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Seb Walsh

@seb_walsh

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Public Heath Doctor and NIHR Doctoral Fellow researching population approaches to tackling dementia @CamPubHealth. Views own, retweets not endorsements.

Cambridge, England
Joined May 2012
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@seb_walsh
Seb Walsh
5 days
Population-level interventions like salt reduction programmes have an important role in protecting our 🧠 as we age, by reducing stroke and dementia risk from hypertension. And if done gradually, people don't notice the difference in taste!
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@seb_walsh
Seb Walsh
7 days
At some point we have to ask whether these sports, in which the aim is to punch someone else in the head enough times that they are no longer conscious, can continue to exist despite so much evidence that it can kill, and increase risk of dementia
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@seb_walsh
Seb Walsh
11 days
RT @pash22: 2/n ... Health System, Community-Based, or Usual Dementia Care for Persons With Dementia and Caregivers: The D-CARE Randomized…
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@seb_walsh
Seb Walsh
12 days
RT @ProfRobHoward: @pash22 @EmilyStearn @ajlees @dr_shibley @seb_walsh Disappointed that Emily didn’t print my offer to talk to anyone who…
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@seb_walsh
Seb Walsh
13 days
Worth reading from @kathy_y_liu on various re-hashings of v small treatment effects of AD MABs to persuade regulators of meaningfulness My heuristic: if it's debatable, it's probably not meaningful. If asserted through post-hoc re-framing, it's almost certainly not meaningful!
@ProfRobHoward
Robert Howard
15 days
Our new OA paper with @kathy_y_liu. Why we should be suspicious of claims to evaluate meaningful within-individual change from parallel-group trials of Alzheimer’s treatments. It’s a causal fraud!
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@seb_walsh
Seb Walsh
14 days
No ⬇️ in dementia incidence across MAPT and preDIVA despite some risk factor improvements We won't make big (any?) dents in dementia incidence, a complex syndrome for which risk develops across lifecourse, through individual lifestyle interventions
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@seb_walsh
Seb Walsh
18 days
More recent generations of older people are reaching old age with greater intrinsic capacity (in better knick). Something to be celebrated. But we also need to work out how to maintain these trends, and reduce inequalities within them, moving forwards
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@seb_walsh
Seb Walsh
21 days
So excited for this event on Population-Level Approaches to Dementia Risk Reduction (PLADRR) next month in NZ. Hybrid talks from Carol Brayne, me, and Etu Ma'u. Free! Link below! Join us! 🇳🇿 27th Feb 9:00 🇬🇧 26th Feb 20:00 🗽 26th Feb 15:00 @SusanneRoehr
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@seb_walsh
Seb Walsh
26 days
Very significant study in @NatureMedicine from the ARIC study team 42% lifetime risk of dementia for those aged 55. Much higher than previous estimates, which they attribute to better ascertainment and move diverse sample Median age of dementia 81, sex difs show only after 85
@NatureMedicine
Nature Medicine
28 days
A cohort study of over 15k U.S. adults found that 42% developed #dementia by age 95, with the highest risk in #APOE 𝜀4 carriers, women, and Black adults, and projected that around 1 million U.S. adults will develop dementia annually by 2060.
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@seb_walsh
Seb Walsh
26 days
Comparison of PAFs, PIFs, and national and subnational population-level policies, for dementia risk reduction in 🇮🇹. A tour de force of a paper from @SimoneSalemmeMD and colleagues
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@seb_walsh
Seb Walsh
27 days
@A_MacLullich @smead2 Yes. NCD has currency in public policy circles. But it’s often rooted in loss of economic productivity/premature mortality and the article is pushing for more inclusion of old age diseases
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@seb_walsh
Seb Walsh
28 days
@smead2 @A_MacLullich Perhaps we should distinguish “communicable dementia” from the other 99%, rather than losing the clarity of message?
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@seb_walsh
Seb Walsh
1 month
Objectively this would be very, very funny. If only the harm she caused when she *did* crash the economy wasn't so real
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@seb_walsh
Seb Walsh
1 month
Text message reminders with or without nudges, with or without chatbots, had no effect on adherence to chronic CVD meds. Nice trial showing that simple answers to complex problems don't work!
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@seb_walsh
Seb Walsh
1 month
A new review says yes... But this commentary might make you think again:
@EricTopol
Eric Topol
1 month
Is fluoride exposure associated with lower IQ scores in children? A new systematic review of 74 studies says yes. The accompanying editorial says it's time to reassess fluoride exposure @JAMAPediatrics
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@seb_walsh
Seb Walsh
2 months
What to do about towns in England? A very thoughtful longer read blog from @timleunig
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@seb_walsh
Seb Walsh
2 months
…but do they have raised p-tau 217?
@bmj_latest
The BMJ
2 months
Almost all leading large language models or “chatbots” show signs of mild cognitive impairment in tests used to spot early signs of dementia, finds study. The results also show “older” versions of chatbots tend to perform worse on the tests #Christmas BMJ
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@seb_walsh
Seb Walsh
2 months
RT @bmj_latest: Almost all leading large language models or “chatbots” show signs of mild cognitive impairment in tests used to spot early…
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@seb_walsh
Seb Walsh
2 months
Unpicking the relationship between hearing loss and dementia is complex. Good paper in Am J Epi from @matthias_klee @AnjaLeist and team
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