Peter Wang
@wyppeter
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PhD candidate, Bartel Lab, MIT/@WhiteheadInst. Biochemical + biophysical principles of protein/RNA mechanisms. MicroRNA/siRNAs & AGO proteins.
Cambridge, MA
Joined June 2014
Happy 2025! Excited to finally share our published slicing structure of human AGO2, the catalytic structure for RNAi by siRNAs and miRNAs. This was an amazing collab effort between @seyvos lab and Bartel lab with @AMohamed_98
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RT @bioSavinov: Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living c…
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RT @GeneWeiLiLab: Thrilled to announce the final version of our paper on computational discovery of protein fragments that can inhibit cell…
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RT @KarinaJouravl: Our review on small endogenous RNAs in animals is online. We thank @MartinjSimard, @SvobodaLab and the third, anonymous,…
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RT @HHMINEWS: Today we're thrilled to announce our 2024 #HannaGrayFellows! Please join us in welcoming and celebrating these outstanding ea…
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In this updated paper, we further described conformational changes required for catalysis, and a network of interactions near the active site that support slicing. Read more here:
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Excited to be presenting our latest work at the Keystone noncoding RNA meeting in January. Looking forward to meeting fellow researchers in the field, both old & new -- at the talks and posters, or on the ski slopes! #KSncRNA25
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RT @Mendell_lab: I’m thrilled to share this story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu! We…
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RT @NobelPrize: BREAKING NEWS The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the disc…
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This work was a wonderful collaboration with Abdallah Mohamed (@AMohamed_98) in Seychelle Vos' group (@seyvos), who overcame many technical obstacles to make this structure possible, providing us with this snapshot of AGO2's final conformational changes before slicing. (5/5)
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We observe critical conformational changes in AGO2 and the RNA strands, as well as dynamic structural flexibility in the ternary complex, that allow AGO2 to accomodate a fully paired guide−target RNA duplex. (3/5)
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After years of planning & hard work, we are excited to present the structure of human AGO2 in the slicing conformation, paired to a fully complementary RNA target, revealing the structural basis of the reaction that powers RNAi. (1/5) @AMohamed_98 @seyvos
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Glad to finally share our paper in its published form, in which we deciphered the RNA sequence determinants and conformational requisites of AGO2, the cellular machinery for RNAi:
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