Amanda Lund Lab
@theLundLab
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the Laboratory of Lymphatic Immunobiology - exploring the contribution of lymphatic transport to dermal and anti-tumor immunity @nyulangone
New York, NY
Joined May 2018
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It's finally here 🍾!! Excited to share our work led by
@MariaMSteele20
out today in
@NatImmunol
investigating the impact of T cell egress on anti-tumor immune responses
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Was honored to receive the AACR-BMS Midcareer(!😬) Female Investigator Grant in I/O award at
#AACR22
this past week to expand our work investigating the impact of lymphatic transport on T cell trafficking and memory in melanoma
@AACR
@bmsnews
Congrats to
@theLundLab
, on the 2022
@AACR
@bmsnews
Female Investigator Grant: Targeting lymphatic transport to boost immune memory & reduce recurrence.
@AACR
believes this project will have great impact, & recognizes her as a future leader in the field.
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The
#LundLab
turns 10 this week 🤯 - thankful for our team (past and present) and excited for all the new lymphatic biology we will learn in the next 10
@Perlmutter_CC
@nyugrossman
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Excited to share our review out today in
@SciImmunology
- congratulations to authors
@H_du_Bois
and Taylor Heim for their excellent work discussing tumor-draining LNs in metastasis and immunity! (cover by H. du Bois and A. Chen)
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We have FUNDED POSTDOC positions available exploring lymphatic remodeling in fluid, antigen, and cell transport in the context of both infection and tumors .
#SITC21
#melanoma
#postdoc
@BlackinCancer
@BlackInImmuno
@AcademicChatter
@nyuwomeninstem
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A good week in the
#LundLab
!! Accepted paper, fundable scores, new people, and more! Time to celebrate 🍾
@H_du_Bois
@MariaMSteele20
@Triantafyllia14
@katie_ventre
👩🏼🔬👩🏻🔬👩🏽🔬
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Always show up to
@NYUGSOMimcg
meetings - might just be a surprise tenure celebration!! ❤️ my colleagues
@nyugrossman
@Perlmutter_CC
🫧🫧
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Excited to announce the start of our collaborative U54 funded by
@theNCI
MetNet to explore mechanisms of early dissemination in
#melanoma
.
Join us, we are hiring!
Eva Hernando
@drosmannyu
@kruggle
@ItaiYanai
Markus Schober Mayumi Ito (and us too!)
@Perlmutter_CC
@NYUGSOMimcg
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Check out our latest led by
@TaylorAHeim
published today in
@SciImmunology
- we show how T cell exit from infected skin via lymphatic vessels is necessary and sufficient to seed a second layer of resident memory in the draining lymph node
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We are looking for postdocs/scientists to work on multiple funded projects exploring lymphatic transport, T cell trafficking, and lymph node biology! Check us out, shoot me an email, or find me at the Lymphatics Gordon in Tuscany and
#SITC22
in Boston!
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We are recruiting a Senior Research Technician! Looking for someone who has 🐭 experience and is excited to contribute to a dynamic team exploring the impact of lymphatic transport on immunology, and metastasis. Feel free to reach out directly!
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👀 Our latest pre-print is out by
@MariaMSteele20
! We knew T cells could leave tumors through lymphatic vessels but we didn't know why or what it meant... 🤷🏻♀️
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That feeling when your flow antibodies finally arrive... 🤩
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a summer
#LundLab
update - the international version 🇺🇸🇮🇹🇪🇸🇬🇷🇮🇩🇲🇦🇧🇷 (missing Annie 🇺🇸/🇨🇳, Luiz 🇧🇷, and Ochapa 🇳🇬)
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Made it to Associate...with all the ups and downs of this job, June 2019 has definitely been an up. So cheers to the ups! 🍾 thank you to my mentors (
#LisaCoussens
,
@DrSancy
, and
#MelodySwartz
), letter writers, and most importantly my lab past and present
#theLundLab
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Tons of fun in pre-K today! We talked about what scientists do, who can be a scientist (spoiler everyone 👩🏻🔬🧑🏿🔬👩🏼🔬🧑🏽🔬👨🏻🔬👩🏾🔬!) and made blood! Exactly the energy I needed! If only they were my reviewers (ps those are platelets not bacteria or mouse poop…don’t hate)
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@theLundLab
is hiring - 👀 for postdocs for a range of funded projects 👇. Flexible funds are available for independent exploration. Come join our team working at the intersection of endothelial biology, immunology, cancer, and infection in NYC!! 🐭🔬🧫
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Vessels are not just vessels! - using multiplexed IHC
@OHSUKnight
we reveal vascular heterogeneity that associates with immune infiltrates in primary cutaneous
#melanoma
including
#lymphoidaggregates
#TLS
#JuliaFemel
@theLundLab
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Congrats to
@katie_ventre
who officially became a PhD candidate today!!🍾 well done!
#spacematters
🪐🛸
#theLundLab
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Said goodbye and more importantly good luck to a phenomenal postdoc today
@MariaMSteele20
who has helped me build my program, mentor students, move the lab, and push lymphatic vessels into the field of immunotherapy - she will be so greatly missed
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Our latest - lymphatic capillaries are active barriers to viral dissemination - congrats to first author Madeline and the team who got this done despite a cross country move and a pandemic...
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Excited to announce that
@theLundLab
is moving to
@nyuschoolofmed
@nyulangone
in 2020 to join the Ronald O. Perelman Department of Dermatology and Perlmutter Cancer Center.
@MariaMSteele20
@H_du_Bois
#TaylorHeim
1/3
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Active mechanisms of lymphatic transport impact host defense and adaptive immunity!! Our latest from
@MadJChurchill
with help from the team
@H_du_Bois
@MariaMSteele20
, Taylor, and Tenny through a lab move and pandemic.
@JExpMed
Not just going with the flow! New work from Madeline Churchill in
@theLundLab
suggests lymphatic vessels can shut down fluid flow and be an active barrier to viral spread from skin.
@OHSUSOM
@ohsummi
@nyugrossman
@Perlmutter_CC
#InfectiousDisease
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Feeling better now that equipment is unpacked and mice are makin' babies! 🧫🔬🐭
It's a troubling time for all, but if you are finishing up your PhD and interested in chatting about a postdoc plz reach out - we will be hiring on multiple funded projects this yr @ NYU
#lymphatics
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Happy
#Immune2Cancer
Day! I look forward to introducing my group and the work we are doing to understand the immune response to cancer next week
@CancerResearch
👩🏼🔬🧫🔬🗽🍎
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New Preprint‼️ Taylor Heim tracks T cell egress via lymphatic vessels from infected skin and determines their fate. Do T cells that egress from primary infection form LN TRM as reported after flu (lung) and Ag restim?... answer👇
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Check out our latest review online today
@NatureRevCancer
- we synthesize the lymphatic vessel literature in the context of the rapidly evolving field of cancer immunotherapy
@Triantafyllia14
#TennyM
@Perlmutter_CC
@nyugrossman
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For your Friday evening distraction: Afferent Lymphatic Transport and Peripheral Tissue Immunity
Excellent work by
@MariaMSteele20
#theLundLab
@J_Immunol
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Any suggestions for beginner R courses/tutorials? Seems like a good time to build our computational literacy.
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This is important and there are many parts of the job that are hard to fix - what’s not hard? Stop passing administrative burden to overworked and understaffed faculty in order to check newly created regulatory boxes - also, help us pay our teams a living wage
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Congratulations to Taylor Heim who defended his thesis today
@nyugrossman
with flying colors. Watch him, he will do great things!! End of the
#theLundLab
Portland era.
#Lymphatics
#Trm
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We are excited to welcome
@mll_oliveira
🇧🇷 to the lab! Lots to learn about
#melanoma
#lymphatics
and
#immunotherapy
🧪🔬
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Beyond honored to be one of the first 5 CRI Lloyd J. Old STAR recipients - thank you to
@CancerResearch
for their vision, continued support of basic tumor immunology research and mid career scientists!!
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What an honor to have our recent
@JExpMed
paper highlighted by
@NatureRevCancer
!!!👇🏼Lymphatic vessels and the non-hematopoietic stroma are critical components of the response to
#Immunotherapy
New study from
@theLundLab
shows IFNγ-mediated activation of the lymphatic vasculature limits CD8+ T cell accumulation in
#melanoma
in mice as a mechanism of immune suppression.
#ResearchHighlight
@NatResCancer
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Lymphatic vessels disseminate antigens, leukocytes, lipids, metabolites, and tumor cells between normal and malignant tissues dynamically reprogramming the host over time 👇 - still lots more to learn about their impact on micro and macro tumor progression and immunotx
Tumour-associated lymphatic growth & remodeling were once viewed as passive means for lymphatic spread. In this
#Review
,
@theLundLab
provide a working framework for the role of the lymphatic system in tumour progression & response to immunotherapy.
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Found this gem in the archives…February 2020. Can’t believe the
#Lundlab
has officially been at
@nyulangone
@NYULangonePCCSM
@nyugrossman
for almost 2 years!
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realizing today was the day one year ago when I found out our new NYC apt would be banning move-ins and our mice/lab might be stuck at OHSU - after an 8am desperation 🍺, we packed our house, loaded a UHAUL, and made a mad dash to the center of the pandemic - what a year...
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#TheLundLab
is growing! Happy to welcome Tenny Mudianto and Ian Dryg (
@idryg
) to our team
@nyulangone
@nyugrossman
#lymphatics
#melanoma
#immunology
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So much exciting science to be done thanks to both of these fantastic organizations
@CancerResearch
@TheMarkFdn
- want to be involved? come join us in NYC
@nyulangone
!!
Congratulations CRI LJO STAR Dr. Amanda Lund (
@theLundLab
) of
@nyulangone
on receiving
@TheMarkFdn
2020 Emerging Leaders Award 🎉
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A welcome distraction during late night R01 writing...East River fireworks
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Have non-scientists read your grants and listen to them when they say it doesn’t make sense - my non-native English speaking, non-scientist husband definitely just made my R01 better (fundable 🤷🏼♀️, but definitely better)
#unsolicited
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Excited to be at
#AACR22
with
@katie_ventre
@Triantafyllia14
to celebrate good science and funding from
@AACRFoundation
@bmsnews
@Perlmutter_CC
@NYUGSOMimcg
@nyulangone
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We are growing🌱!! - meet new lab members Ines Delclaux (
@InesDelclaux
🇪🇸) and Sunny Son!!
#theLundLab
#Lymphatics
#melanoma
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@NYUGSOMimcg
in beautiful Napoli !
#melanoma
#MelBridge21
@JaniceM10
@drosmannyu
@DrKrogsgaard
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A long 2 weeks of amazing science across two different continents
#Lymphatics
@GordonConf
and
#SITC2022
@sitcancer
- awesome feedback, wonderful people, this is a pretty awesome job
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So proud of
@MadJChurchill
who defended her thesis today- traversing tissue sites, rare non-hematopoietic cells, and two labs.
@RauchLab
@theLundLab
@ohsummi
#LECs
#Tuftcells
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You haven’t passed your quals until you learn how to open a bottle of champagne 🍾 🍾Congrats to Tenny!!
#LundLab
… one down one to go ;)
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Modeling melanoma requires constant consideration of interrelated and complex processes from oncogenes to environmental exposures that evolve with time and therapeutic pressure - no one model is enough but all models are useful
@MelanomaReAlli
#melanoma
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An incredible evening celebrating our team and collaborators🥂🍾 lots more science to come!
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#LundLabLadies
love
#Lymphatics
everyday but especially on
#InternationalWomensDay
- proud to have the opportunity to work with each and every one of them (pictured and not!)
@MariaMSteele20
@H_du_Bois
@katie_ventre
@Triantafyllia14
@m_staffenson
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Moving your family and your lab from OR to NYC amidst a pandemic??...not ideal in case you were wondering :) I'll just be here stress eating cheetos until it's over
#theLundLab
#wevegotthis
#WashYourHands
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Looking forward to
#CICON22
today in NYC! If you're attending and on the postdoc market now or in the future and want to chat about what we are doing to explore lymphatic transport and lymph node biology in immunotherapy don't hesitate to find me!
@CancerResearch
@AACR
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Very thankful for this support and congrats to all the other grantees (especially my colleague Jeff Tyner of
@OHSUKnight
)!
#melanoma
#lymphatics
Introducing our 2020 Emerging Leader Award grantees! Read more about them here: CC:
@VanAllenLab
@theLundLab
@MarioSuva
@PittHealthSci
@DanaFarber
@MassGeneralNews
@OHSUNews
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Another 🔥 end of the summer presentation in the
#LundLab
from Lina (
@TuftsUniversity
) -
#lymphangiogenesis
#GCs
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#WFH
the scenery has changed but the work remains the same. Excited to be in NYC even in these trying times.
#theLundLab
@nyulangone
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Lund Lab Libations
#AnnualCelebration
@idryg
@H_du_Bois
@katie_ventre
@MariaMSteele20
@Triantafyllia14
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Not me having dinner @ SFO to not miss the UCONN game before speaking at
@Stanford
tomorrow
#Huskies
#CT
#lymphatics
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Conference all weekend so we pumpkin patch today 🎃 (after she joined
#theLundLab
weekly meeting of course)
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Excited to have two new
#WomeninSTEM
join the
#LundLab
#Lymphatics
team
@nyulangone
. Welcome Filio (
@Triantafyllia14
) and Alex!
#WomenInScienceDay2021
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#theLundlab
@ the
#Lymphatics
@GordonConf
rocking their presentations in Italy. Congrats to
@H_du_Bois
and
@tennymudianto
- well done! 🇮🇹
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Happy to officially welcome
@katie_ventre
as the newest member of the
#LundLab
@nyugrossman
@nyulangone
!!
#Lymphatics
#Melanoma
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Congrats to
@katie_ventre
who received a F30 award from the
@theNCI
for her work studying the innate barriers to LN metastasis in
#melanoma
!!
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A wonderful visit
@McGillSBMS
@McGillGCI
and my first snow of the season - thank you for the invite and an amazing day of science
@DanielaQuail
@King_Lab_McGill
@MandlLab
!
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Congrats to
@InesDelclaux
for successfully passing her qualifying exam today!!
#Tcellworld
#Lymphatics
#Melanoma
@nyugrossman
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Incredible imaging of the rerouting of lymphatic flows in vivo during inflammation 👏🏻
Tour-de-force by
@rafacze
,
@ZinselmeyerB
, Emma Erlich,
@EmilyJeanOnufer
, Mike Davis,
@ScallanLab
& our collaborators revealing that ileitis-associated TLOs arise at lymphatic valves and obstruct cellular/molecular outflow. Check out the intravital imaging!
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Can’t believe we said goodbye to
@LaneO714
today (for real). The 1st
#LundLab
grad student - feels like the biggest milestone yet. Can’t wait to see what you do Ryan! Good luck at
#Genentech
with
@TurleyLabGNE
... and ... go 49ers??
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Congrats to grad student Taylor Heim who's (first) first author paper is now available on bioRxiv
Ever wonder why CXCR6 is so ubiquitously expressed on TRM ?? we did too 👇
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Still so much to learn about how the lymphatic system and
#Lymph
(!) contribute to melanoma progression - congrats to
@j_ubellacker
and
@SJMorrison_
on this exciting work (
@nature
), it was a pleasure to highlight it with
@msmelanoma
for
@Cancer_Cell
Melanomas are champions at metastasis. In this
@Cancer_Cell
Spotlight,
@theLundLab
and I review exciting new results by
@SJMorrison_
lab (
@nature
) on how melanoma cells benefit from the lymph and discuss other protumorigenic roles of the lymphatic system
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That feeling when your 1.5 year old kicks you out of the office because she has things to do...”are you busy? Should I close the door?” “Oui, buh bye” 😂 here’s hoping she’s reviewing that manuscript for me🤞🏼
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The best science is somehow the best friendship
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So...We are recruiting! If you are interested in
#lymphatics
#tumorimmunology
#immunotherapy
#skin
#melanoma
or all of the above please contact me to learn about funded opportunities to join our team in Manhattan 🍎🚕🗽 for more info see . Please RT. 3/3
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Exactly this but for everything - if you think you're good...make yourself uncomfortable, test your limits, find your fail point...only that will make you better
Every young player in America needs to listen to this.
"If you want to be successful, you need to be bad, then you need to be good. Then when you're good, you need to fail. Then when you fail, you're going to figure it out... ”
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6K
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Check out this work that revealed conserved cancer cell states across solid tumors! Congrats to
@BarkleyDalia
,
@ItaiYanai
, and rest of the team including
@idryg
who worked hard to set CODEX up for us
@nyugrossman
@theLundLab
Paper is finally out in
@NatureGenet
! "Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment"
Check out our catalog of conserved cancer cell states defined by scRNA-Seq & ST. Congrats
@BarkleyDalia
!
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VEGF-C expression boosts vaccine immunity
#Lymphatics
💉 - Happy to have had the opportunity to highlight this work from my postdoctoral mentor Melody Swartz with
@WilsonLabVU
@ScienceAdvances
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We show that the peripheral lymphatic vasculature is a dynamic and active player in anti-tumor immune responses - loss of IFNgR On lymphatic vessels is sufficient to drive T cell dependent tumor control!!
#Lymphaticsmatter
#Stroma
#TME
#melanoma
@LaneO714
Lane et al. demonstrate that IFNγ-induced, nonhematopoietic PD-L1 suppresses anti-melanoma immunity and identify lymphatic vessels as key mediators of response
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Will be here all day 👇🏼 sharing the work we do on
#Lymphatics
!!
Hello world👋! I am Amanda Lund, Associate Professor
@Perlmutter_CC
@Nyulangonehealth
. I trained at
@RPI_Biology
Troy, NY and with
@Swartz
-lab
@EPFL_en
in Lausanne, Switzerland🇨🇭🧀 - started my lab
@OHSUSOM
in 2014, before moving to NYC.
@theLundLab
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We will probably never compare to the women who have blazed these trails before us, we can only hope to try. Dr. Werb catalysed generations of science to come and her impact will be with us for a long time. My sincere condolences to those who knew her best.
I am heartsick over the passing of Zena Werb. Lucky to have been taken under her wing. Tremendous loss to science and humankind. Fav photo from 2019 AACR Fellows induction.
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Using FTY720 to understand mechanisms of response to ICB ??👇🏼‼️ important work from Susan Schwab
@nyugrossman
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#immunologynyc
👯♀️
#WINNers
(women immunologist in New York)
@theLundLab
@DiehlLab_MSK
@LaughneyLab
@AgnelSfeir
@jeanklim
Susan Schwab Michelle k niro and many more!!!
#girls
club!!!!
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Eva Hernando is looking for a postdoc
@nyulangone
! Interested in melanoma metastasis and intratumoral heterogeneity? Great models, exciting questions, and fantastic mentor - plus we collaborate so fun all around!
Exciting post-doc opportunity available in the Hernando Lab ()!
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The
#LundLab
is excited to be at
#KSstromal
in Victoria, BC. Talks from the lab by grad student
@Madelin08824820
(Feb 19) and postdoc
@MariaMSteele20
(Feb 23) - lymphatic vessels regulating immunity from the 'beginning' to the 'end'!!
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@theLundLab
does NY Skin Club
@SBDRCatMtSinai
👏🏼👏🏼 !!!
#melanoma
#lymphnodes
#lymphatics
@H_du_Bois
@katie_ventre
@Triantafyllia14
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Enjoyed digging into the interesting data in the recent
@CellPressNews
paper from
@RetickerFlynn
with
@Triantafyllia14
and
@katie_ventre
for
@trendscancer
Check out our perspective 👉
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