergoing D-dimer testing.

Continuous renal replacement therapy began in the early 1980s. It was codified, and its techniques explained by the Acute Disease Quality Initiative1 with more than 5785 publications as of April,...