📢Thrilled! My 1st piece of work of my postdoc at
@Arlottalab
is out
@Nature
! This has been a huge co-lead effort with
@IreneFaravelli
👩🔬👩🔬🤩
Link:
Tweetorial 👇🧵
📢📢Today our 🧠 cortical Chimeroid model is out in
@biorxivpreprint
👀. Very excited to share the first piece of work from my postdoc in
@Arlottalab
. This has been a huge co-lead effort with
@Irene_Faravelli
. 👩🔬👩🔬🤩. See the “tweetorial” below 👇👇
🌟Huge congratulations to
@BolanosAnton
and
@Irene_Faravelli
for their prestigious recognition by
@broadinstitute
! Their exceptional work has earned them an award for outstanding contributions to science, embodying the mission and values of the Broad. We're beyond proud! 👏👏
Extremely honored to receive the prestigious Cajal Club Kreig Cortical Scholar award for my PhD contribution to the understanding of cerebral cortex development and the role of early thalamic input. Thank you
@GLB_Lab
,
@NeuroAlc
,
@ArlottaLab
and everyone involved in this journey!
Very happy to have received the poster award in
#ISSCR2023
! Thanks to my scientific partner in crime
@Irene_Faravelli
for the fantastic team work 🤜🤛 and
@ArlottaLab
for the support! 🧠🧫🔬
More than thrilled to see that
@BolanosAnton
and
@Irene_Faravelli
got the poster award at
#ISSCR2023
. Fantastic team effort 👩🔬👩🔬 developing multi-donor brain Chimeroids as a useful platform to better understand human inter-individual variability in disease🧫🧠🧬🔬.
Extremely happy to be one of the awardees of the
@EMBO
postdoctoral fellowship and honored to be part of the international
@EMBOfellows
community! Looking forward to bringing exciting science to the field in
@ArlottaLab
! Many thanks to everyone supporting me in this journey!
Amazing talk given by
@GiorgiaQuadrato
at
#2019SDB
. Organoid brain models are opening new avenues to understand developmental human diseases!! Very exciting!!
Extremely happy!! ✨✨Yesterday I had the pleasure to attend the award zoom ceremony of the Cajal Club surrounded by scientific rockstars!! Today, I received an amazing certificate with the coolest stamp that a Neuroscientist can dream of. Thank you Cajal Club! 🧠👩🔬🔬
🔝 La nostra
#STEMita
d’avui és la Noelia
@BolanosAnton
! Neurocientífica i postdoctoral fellow a l’
@ArlottaLab
de
@Harvard
: “He tingut la sort de tenir mentores que m’han ajudat i permès explorar. Treballar en les STEAM em sento feliç”. No et perdis el seu testimoni!
#STEMitas
@ArlottaLab
presenting the multi-donor “chimeroid” work at
@CSHL
human development at 3D modeling conference. Perhaps, a way to better understand genetic background susceptibilities to neurotoxic insults 🧠🧫👩🏼🔬.
#cshlbrain
@Irene_Faravelli
Check it out! Do you want to learn more about development of the human brain and reproducible cortical organoids? New pre-print from
@ArlottaLab
lead by
@uzquiano_a
and
@AKedaigle
.Proud to be part of such an amazing team!
Happy to share our lab’s latest pre-print! Led by
@uzquiano_a
&
@AKedaigle
, this single cell multiomic atlas of cortical brain organoid development has led us to exciting discoveries, and we hope it will enable many more in the future!
I am excited to be among the
#ISSCR2023
Poster Award Winners sharing our latest research at the ISSCR Digital Webinar on 28 August. Join me and the
@ISSCR
as we explore the role of stem cells in human health and disease.
@ArlottaLab
Registration is free. Hope you can make it!
Muy contenta de abrir la conferencia inaugural del máster de Neurociencias del Instituto Federico Olóriz. Orgullosa de recibir el premio jóvenes investigadores. Muchísimas Gracias
@GLB_Lab
@GuilleLBendito
@NeuroAlc
y todos los que lo habéis hecho posible!
Thank you so much to my partner in crime
@Irene_Faravelli
for moving forward the project together. To the organizers for the coolest mug 😎and for such a great conference about human development and 3D modeling 🧠🧫Very interactive and nice community!
@ArlottaLab
#cshlbrain
Congratulations to the winners of the poster session
#1
@CSHL
conference on brain development and 3D modeling who received a special prize highlighting consensus work of the field 👏👏👏
#cshlbrain
New paper from the lab 📢📢! Our single cell molecular atlas of human dorsal cortical organoids is out today in
@CellCellPress
! Congratulation to
@AKedaigle
and
@uzquiano_a
and all the authors! Amazing team work!🧠🧫
We are super proud to share that
@uzquiano_a
and
@AKedaigle
's paper is out in
@cellcellpress
today! We built a single cell molecular atlas of human cortical organoid development. Check it out here:
New study from
@ArlottaLab
👀! Beautiful work co-lead by
@Pigoni_Martina
and team deciphering the developmental role of PTEN in human cortical organoids. Congratulations to all co-authors! ! 👏🏼👏🏼Check it out! 📣📣
📢Thrilled to share our last work utilizing human cortical organoids to explore developmental events influenced by mutations in the ASD-risk gene PTEN. KUDOS to the team! It has been an incredible journey, and I'm grateful to have worked with such talented and dedicated group.
Outstanding talk by
@BolanosAnton
from
@ArlottaLab
at our
@NeuroAlc
Christmas Meeting 2022, on her establishing cerebral chimeroids to understand individual variability in brain development and disease, and maybe brain evolution… Bravo 👏🏻👏🏻👏🏻
Join us tomorrow at this exciting webinar organized by
@Dev_journal
where we discuss new tractable approaches to understand human brain development! 🧠🧫🧬🔬
#BuildingBridges
🇺🇸🇪🇸 compartimos la pasión por el deporte y en el terreno de juego somos aliados en el fomento de la diversidad, la equidad y la inclusión. En este mes dedicado a las mujeres os presentamos ejemplos de cómo el deporte nos une, en femenino. 📽️Hoy
@BolanosAnton
.
Thank you for such warm welcome! It was an honor to share my research on multidonor human cortical chimeroids from
@Arlottalab
and
@broadinstitute
at the SPiNES Seminar Series. Engaging with such a thoughtful and insightful audience was truly inspiring!
Spanish neuroscience is mourning today. We are going to miss you Miguel. Incredible mentor with a big hearth and extraordinary passion for science. He always helped and gave his precious view at any moment… I feel very fortunate to had the opportunity to work with you. Thank you
I already miss you so much! You've been an extraordinary friend and mentor throughout these more than ten years of working together. One of those few scientists truly motivated by heart and passion. Thank you, Miguel, for all you have taught me about science and life.
@GLB_Lab
La ilicitana
@BolanosAnton
, investigadora de la Universidad de Harvard, es la capitana del Boston Team Handball y fue nombraba como MVP de la pasada liga en Estados Unidos.
Otra jugadora formada en el
@cbm_elche
que ha hecho carrera más allá de nuestras fronteras.🤾♀️👌🏼
Happy Halloween everyone! In Arlotta lab 🧠🔬 we had a lot of fun carving our pumpkins to celebrate the season, join us and share your favorite pumpkin!! 🎃🎃
Check it out! A new preprint from
@GLB_Lab
,
@AlvaroHerrero1
! Amazing work about brain region specific inheritance of transcriptomic and epigenitic signatures after astrocyte to neuron reprogramming. The maintenance of a common ground state is in the plate!
Proud to share a review by our very talented team
@SilviaV74098895
and
@bruna_paulsen
; highlighting the current knowledge on brain organoids, comparing with the endogenous human brain, and discussing experimental strategies to pioneer understanding of neurodevelopmental disorders
5🧵The great potential: 💪Chimeroids allowed us to pinpoint donor-specific differences in response and unveil the stratification of donor lines based on susceptibility to neurotoxic stressors.
📢 Excited and proud to share our first preprint! We discovered a novel function for the autism-associated gene SYNGAP1 at the early stages of human cortical neurogenesis. Work co-lead by the very talented
@MarcellaBirtele
postdoc and
@DossoAshley
PhD candidate in our lab🧵 1/8
2🧵Introducing “Chimeroids”: a highly reproducible Multidonor human 🧠🧫 cortical organoid model, generated by the co-development of cells from a panel of individual donors in a single organoid.
6🧵Key Findings: 📊Our research underscores that inter-individual variation is a major contributor to susceptibility to neurotoxic triggers. Chimeroids emerge as a scalable platform for measuring biological response variation in human brain tissue. 🧠🔬
2/ Introducing “Chimeroids”: a highly reproducible multi-donor human 🧠 cortical organoid model, generated by the co-development of cells from a panel of individual donors in a single organoid.
So excited to be awarded an embo postdoctoral fellowship!🥳🎉 Thank you
@embo
for supporting my work in
@ArlottaLab
@HSCRB
using 🧠
#organoids
to understand autism spectrum disorder.
I'm thrilled to share that my postdoctoral project, conducted at
@MSKCancerCenter
, has been published in
@ScienceAdvances
. We reveal how embryo-derived macrophages regulate sterol hormone production by sensing nutritional status during development.
6/ Key Findings: 📊Our research underscores that inter-individual variation is a major contributor to susceptibility to neurotoxic triggers. Chimeroids emerge as a scalable platform for measuring biological response variation in human brain tissue. 🧠🔬
4🧵Investigating Inter-Individual Variation: 👩🔬👩🔬 🔎Using Chimeroids, we probed susceptibility to neurotoxic stressors with significant clinical phenotypic diversity, like EtOH (linked to Fetal Alcohol Syndrome) and the anti-epileptic drug VPA.
📢📢Amazing line-up of speakers tomorrow in
@nyscf
2023 conference! Don’t miss it! 👀
@Irene_Faravelli
will give a lightning talk about Chimeroids and Inter-individual susceptibility to neurotoxic stressors. 🧠🧫
Beautiful work conducted by
@xinniej
@ArlottaLab
and colleagues! Scratching the amazing possibilities of in vivo perturb-seq to better understand neurodevelopmental disorders. Congrats!
1🧵Genetic variation plays a crucial role in differential susceptibility to disease triggers such that different individuals show heterogeneous responses to disease risk factors and effects of human genetic variation can be detected in in-vitro systems. 🧫🧠🧬
Estamos rozando términos muy peligrosos, prohibir la libertad es algo muy serio. Espero que los votantes españoles digan NO a esta barbaridad es las urnas.
3/ Chimeroids are generated by fine-tuning the developmental stage when donor line multiplexing occurs, this way we diminished differences in growth biases among donors resulting in highly reproducible systems indistinguishable from our current cortical organoids.
1/Genetic variation plays a crucial role in differential susceptibility to disease triggers such that different individuals show heterogeneous responses to disease risk factors and effects of human genetic variation can be detected in in-vitro systems. 🧫🧠🧬
3🧵 Chimeroids are generated by fine-tuning the developmental stage when donor line multiplexing occurs, this way we diminished differences in growth biases among donors resulting in highly reproducible systems indistinguishable from our current cortical organoids.
5/ The potential of Chimeroids: 💪Chimeroids allowed us to pinpoint donor-specific differences in response and unveil the stratification of donor lines based on susceptibility to neurotoxic stressors.
Huge congratulations to
@GuilleLBendito
on being awarded with the Rei Jaume I Prize 2023 for the category of medical investigation! A great honour for Guille and the whole lab! To many more 👏👏
@NeuroAlc
@PremiosReiJaume
4/ Investigating Inter-Individual Variation: 👩🔬👩🔬 🔎Using Chimeroids, we probed susceptibility to neurotoxic stressors with significant clinical phenotypic diversity, like EtOH (linked to Fetal Alcohol Syndrome) and the anti-epileptic drug VPA.
Thrilled to start off the new year with a new lab publication, titled: "Human Cerebellar Organoids with Functional Purkinje Cells", led by the exceptionally talented PhD candidate
@AlexanderAtami1
@CellStemCell
🧵 1/11
Extremely happy to share our review published today on the role of spontaneous activity in thalamic and cortical circuits development! So proud of this one!
@GLB_Lab
@NeuroAlc
.
I am really happy to see my postdoctoral work out finally! I hope it will be welcome to the world.
The macrophage genetic cassette inr/dtor/pvf2 is a nutritional status checkpoint for developmental timing