Simanshu Dhirendra
@simanshu
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Group lead (Structural Biology) at NCI RAS Initiative @FredNatLab; RAS/RAF/PI3K structural biology and drug discovery
Frederick, MD
Joined April 2009
This work was led by Daniel Czyzyk and Wupeng Yan in the laboratory, in collaboration with RAS Initiative colleagues and researchers at Daiichi Sankyo.
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Our structural-guided insights contributed to the design of BBO-8520, a first-in-class dual inhibitor targeting both GTP-bound (ON) and GDP-bound (OFF) KRAS G12C. Excited to see this work now published in @CD_AACR! @FredNatLab @BridgeBioPharma
Now online in @CD_AACR: Discovery of BBO-8520, a First-in-Class Direct & Covalent Dual Inhibitor of GTP-Bound (ON) & GDP-Bound (OFF) KRAS G12C - by Anna Maciag, James Stice, Bin Wang, @frankpmccormick, Pedro Beltran, et al. @FredNatLab @BridgeBioPharma
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RT @castel_pau: Check out our latest review regarding the biology of RAS GTPase effectors! It was fun to write this with @AmMozzarelli and…
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The collaborative work was led by Lorenzo Finci, Mayukh Chakravarti, Gulcin Gulten, @dailyusbalius, @domespo and other members of the RAS initiative @FredNatLab
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Our latest study in @ScienceAdvances delves into KRAS4a, an overlooked splice variant, alongside KRAS4b. We uncover their unique structural and functional traits, emphasizing how HVR variations modulate interactions with PDEdelta, RAF, and PI3K. #KRAS4a
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In this issue, we review the SHOC2-MRAS-PP1C (SMP) complex assembly, the substitution of MRAS by the canonical RAS proteins, and explore potential therapeutic approaches for targeting the SMP complex in RAS/RAF-driven cancers and RASopathies.
Interested in #StructuralBiology & #transcription? Don't miss our latest issue! Check out our interview with Lori Passmore @lapassmore, Group Leader @MRC_LMB, as well as related Reviews & Original Articles. ➡️ It's all available now at #mRNA #transcriptome
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@arshukla @CellCellPress Congratulations, Arun and the entire team! Loved all the figures! Science is all about collaboration, and you have been able to do that across continents! Keep up the great work!👏👏
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RT @ktr_nakanishi: Happy to host @simanshu, an expert on RAS proteins @FredNatLab. His seminar is at 006 Psychology from 4:10 pm on 10/5 (T…
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In this work, we show that an allosteric network involving lysine 104 and switch-II domain residues is essential for KRAS oncogenic activity, offering potential targets for inhibiting this activated oncoprotein.
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