CardioNerds Journal Club
@CardioNerdsJC
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A monthly #Cardiology journal club that meets on Twitter produced by @CardioNerds ‼️ Use #CardsJC & join the conversation!
Joined January 2021
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To date, there have been many studies in HFpEF utilizing novel meds, but very few that exhibited significant benefit in this patient population.
Would anything change this troubling streak?
#CardsJC
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Hey there! ♥️🤓
@CardioNerds
everywhere, the October
@CardioNerdsJC
is starting in 30 minutes!
Let's discuss the EMPEROR - Preserved trial. Do SGLT2 Inhibitors improve outcomes in HFpEF?
#CardsJC
#HouseJones
0
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Although HFpEF and HFrEF have similarly poor outcomes, HFpEF trials have consistently failed to show a reduction in morbidity and mortality.
Here’s a quick overview of the major HFpEF 📜trials by
@CardioNerds
Academy Fellow
@OAmidiMD
#HouseEinthoven
#CardsJC
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89
Check out this table summary of relevant Omega-3 RCTs! Has your practice changed based on these trials?
#CardsJC
5
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64
The patient is rushed to the cath lab. You get access and quickly engage the coronaries to see what you are dealing with.
#CardsJC
❓What do you see in the angiogram? What is the culprit vessel? What do you think about the complexity of the lesions seen?
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9
61
Contrast this with HFrEF, for which numerous life-prolonging ⌛️ strategies are available. Check out an overview of these treatments for HFrEF by
@CardioNerds
fellow
@TDonisan
#HouseTaussig
#CardsJC
2
19
62
Join us for the first
@CardioNerds
journal club of ✨2023✨ we'll be discussing ECMO-CS trial!
⏰ Tonight at 8 pm EST
📍
@CardioNerdsJC
#CardsJC
Check out our article summary and visual abstract ⬇️⬇️
0
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2
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Rate vs rhythm control is an old controversy – initial trials found no differences in either strategy w/ regards to MACE, but newer studies reveal benefits for rhythm control.
#CardsJC
❓Any other rate/rhythm control trials that you've based your practice on?
7
14
55
The
@CardioNerds
are back again with a new
#CardsJC
Journal Club!! 🤩🎉
Join us on twitter Thursday🗓️, 7/27/23, 8:00 PM EST🕗in our🔥discussion on the
#ELAN
trial🫀
Get the inside scoop from our experts to help you decide when to start AC💊in your patients with stroke🧠and AF🫀
0
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⛱️
@CardioNerds
is kicking off the 🌞season with a new
#CardsJC
Journal Club. Join us on Twitter this Thursday, 6/29 at 8pm EST. Several experts will join us for a 🔥discussion on the
#RapidHF
trial: this one has something for everyone- from
#HFpEF
to
#EP
! See you there! 🫀🌞🌊
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29
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✏️LoDoCo trial (2013): Colchicine dec. risk of CV events in stable CAD (open label)
✏️CANTOS trial (2017): Canakimumab (IL-1β inhibitor): CV events lower compared to placebo
✏️COLCOT trial (2019): Colchicine improved CV outcomes in pt w/ recent MI
#CardsJC
0
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Didn’t have a chance to read CANARY? 🦜
We’ve got you covered!
Check out this awesome visual abstract created by
@DocBrilliant
and reviewed by our chief
@TDonisan
and
#CardsJC
director
@DeveshRaiMD
.
The full-text article can be found here ➡️
3
27
54
Check out the EARLY-AF and STOP-AF article summaries by
@dinubalaescu
and
@Gurleen_Kaur96
( to
@DrRachitaEP
&
@AjayPMD
for peer review). Don’t miss the iconic visual abstract created by
@OAmidiMD
#CardsJC
2
14
53
Before we get too wrapped up in the
#CardsJC
, please help us give a warm welcome to
@DeveshRaiMD
, who is the new director of the Journal Club for
@CardioNerds
2
9
53
Your clinic patient has chronic, stable coronary artery disease. You've maximized their anti-platelets 🩸, statin 🧡,beta-blocker 💊, but you'd like to reduce their cardiovascular risk further. What can you do?
#CardsJC
21
4
51
Hello! ♥️🤓
@CardioNerds
is bringing you an AMAZING
@CardioNerdsJC
in 30 minutes! Let's discuss the ISAR-REACT 5 trial. Ticagrelor vs Prasugrel in ACS??
#CardsJC
#HouseTaussig
0
13
48
It is 2 am. In the midst of your sleep, the pager beeps.
😴📟 – “ED page – STEMI”
You are sent the EKG. How would you like to proceed?
#CardsJC
- Call & get the hx, vitals, & pt’s current status
- Admit to CCU for monitoring/med mgmt
- Go back to sleep, likely false activation
14
12
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Didn’t have a chance to read ECMO-CS?
Check out our visual abstract and article summary!
#CardsJC
0
15
44
🚨Attention all
@CardioNerds
!!
Join
#HouseTaussig
🫀and a panel of phenomenal experts tomorrow at 8:00 PM EST to discuss the revolutionary results of
#SELECT
🔥
An absolute gamechanger!🤩
Can't wait to see you then! 🕗
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Join us tomorrow
@CardioNerdsJC
to discuss TRILUMINATE Trial with an incredible panel of experts
📅April 27, 8 PM EST🕗 on Twitter only
#CardsJC
@tavrkapadia
@hahn_rt
@DrHurshNaik
@AndreaScotti21
@Almanfi_Cardio
@SachinGoelMD
@SergeHarbMD
@whisenant_brian
0
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💪Check out the STRENGTH article summary and a lovely visual abstract created by
@DCLuCal
#CardsJC
🎓Shoutout to
#HouseTaussig
for the incredible work on today’s journal club!
@CarineHamo
@RichardAFerraro
@EuniceDuganMD
@madhattans
@PatrickZakka
@TDonisan
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The benefits of complete revascularization after a STEMI has been an ongoing topic of trials, with most showing benefits to revascularization in the absence of cardiogenic shock, either w/ FFR or angiographic guidance
#CardsJC
Any other trial worth highlighting?
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12
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To get situated: check out this powerful 👊🏼visual abstract crafted by our one and only
@IsaMathiasMD
The full text article can be found at NEJM: 📰
#CardsJC
0
15
40
We are fellows
@RawanAAmir
@BhavyaVarma12
@The_Doc_Martin
@KateAltaWilcox
@Shivanireddy_1
, and chief
@A_H_Ghoneem
for
#HouseTaussig
. We'll be your hosts; we have no COI. Again, remember to use
#CardsJC
in your tweets!
2
18
40
A BIG THANKS to our
@Cardionerds
Ambassadors
@mapabonp
(
@BrighamFellows
) &
@kellyarps
(
@DukeCardFellows
) for all their help with this
#CardsJC
!
2
10
39
What a phenomenal Clubhouse talk moderated by
@EvelynSongMD
and driven by guest faculty and FIT.
@CardioNerds
#HouseEinthoven
thank you for not only preserving the discussion, but turning it into high output! Looking forward to our next
@CardioNerdsJC
#CardsJC
discussion!
1
6
38
Enter: SGLT2 inhibitors.
The data has been robust, including for patients with heart failure! But what about HFpEF?
EMPEROR-PRESERVED answered this by evaluating the SGLT2i empagliflozin 10mg daily vs placebo in patients with EF>40%
#CardsJC
1
7
39
Didn’t have a chance to get to CLEAR? No problem!
Check out our visual abstract and article summary! Remember to include
#CardsJC
in your tweets!
3
12
36
But first: check out this amazing visual abstract created by
@AshishCorrea
with review by
@dranulala
.
The full text article can be found at The Lancet: 📰
.
Here is our article summary!
#CardsJC
0
19
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Hey there! ♥️🤓
@CardioNerds
everywhere, the December
@CardioNerdsJC
is starting in 30 minutes! Let's discuss the Salt Substitution trial. Does salt substitution safely improve cardiovascular outcomes?
#CardsJC
#HouseThomas
#CardsJC
#SSaSS
0
10
39
Didn’t have a chance to read ADVOR? We got you covered. Check out the amazing visual abstract created by
@Gurleen_Kaur96
, with review by chief
@jholtzman3
& director
@DevesRaiMD
. The full text article can be found here:
#CardsJC
1
22
37
And now to discuss our article
#CardsJC
COMPLETE: A multinational, randomized, parallel, comparative effectiveness trial.
Staged non-culprit PCI post STEMI + 💊
Vs
No revascularization of non-culprits + 💊
4041 patients with median follow up of 3 years
0
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37
Check out the amazing visual abstract created by
@anjaliagarwalla
, with review by chief
@jholtzman3
& director
@DevesRaiMD
. The full text article can be found here:
#CardsJC
1
19
37
Join in, ask & answer Qs, learn from our amazing content experts 👇🏾and
@CardioNerds
Faculty, FITs & Family ❤
#CardsJC
@dranulala
@RyanTedfordMD
@noshreza
@FloridoRoberta
@DukeHFDoc
@Ron_Witteles
@RBPatelMD
@robmentz
@MarkDrazner
@DrNasrien
@DrMarthaGulati
@ChonyAlbertMD
1
9
38
Great infographic by
@JuliettePower44PAH
on PAH therapies w/ proven clinical benefits
What is your practice regarding PAH treatment?
PH podcasts
#CardsJC
2
22
37
Our brilliant friends over at
@NephJC
created this fantastic visual abstract for their recent discussion, as well!
#SSaSS
#NephJC
@nefron1310
@kidney_boy
@Nephro_Sparks
0
13
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Here’s an overview of trials associated with ablation and AF:
0
6
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Decreases in dietary Na+ and increases in dietary K+ have both been associated with reduced SBP and DBP, as well as improved CVD outcomes.
#CardsJC
#SSaSS
@DrNeilStone
@VietHeartPA
@AnastasiaSMihai
@cingolani_oscar
@SethShayMartin
@seamuswhelton
@BrunoLimaMDPhD
@AlizaHussainMD
3
12
34
Didn’t get a chance to read the ARTESIA trial? No worries!
Check out our visual abstract and article summary! Remember to include
#CardsJC
in your tweets.
1
14
35
Thank you so much to the wonderful team of
@CardioNerds
#HouseThomas
for this amazing night of
#CardsJC
discussing ECMO-CS! ♥️🔝🙌🏼
2
8
33
A BTS pic of the
@CardioNerds
team behind the
#CardsJC
tonight! Everyone involved had a BLAST!
Thank you to all our faculty members,
#FITs
and audience who enriched our discussion!
1
6
33
If you didn’t get a chance to read the original PARAGON-HF Trial article, please check out our 🎨visual abstract and 📜article summary!
#CardsJC
1
11
33
Hello! ♥️🤓
@CardioNerds
is bringing you an AMAZING
@CardioNerdsJC
in 30 minutes! We will be discussing the CHAP trial. To treat or not treat mild chronic HTN during pregnancy?
#CardsJC
#HouseTaussig
0
13
32
Terrific time discussing the FAME 3 trial with the
@cardionerds
and
@CardioNerdsJC
backstage! Thank you everyone for tuning in, and look forward to seeing you at the next
#CardsJC
!
1
4
31
Didn’t get a chance to read REVIVED-BCIS2? Check out the visual abstract and article summary!
#CardsJC
0
15
32
If you didn’t get a chance to read the original trial article, please check out our visual abstract and article summary!
#CardsJC
0
7
30
Sotatercept (new drug class) w/ distinct mechanism than current therapies. It’s a fusion protein of activin receptor type IIa that traps TGF-B superfamily members rebalancing PA homeostasis
#CardsJC
1
7
30
Thank you for being an incredible audience and for being
#CardioNerds
!
@TDonisan
and
@PatrickZakka
signing off for
#CardsJC
.
See you next time!
3
4
30
Didn’t get a chance to read the STELLAR trial? No worries!
Check out our visual abstract and article summary! Remember to include
#CardsJC
in your tweets.
1
14
30
Twitter Journal Club Archive for SOLOIST-WHT trial is out thanks to
@PatrickZakka
- if you missed the event- check out the highlights & key takeaways!
2
8
29
Join us tomorrow for
#CardsJC
for TRILUMINATE Trial discussion at 8 PM EST on Twitter only!!
Review the incredible infographic by
@KarlaAsturias
and
@hanchateshivani
and amazing
#CardsJC
planned by House Thomas and House Einthoven of
@cardionerds
Academy
#CardioTwitter
1
17
29
To date, RCTs evaluating different PAH therapies have shown a variable degree of relevant clinical outcomes improvement. The best PAH treatment regimen remains debatable.
#CardsJC
0
11
29
Another great
#CardsJC
night with
#HouseTaussig
&
@Cardionerds
. Hope you had as much fun as we did. Thank you, everyone!
0
11
29
Let’s set the stage! This terrific visual abstract by the talented
@jholtzman3
provides a great overview of the FAME 3 Trial.
The full text article can be found at NEJM: 📰
#CardsJC
#FAME3
0
14
28
If you didn’t get a chance to read the original EMPEROR - Preserved trial, please check out our visual abstract and article summary!
#CardsJC
2
4
28
Here we go with question 1!
EXPLORER-HCM and VALOR-HCM are the first trials exploring
#Mavacamten
as a treatment of obstructive HCM.
What are the most notable differences between EXPLORER-HCM and VALOR-HCM?
#CardsJC
@DesaiMilindY
@SrihariNaiduMD
@gcfmd
@iamritu
5
13
28
PARADIGM-HF found a significantly decreased risk of ☠️ death in HFrEF patients treated with sacubitril-valsartan vs enalapril.
#CardsJC
1
5
28
Get ready for
@CardioNerds
to discuss STRONG-HF! 💪
@CardioNerdsJC
right here in 30 minutes!
Is rapid up-titration of GDMT before and shortly after discharge from an acute heart failure admission effective and safe?
#CardsJC
#HouseEinthoven
1
7
27
Check out the EAST-AFNET4 article summary by
@PatrickZakka
and the ⚡charged⚡ visual abstract created by
@madhattans
#CardsJC
#EPeeps
@CardioNerds
3
10
26
Thank you to our AMAZING 🫀🤓
@CardioNerds
team and academy fellows, and shout out to
#HouseTaussig
!!
@PatrickZakka
@TDonisan
@madhattans
@LMCalderonMD
@EuniceDuganMD
@RichardAFerraro
@CarineHamo
#CardsJC
0
8
26
Let’s get started with RAPID-HF!
Chronotropic incompetence is common in pts w/ HFpEF & a potential driver of exercise intolerance.
Rate-adaptive pacing is a IIa, expert consensus recommendation for symptom management.
#CardsJC
3
8
26
Join in, ask & answer Qs, learn from 👇 amazing content experts and
@CardioNerds
!
#CardsJC
❤Faculty:
@DLBHATTMD
@Drroxmehran
@SVRaoMD
@RaniKHasan
@seyi_dr
@Pooh_Velagapudi
@AnkurKalraMD
@claireraph
@mirvatalasnag
@Jared_OLeary
@GrantReedMD
@smuktas
@AliNsairMD
@yourheartdoc1
1
15
26
Happening tonight!!!
Are you ready for the next
#CardsJC
⁉️
Join the
@CardioNerds
Journal Club to discuss:
💊🫀PARAGON-HF
🌟Tue, May 11th:
🕗8pm EST on Twitter
🕘9pm on Clubhouse:
In collaboration w/
@HFSA
🤝
Follow
@CardioNerdsJC
& tag "
#CardsJC
" ❤️🤓
5
39
122
0
13
26
Greetings! ♥️🤓
@CardioNerds
everywhere, the January
@CardioNerdsJC
is starting in 30 minutes! Let's discuss the FAME 3 Trial. Is FFR-guided PCI noninferior to CABG for revascularization of patients w/3v-CAD?
#CardsJC
#HouseThomas
#FAME3
1
8
25
If you didn’t get a chance to read the original SURMOUNT trial, please check out our visual abstract and article summary!
#CardsJC
0
11
25
We are
#HouseJones
,with Academy interns
@ApurvaChalla
@cardioatheart
Fellows Drs.
@CaliRClark
,
@Hamza_Patel123
,
@goodmra1
,
@ApurvaChalla
,
@CFAndersenMD
, led by chief
@DrAlaaDiab
.
No COIs.
#CardsJC
1
11
23
Thanks to
@ASPCardio
for this collaboration and to
@DrMarthaGulati
for mentorship in making our first
@cardionerds
#CardsJC
a reality!
1
3
25
Before we begin – here is the visual abstract by
@The_Doc_Martin
to get you up to speed!
Link to
@Cardionerds
summary:
The full text article can be found at NEJM: 📰
#CardsJC
0
10
25
Don’t have time to read the full NEJM article? Don’t fret! Check out this rad visual abstract by
@CardioNerds
fellow extraordinaire
@BrainmanM
#CardsJC
1
8
25
Get ready
@CardioNerds
to discuss REVIVED-BCIS2!
@CardioNerdsJC
starting in 30 minutes! ♥️ Does percutaneous revascularization for ischemic left ventricular dysfunction improve mortality and HF?
#CardsJC
#HouseEinthoven
0
8
24
Join us tonight at 8 PM to learn and discuss ELAN trial with a great team of experts and House Taussig!!
#CardsJC
@DrMarthaGulati
@JonChrispinMD
@MoussaMansour10
@mmkansal
@hafizakmd
@NehalMehtaMD
@DrJMarine
@VietHeartPA
@KTamirisaMD
@a_l_bailey
@UsmanA_24
2
13
24
It's almost⏲️for this months
#CardsJC
!
Come hang out with us to discuss one of the🔥trials of the year,
#ULTIMATEDAPT
with this stellar group of nerds!
When🕗: Tomorrow 5/9, 8PM EST.
We can't wait to see you there!!
#CardsJC
0
12
24
🔥Join us tonight for
#CardsJC
to discuss the
#STEPHFPEF
trial with an incredible team of experts at 8 PM EST 🕗
Planned by
#HouseThomas
@ryantedfordmd
@DrMarthaGulati
@gcfmd
@RBPatelMD
@WilsonTangMD
@VietHeartPA
@AshishCorrea
1
9
24
Didn’t have a chance to read STRONG-HF? We got you covered.
Check out the amazing visual abstract created by
@TySweeney6
, with review by chief
@jholtzman3
&
#CardsJC
director
@DevesRaiMD
.
The full text article can be found here:
0
15
24
Let’s get started! Loop diuretics remain a mainstay of decongestion in acute decompensated heart failure. When do you find yourself reaching for sequential diuretic therapy (e.g. adding on acetazolamide)?
#CardsJC
6
3
22
You just diagnosed your patient with HFpEF. What is your go-to initial treatment and why?
#CardsJC
MRA
137
ACEI/ARB
164
Diuretic
214
Other (reply!)
30
9
9
21
Behind the scenes with the creator's of tonight's
#CardsJC
!
@Ronaldo_CFF
@Gurleen_Kaur96
@kamal_mz
@ShivaniReddy_1
@joyfuldockemi
@paulmontanamd
3
6
22
Thank you for being an incredible audience and for being
#CardioNerds
! Najah Khan
@najahakhan
and Ahmed Ghoneem
@a_h_ghoneem
, signing off for
#CardsJC
. See you next time!
0
3
23
You just diagnosed your patient with new-onset AF. What is your go-to initial treatment and why?
#CardsJC
Rate Control
223
Rhythm Control
287
Cardioversion
198
Other?
47
14
8
23
We are
#HouseThomas
, with Academy Fellows
@KarlaAsturias
,
@SaahilAJ
,
@SukritiBanthiya
,
@DocBrilliant
, and chief
@TDonisan
.
And
#HouseEinthoven
with
@joyfuldockemi
,
@HanchateShivani
,
@Ronaldo_CFF
,
@Kamal_MZ
, and
@PaulMontanaMD
, and chief
@Gurleen_Kaur96
.
No COIs.
#CardsJC
0
8
23
If you want to learn more about AF in the setting of HF, don’t forget to check out our
@CardioNerds
podcast episode created in collaboration with
@rsloungani
@JonPicciniSr
@DukeCardFellows
#CardsJC
0
7
23
If you didn’t get a chance to read the original Salt Substitution trial, please check out our visual abstract and article summary!
#CardsJC
#SSaSS
🧂🧂
👀👀Visual abstract by
@HussainMKCards
📜📜Article summary by
@jholtzman3
1
10
22
Let's start with a question re: inclusion criteria.
Patients included in the trial were specifically NOT taking anti-anginals. Why was this important to establish? Does this impact generalizability?
#CardsJC
6
6
22
⚡ Early-rhythm control therapy ⚡ in patients with early AF was associated with ↘️ CV death, stroke, or hospitalization for HF or ACS than usual care (absolute difference in risk, 1.1 events per 100 person-years)
#CardsJC
1
3
22
✨ To get your juices flowing, take a look at this outstanding visual abstract crafted by star fellows
@KarlaAsturias
and
@HanchateShivani
Please click below to see the full-text article:
#CardsJC
0
7
21
❌ No difference between 💊rate and ⚡ rhythm control with regards to:
•Number of nights spent in the hospital (2nd primary outcome)
•Symptoms, quality of life, and LV function at 2 years
•Cognitive function.
❓ Is this result surprising to you?
#CardsJC
6
5
21
...Also, effects were noted to be statistically significant within one month of use in the acute population. NNT 4.
#CardsJC
1
5
21
We're👩🏼⚕️
@TDonisan
and👨🏻⚕️
@PatrickZakka
,
@CardioNerds
Academy Fellows,
#HouseTaussig
,
We'll be your hosts for this Journal Club, we have no COI.
We want to hear from all of you, so tag your tweets with
#CardsJC
. Introduce yourselves and declare any COI.
2
10
22
Let’s go to the results!
117 patients were randomized
➡️ Immediate VA-ECMO: 58
➡️ Early conservative therapy: 59
🚨 Cross-over from conservative therapy to VA-ECMO: 39% 🚨
#CardsJC
3
8
21