It's finally here 🍾!! Excited to share our work led by
@MariaMSteele20
out today in
@NatImmunol
investigating the impact of T cell egress on anti-tumor immune responses
Was honored to receive the AACR-BMS Midcareer(!😬) Female Investigator Grant in I/O award at
#AACR22
this past week to expand our work investigating the impact of lymphatic transport on T cell trafficking and memory in melanoma
@AACR
@bmsnews
Congrats to
@theLundLab
, on the 2022
@AACR
@bmsnews
Female Investigator Grant: Targeting lymphatic transport to boost immune memory & reduce recurrence.
@AACR
believes this project will have great impact, & recognizes her as a future leader in the field.
The
#LundLab
turns 10 this week 🤯 - thankful for our team (past and present) and excited for all the new lymphatic biology we will learn in the next 10
@Perlmutter_CC
@nyugrossman
Excited to share our review out today in
@SciImmunology
- congratulations to authors
@H_du_Bois
and Taylor Heim for their excellent work discussing tumor-draining LNs in metastasis and immunity! (cover by H. du Bois and A. Chen)
Check out our latest led by
@TaylorAHeim
published today in
@SciImmunology
- we show how T cell exit from infected skin via lymphatic vessels is necessary and sufficient to seed a second layer of resident memory in the draining lymph node
We are looking for postdocs/scientists to work on multiple funded projects exploring lymphatic transport, T cell trafficking, and lymph node biology! Check us out, shoot me an email, or find me at the Lymphatics Gordon in Tuscany and
#SITC22
in Boston!
We are recruiting a Senior Research Technician! Looking for someone who has 🐭 experience and is excited to contribute to a dynamic team exploring the impact of lymphatic transport on immunology, and metastasis. Feel free to reach out directly!
👀 Our latest pre-print is out by
@MariaMSteele20
! We knew T cells could leave tumors through lymphatic vessels but we didn't know why or what it meant... 🤷🏻♀️
Made it to Associate...with all the ups and downs of this job, June 2019 has definitely been an up. So cheers to the ups! 🍾 thank you to my mentors (
#LisaCoussens
,
@DrSancy
, and
#MelodySwartz
), letter writers, and most importantly my lab past and present
#theLundLab
Tons of fun in pre-K today! We talked about what scientists do, who can be a scientist (spoiler everyone 👩🏻🔬🧑🏿🔬👩🏼🔬🧑🏽🔬👨🏻🔬👩🏾🔬!) and made blood! Exactly the energy I needed! If only they were my reviewers (ps those are platelets not bacteria or mouse poop…don’t hate)
@theLundLab
is hiring - 👀 for postdocs for a range of funded projects 👇. Flexible funds are available for independent exploration. Come join our team working at the intersection of endothelial biology, immunology, cancer, and infection in NYC!! 🐭🔬🧫
Said goodbye and more importantly good luck to a phenomenal postdoc today
@MariaMSteele20
who has helped me build my program, mentor students, move the lab, and push lymphatic vessels into the field of immunotherapy - she will be so greatly missed
Our latest - lymphatic capillaries are active barriers to viral dissemination - congrats to first author Madeline and the team who got this done despite a cross country move and a pandemic...
Active mechanisms of lymphatic transport impact host defense and adaptive immunity!! Our latest from
@MadJChurchill
with help from the team
@H_du_Bois
@MariaMSteele20
, Taylor, and Tenny through a lab move and pandemic.
@JExpMed
Feeling better now that equipment is unpacked and mice are makin' babies! 🧫🔬🐭
It's a troubling time for all, but if you are finishing up your PhD and interested in chatting about a postdoc plz reach out - we will be hiring on multiple funded projects this yr @ NYU
#lymphatics
Happy
#Immune2Cancer
Day! I look forward to introducing my group and the work we are doing to understand the immune response to cancer next week
@CancerResearch
👩🏼🔬🧫🔬🗽🍎
New Preprint‼️ Taylor Heim tracks T cell egress via lymphatic vessels from infected skin and determines their fate. Do T cells that egress from primary infection form LN TRM as reported after flu (lung) and Ag restim?... answer👇
This is important and there are many parts of the job that are hard to fix - what’s not hard? Stop passing administrative burden to overworked and understaffed faculty in order to check newly created regulatory boxes - also, help us pay our teams a living wage
Congratulations to Taylor Heim who defended his thesis today
@nyugrossman
with flying colors. Watch him, he will do great things!! End of the
#theLundLab
Portland era.
#Lymphatics
#Trm
Beyond honored to be one of the first 5 CRI Lloyd J. Old STAR recipients - thank you to
@CancerResearch
for their vision, continued support of basic tumor immunology research and mid career scientists!!
The CRI Lloyd J. Old STAR Program provides long-term funding to mid-career scientists. We are excited to present three of the first five recipients at this event: Drs. Yvonne Y. Chen, Amanda W. Lund, and Gregory F. Sonnenberg.
#IOfuture
#CIM19
What an honor to have our recent
@JExpMed
paper highlighted by
@NatureRevCancer
!!!👇🏼Lymphatic vessels and the non-hematopoietic stroma are critical components of the response to
#Immunotherapy
Lymphatic vessels disseminate antigens, leukocytes, lipids, metabolites, and tumor cells between normal and malignant tissues dynamically reprogramming the host over time 👇 - still lots more to learn about their impact on micro and macro tumor progression and immunotx
Tumour-associated lymphatic growth & remodeling were once viewed as passive means for lymphatic spread. In this
#Review
,
@theLundLab
provide a working framework for the role of the lymphatic system in tumour progression & response to immunotherapy.
realizing today was the day one year ago when I found out our new NYC apt would be banning move-ins and our mice/lab might be stuck at OHSU - after an 8am desperation 🍺, we packed our house, loaded a UHAUL, and made a mad dash to the center of the pandemic - what a year...
Have non-scientists read your grants and listen to them when they say it doesn’t make sense - my non-native English speaking, non-scientist husband definitely just made my R01 better (fundable 🤷🏼♀️, but definitely better)
#unsolicited
Modeling melanoma requires constant consideration of interrelated and complex processes from oncogenes to environmental exposures that evolve with time and therapeutic pressure - no one model is enough but all models are useful
@MelanomaReAlli
#melanoma
Moving your family and your lab from OR to NYC amidst a pandemic??...not ideal in case you were wondering :) I'll just be here stress eating cheetos until it's over
#theLundLab
#wevegotthis
#WashYourHands
Looking forward to
#CICON22
today in NYC! If you're attending and on the postdoc market now or in the future and want to chat about what we are doing to explore lymphatic transport and lymph node biology in immunotherapy don't hesitate to find me!
@CancerResearch
@AACR
Tour-de-force by
@rafacze
,
@ZinselmeyerB
, Emma Erlich,
@EmilyJeanOnufer
, Mike Davis,
@ScallanLab
& our collaborators revealing that ileitis-associated TLOs arise at lymphatic valves and obstruct cellular/molecular outflow. Check out the intravital imaging!
Can’t believe we said goodbye to
@LaneO714
today (for real). The 1st
#LundLab
grad student - feels like the biggest milestone yet. Can’t wait to see what you do Ryan! Good luck at
#Genentech
with
@TurleyLabGNE
... and ... go 49ers??
Congrats to grad student Taylor Heim who's (first) first author paper is now available on bioRxiv
Ever wonder why CXCR6 is so ubiquitously expressed on TRM ?? we did too 👇
Melanomas are champions at metastasis. In this
@Cancer_Cell
Spotlight,
@theLundLab
and I review exciting new results by
@SJMorrison_
lab (
@nature
) on how melanoma cells benefit from the lymph and discuss other protumorigenic roles of the lymphatic system
That feeling when your 1.5 year old kicks you out of the office because she has things to do...”are you busy? Should I close the door?” “Oui, buh bye” 😂 here’s hoping she’s reviewing that manuscript for me🤞🏼
AACR members have elected Lisa M. Coussens, PhD, FAACR, as their President-Elect for 2021–2022. Dr. Coussens will become President-Elect on April 12, 2021, during the
#AACR21
Business Meeting of Members and will assume the Presidency during
#AACR22
.
Exactly this but for everything - if you think you're good...make yourself uncomfortable, test your limits, find your fail point...only that will make you better
Every young player in America needs to listen to this.
"If you want to be successful, you need to be bad, then you need to be good. Then when you're good, you need to fail. Then when you fail, you're going to figure it out... ”
Paper is finally out in
@NatureGenet
! "Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment"
Check out our catalog of conserved cancer cell states defined by scRNA-Seq & ST. Congrats
@BarkleyDalia
!
Congrats to Taylor Heim who presented his work on CXCR6 and Trm in skin today at
#AAI2022
@AAI
- if you missed it check out his poster tomorrow at 2:30 P588
VEGF-C expression boosts vaccine immunity
#Lymphatics
💉 - Happy to have had the opportunity to highlight this work from my postdoctoral mentor Melody Swartz with
@WilsonLabVU
@ScienceAdvances
We show that the peripheral lymphatic vasculature is a dynamic and active player in anti-tumor immune responses - loss of IFNgR On lymphatic vessels is sufficient to drive T cell dependent tumor control!!
#Lymphaticsmatter
#Stroma
#TME
#melanoma
@LaneO714
Lane et al. demonstrate that IFNγ-induced, nonhematopoietic PD-L1 suppresses anti-melanoma immunity and identify lymphatic vessels as key mediators of response
We will probably never compare to the women who have blazed these trails before us, we can only hope to try. Dr. Werb catalysed generations of science to come and her impact will be with us for a long time. My sincere condolences to those who knew her best.
I am heartsick over the passing of Zena Werb. Lucky to have been taken under her wing. Tremendous loss to science and humankind. Fav photo from 2019 AACR Fellows induction.
Eva Hernando is looking for a postdoc
@nyulangone
! Interested in melanoma metastasis and intratumoral heterogeneity? Great models, exciting questions, and fantastic mentor - plus we collaborate so fun all around!
The
#LundLab
is excited to be at
#KSstromal
in Victoria, BC. Talks from the lab by grad student
@Madelin08824820
(Feb 19) and postdoc
@MariaMSteele20
(Feb 23) - lymphatic vessels regulating immunity from the 'beginning' to the 'end'!!