Systematic Trading Fun 🇨🇭
@systematic_fun
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Zug, Switzerland
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@DaniBeckman
@limits_stop
@Marc_Veld
Marc Veldhoen has a history of aggressive and threatening behavior, particularly towards women.
Suggest you block as well and keep your distance.
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@LiamThorpECHO
A big part of your immune system (plasmacytoid dendritic cells) is missing after a COVID infection for at least 7 months - possibly for longer than that.
No surprise that an increasingly immunodeficient population is frequently sick.
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@keetmuise
We already know that COVID patients are missing dendritic cells in their blood, and that they are up-regulated and collecting in the gut: this is bad, as it is principal driver in the progression to AIDS after HIV.
But the damage to CD8+ cells is markedly worse than HIV… 1/
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@TheAtlarntic
@limits_stop
Whoever is behind this account is doing god’s work.
At the very least, thanks for all the laughs 🤣🤣🤣
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@1goodtern
A majority of the population appears to believe that we can change *physical* reality through sheer willpower.
As if everyone is under a spell after reading "The Secret".
Perhaps we are the last individuals on earth who have not been hypnotized by this belief? (😂)
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@BlakeMMurdoch
What's even wilder, as you know, is that only upgrading schools, hospitals and nursing homes is probably enough to reduce transmission by 80% nationally.
Add in public transport and shops, and you're probably looking at 90%+.
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@1goodtern
This is becoming more common.
Someone I know told me I needed to "lose the mask." I asked why they cared if I wore a mask or not?
"What makes you think you're so special that you don't have to get Covid like everybody else?"
This pandemic has weird layers to it. 😐
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@inkblue01
One paper hypothesized that the “bullet train” used by SARS-CoV-2 are infected dendritic cells which distribute the virus throughout the body via transfection.
This is exactly how HIV is quickly disseminated as well.
Perhaps why it was hard to see.
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@inkblue01
The reaction to Soon-Shiong is as if COVID is happening in some distant land of no consequence for most people.
I understand the need to think this way for mental health, but it’s completely destructive since denying reality causes worse harms down the road.
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@1goodtern
Yes, we see significant damage to CD8+ cells (responsible for cancer surveillance) following COVID, and to a far greater degree as compared to HIV.
One would expect cancer to accelerate as a result. Thread below:
@Ashtonica
@keetmuise
Need to find this study, but there was a great paper showing T-cell health following acute COVID and HIV.
COVID was worse for CD8s specifically (lower count, biomarkers showing exhaustion).
CD8s primarily do cancer surveillance - you are constantly fighting it off... 1/
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@1goodtern
Time is a cruel teacher, I just wonder how many infections are necessary before a majority figure out this is unsustainable.
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@idea_alchemist
The study relies on self-tests. The unmasked don’t test and thereby don’t get COVID (according to their “logic”).
It’s just denial.
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@MeetJess
This sounds a lot like what Novavax has today - a focus on S2 epitopes without which the virus cannot enter a cell.
If their presentation to the FDA over the summer was true, their vaccine is already blocking 80-90% of infections across all variants.
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@RPLerias
If you happen to have mouthwash that contains Cetylpyridinium chloride (CPC), both you and your wife should absolutely use that today.
I have more ideas for antiviral prophylaxis based on real studies if interested. Good luck!
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@RPLerias
The combination of missing immune cells, significant lung damage, and latent TB in the population (something like 20% of the population in the West is chronically infected) means we should absolutely expect TB to make a comeback.
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@DrMLivingston
I would go further, and suggest my point about missing pDCs is central to both diseases. There are serious consequences to constant immune activation in response to a viral reservoir.
@DeVerdadera1
After SARS-1, those who did not experience “long SARS” following the initial infection (debilitating fatigue, breathing difficulties, etc.) led normal lives.
Beyond the prospect of repeated infections, there is another aspect that makes SARS-2 worse than SARS-1.
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@1goodtern
Denial of harms caused by a pathogen appears to be part of human nature.
Following the 1918 pandemic, for example, many simply erased it out of memory and refused to discuss it or even accept that it happened.
COVID is much worse, because it's still happening!
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@fitterhappierAJ
And now comes the next sleight of hand: “immune dysregulation is not the same as immune deficiency. Stop comparing COVID to HIV.”
There is no arguing in good faith with these people. They will deny to the end.
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@keetmuise
…this opens up the possiblity that even treating COVID with lifelong antivirals (the way we treat HIV+) may be insufficient to preserve life expectancy.
That’s because this much CD8+ dysfunction would almost certainly cause the immune system to lose control of cancer. 2/end
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@VirginiaBuysse
Can you appreciate that someone who researched T-cell dysfunction in a cancer lab prior to the pandemic may have an insight into T-cell dysfunction following COVID?
In other words, he is drawing parallels from his previous work to the current pandemic?
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@1goodtern
I watch India very closely because they have reasonably good testing data (test positivity) and they have been infected more (large families living together).
UK/Western families aren't at their breaking point yet because they haven't experienced what India is going through.
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@Ashtonica
@keetmuise
Need to find this study, but there was a great paper showing T-cell health following acute COVID and HIV.
COVID was worse for CD8s specifically (lower count, biomarkers showing exhaustion).
CD8s primarily do cancer surveillance - you are constantly fighting it off... 1/
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@TristanVeness
It’s great that you are documenting and sharing your lymphocyte subset panel.
This data breaks the illusion that the disease is “like a cold” (so is HIV!).
For anyone not fully in denial, it raises their concerns.
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@DeVerdadera1
After SARS-1, those who did not experience “long SARS” following the initial infection (debilitating fatigue, breathing difficulties, etc.) led normal lives.
Beyond the prospect of repeated infections, there is another aspect that makes SARS-2 worse than SARS-1.
1/n
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@mrmickme
I think we can look at South Africa in the 1990s to predict what is coming.
Interesting anecdote: their life expectancy has been falling at a faster rate today as compared to the HIV outbreak in the 90s.
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@SalvMattera
Some combination of autoimmunity and viral persistence seems to define LC and becomes more likely the more times you are infected.
As I’ve told you before, the virus is very good at molecular mimicry, reshaping the immune system to attack itself.
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@SwaledaleMutton
@mocoband
@fitterhappierAJ
@AndrewEwing11
@DavidSteadson
Credentialism is a weak argument.
Since you cannot refute Leonardi’s scientific arguments, you resort to ad hominem instead. And you…run a mutton company.
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@SalvMattera
You might find this study quite interesting:
The specific changes in the microbiome map to specific symptoms. More importantly, this formula has shown remarkable rates of recovery in those already suffering from LC.
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@GayFabFourFan
A very painful way to go, and coming for many as lung function decreases significantly after each infection.
You may recall Bryan Johnson (live forever guy) lost 15% of his lungs despite all his supplements.
My condolences for your friends.
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@DeVerdadera1
Plasmacytoid dendritic cells (pDCs) are the “control tower” of the immune system, helping to activate all available cells during an infection. They also directly regulate the gut micro biome and the formation of new cells in the bone marrow.
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@fitterhappierAJ
Making these kinds of threats is a criminal offense in many countries, and has no place in civil society.
That such an individual claims to be in academic as an authority is especially appalling.
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@DcrInYYC
Since viral persistence is happening in an immune privileged site (the gut), combinatorial antivirals are probably are best bet for managing the disease.
Before this work can get started, however, we need to actually accept that viral persistence is happening.
@dbdugger
The clearest sign of viral persistence is elevated IgA production in those suffering from Long COVID, an attempt by the immune system to clear a viral reservoir.
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@DeVerdadera1
In SARS-1 a type of immune cell (plasmacytoid dendritic cells) fall dramatically during the acute infection, and then reconstitute after 7 weeks.
In SARS-2, a small study showed they were entirely missing 7 months following non-hospitalized (“mild”) infections. So what?
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@Ashtonica
@keetmuise
and cancer risks are already elevated following HIV, even if you are quick to start antivirals. This is simply because the initial infection causes CD8+ damage.
My point is that it's worse here with a single infection, let alone multiple. So cancer risks will very high. 2/end
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@MamaSitaa__
A German guy took 217 vaccines on behalf of others (vaccine certificate fraud). He was never infected (no antibodies against the physical virus, and no T-cell recognition either).
And he had a massive number of abs in his saliva. Probably the world’s only truly immune guy.
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@1goodtern
Oh dear, how I wish we could hit fast-forward to a future era where the reasonable majority accept the cumulative harms from repeated COVID infections.
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@mrmickme
This is why future vaccines, even if updated, are unlikely to block an infection. They may help in reducing the viral load/disease severity.
As William Haseltine, one of the world’s top HIV scientists has said, we need to focus on daily antivirals as prophylaxis instead.
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@1goodtern
Humans copy each other mindlessly when in extreme fear - it’s a common response across the animal kingdom.
The phenomenon very accurately predicts stock market crashes - as stocks will start behaving exactly the same, right before a huge bust when reality becomes unavoidable.
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@DeVerdadera1
If they are mostly missing and dysfunctional following a majority of mild COVID cases, this is quantifiable immunodeficiency. It also suggests a chronic bone marrow infection (where new pDCs are created), preventing pDC counts from rising.
But it’s worse than that.
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@DeVerdadera1
Dysfunctional pDCs are directly killing off CD4 cells. Over time, this leads to the progression from HIV to AIDS, and usually death.
Those with a chronic pDC deficiency (measurable via a test) are likely to be progressing towards this scenario.
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@HmpxvT
Dengue fever is exploding in every country where it is endemic.
We need to understand whether missing plasmacytoid dendritic cells (pDCs), which happens following COVID, is a contributing factor.
If so, we should expect this to be the new normal.
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@DeVerdadera1
We do not know what proportion have pDC deficiencies following an infection, but an initial study suggests it happened in the majority. Even if it occurs in only 5% of all infected individuals, the outcome will be catastrophic.
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@inkblue01
As I’ve written before, we have great data from both Novavax and the Cuban vaccine (corroborated by antibody data).
Such a shame we launched with mRNA vaccines.
@inkblue01
@Marc_Veld
Look at the data from the Cuban sub-unit protein vaccine. It's 85% protective against an infection! Now look at Japanese Novavax data, 70% protection against an infection over 12 months!
Rolling over and giving up is loser-think. Prophylaxis is feasible.
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@CoClarified
In 2023, very few are solely concerned about the survival rate following an acute infection.
You will eventually learn, through harsh reality, that there is a steep price to be paid from repeated infections.
And yes, I know you will deny repeated infections.
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@samchao_wang
@WalterDeemer
From Walter’s old tweets:
Breadth divergences can be and often are resolved in due time, but the longer they persist the more concerning they are.
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@DrMLivingston
Dr. Livingston - some studies suggest a significant decline in plasmacytoid dendritic cell counts following non-hospitalized (“mild”) COVID infections. As pDCs play a central role against RSV, this is a likely factor.
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@cojehp
Everyone assumes they will win the natural selection contest, until they get Long COVID.
I didn’t realize most human beings suffer from “god complex” until the pandemic.
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@DrJohnHhess
Dr. Hess - I would strongly suggest also taking a closer look at your patients plasmacytoid dendritic cell counts. There is now an available test from Mayo Clinic Labs:
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@LongCovidHell
Most unvaccinated folk have discovered a new way to blame the vaccine as victims of “vaccine shedding” 🤦♂️🤦♂️🤦♂️
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@inkblue01
I truly wish we were measuring dendritic cell counts. I am confident a significant portion of the population has deficiencies with serious repercussions coming down the line.
@RPLerias
@limits_stop
@RadCentrism
I really wish pDC health was easily measurable.
I have only found one such test in the US, and I'm confident we'd see a lot of defects if we measured pDC health on a big enough sample size.
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@DrNeilStone
Except that many scientific studies have already drawn these parallels.
For example, the fact that the virus uses the same pathway to infect T-cells (LFA-1) as HIV.
Or the fact that plasmacytoid dendritic cells make contact with the virus via the DC-SIGN receptor, like HIV.
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@DeVerdadera1
We think of AIDS as a disease that causes CD4+ cells to deplete, which is true.
We have only recently discovered that a chronic infection of the bone marrow causing dysfunctional pDCs (also seen following HIV) is the direct cause of CD4 death. This is because…
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@Ashtonica
@keetmuise
Yes, the science is clear. We cannot respond appropriately to these findings because of deep denial.
I’m watching India closely, they were ~60% infected in 2020. If I’m correct, we should start to see mass death in late 2024, which will ultimately be repeated everywhere else.
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@SalvMattera
Early data suggests higher levels of T-cell activation following a second infection, likely a contributor to worsening LC.
So your intuition here (“everyone gets LC eventually”) is probable correct. Here’s the source for the image:
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@Ashtonica
@keetmuise
pDCs (which I talk about endlessly) are almost entirely gone from the blood 7 months following a mild infection.
New ones that are created in the bone marrow are hyper-activated and some are sent directly to the gut, where they kill off T-cells (this is how AIDS progresses).
@DrJohnHhess
In other diseases with declining T-cell counts, there is a specific biomarker on plasmacytoid dendritic cells that causes this depletion.
We see the same activated biomarker following COVID, but it is unclear if most pDCs (expressing TRAIL) are being trafficked into the gut.
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@ShaneyWright
@Harvard2H
Yes evidence points to a chronic infection, with a reservoir in the gut, central nervous system and/or other immune privileged areas. Follow
@dbdugger
for more insights.
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@1goodtern
The data we desperately need is “what proportion have a chronic infection following the acute infection”, via a viral load test.
It is certainly larger than those who are only showing symptoms today.
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@drajm
@fitterhappierAJ
Debating Meaghan is a waste of time. She uses the same playbook as her bosses to discredit research:
- But pre-Omicron
- But unvaccinated
- But only for xx months after
- But actually immunocompromised means x
Anyone not in denial would see the immune dysfunction.
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@T_Brautigan
We knew this once we learned all the plasmacytoid dendritic cells (pDCs) disappeared following a mild infection.
Where did they go? Most likely migrated to infected tissue throughout the body.
What other disease does this? HIV.
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@laurieallee
If you grew up in LA when the first HIV+ individuals (mostly young gay men) started dying of AIDS and you remember the history, the parallels are impossible to ignore.
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@SalvMattera
One issue with the surveys: a majority now also claim that they’ve never had COVID - which is obviously wishful thinking and likely a trauma-based response.
It thereby follows (using this “logic”) that prevalence of LC is falling in surveys.
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@allstarcharts
Not a perma bear, but it’s because credit spreads don’t lead the market (despite the belief). They are a coincident indicator at best. Have backtested this extensively.
Market sectors (eg low beta vs. high beta) provides a much better and reliable lead.
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@Spotzzun
@DeVerdadera1
Here is the study specifically on missing pDCs following non-hospitalized SARS-2. Note missing pDCs in 100% of the cohort.
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@mnicoletos
HKMA aggregate balance down 10% in a week!
Down from ~$170B HKD last year. As you’ve said before, USDs fleeing China.
HKMA sold $1.153 and bought HKD 9.051 to defend the currency peg.
Aggregate Balance will reduce to HKD 57.164 billion
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@GidMK
Except that in both diseases we see dysregulated plasmacytoid dendritic cells (expressing TRAIL) being trafficked into the gut, and can see a comparable loss of pDCs in blood.
We do not know the long-term consequences, but can see many LC sufferers with declining CD4+ counts.
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@ENirenberg
@marcfavell
There are an endless number of studies showing immune system dysfunction following COVID.
It is of course much easier to protect one’s ego and deny reality instead of addressing the harsh truth.
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@JaclynMcCosker
Sorry to hear. You may know that you are much more likely to become infected in the two-week period following any vaccine.
This is the case for all vaccines, but of course COVID is ubiquitous year-round unlike other diseases!
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@MrRBourne
“Europe” also isn’t a country.
Switzerland is much richer than the United States across all key metrics and enjoys better health/healthcare, safety, and government.
It’s hard to group Switzerland and the UK together, although they are in the same region.
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@mrmickme
Agreed!
While SARS-CoV-2 doesn’t cause a degenerative disease to the same extent as HIV, repeated infections cause serious harms in the form of dysfunction across most immune cells and autoimmunity.
Once the herd is this weak, normal life breaks down entirely.
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@mrmickme
This specific trick used by the virus (reprogramming your immune cells after infecting the bone marrow) is also a clue for developing sterilizing vaccines.
If we can do the same with a vaccine, we’ll have immune cells resistant to infection, defeating the virus. 1/
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@Prof_J_Lawton
When people in deprived areas say they have LC, it means they are in a lot of pain and heavily restricted in what they can do.
This is a preview for what is coming for all of us until we learn to limit transmission.
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@interpretantion
Even if this is fake, I have a lot of sympathy for this view - although I would never want to be in prison of course.
Modern life is becoming too complex, and perhaps a simpler life is what many yearn for.
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@outbreakupdates
I genuinely wonder if lung function (following many rounds of COVID) has decayed to the point where ordinary bacteria are causing life-threatening pneumonia.
It could also be COVID itself, as well as immune dysfunction.
@mrmickme
,
@limits_stop
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@GabrielBauman
@MeetJess
I'm doing my best to make it happen :)
@SocialFuzzer
I got my Novavax booster three weeks ago btw, will test my antibodies next week (30 days following vaccination) and share my numbers with you.
I encourage you to beat me :)
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@Spotzzun
@DeVerdadera1
With all relevant references. Should have included this is the thread above.
@limits_stop
@RadCentrism
@RPLerias
An elegant study in humanized mice explains how pDCs (which produce the lion's share of interferon-alpha) are helpful at the outset of an HIV infection, but are harmful at the latter stages of an infection. In other words, they are both our friend and foe
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@dbdugger
FYI: “Anne Bhéreur, MD, a family doctor in Quebec who has long COVID, says even with her recent thinking problems, she aced one of the most widely used tests, the Montreal Cognitive Assessment, because it was designed for older people…with more advanced difficulties.”
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@fitterhappierAJ
Have you seen if T-cell memory also wanes for vaccine-acquired immunity?
A paper from Cell (La Jolla study) suggested waning in mRNA-vaccinated individuals, but very interestingly, showed an increase over time (a 6 month period) for those who received Novavax.
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@MarmotRespecter
Weird how they’ve found a persistent viral infection in ME/CFS and Long COVID sufferers.
Don’t let facts get in the way of your preferred narrative.
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@JamesThrot
So much pain and suffering is coming.
As the vast majority of children have not been vaccinated, who will they blame they find out their children are infertile?
1.I have sad news to share with LC community. My extra low Anti-Mullerian Hormone (0,1 ng/ml) +high FSH during follocular phase show - my gynecologist and my doctors told me so - that multiple
#sarscov2
infections have exhausted my eggs. It means I became almost total infertile👇🏼
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@DrJohnHhess
In other diseases with declining T-cell counts, there is a specific biomarker on plasmacytoid dendritic cells that causes this depletion.
We see the same activated biomarker following COVID, but it is unclear if most pDCs (expressing TRAIL) are being trafficked into the gut.
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@Talshumy1
@keetmuise
That’s what he’s being told by his scientific advisors (who deny the facts presented above, they are too painful to accept).
It is true that the acute disease is usually mild, but most of the harms are in the chronic infection (as you know) that happens over time.
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@dbdugger
The clearest sign of viral persistence is elevated IgA production in those suffering from Long COVID, an attempt by the immune system to clear a viral reservoir.
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@limits_stop
@RadCentrism
@RPLerias
We are now finding early indications (from autopsies of non-COVID deaths) that the bone marrow is chronically infected. It would not be unreasonable to assume that the progression towards AIDS is occurring in many.
Why is there no real effort spent on determining the source of spike persistence in
#longcovid
?
We already know an immuno-privileged site that harbors spike protein *months* after initial COVID infection = bone marrow
Why has no one identified the cell line in the marrow that
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@JamesThrot
I’d like to believe this, but I’ve seen most deny their poor health all the way to the end (ie death).
Only if they are completely hobbled by long Covid (ie bedridden) would they accept that they are now disabled.
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@maosbot
The culture will eventually be forced to change due to circumstances.
It already changed once in 2021 (for the worse), whereby we now accept both being infected and infecting others.
This doesn't work with a virus that causes immune deficiency, so we will have to change again.
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@crr7310
Do you mind sharing (roughly, no specifics necessary) where you are seeing this?
Seeing a small rise in cases here in Switzerland, but not a large wave yet.
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@GabrielBauman
The magic of Novavax requires at least 3 months (preferably more) between shots - this is how long it takes you to develop fully matured memory B-cell responses.
If you want pan-variant protection, there is no way out - this is my plan today.
@Emilitaa23
@SocialFuzzer
Novavax themselves are running a trial with 2x shots 5 months apart for those previously vaccinated with 2-3x mRNA.
This would strongly suggest it’s ok to wait - at the very least, this is Novavax’s own hypothesis.
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@inkblue01
This strongly corroborates the study we saw yesterday suggesting weak antibody responses upon a second COVID infection.
We may have lost vaccines entirely at this point. 🤯
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@Spotzzun
@DeVerdadera1
@Spotzzun
- FYI, some astute doctors now picking up on the implications of a chronic bone marrow infection
This is fascinating work. We need to acknowledge that clearly some individuals have persistent viral reservoirs AND if that includes the bone marrow in SOME with mild or moderate disease (yet to be proven but likely based on this study) that has profound implications.
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@1goodtern
German health minister (sorry not trying to be annoying).
But you are otherwise correct of course.
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@GrGuenter
Ein weiterer Zufall ist, dass sich das CD4/CD8-Verhältnis (eine bekannte Ursache für Autoimmunität) nach COVID ebenfalls umkehrt, und natürlich auch die CD4+-Zellen langsam abnehmen.
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@1goodtern
There are endless stories like the one below, and it's also being covered in the media. Unlike the West, Indian doctors/scientists are more willing to make the connection to COVID and not lockdown/vaccine harms (🙄)
@gil_e_liane
@EnemyInAState
Yes they are! I am trying to find a Covid aware paediatrician in my city at a reputed hospital for my child; I think most doctors are not acknowledging the immune damage Covid does so panic doesn’t set in among parents; but many doctors in my city (& other states seen on SM) are
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@sun_in_winter12
Researchers everywhere shocked that HIV drugs work on chronic SARS-2 infections and insist that there is absolutely no similarity between the two viruses!
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@Ashtonica
@keetmuise
AIDS deaths starts at year 4 following HIV in Africa (~80% survival rate). So you should see it in a huge country like India.
I am assuming at least a similar progression, and not accounting for multiple infections and worse CD8+ damage.
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@Emilitaa23
@SocialFuzzer
Novavax themselves are running a trial with 2x shots 5 months apart for those previously vaccinated with 2-3x mRNA.
This would strongly suggest it’s ok to wait - at the very least, this is Novavax’s own hypothesis.
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@ejustin46
A large proportion of the population, following multiple COVID infections, is missing plasmacytoid dendritic cells (pDCs) in their blood.
PDCs are the key immune cells in defending against diseases like COVID, dengue, RSV, Strep A and influenza (see a pattern)?
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@SalvMattera
The virus uses molecular mimicry to evade the immune system - in other words, it looks just like human proteins. More specifically: blood cells.
This causes your immune system to develop antibodies against itself and why you see heart issues/clotting.
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