Dr. Len Zon
@leonard_zon
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Director of the Stem Cell Program @BostonChildrens
Boston, MA
Joined December 2008
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A dream comes true. Tonight I threw out the first pitch at Fenway for the Red Sox-Braves game. This was in honor of my election to the National Academy of Sciences. Pretty happy with the pitch!😀
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The Zon lab is excited to present a method to avoid reformatting of papers with every submission to a new journal. We feel this will save time for scientists.
A uniform format for manuscript submission
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Honored to be elected to the NAS today. I want to thank all of my lab members whose hard work made this possible, my mentors and my family for all their support over the years.
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Very excited to see our new Science paper by my student Sam Wattrus. Macrophages interact with stem cells and determine which clones to selectively amplify or to destroy, providing a quality assurance mechanism for determining which stem cells contribute to adult blood.
Thrilled to share the final published version of much of my PhD work with
@leonard_zon
@BCHStemCell
, now available in Science.
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Very happy to receive the Christiane Nusslein-Volhard Award today. Presented to me by Liz Patton. The award trophy is so cool - it is a mold of a zebrafish embryo!!
Very honored to receive the Christiane Nusslein-Volhard Award of the European Zebrafish Society for 2022. Janni (Christiane) and the early Tubingen group was incredibly kind to my lab in collaborating on blood mutants from the major zebrafish screen.
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Congrats to my postdoc Cecilia Pessoa Rodrigues on her Science paper. We show that dsRNAs from endogenous viral elements bind to TLR3, inducing the don't eat me signal, B2m, on HSCs. This protects the stem cell from phagocytosis by macrophages.
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A great honor to receive the ASH Mentor Award. Thanks to all my trainees and friends.
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Excited about the opportunities for cellular barcoding to study stem cell clones and cancer. Great to see some highlights on our recent Science paper.
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I am attending the 20th International Society for Stem Cell Research (ISSCR) meeting in SF. Hard to believe it has been 20 years since I started the society! It has over 4300 members and is doing a fantastic job at moving the stem cell field forward. Very proud of ISSCR.
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Very happy and honored to be selected for this year's American Society of Hematology Mentor Award.
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Congrats to my daughter, Becky, on completing three years of her Oncology Fellowship at Dana-Farber Cancer Institute. Becky is planning on continuing her work in Ben Ebert’s lab and will see patients in Hematology clinic.
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Very happy and honored to be selected for this year's William Silen Lifetime Achievement in Mentoring Award at Harvard Medical School. It has been a privilege to work with some many talented scientists and doctors through the years.
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I would like to congratulate my daughter, Becky, for receiving this Damon Runyon grant. Very proud of her research!!
@beckyzon
is working to understand why thalidomide derivatives, a class of drugs used to treat multiple myeloma, increase the likelihood of blood clots for cancer patients. She hopes to translate her findings into more targeted medications that can improve treatment outcomes.
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Congrats to my son, Tyler, on graduating from Harvard Business School. We are very very proud of you.
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We're excited about our new paper on the evolutionary reason that bones were selected to house blood stem cells! Check out more at the following links:
--The paper itself:
--A short video explaining the paper's findings:
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Congrats to my wife, Lynda Schneider, on giving the Robert A Cooke Memorial Lectureship at the AAAAI meeting. This plenary session talk honors Lynda's years of work on Atopic Dermatitis or Eczema.
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Very honored to receive the Christiane Nusslein-Volhard Award of the European Zebrafish Society for 2022. Janni (Christiane) and the early Tubingen group was incredibly kind to my lab in collaborating on blood mutants from the major zebrafish screen.
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Congrats to Marlies Rossmann on our recent paper in Science. We found that mitochondrial metabolism and coenzyme Q synthesis directed by the cell-specific transcription factor TIF1g is required for blood cell development.
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Happy to celebrate tonight the HMS/BCH Professorship of Pediatrics in the Field of Regenerative Medicine and the appointment of Carla F. Kim, PhD as the inaugural incumbent. Eventually it will be renamed the Leonard Zon, MD, Professorship of Pediatrics.
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Very excited to show this video that depicts macrophage - stem cell interactions. Someday, we hope to alter this interaction to remove pre malignant or leukemic clones of stem cells.
In recent
@ScienceMagazine
,
@SamWattrus
@leonard_zon
+ al in
@BCHStemCell
show
#macrophages
in
#zebrafish
embryos ensure quality of
#hematopoietic
#stemcells
by “grooming” or “dooming” them
Paper
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Congrats to Becky Zon on her fantastic talk at ASH on heparin induced thrombocytopenia.
@beckyzon
@connors_md
#ASH22
#ASHkudos
Very proud of my daughter!
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I was very excited to see our recent Science paper's work on the mechanism of clonal hematopoiesis covered by the New England Journal of Medicine. Thanks Nancy Speck for writing the review.
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Played a wonderful concert today at Boston Symphony Hall with the World Doctor's Orchestra. Met wonderful new friends, great doctors, and excellent musicians.
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Having watched closely through the development of this story for over 30 years, this is a marvelous day. Congrats to my mentor and friend, Stu Orkin, who discovered the mechanism of hemoglobin switching and pointed to the place to target.
Today we approved two milestone treatments - the first cell-based gene therapies to treat sickle cell disease in patients 12 years and older.
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Here in New Orleans at American Society of Hematology. Met a few friends- the Red Cell and White Cell!!!
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Lynda and I are so proud of Becky as she graduates from her Internal Medicine Residency at the Brigham. She will be moving onto her hematology oncology fellowship at Dana-Farber Cancer Institute/Brigham and MGH.
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Honored and proud to have been elected as an EMBO associate member.
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Fun lab retreat yesterday at the Cape!! So fortunate to have these amazing people in the laboratory.
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In Serine and Jon's work () we competed normal and mutant stem cells in a zebrafish while marking the clones in different colors. We modeled mutations causing clonal hematopoiesis of aging- found a pathway to restore clonal balance.
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Had a great Pan Mass Challenge ride - 160 miles. Congrats to all of the riders!
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Happy to announce our paper in Nature Genetics on NECTIN1 mutations in melanoma that leads to tumor spreading. Julien Ablain is the lead author and has his own laboratory in Lyon studying cell-cell interactions lead to tumor formation or spreading.
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Enjoying a wonderful day to present at the Nobel MiniSymposium - "From Models Towards Regenerative Therapies." Fun to visit the Nobel Forum.
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Congrats to my wife, Lynda Schneider, for being honored tonight at the Asthma and Allergy Foundation of America New England Gala. Very proud of all of her accomplishments in helping children with allergies and atopic dermatitis.
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30 years of playing together with Wolfram Goessling in the Longwood Symphony.
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Congrats to David Langenau, Trista North, and Wolfram Goessling on having a lab for 15 years! So proud of all of you.
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Very happy to have Boston Children's Hospital cover our recent Science paper on macrophages quality assuring stem cells by sensing ROS (dooming) or endogenous viral elements (grooming). This discusses our future plans.
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Very exciting. Congrats to Cristina and Audrey from my lab on their Nature Cell Biology cover. They depicted the structure of the drug leflunomide with embryos stained for expression of a neural crest marker.
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Very excited about the Longwood Symphony concert tonight. Ben Wright of the Boston Symphony is playing the Haydn Trumpet Concerto. Also we are doing Sibelius Symphony no 2.
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Congrats to TX Han for defending his PhD thesis today. His work on making marrow niche endothelial cells from ipsc is fascinating. He is my 37th graduate student to defend.
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I want to congratulate my wife, Lynda Schneider, on being the first incumbent of the Sidman Family Chair in Immunology. Lynda has spent her entire career doing excellent clinical research in atopic dermatitis and food allergy. She is an amazing doctor and cares for her patients.
I am greatly honored and humbled to be the first incumbent of the Sidman Family Chair in Immunology at Boston Children’s Hospital. This will greatly accelerate our research on atopic dermatitis and food allergy.
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Excited about our recent paper in Dev Cell on reprogramming endothelial cells to make a new blood forming niche. Here is a review about our paper.
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Very proud to do the Ride for the Cure today for Boston Children's Hospital. I played God Bless America on my trumpet at the beginning in honor of Veteran's Day. Then talked about research. Team Zebrafish did an amazing job (with Chloe Baron, Gabriela Arias, and Becky Zon)!!
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Our review on the use of zebrafish to study cancer was just published in Nature Reviews Cancer.
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Congrats to Megan Insco on our new paper in Science on CDK13 mutations in melanoma. This shows tumor suppression by RNA surveillance. Megan recently started her lab at Dana-Farber Cancer Institute. Thanks Robert Fisher for the Perspective on our paper.
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Check out our newest cover of Nature Cell Biology tracking stem cells with different colors!
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Very excited to have been chosen as a Crazy 8 grant recipient from
@AlexsLemonade
! Our team will use new cellular barcoding technology to track the cell of origin of pediatric leukemia
#AlexsCrazy8
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Want to thank Legal Sea Foods for being such a great partner for many years. With their support, we have used our Zebrafish research to discover new disease mechanisms and therapies.
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Fun concert with the Longwood Symphony last night at the New England Conservatory. Mahler 4 is such a great piece. Enjoyed playing with Jorge Soto.
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Great article about our recent Science paper.
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In recognition of International Day of Women and Girls in Science, I would like to congratulate my daughter (Becky Zon
@beckyzon
) and my wife (Lynda Schneider
@theallergyMD
) on all that they do for their fields and their patients.
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Father-Daughter Combo! Come see each of our talks.
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Our incredible Father-Daughter dance at
@beckyzon
and
@kmcpartyland
's wedding in July 2022. A year of dancing lessons was worth it. Thanks again to Colleen Royal and Readysetfilm.
Check out our epic father-daughter wedding dance! I rap and
@leonard_zon
shows off his sweet dance moves 😍 thanks so Colleen Royal (choreo) and
@readysetfilm
(video)!
#Zons
#likefatherlikedaughter
@kmcpartyland
@HummingbirdWed
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So much fun at the Longwood Symphony Gala last night. Hard to believe I have been playing in the orchestra for almost 40 years. Thanks for everyone who came to the event and for the years of support.
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Great to put this review on drug discovery in zebrafish with Liz and David
Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials - a new review published today by Elizabeth Patton,
@leonard_zon
and David Langenau
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Congrats to Becky Zon, my daughter, on receiving the Research Training Award for Fellows (RTAF) grant from ASH. Very proud of her work on thrombosis in cancer.
So grateful to
@ASH_hematology
for this incredible award! Thanks to my amazing mentors and sponsors for supporting me: Ben Ebert, Beth Battinelli, Nancy Berliner,
@connors_md
,
@NTConnell
,
@DrLaCasce
, Arielle Langer, and more!!
#thrombosis
#hematologyisthebest
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Congrats to my graduate student, Ji Wook Kim, for his excellent talk on blood stem cell egress from the niche, at the Boston Angiogenesis Meeting today.
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Congrats to Georgia Stirtz for doing a great job at her PhD defense yesterday. She has done fantastic work on the melanoma niche and using imaging to visualize immune cell and tumor interactions in the zebrafish.
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Fun Longwood Symphony concert last night at Jordan Hall. We played Vaughn Williams 5. Really great piece!
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Congrats to Becky Zon on her fantastic talk at ASH 23 on clonal hematopoiesis and venous thromboembolism
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Fantastic ISSCR meeting. Congrats to Melissa Little and Amander Clark for program. The last day - fantastic talk by Joanna Wysocka, amazing talks using stem cell-derived tissues in the clinic by Naldini (SR-TIGET), Takahashi (Visioncare), Valamehr (Fate) and Meininger (Vertex).
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We had our virtual holiday party for my lab. For the party, we produced a video of lab members playing Jingle Bells. I am lucky to have a great lab. Happy holidays!! Excellent triangle by
@chloe_s_brn
and wonderful steel drum by Georgia.
@plexusplay
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Great pic.
We started it in SF last year, it’s a tradition now!
#ISSCR2023
@SamWattrus
Twitter-less Serine
#favoritepeople
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Congrats to Jing-mei and Emily on our collaboration with Nancy Speck's lab about the role of CHD7 in hematopoiesis.
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Join me in April 2021 for the
@KeystoneSymp
virtual
#eSymposia
,
#Hematopoiesis
, to explore emerging
#hematology
research and technology, with interactive discussions and networking opportunities! Register today at
#VKSHemato21
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Thanks to Legal Sea Foods for supporting our zebrafish research on blood stem cells and cancer.
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Thanks so much for your support of my lab at Boston Children’s Hospital. Our partnership with Legal Sea Foods is very special and fits perfectly with our work on blood diseases and cancer by studying zebrafish. We are very appreciative!!
We’re proud to support Boston Children’s Hospital with our recent donation. This will directly support
@BostonChildrens
groundbreaking Stem Cell Research Program, which utilizes fish to find cures for cancer. Learn more at
#LegalSeaFoods
#Boston
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Thanks for all that you do for my lab! It has been a wonderful pleasure to partner with Legal Sea Foods.
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It has been 8 years since Tim Springer and I founded Scholar Rock. It is so rewarding to see the development and clinical trial of a drug, SRK-015, that could help patients with spinal muscular atrophy.
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Great concert for the Longwood Symphony. Copland 3 is a terrific piece. Fun evening.
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Fantastic meeting on tumor heterogeneity at Les Treilles. Thanks to excellent organizers Cedric and Patrick.
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Connie was an amazing scientist and a good friend. She loved to talk about experiments, even about Zebrafish. She was very rigorous. She helped ISSCR. I will really miss her.
A true giant of Canadian cancer research, exemplary scientist and mentor and extraordinarily kind and lovely person. Dr. Connie Eaves RIP.
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Congrats to Richard Gregory for being named the first occupant of the Stem Cell Biology Chair at Boston Children’s Hospital. That is a big honor. Great celebration today including Harvard Medical School Dean, George Daley.
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NIH zebrafish research included in U.S. Postal Service’s “Life Magnified” stamps | National Institutes of Health (NIH). Got to love a Zebrafish stamp!!
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Privileged to give my talk today in Lund with Victoria, Crown Princess of Sweden, in the audience. Was an absolute pleasure to meet her, and discuss the impact of basic science to clinical medicine.
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Cellular barcoding is a new technology that is now being applied to the study of development and disease. Hope everyone can join us to learn about this technology in this amazing ISSCR virtual meeting that includes many leaders in the field.
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Eager to head to
@uoregon
to deliver the 33rd George Streisinger
Memorial Lecture, which honors the founder of the zebrafish field.
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Fantastic Annual Ski Retreat for the Zon lab. Gunstock and then Oliver Lodge in NH. I’m lucky to work with such a wonderful group.
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I'm looking forward to tomorrow's
@BostonChildrens
Stem Cell Program’s 15th Anniversary, a day full of exciting presentations from premier stem cell scientists, including a keynote address by Nobel Laureate Shinya Yamanaka.
#stemcell_bostonchildrens
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Celebrating our 15th anniversary of the Boston Stem Cell Program.
#stemcell_bostonchildrens
via
@YouTube
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At Jon Epstein’s house at MDIBL. Massive feast of culinary excellence. Gazpacho, lobster ravioli, baked cod with roasted peppers and chimichurri, crab meat salad. Mmmmmm.
@jonepstein1
@MaggyMyers
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Martin Pera does an amazing job as editor of Stem Cell Reports, the journal of the ISSCR.
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Fun playing Beethoven's 5th Finale with the Longwood Symphony. Played my rotary valve trumpet for this performance.
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Working with Marie Arturi and the team at buncee to help K12 and STEM. Fun to tell the story of zebrafish in my lab.
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Congrats to Chloe Baron on winning the Poster Award at ISSCR. This was for her work on leukemia and the clonality of niche cells in zebrafish.
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Last time for organizing the Myeloid Workshop at ASH. Parting gift was a baseball glove signed by the organizers. 15 years went fast!
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The best lab. Thanks for a great evening!!!
Evening out to celebrate our fearless leader
@leonard_zon
@LongwoodSymOrch
and our unofficial lab king
@B_Gheller
’s bday 🥳
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We are so excited to have Ryan Flynn as a new faculty in the Boston Children's Hospital Stem Cell Program and the Stem Cell and Regenerative Biology Department at Harvard!
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We had our first Zon lab camp for 12 high school students. They worked in two teams and did blood and cancer research. They presented their work to my lab at the end in a side show. It was very inspiring. Training the next generation.
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Congrats to Maurizio and Ellen for their work on SATB2 as a driver of melanoma spreading.
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So happy for you, Trista. You have done such wonderful work. Happy to see your career blossom here in the Stem Cell Program. Congratulations!!!!
Excited to share that I've been promoted to Professor at
@harvardmed
! So incredibly thankful for endless support of
@leonard_zon
@LabSpeck
@G_Q_Daley
@WGoessling
, the fabulous North lab folks, our
@drb_hms
&
@BCHStemCell
crew, & all my amazing friends/colleagues/collaborators! 🥰
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Congrats to Sean Morrison and CRI. Very impressive group of investigators!
Thank you to
@leonard_zon
for delivering the keynote speech at CRI’S 12th-anniversary symposium! We appreciate all the speakers and attendees who joined us today to celebrate our institute.
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Excited to announce that the Stem Cell Program now has a Twitter! Give it a follow to stay up to date with our program. It has been a great 15 years.
@BCHStemCell
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Camp Zon applications are now open - tell the high schoolers in your life!
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