Christoffer Clemmensen
@ClemmensenC
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Associate Professor, University of Copenhagen || Co-founder and CSO, Ousia Pharma ApS
Copenhagen, Denmark
Joined December 2012
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Our new paper "GLP-1-directed NMDA receptor antagonism for obesity treatment" is out today in
@Nature
We describe the engineering and preclinical development of a new drug candidate that targets NMDA receptors in GLP-1 receptor neurons.
1/8 🧵👇
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Why are some people protected from weight gain? This is one of the 'Unsolved Mysteries' in obesity research. In
@PLOSBiology
we argue that obesity resistance might be mediated by an unidentified hormonal defense. Curiosity piqued? Twittorial 👇and article
8
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357
Excited to see our work on the hormone GDF15 in energy homeostasis and exercise behavior out in
@NatureComms
Superb team effort led by
@BueKlein
and
@NicolaisenSand
- made possible by many excellent collaborators
@Metabolcenter
@koebenhavns_uni
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Our latest research sheds light on the intricate cross talk between GLP-1 (liraglutide) and nicotine biology. As the clinical use of GLP-1 based drugs increases, understanding the interaction with nicotine/tobacco consumption becomes increasingly relevant
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1/8 New preprint: GDF15 is not required for metformin-induced weight loss. Our findings were unexpected and emphasize that more work is needed to understand the physiology of GDF15 and the mechanisms underlying metformin’s effect on body weight. 🧵👇
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Ever wondered how
#exercise
mode (endurance vs. resistance) differentially influences plasma metabolites?
Check out our new paper in
@CellReports
to find out!
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1/2. Thrilled to share our latest publication on exogenous lactate, which we hope will offer significant insights to the metabolite community. We extend our gratitude to
@NatMetabolism
for publishing work with emphasis on substance over sensationalism.
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1/4 Our latest paper, featured on the cover of
@MolMetab
, contains whole-brain activity signatures in response to wheel running vs. treadmill running in mice. Curious about how exercise impacts your favorite brain regions? Dive in:
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Curious about the role of GDF15 in energy metabolism and exercise motivation? Check out this new preprint from our lab, led by:
@BueKlein
and
@NicolaisenSand
@Metabolcenter
@koebenhavns_uni
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(1/9) New paper out in Translational Psychiatry in which we do a deep dive pre-clinical evaluation of the psychedelic, psilocybin, for obesity treatment. Credit to PhD candidate
@nicolefadahunsi
+ several lab members for excellent execution.
Open access:
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Enabled by an investment from
@BioCPH
it is with great excitement that we launch Ousia Pharma, a biotech company developing next-generation anti-obesity drugs. This innovation journey is made possible through support from
@Metabolcenter
and the TTO at
@UCPH_health
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Particularly proud of this innovation grant that enables us to intensity our efforts on developing new therapies to combat overweight and obesity.
@koebenhavns_uni
CBMR wins innovation funding from
@novonordiskfond
's BioInnovation Institute! 🎉
@w_thue
and
@ClemmensenC
each won DKK3.5M to develop new drugs for treating
#cancer
and
#obesity
, respectively. 💊
Read more👇
#researchtranslation
@UCPH_health
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GDF15 is not required for the effects of metformin on food intake and body weight. Happy that our somewhat "negative"
@biorxivpreprint
was picked up by
@CellReports
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What is the role (if any) of exercise-induced GDF15? Is GDF15 a relevant physiological regulator of appetite and body weight? These and other questions are being discussed in this Mini-Review
@BueKlein
@kleinert82
and
@proferikrichter
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I rarely acknowledge how great the work environment is at
@Metabolcenter
but the surprise on my desk from
@SassFrederike
from
@Z_GerhartHines
Lab is an illustrative example (one of many) thereof 🧠GPCR in brainstem?! 👍
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Fascinating developments in weight loss drugs! Eli Lilly's triagonist phase 2 data: Nearly half of participants achieved >25% weight loss, with a quarter surpassing the impressive >30% mark. The bar continues to rise for incretin-based therapies.
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Nordic Obesity Meeting 2022
@jens_lund
lecturing on constitutional thinness and why it is important to study the phenotype of lean individuals to better understand causes of obesity.
@Metabolcenter
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Excited about 3 days of
@KeystoneSymp
science ahead on early drivers of type 2 diabetes. Organized by
@LoraHeisler
Martin Myers and C. Rhodes. Started out with a bit of pre-meeting “fun” with
@tunepers
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Does energy excretion play a relevant role in body weight regulation?
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Pleasure to take a deep dive into the recent exciting work on exercise-induced Lac-Phe by
@longlabstanford
@proferikrichter
and many other collaborators. Credit to the Preview co-writers, Master of Metabolites
@Thue_Schwartz
and rising star
@jens_lund
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Public and scientific interest in serotonergic
#psychedelics
is rapidly growing. We discuss the promises and pitfalls of psychedelics for treatment of
#obesity
and disordered eating
@NatureRevEndo
@GitteKnudsen2
@nicolefadahunsi
@Metabolcenter
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7
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Last night,
@M_B_Petersen
and I discussed the interactions between
#COVID19
and
#obesity
on
@dr2deadline
(in Danish). We also briefly covered the recent UK anti-obesity initiative - much in agreement with the (critical) points raised by
@GilesYeo
@uni_copenhagen
@AarhusUni
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Excited to be presenting our work on GDF15 in energy metabolism tonight at
@KeystoneSymp
#VKSDiabetes21
#VKSObesity21
@Metabolcenter
@koebenhavns_uni
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3
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Received great news from
@NatureRevEndo
that our 2019 Review on emerging pre-clinical treatment avenues for metabolic diseases is a ‘Highly Cited Paper’ by Web of Science (1%, similar age, clinical medicine).
@Metabolcenter
@HelmholtzMunich
Check it out:
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PhD student
@gil_claudia8
presents our emerging project on the paradoxical interplay between food insecurity and obesity at
#NeuroEndo24
@DDEA_Denmark
@Metabolcenter
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Will the societal strategies implemented to oppose spread of COVID-19 ultimately end up worsening the obesity epidemic?
Together with colleagues prof. Thorkild Sørensen and prof.
@M_B_Petersen
, we discuss this dire outlook in
@NatureRevEndo
Twittorial 👇
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8
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Is thyroid hormone signaling in skeletal muscle important for T3-induced energy expenditure? Follow link to find out:
@NicolaisenSand
@BueKlein
@jens_lund
@Z_GerhartHines
@proferikrichter
@AndreasMaechel
et al.
@Metabolcenter
@science_ku
@UCPH_health
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Excited to share our new data on targeting neuroplasticity for weight loss. One of the assets in our biotech startup Ousia Pharma
Check out session 4 of our upcoming conference, on "
#Metabolism
and
#Cardiovascular
Diseases":
🎡Michael Lehrke
🎡Bart Staels
🎡James Goodman
🎡Rachel Perry (
@RachelPerryLab1
)
🎡Christoffer Clemmensen (
@ClemmensenC
)
Registration:
#HelmholtzDiabetes2022
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For years, I collaborated with
@Mettekorsgaard
on 'The Unfair Body Fight'—a powerful documentary where she bravely explores weight loss firsthand. Catch the premiere in Copenhagen this Saturday or look out for streaming soon. An important piece of public service cinema!
@cphdox
It's a paradox that the world's population is getting fatter and fatter when many dream of being thin. Why can't weight be controlled?
This is the premise of
@Mettekorsgaard
documentary 'The Unfair Body Fight' that recently had its premiere at this year's
@cphdox
film festival.
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This afternoon Jonas Petersen successfully defended his PhD thesis "Development of peptide-drug conjugates for obesity treatment". You make mentoring look easy
@OdgaardJonas
:) Big shout-out to the assessment committee
@NielsJessen1
@tuomaskilpela
and
@SpringGroupChem
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Interested in studying the biological defense mechanisms against excessive weight gain? Apply for a 3y fully funded interdisciplinary and collaborative project involving several labs at
@Metabolcenter
e.g.
@CamillaScheele
@atul_deshmukh1
and
@Z_GerhartHines
Feel free to RT
The CBMR International Postdoctoral Programme is now open for applicants! 👩🔬👩⚕️
Preferred candidates are familiar with integrative research approaches within basic metabolic research with applications in human pathophysiology.
👉
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Looking for a PhD position?
Come join us at the Bioscience cluster in Copenhagen. Superb 1+3 year program, fully funded. Deadline for applications: January 12.
@Metabolcenter
Thinking about what to do in 2021? 🤔
How about starting a
#bioscience
#PhD
in beautiful
#Copenhagen
? 👩🔬👨🔬🇩🇰
One week left to apply for
@cphbiosciphd
! 🤩
@Metabolcenter
@DTUBiosustain
@UCPH_DanStem
@NNFCPR
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Our study on 'Coordinated targeting of cold and nicotinic receptors for treatment of the metabolic syndrome' is now out
@NatureComms
@MatthiasTschop
@kleinert82
@koebenhavns_uni
@Metabolcenter
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1/3. Excited about GDF15's role in pregnancy?
Check out our new preprint just posted on
@biorxivpreprint
: "Cross-species comparison of pregnancy-induced GDF15."
We explore differences between humans, macaques, rats, and mice.
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Insightful summary of the discovery and development of the first generation of efficacious (and safe) drugs for treatment of obesity
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Research Highlight in
@NatRevDrugDisc
covering our recent paper on targeted NMDA receptor antagonism for obesity treatment
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Excited about the opportunity to share some of our work and recent ideas on body weight regulation and anti-obesity drugs with the
@MonashBDI
Early bird CET 🐦🌄
ON TOMORROW Don't miss our next Seminar!
𝗦𝗽𝗲𝗮𝗸𝗲𝗿: A/Prof
@ClemmensenC
𝗧𝗼𝗽𝗶𝗰: Emerging pathways: Body weight biology and weight loss pharmacotherapy
𝗪𝗵𝗲𝗻: Tue 5 Sep 4-5pm AEST
𝗛𝗼𝘀𝘁: Dr
@ClaireFoldi
Zoom details for BDI's Seminars:
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We have examined the relative importance of nicotinic receptor subunits alpha5 and beta4 in physiological and pharmacological regulation of energy and glucose homeostasis. Credit to
@AlberteBreum
for steering the project
@Metabolcenter
@UCPH_health
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5
35
The Novo Nordisk Foundation reached out for a discussion on our "Unsolved Mystery" piece in
@PLOSBiology
on the hormonal regulation of body weight.
@novonordiskfond
@Metabolcenter
@UCPH_health
Danish researchers have set out to investigate out how nature has shaped us to put weight on more easily than shedding the kilos again.
The researchers are from the Novo Nordisk Foundation Center for Basic Metabolic Research, Uni. of Copenhagen.
#research
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Scientific illustration team event! Stay tuned for some mind-blowing images coming out of the Clemmensen Lab 🔬
@Metabolcenter
@UCPH_health
@novonordiskfond
@lundbeckfonden
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Lipidation of incretin analogues has revolutionized their success in weight management. But how do these modifications impact their passage into the brain? New work from
@GubraBiotech
. Delighted to have played a small role.
@Metabolcenter
@HecksherS
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NEW ISSUE: On the cover, Deshmukh et al. describe the human white and brown fat secretome and identify EPDR1 as a novel batokine involved in brown fat differentiation.
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New preprint in which we evaluate changes in energy intake, E-expenditure and E-excretion in mice exposed to controlled overfeeding. Technically challenging to combine the intragastric infusion with the metabolic chambers, but masterly achieved by
@pranea
and
@CamillaLund92
Check out our last study
@ClemmensenC
lab
@Metabolcenter
now on
@biorxivpreprint
. We studied the changes in energy balance upon intragastric overfeeding (150% - 7 days), including voluntary food intake, energy expenditure and fecal energy excretion
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Proud to have played a small role in writing this comprehensive review on animal models of
#obesity
and
#diabetes
@NatureRevEndo
@kleinert82
@Prof_M_Ristow
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11
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Our article builds upon important work made by Drs Ruth Harris, Leibel, Ravussin, Bouchard, Levitsky, Ethan Sims,
@sorahill
and many others. We hope to encourage our colleagues to join the pursuit of Unidentified Factors of Overfeeding.
@Metabolcenter
@CamillaLund92
@jens_lund
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4
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Interested in the mechanisms that regulate body weight? See informative thread by
@pranea
on our recent review on experimental overfeeding in animals published in
@MolMetab
Super fascinating experimental intervention - surprisingly underutilized.
Here is the review
@jens_lund
@ClemmensenC
and I`ve written about experimental overfeeding in animals for the special issue
@MolMetab
"The Biological Regulation of Body Weight" Follow this thread to learn more! 🧵 1/n
#obesity
#bodyweight
#metabolism
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GLP-1/dexamethasone conjugate drug reverses (rodent) obesity by inhibiting food reward. Paper just out
@LeaDSpain
@Physettes
@MatthiasTschop
@helmholtz_diabc
@Metabolcenter
@UCPH_health
1
12
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Always enjoyable to discuss and communicate our research at the Democracy Festival of Denmark (
#folkemoedet
) - thanks to
@lundbeckfonden
for organizing a session on how we can optimize brain health
@UCPH_health
@Metabolcenter
Hjerne-wellness på
#Folkem
ødet!
Hvordan passer du bedst på din hjerne?
Kl. 15 har vi inviteret forsker i sundhed Christoffer Clemmensen (
@ClemmensenC
) og latterekspert Søren Dinitzen på scenen (J5). De vil booste din hjernesundhed på blot 60 min.
#FMDK22
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I enjoyed my podcast interview with
@ihmc_stemtalk
where we covered several topics including body weight biology, exercise science and emerging anti-obesity drugs
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Honored to be a part of the speaker lineup for this exciting meeting.
We will be accepting posters for presentation. Speakers /session chairs include
@sorahill
@bcorkey
@MichelleCardel
@danasma70194694
@ozannelab
@Farooqi_Lab
@ClemmensenC
@HermanPontzer
Please retweet.
@royalsociety
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Team has aged! Metabolism strikes again.
@Metabolcenter
@UCPH_health
@jens_lund
@CamillaLund92
@nicolefadahunsi
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Differences in human body weight is largely related to genetics. Lean people are protected from an obesogenic environment-not because of willpower, but because of 'lean' genes (
@Farooqi_Lab
). But what do these genes encode for? A "hungry brain"?
@whsource
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Muscle-proteomic analysis human muscle reveals fiber type-specific adaptations to exercise training. Congrats to
@atul_deshmukh1
and colleagues
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@BevTchangMD
The asymmetrical/unidirectional role of the leptin-melanocortin pathway aligns with the dual intervention point model proposed by
@JohnSpeakman4
and reflected upon by
@jens_lund
in this work:
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Very well-written summary of the current state- and future of weight loss pharmacotherapies.
For tackling global obesity (with pharmacology), however, we likely need an inexpensive and orally available solution.
The Future of Weight Loss
My latest article is about the science & history of Wegovy (semaglutide), the highly effective new weight loss drug-- and why it's only the beginning.
Based in part on interviews with leading researchers in academia & industry.
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Impressive and well-deserved farewell to our successful Dean yesterday. A lot of nice talks, including, from our own
@Thue_Schwartz
👍🏻Excited to pursue the next chapter with
@BenteStall
in the driver’s seat.
@Metabolcenter
@UCPH_health
Great Honor to pay tribute to superwoman Ulla Wewer incredible turbo-driven Dean transforming SUND to a top leading Medical Faculty: Building Super Centers (incl.
@Metabolcenter
), Mærsk Tower; fantastic recruitments; top-noth infrastructure; Fusions incl. GLOBE; etc.etc.etc. TAK!
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Thrilled to welcome these two talented MSc students to our Lab after the summer. Passion and innovative thinking to ignite new ideas and discoveries🧠🧠
@Chr_Merrild
and
@VBIJohansen
@UCPH_health
@Metabolcenter
How does a high-fat diet impair hepatic Ca2+ signalling?
@Chr_Merrild
and
@VBIJohansen
(
@UCPH_health
) show how in this article!
📜
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What a list of speakers, well done on the organisation
@nicwin98
Clearly a must-attend meeting if you have the slightest interest in glucagon
To highlight a few speakers (on Twitter):
@DanielJDrucker
@JCampbellLab
@Filip_Knop
@TimoMueller_IDO
@Kristine_Faerch
Join us 1-2Nov2022 in Copenhagen to celebrate the 100 years birthday for glucagon
Check out the program at
This will be so much fun!
#glucagonconference
#metabolism
#diabetes
@novonordiskfond
@Metabolcenter
@UCPH_health
@Stenodiabetes
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Looking forward to share some of our recent results and to discuss what the important future questions and challenges in the field are. Thanks for the invitation
@StenoAarhus
@StenoAarhusRes
📢
#StenoThursdays
🌍 in April
We're looking forward to this month's seminar by
@ClemmensenC
@Metabolcenter
on 'Body weight biology and obesity pharmacology'. Feel free to share the announcement (RT) & join the scientific discussion on Zoom. Register👉
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Todays Lab-Zoom meeting. Topic: How to stay on top of the scientific literature. Excellent presentation and list of recommendations from
@jens_lund
Following the omnipresent
@DanielJDrucker
twitter-account one of the central recommendations 👍
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Today we have the honor of hosting Prof. Michael Cowley for a presentation on "Melanocortin Agonists for the Treatment of Type 1 Diabetes". Feel free to join the seminar if you are in the (Copenhagen) area
@Metabolcenter
@NEXSKU
@BiomedUCPH
@UCPH_health
0
2
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New insights into the molecular biology of mechanical sensing in skeletal muscle by
@BekkerJensenLab
Happy to have contributed a small part.
@UCPH_health
@Metabolcenter
We are very excited to share our latest publication in
@embojournal
on how the ZAK beta kinase senses mechanical stress and activates
#MAPK
signalling.
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Fantastic recruitment to our Center 🙂
@Metabolcenter
@koebenhavns_uni
We are proud to announce that Professor Ruth Loos is joining CBMR! 🎉
The move sees her establish a group and take on the role of Vice Executive Director, financed by a 7-year DKK50 million Laureate Research Grant from
@novonordiskfond
.
Read more👇
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Postdoc position available in Copenhagen. Neurobiology of motor control and energy homeostasis
@UCPH_health
. Excellent research environment & attractive employment conditions. Collaboration with Prof. Ole Kiehn.
Please Retweet
@Metabolcenter
2
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Congratulations to
@BekkerJensenLab
on their exceptional work unraveling the molecular mechanisms tied to ROS in obesity and aging. It's been a pleasure to contribute
@Metabolcenter
🔥Hot from the press: Our new publication in
@ScienceMagazine
about
#oxidative
#stress
and how it mediates
#metabolic
decline via the
#ribotoxic
stress response kinase
#ZAK
α!
#MAPK
#metabolism
#translation
#NASH
#aging
#obesity
@UCPH_Research
@UCPH_health
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Had a nice chat with
@JaisBKoch
and
@Hamderab
for the podcast “Brainstorm”, on the biology of weight regulation (in danish 🇩🇰).
@Metabolcenter
@koebenhavns_uni
70 procent af din vægt kan forklares ud fra din genetik, og blandt andet derfor er det altså ikke helt let at slippe af med dellerne.
Lyt med i det nyeste afsnit af Brainstorm 🧠
#dkvid
#dkpodcast
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Apply 👇🏻👇🏻 10 fully funded 3-year postdoc projects in metabolism research
@Metabolcenter
Ten International Postdoctoral Fellowships in Metabolism - Novo Nordisk Foundation Center for Basic Metabolic Research
@Metabolcenter
@UCPH_health
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Exciting research powered by the Labs of
@kleinert82
and
@AndreasMFritzen
We reveal an unexpectedly robust induction of plasma GDF15 in response to a dietary intervention (medium chain fatty acids). Don't miss out on the thread shared by Max 👇
@Metabolcenter
Our new! paper examines how dietary medium-chain fatty acids (MCFAs) reduce food intake
🔑points -> MCFAs:
↗️Gdf15 in liver & intestine
↗️circulating GDF15
↘️food intake via GDF15-GFRAL
Let's delve into how these unique lipids reduce food intake.🧵1/9
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One of the postdoc positions advertised by
@kattesch
revolves around a super exciting and close collaboration with our lab at the
@Metabolcenter
-> glycomics & body weight biology. APPLY!
We are hiring! Come join the greatest
#Glycotime
labs
@cphglyco
@UCPH_health
Schjoldager lab and Miller lab have in total 4 post doc positions available. More specifics here
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Overfeeding shows some easily gain weight while others resist weight gain. This difference might relate to inherited 'defects' that once protected our ancestors from excess adiposity, according to
@JohnSpeakman4
's 'drifty gene hypothesis'
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Clemmensen Lab Retreat: Group service check - flourishing in science and in life!
0
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Most scientists (in Denmark) prefer small and mid-sized research grants Congrats on getting this important message out to a broader audience
@h_dimke
@mtnorn
@DetUngeAkademi
0
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Just out: our review in
@NatureRevEndo
on the current landscape of combinatorial drug candidates for obesity and T2D
@MatthiasTschop
@helmholtz_diabc
@UCPH_health
@Metabolcenter
New content online! Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases
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Great work led by
@Carmelo_Quarta
and
@lab_cota
on a novel combinatorial treatment approach for obesity. Delighted that our Lab was able to contribute a small part
@S__Falk
@Metabolcenter
Very excited to share this work showing that CB1 and GLP-1 receptors can be co-modulated pharmacologically to ameliorate obesity. Congrats to Philippe Zizzari,
@lab_cota
, and all collaborators!
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Low levels of leptin powerfully stimulates hunger. It is less clear whether high leptin levels also protect against weight gain. These points have been discussed in perspectives by
@jflier
&
@Maratosflier
and Leibel & Ferrante and
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Exciting discovery on the central mechanisms of FGF21. Congrats
@MatthewGillum6
and team
@Metabolcenter
@koebenhavns_uni
FGF21 Signals to Glutamatergic Neurons in the Ventromedial Hypothalamus to Suppress Carbohydrate Intake
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5/8 Standing on the shoulders of antibody-drug conjugates and ´Masters of Metabolic Drug Targeting´
@MatthiasTschop
and Richard DiMarchi (and
@Fintasti
and
@TimoMueller_IDO
), we developed the first-in-class peptide-NMDA receptor antagonist conjugates
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“... 62 loci of which the same allele is significantly associated with both higher adiposity and lower cardiometabolic risk.” Interesting work. Congrats Ruth Loos,
@tuomaskilpela
and colleagues.
@Metabolcenter
@koebenhavns_uni
Discovery of genetic loci that uncouple excess adiposity from its comorbidities out in
#NatMetabolism
Thanks to
@LamOpalHuang
, Ruth Loos and the team for this excellent collaboration
@Metabolcenter
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Our work on the potential use of psychedelics for modulating the defended level of adiposity, weight homeostasis and eating behavior featured by
@PsyPost
Scientists have started to examine whether “magic” mushrooms can help in the fight against obesity
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Hvis der er en genuin (bred) politisk interesse for at forstår og drøfte vægt/fedmeforskning så stiller jeg gerne op med en oversigt over emnet. Måske ekstra relevant i lyset af den spændende udvikling vi ser på det medicinske område
@olebirkolesen
@LiberalAlliance
Det er frustrerende, hvor meget “de får mange børn, hvor der er mange storke, ergo kommer storkene med børnene”-forskning og -journalistik, vi bliver fodret med.
Senest får vi at vide, at børns overvægt kun i ringe grad er knyttet til motion og fødeindtag hos børnene, men i
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Stor ære og en unik mulighed for at bidrage til at styrke dansk forskning.
Stort tillykke til Lundbeckfonden Fellow
@ClemmensenC
, der netop er blevet optaget i Det Unge Akademi – en del af Det Kongelige Danske Videnskabernes Selskab! Se alle de nye medlemmer her:
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Excited to see our work on RYGB and GDF15 out.
NEW: Bariatric surgery and growth differentiation factor 15 by researchers
@ClemmensenC
@kleinert82
@proferikrichter
@Metabolcenter
@UCPH_health
Click here for details:
#bariatricsurgery
#GDF15
#obesity
#diabetes
#energyhomeostasis
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7/8 We continue to expand on this concept at
@Metabolcenter
and envision that targeted modulation of neuroplasticity holds promise for treating brain disorders beyond obesity. Together with
@BueKlein
, we have also formed a biotech, Ousia Pharma, to pursue this work commercially.
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Excited to deliver an overview of our activities, as well as to connect with students and colleagues from
@CamMetaboNet
Even a upcoming
#Brexit
will not prevent the
@DDA_Denmark
for organizing world class educational events in collaboration with UK research institutions. PhD students and early stage postdoctoral researchers can apply for participation.
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Gut-brain cross-talk in metabolic control! From physiology to pharmacology. Free access
@CellCellPress
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What a way to set the bar sky-high!
Selected combined publication highlights:
And both have A LOT more interesting stuff in the making!
@Metabolcenter
FIRST THESIS DEFENCES FROM DDA-FUNDED PHD STUDENTS
Both
@jens_lund
and
@metteludwig
will defend their PhD thesis this Friday at
@koebenhavns_uni
. They are the first two PhD defences from DDA grant recipients.
👉 Read more here:
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Nice little video featuring super talented PhD student
@nicolefadahunsi
sharing her experience doing a PhD at
@Metabolcenter
👩🏾🔬“I was quite amazed when I arrived at CBMR!"
PhD student
@nicolefadahunsi
joined CBMR through the
@cphbiosciphd
program in 2018. Watch the video below to learn more about what it's like to be a
#PhD
student at CBMR! 👇
#findaphd
#phdposition
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Targeting specific nicotinic receptor subtypes to treat diabetes. Fruitful collaboration
@HelmholtzMunich
@helmholtz_diabc
@Metabolcenter
@UCPH_health
Our latest paper on the potent
#insulin
sensitizing effects of α3β4
#nicotinic
receptor activation: great
@IDO_Helmholtz
@NEXSKU
collab.
@AndreasMaechel
@proferikrichter
@ClemmensenC
@StephanJSachs
@TimoMll13033856
@DiabetologiaJnl
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2/8 Fascinated by the genetic data pointing to a role for glutamatergic neuroplasticity in body weight homeostasis, we started contemplating targeting this neurotransmitter system for weight loss. PMID: 25673413
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Looking forward to reconnecting with Nick Jikomes (
@trikomes
) on the Mind and Matter podcast to expand on our previous discussion about psychedelics and targeting neuroplasticity for sustained weight loss.
Talking with
@ClemmensenC
this week on the podcast about novel drugs for obesity & metabolic disorders. We will discuss the very popular GLP-1 agonists like Ozempic, as well a novel drug which combines GLP-1 agonism with NMDA receptor antagonism (GLP-1-MK-801; see pic).
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3/8 This was further spurred by the excitement for NMDA receptor antagonism for treatment resistant depression (and Alzheimers Disease). Envision if we could harvest similar benefits for appetite reduction and weight loss? PMID: 37340091
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Check out our latest paper: Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans
@JCI_insight
@Metabolcenter
@UCPH_health
@thomas_morville
#exercise
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This aligns with
@JohnSpeakman4
's dual intervention point model of body weight homeostasis and we argue that breaching the upper body weight "boundary" leads to secretion of a hormonal factor that drives weight back to baseline.
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Just out: An updated overview of challenges and opportunities related to engineering polyagonist treatments for obesity and T2D. Collaborative writing process headed by super PhD student
@OdgaardJonas
@Metabolcenter
@UCPH_health
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That is a lot of metabolic phenotyping! Valuable resource for our field
@Metabolcenter
We have a new preprint out describing factors the contribute to metabolic rate in mice, based on
@NationalMMPC
and
@impc
datasets on more than 30,000 mice.
"A big-data approach to understanding metabolic rate and response to obesity in laboratory mice"
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😅😅
Postdoc: "Sir, I've almost completed the submission but the system requires a graphical abstract"
Professor: "Goddammit! Fine, let's give 'em an abstract! Draw a dude surfing on a statin-board on a COVID-wave and non-users drowning!"
"Sir, I don't thi-"
"SUURRFEEEERR!!"
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Credit to GDF15 team and collaborators, some of which are on Twitter:
@kleinert82
@BueKlein
@NicolaisenSand
@JohannKornelia
@AndreasMaechel
@MathiesenVad
@gil_claudia8
@seeleyrj
@J_Salling_Quist
@Kristine_Faerch
@jens_lund
@Metabolcenter
@UCPH_health
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