Irene Cantone
@CantoneIrene
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Scientist, leader & carer. Investigating Epigenetics of sex-dosage compensation in humans. Editor @scienceadvances Previous @HFSP @EMBO @MSCActions . Mamma.
Italy,UK,Switzerland,Germany
Joined February 2018
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Last Seen Profiles
A beautiful paper suggesting women develop a greater sense of smell upon birth to recognise their pups. Giving birth gives birth to neurons |
@ScienceMagazine
3
55
333
Today I received the rejection letter for
#ERC
starting grant. I still feel blessed to have reached interviews after 3 years career break. I can put the break behind my shoulders and move on. Thank to reviewers and committee for taking the time to score my application
4
0
155
A
#milestone
paper: the
#female
#sex
determination gene discovered! Three aminoacid change in
#WT1
shut down Sry and determine development of
#ovaries
.
@ScienceMagazine
2
25
130
We are looking for a
#postdoc
to join our group (up to 3yrs):
- Develop a project on the
#epigenetics
of
#sex_bias
in
#autoimmunity
using our favorite model system:
#XChromosomeInactivation
- Use genome-engineering, flow-cytometry, single-cell transcriptomics and more
Please RT
13
92
129
Dear
#Reviewer
2 of the Italian
#ERC
grant scheme: the fact that you can make
#blastoids
from
#human
pluripotent stent cells
#iPSC
#ESC
does not mean that these cells have a normal
#epigenome
. Do you know what
#imprinting
is? Do you know that it is lost in any
#naive
medium? 1/6
10
6
128
Are there regions permissive and not permessive to transcription in the nucleus?
@mitchguttman
shows
#transcription
occurrs within B compartment and proximal to
#nucleoli
1
14
111
Looking for a
#postdoc
in the sunny side of the Italian peninsula? Interested in
#chromatin
mediated
#epigenetic
mechanisms of
#sexbias
in autoimmunity? I have an opening to start immediate (or by August 2024). Have a look 👇🏻
2
73
105
We are recruiting a Pre/Post doctoral fellow in
#computational
biology to dive into
#SingleCell
#genomics
and the
#epigenetics
of
#autoimmunity
Start date : january 2024. Hurry up!
3
56
87
Another fantastic paper showing embryonic/extraembryonic lineage decisions are reversible at early stages. JAK /STAT and
#pluripotency
related
#TranscriptionFactors
safeguard an
#enhancer
landscape permissive for multi-lineage differentiation allowing 1/2
1
20
84
#Chromatin
#Epigenetic
#autoimmunity
#XChromosomeInactivation
people: anybody looking for a
#postdoc
to start in 2024???👇 or visit our website!
0
47
75
The
#CantoneLab
reset and reloaded made it to the first lab
#hike
: the “Path of Gods”! Blessed by the
#sun
one of the most breathtaking views on the
#sea
… with
#food
! And see who we found along the path 👇🏻1/3
3
2
71
Very happy to announce that I have been awarded a CDA from the Italian Foundation for
#MultipleSclerosis
to investigate the role of the
#X_chromosome
in disease
#SexBias
Stay tune for
#postdoc
#PhD
advertisements or DM
14
2
70
Transcription starts chromatin remodeling. RNA polII stabilizes BAF chromatin occupancy leading to nucleosome eviction and facilitating binding of TF for persistent chromatin remodeling
0
7
66
Visualising transposable accessible chromatin reveals a role for
#CTCF
in distancing active genomic regions. Wonderful work
@TjianDarzacq
@nature
0
20
63
Today we celebrate the award of a PRIN grant from the Italian Ministry of University and Research to investigate the role of
#Xchromosome
inactivation in
#FOXP3
expression and
#Treg
function in
#MultipleSclerosis
together with
#VeronicaDeRosa
@CNRsocial_
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0
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simultaneous
#single_cell
#HiC
and
#RNA_seq
shows that widespread chromatin rewiring occurs before transcription activation during lineage specification
@ScienceMagazine
0
16
53
In vitro reconstitution of
#epigenetic
#reprogramming
in the
#human
#germ
line mediated by BMP-mediated replication independent
#DNAdemethylation
. Loss of
#TET1
leads to extraembryonic differentiation and reactivation of
#bivalency
genes! Masterpiece! 👇🏻
0
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48
4
4
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My daughter has been taken away by my husband
@AntonioAbate83
who’s asking divorce. He is keeping her somewhere in Milan against Italian law. Police is looking for them. He sued me and despite being a
@HZBde
director he is asking me to pay him a wedge because he declares 🇮🇹 1/n
9
14
46
We are looking for a wet-lab postdoc to join us! Fancy epigenetics and autoimmunity? do you want to apply single cell genomics to a clinical context? APPLY
0
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Working from home day1... school closed...tomorrow working from garage ;)
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#Tet
-mediated DNA demethylation promotes cell fate specification and the DNA damage response
@ScienceMagazine
0
4
35
Sometimes you enter a room to lose a phone charger and get a brightful new web site! Enjoy is live :)
6
4
34
As
#PhD
schools are opening their applications soon, if you are interested in
#chromatin
mediated
#epigenetic
mechanisms underlying
#sexdifferences
and
#sexbias
in human
#immune
diseases send CVs and motivation letters.
1
11
30
PS2: the other 2 reviewers scored the application 22/25 and 25/25. You gave me 10/25… and even with that I missed the interview for a 0.3. Thank you very much!
3
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Evolution of sex determination unveiled
0
8
26
It was such an amazing meeting
#EMBOxChromosome23
! And I was very happy to stay with the person who initiated me to the FISH world:
#TatyanaNesterova
from
@BrockdorffLab
. Great get together!
0
0
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Beautiful review discussing the role of
#imprinted
genes expressed in the offspring influence the quality of maternal
#caregiving
👇🏻 what is the
#physiologicalrelevance
#epigenetic
?
0
7
23
With the heat wave and super sunny weather, here it comes our first lab picture
0
0
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#EMBOxChromosome23
#AndreaBallabio
@Tigem_Telethon
telling the story of how XIST was discovered in Naples thanks also to
#GraziellaPersico
1
5
22
#EMBLchromatin
starting soon. If you are interested in
#X__Chromosome
reactivation visit my poster and consider joining the lab. A postdoctoral position is available to study the role of the X in the
#sexbias
of
#MultipleSclerosis
1
12
21
#RNApolymerase
II depletion from the inactive X chromosome territory is not mediated by physical compartimentalization. Finally out! And on time for
#EMBOxChromosome23
.
@heard_lab
@TjianDarzacq
0
2
21
Recruiting please RT
@davidlandeira
@AkisPapantonis
@daph_cabi
@maudborensztein
@jwjach
@JBarau
@maxvcg
@Feli_Bas
@KellerValsecchi
@rafaelgalupa
@FrezzaLab
@celia4science
@gendrelann
@STOPlabPI
@CarmeloFerrai
@Ciavenasc
@hfj22
@CellReproLab
Looking for a
#postdoc
in the sunny side of the Italian peninsula? Interested in
#chromatin
mediated
#epigenetic
mechanisms of
#sexbias
in autoimmunity? I have an opening to start immediate (or by August 2024). Have a look 👇🏻
2
73
105
0
36
19
New work on the quest of
#naive
#epigenetic
#reprogramming
in human
#iPSC
reporting maintenance of
#imprinting
.
@Nature
@ry_lister
and Polo labs.
0
0
17
The
#CantoneLab
enjoying the traditional X chromosome boat trip! Today I will give a talk and the girls are presenting poster 2 - 56 - 72. Come and see our work!
#EMBOxChromosome23
0
0
19
I am also really sorry if from October 2019 until December 2021 I did not publish any paper (apparently required for a starting grant!) considering: 1. Italian university gave 2000 euro as start-up budget, 2. there was covid and 3. my first grant (written in 2019) started in 2021
1
0
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@OdedRechavi
And maybe it’s published on MDPI and meanwhile you’ve been scooped by someone else 😂! … and at the end :who cares except u? 😂😂😂This is so so much Fun!
0
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PS: if you work in any country where you can submit grant without a sponsorship or a contract from any institution let me know where you are... because i wrote plenty of stuff while in career break! It might be useful to other people like me. 6/6
1
0
18
To be or not to be... I think the anwer is the ???
certainly not in the dead people! regardless them being mathematicians or polivalent artists!
#PioneerFactor
hot in the press.
1
2
16
Another review from my favourite Polycomb lab
@DiCroceLab
#Polycomb
group proteins negatively regulate gene expression; their role in hematopoietic differentiation and blood diseases are reviewed here by Di Carlo, Mocavini, & Di Croce
0
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1
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Genome Biology 2017 and did the proofs of Nature Comm 2016 right when my water broke). Also if you want to know what happened from september 2016 until september 2019 I had 4 surgeries in 3 different countries (UK, Italy, Germany) medical documents were in the application 4/6
1
0
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#Leadership
lesson of the day: do not underestimate the power of telling people when they do something good.
0
0
16
Histone H3K36me2 and H3K36me3 form a chromatin platform essential for DNMT3A-dependent DNA methylation in mouse oocytes | Nature Communications
0
4
16
This is a big big WOW!!! Live
#imaging
of
#transcription
at a single gene.
A dream of our lab has been to image the full central dogma from a single endogenous gene, all live and with single molecule resolution. After many years we are happy to unveil a beautiful cell line that makes it possible. Check out our preprint ()! (1/n)
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357
1K
0
1
16
Scientists of Twitter! The world needs more reminders that we're living, breathing human beings.
Quote tweet this with a picture of you doing not-science.
Scientists of Twitter! The world needs more reminders that we're living, breathing human beings.
Quote tweet this with a picture of you doing not-science.
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0
0
16
Do you know that there is no random
#XchromosomeInactivation
in any naive human pluripotent cell culture? 2/6
1
0
15
Men lose Y chromosomes as they age. This leads to hearth fibrosis and earlier death
0
1
15
Decoding
#chromatin
states by
#proteomic
profiling of
#nucleosome
readers - I am very happy to see this rigorous and elegant work out. Congratulations Till!!!
@epigeneticsHMGU
0
0
15
My daughter just communicated me that the good part of my life is finished because after reproduction we have only to wait for death… that’s why I am stressed 😮 Give me a glass of wine please! Or maybe whiskey 🤣
2
0
15
What an incredible
#evodevo
paper! A microRNA controlling dosage compensation in birds that allowed males to survive … and much more to dig into 👇🏻
We are delighted to share our new preprint entitled “A male-essential microRNA is key for avian sex chromosome dosage compensation”
5
60
171
1
4
14
A bang! David Page comes back on the X …. What if all this dosage compensation was not compensated in humans?
The human inactive X chromosome modulates expression of the active X chromosome
Freely available top-read
@CellGenomics
paper
@AKSanRoman
@WhiteheadInst
1
28
125
1
1
15
Phase separation or not Transcription Factories are resumed! Great papers from Ibrahim
@Cisse_lab
@TjianDarzacq
@youngricka
0
3
14
Two great papers on
#pioneer
activity of
#transcription
factors in
#nucleosome
#remodelling
in a week! Congrats
@SchubelerLab
@CramerLab
0
1
14
You also might have missed that I was at
@MRC_LMS
until September 2016 (not 2015 - I do not know where you got this information!!!) sorry I gave birth on July 2016 so I was not physically there from June to September (4 months maternity leave in which I wrote the revision of 3/6
1
0
14
In the way for
#GRC
conference
#chromatin_structure_and_function
. Excited to see old friends and make new ones!
1
0
14
Written entirely during
#covid19
and inspired by
#SexBias
in
#COVID19
. Shout out for our very best co-first
#SaraCarmelaCredendino
and
@christophneum12
(now
@RockefellerUniv
).
1
5
14
Did I say we are looking for a
#postdoc
to work on
#chromatin
#XchromosomeInactivation
#SexDifference
in
#Immunity
and we do study
#autoimmunity
on real patient samples with a range of fancy techniques?
#molecularBiologist
do not be afraid!
Frittata di Pasta welcome day! … and the girls might be mature but still like pink so we got pink chairs 😅!
2
0
9
0
6
14
Can anybody explain me why
#barbie
#scientist
is such a freak with blue hair and… a microscope???
#WomenInSTEM
stereotypes
13
1
14
#Predoc
or
#Postdoc
around the world, do fancy to work on
#chromatin
biology in
#sex_differences
? We have a 1 year slot (to extend for a second year) for one person!!! DM email or send pigeons to join us in sunny Naples!
0
8
14
Revealing combinatorial control of X chromosome silencing by inter species cell fusion
0
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12
“Go where you are embraced, celebrated, valued and supported. Go where you don’t have to fight for people to see your brilliance. And, avoid spaces if they barely tolerate you, even if they’re familiar and beloved.”
#scientist
#academia
"Don’t let anyone talk you into believing you’re worth less than what you know you’re truly worth."
#ScienceMagArchives
7
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238
0
3
11
Correcting
#Downsyndrome
by targeting
#XIST
on human chromosome 21. Second brilliant paper from
#Lawrence
-lab
0
2
13
0
0
13
#InternationalWomensDay
This year I dedicate my pride to the
#Woman
who inspired my life: my grandma! She rebeled her family marrying a university student and worked all her life, raising alone 5 female daughters. She survived one and she is now surrounded by 5 bisgrandnephews 1/
2
0
12
Asymmetric histone inheritance via strand-specific incorporation and biased replication fork movement suggest a mechanism for asymmetric cell fates
0
1
13
1
0
13
#Transcription
factor binding at
#singlecell
resolution shows
#NANOG
binding requires SWI/SNF in embryos but not in culture. Time to reconsider our knowledge of
#pluripotency
from in vitro models!
Looking for TF biding at single cells?
Modified CUT&RUN for TF binding at low/single cells and single embryos.
Only a fraction of TF binding sites are occupied in single cells.
Unlike in culture, NANOG requires SWI/SNF complex in single blastocyst.
0
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83
0
6
12
We closed the lab door for 2023, did our
#SecretSanta
and went downtown
#Naples
for
#Xmas
lunch, walk and chatters… sadly we miss the two sick members but did our best to fit the xtra food 😁!
1
0
12
A collection about
#grant_writing
from my husband. I have never read any… would you suggest one of these?
1
1
12
@EDeLeonibus
@mur_gov_
That’s not my point (I got 90k from mur and 500k from other sources…in 3 yrs. of course not for fundamental research on human pluripotency). A reviewer that does not know the field does not go through the abs and probably takes 10 min to score the application is not appropriate.
2
0
12
An elegant paper from Nichols Lab suggesting how cell of the human placenta arise :
#Human
#trophectoderm
becomes multi-layered by internalization at the polar region: Developmental Cell
0
1
12
Great pleasure to meet with people
@PioneerCampus
. Thanks to my amazing collaborator
@celia4science
for helpful discussion about
#singlecell
#omics
and to
@fabian_theis
for some insights about computational analysis!
Great talk from
@CantoneIrene
sharing her research at
@PioneerCampus
@ICBmunich
@HelmholtzMucEn
on understanding human pluripotency by X
#chromosome
reactivation.
0
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6
1
3
12
0
1
12
@AdrianoAguzzi
I keep a special folder with papers that I found excellent in writing. And I like a lot the 1980s Nature papers when people had to really write down their hypotheses. Apart from that I try to read narrative in English (perhaps Steinbeck and Pope can do a better job than ChatGPT)
1
1
11
A zoom into
#trascription
measuring
#polymerase
#burst
size and frequency into
#single_cells
. Some
#TF
play on size some on frequency… such a pity they did not look at how
#chromatin
context can influence that! Worth a detailed read 👇🏻
0
0
12
#Epigenetic
predictors of
#lifespan
and
#inheritence
across
#mammals
. The end of
#DNAmethylation
#ageing
clock in favour of
#specie
#specific
signatures.
#sexdifference
= female live longer regardless caloric restrictions & more
2
1
12
Interested to know more about
#Xchromosome
#reactivation
? come to see my poster and flash talk.
#emblchromatin
3
0
12
#Postdoc
Just a quick reminder that
#MSCA
#fellowships
are open and
#deadline
is 11 Sept! Before u write me, please check your eleigibility status here. Mobility required! Publications required! Limit post PhD!!!
1
3
11
My girls are going mental... they asked me to buy
#personalized
lab
#pipettes
🤔. I suspect we need to add a Y chromosome
#computational
soon 👇
1
2
11
Materially-transmitted Histone H4 Lysine 16 Acetylation Instructs the developmental programme of the next generation. Beautiful work on intergenerational inheritance
@AsifaAkhtar1
@Iovino_Lab
1
3
11
What a honour to be in the list from the fantastic
@DiMiccoLab
! 10 (out of hundreds) Inspiring women in STEM: pick it up and keep moving
@KellerValsecchi
@CRougeulle
@BlewittMarnie
@VallotCeline
@ChiaraLanzuolo
@stojic_lovorka
@ozgendeniz_
@maudborensztein
@Fran_Cesari_
@apombo1
Thank you
@waskowlab
! Honored to be in the list! 10 (out of hundreds!) fantastic and inspiring women in STEM- Pick it up and keep it moving
@DrShrutiNaik
@karalmckinley
@morris_lab
@RacioppiClaudia
@lydfinley
@PinhoSandra
@stephxie
@Boletta_Lab
@maria_rescigno
@CantoneIrene
0
1
25
1
0
11
Thrilled to give my first department seminar
@unina
! If you like
#science
and want to understand
#human
#pluripotency
and
#epigenetic
#reprogramming
: come by! I will use my two
#X_chromosomes
to explain ;P
0
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