RT @SeBultmann: Pls RT: Together with the Bartke lab and @DefossezPierre from the CNRS/Université Diderot in Paris we have received funding…

@FrezzaLab Thank you, Christian!!

RT @MolecularCell: Online Now: Activation of automethylated PRC2 by dimerization on chromatin

RT @crc1430: Proud of our @crc1430 PhD students for their exciting talks and the engaging scientific discussions at this year's PhD symposi…

RT @ElenaRugarli: Come join us! #CRC1218, #CECAD. We study how mRNAs encoding mitochondrial proteins are regulated.

@ale_annibaldi81 @MolecularCell @paulvictorsauer Thank you very much, Ale 🙂

@EpiStrucStab Thanks, Robert!

@vercellino_ire @NogalesLab @MolecularCell @paulvictorsauer Thanks, Irene 🙂

@BJ_Greber Thank you, Basil!!

RT @NogalesLab: And our work on the activation of automethylated PRC2 by dimerization on chromatin has just been published in @MolecularCel…

Allosteric activation by dimerization adds another layer of complexity to the diverse ways in which PRC2 is able to integrate regulatory cues from its chromatin environment. It will take many more studies to fully understand the implications of this context dependent function!

However, the arrangement that we found is different in that one PRC2 complex serves as an allosteric activator for the other. As a substrate of its own methyltransferase activity, PRC2 auto-methylates a flexible loop (am-loop).

Here’s a brief summary of what we found: Using #cryoEM, we found the chromatin regulator complex PRC2 to form dimers on chromatin. PRC2 dimerization had been shown before, e.g. by Tom Cech, @KJArmache, Xin Liu (UT Southwestern), @vignesh_k757 labs

@MolecularCell @paulvictorsauer Wonderful collaboration with @NogalesLab first an foremost, but also invaluable work by @KarissaScience, @EpiStrucStab, Farnusch Kaschani and their groups, with support by @crc1430 and @CanTarNRW

@BJ_Greber Yes, and thanks Basil!!

@KurianLab Thank you, Leo!