Peter Davis
@peter_brit
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Pinned Tweet
#dcvax
$nwbo
#gbm
@MHRAgovuk
@NICEComms
@US_FDA
@YorkshireBTC
@OuthouseThought
@NBTStweets
@ourbrainbank
@brainstrust
@theIBTA
@NIHBrainTumor
@braintumourrsch
@NIH
@brainstrust_nth
@CancerResrch
Northwest Biotherapeutics, Inc is a clinical stage biotechnology company focused
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#dcvax
#allsolidtumors
$nwbo
#gbm
$nwbo Management buzzing with confidence...
"Have a great Holiday and enjoy the Release - which is only the beginning of what can potentially follow"
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#dcvax
#allsolidtumors
$nwbo
#gbm
In a nutshell...
I asked Microsoft's AI to provide the following response to the article by Ethan Chen, Alexander L Ling, David A Reardon, E Antonio Chiocca
Thank you for your question. I have analysed and commented on the article by Chen
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#dcvax
#allsolidtumors
$nwbo
#gbm
Great to see, congratulations Linda Liau winning the Charles B. Wilson Excellence Award 2023:
Established by the Brain Tumor Society in 2004, this award recognizes outstanding contributions of a clinician to the field of neuro-oncology.
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#dcvax
#allsolidtumors
$nwbo
#gbm
New
#nwbo
PR just released:-
Northwest Biotherapeutics Moves From Optimization of Flaskworks Prototype to Fabrication of GMP-Compliant Units For Installation, Validation and Final Testing Prior to Regulatory Certification
key development work
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#dcvax
#allsolidtumors
$nwbo
#gbm
Important to note:
Not only does Linda Liau present on both Friday and Saturday at the Texas Association of Neurological Surgeons (TANS) but is also listed as a KEYNOTE speaker at this event. Obviously Linda has something important to
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#dcvax
#allsolidtumors
$nwbo
#gbm
HEALING WITH A BRAIN TUMOR
13 Dec 2023 — "Without a doubt, I needed a top-notch medical team, and I found one led by Linda Liau, MD. PhD, a neurosurgeon and neuroscience expert Dr. Liau is one of the top 1% of neurosurgeons in this country as
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#dcvax
#allsolidtumors
$nwbo
#gbm
The full text of preprint article currently awaiting peer-review with 'Nature' journal:-
Dendritic Cell Vaccination in Conjunction with a TLR Agonist Polarizes Interferon Immune Responses in Malignant Glioma Patients
Posted Date: September
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#dcvax
$nwbo
#gbm
Excellent post by
@d_stock07734
Dr. Pawel Kalinski had $14.5M grant from NCI. According to the article, OmniSeq Inc is the company which will conduct molecular testing. The interesting part is that OmniSeq was acquired by a company
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#dcvax
#allsolidtumors
$nwbo
#gbm
Professor Keyoumars Ashkan:
"The next stage is to get the drug approved. In the UK, things are a little bit simpler and we have got a very efficient way of approval so that is good news and we are trying to get the drug approved, first in
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#dcvax
#allsolidtumors
$nwbo
Evidence is building about the combo trial with Merck
First there was those trying to spread fear, uncertainty and doubt saying it was not DCVax, now we have proof that it is DCVax being used....
"Now we have 2nd slide that says UCLA combination
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#dcvax
#allsolidtumors
$nwbo
#gbm
$dcvax being the first to be designated 'Promising Innovative medicine' in the UK and being granted 'Orphan' status for the treatment of
#gbm
with DCVax®-L in both the US and EU comes with with very useful benefits to assist
#nwbo
with it's
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#dcvax
#allsolidtumors
$nwbo
A few initial finds on the 10Q
The Company is now in the final stages of preparing an application for regulatory approval of DCVax-L.
The Company and Advent are working together to prepare for potential commercial operations. The buildout of Phase
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#dcvax
$nwbo
#gbm
@TheLancet
Safe and effective cancer care: how long must we wait?
The Lancet Oncology
Published:March, 2024
DCVax® - personalized immune therapies for solid tumor cancers.
DCVax® - "The benign safety profile observed can enable treatment of patients
Safe and effective cancer care: how long must we wait? - The Lancet Oncology
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#dcvax
$nwbo
#gbm
EndBrainCancer Initiative
@EndBrainCancer
The End Brain Cancer Initiative (EBCI) is advocating for FDA approval of DCVax-L, a novel treatment for Glioblastoma (GBM) brain tumors, in anticipation of submittal of the application for FDA approval by
#NorthwestBio
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#dcvax
#allsolidtumors
$nwbo
#gbm
Wow... the first 20 pages detail $nwbo's catalogue of worldwide patents, I say again 20 pages! It is truly a fascinating insight and further indication of the company's potential. Applications to the four Regulators where the P3 trial took
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#dcvax
$nwbo
#gbm
Excellent post by
@ATLnsider
Thanks ae kusterer, one thing that a lot of NWBO longs are failing to grasp or understand, is that now when Dr. Linda Liau speaks about DCVax-L (DC Vaccine) alone, she actually means DCVax-L along with poly-ICLC.
This is because
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#dcvax
#allsolidtumors
$nwbo
#gbm
Excellent find by Lykiri
Penn Cancer CME Event
Neuro-Oncology Brain Tumors Symposium 2024
FRIDAY, JANUARY 26, 2024
11:20 am – Overcoming Barriers to Extend Survival: Promising results of clinical trials for glioblastoma
Interesting that
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#dcvax
$nwbo
#gbm
I find it interesting UCLA have chosen now to post details of this with the article being published Sep 1 2023. At a time when we are expecting significant news on
#dcvax
#gbm
treatments including imminent MHRA approval, nature peer-review article on poly-iclc
In this article, Drs. Robert Prins, Won Kim
@inspired_brain
, Linda Liau, Richard Everson, & colleagues identified distinct alterations in the immune landscapes of the tumor microenvironments in
#metastatic
brain cancer & recurrent
#glioblastoma
. Read more:
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#dcvax
#allsolidtumors
$nwbo
#gbm
And with the newly confirmed DCVax® Trademark update November 10, 2023 comes this impressive list stated as 'Goods or Services'
Immune cells, namely cells for medical or veterinary use; Biotechnology preparations for the prevention,
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#dcvax
$nwbo
#gbm
I find it hilarious that
@adamfeuerstein
is reduced to posting about potential of a short squeeze and dilutions. Of course he is running out of anything credible to say against $nwbo.
The P3 results were peer-reviewed and published in JAMA
The recent
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#dcvax
#allsolidtumors
$nwbo
#gbm
Important to note that in the MHRA update provided by
@HenryMuney
the attached letter from MHRA states the following:-
Concerns on potential long term safety and efficacy issues in relation to paediatric use = NO
A particularly important
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#dcvax
#allsolidtumors
$nwbo
#gbm
@theIBTA
Nice to see IBTA reporting $nwbo's excellent news.
International Brain Tumor Alliance:
"Northwest Biotherapeutics has announced that a Marketing Authorization Application (MAA) has now been submitted to the Medicines and Healthcare
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#dcvax
#allsolidtumors
$nwbo
Linda Liau pressentation slide:
DC Vaccination (DCVax)+ TLR-3 agonist (poly-ICLC enhances pro-inflammatory immune response and correlated with extended survival.
Dr Liau's comments:-
1."Even more interesting".....
2."Actually the patients lived
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#dcvax
#allsolidtumors
$nwbo
#gbm
Another reason to be cheerful 😆It has been well documented that $nwbo was the first drug to be awarded the UK’s ‘Promising Innovative Medicine’ (PIM) designation however, I have not seen mention of another important and positive
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#dcvax
#allsolidtumors
$nwbo
#gbm
Excellent post by
@d_stock07734
IMO, what will happen to NWBO this year is going to make all these acquisitions like sideline story.
Ask yourself why high-caliber scientists from NCI did genetic profiling analysis for p3 trial from NWBO. Has
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@d_stock07734
#dcvax
$nwbo
#gbm
This recommendation by King's college hospital spells it out clearly...
Roadmap to developing and delivering world-class research 2024-2026 - King's college hospital NHS
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#dcvax
#allsolidtumors
$nwbo
#gbm
Sentiment Stocks
@sentimentstock
"Gotta love the judge's statement near the end, Judge Stein: “..if you have a GAZILLION... canceled orders & a GROSS imbalance in the sell side vs the buy side on the book ... it seems like you could infer
@sentimentstock
@CohenMilstein
that was one of my favorite parts - and the fact that it came at the end shows where the judge's head was at the end of this hearing
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#dcvax
#allsolidtumors
$nwbo
#gbm
Excellent post by
@ATLnsider
ATLnsider
As NWBO shareholders, we’re living in interesting and exciting times. I believe 2024 will usher in a lot of new positive developments for NWBio and its future partners.
I am looking forward to future
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#dcvax
#allsolidtumors
$nwbo
#gbm
The neurosurgeon who was inspired by her own mother's cancer journey - Linda Liau
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#dcvax
#allsolidtumors
$nwbo
#gbm
From $nwbo's e-mail notification:-
"as we manage multiple pathways in the next phase of our strategic plan"
We are pleased to send you our most recent release from this morning, announcing a key addition to Northwest Biotherapeutic's
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#dcvax
$nwbo
#gbm
Nature too... there seems to be a concerted effort to promote the use of cancer vaccines...
nature
@Nature
1h
"After decades of slow progress, therapeutic vaccines that direct the immune system to attack tumours could soon become a fixture of cancer
After decades of slow progress, therapeutic vaccines that direct the immune system to attack tumours could soon become a fixture of cancer treatment
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#dcvax
#allsolidtumors
$nwbo
As we await submission of MHRA License application let us remind ourselves of three huge positives we have supporting the peer-reviewed results:-
1. DCVax was the first drug to be designated by UK Authorities as a " Promising Innovative Medicine
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#dcvax
#allsolidtumors
$nwbo
#gbm
Another one of Linda Liau's patients surviving 8 year+
Lovely story.
"He said my tumor looked like it had gotten so big so fast that it was probably fatal and I wouldn’t have many years left to live. ASSHOLE is no longer my oncologist and
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#dcvax
$nwbo
#gbm
Dr. Thomas Ichim is not just some casual observer who likes DCVax technology. Look at his profile below, when he says "$nwbo is a game changer" this is from somebody who seriously 'knows his stuff' 🤔
$nwbo is a game changer that must be supported…decades of
@KryptyPop
@Boomchrisy
Right on Right on my friend
$nwbo is a game changer that must be supported…decades of tumor
#immunology
transformed into a cure
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#dcvax
#allsolidtumors
$nwbo
#gbm
JOURNAL ARTICLE
CTIM-15. T CELL RESPONSE DYNAMICS IN PHASE 3 GLIOBLASTOMA PATIENTS IMMUNIZED WITH AUTOLOGOUS DENDRITIC CELLS PULSED WITH AUTOLOGOUS TUMOR CELL LYSATE Get access Arrow
Marnix Bosch, Linda Liau, Keyoumars Ashkan
Neuro-Oncology,
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#dcvax
#allsolidtumors
$nwbo
#gbm
Another excellent post by
@d_stock07734
"It blows my mind any time I take a look at the measures they adopted for the combo trial. All these indices are correlated to PFS and OS. It strikes me that the current trial is pilot one in a sense
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#dcvax
$nwbo
#gbm
@GovCanHealth
@braincancercan
"First Canadian to get a life-extending brain cancer treatment administered in Canada, even though it’s not yet approved" (DCVax)
The federal government estimates that on average 27 people a day in this country are diagnosed with
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#dcvax
#allsolidtumors
$nwbo
#gbm
Excellent post by
@d_stock07734
with further related information from
@FlemmingBruce
I believe the inclusion of Murcidencel (AKA - DCVax) to the high cost drugs list proposed for 2024/2025 to be significant as it shows consideration for
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#dcvax
#allsolidtumors
$nwbo
Dr Linda Liau is a KEYNOTE speaker at the 2024 Annual Conference of TANS (Texas Association of Neurological Surgeons) February 2-4, 2024
No further details at present!
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$NWBO
#DCVAX
People like
@Dougielarge
and
#CitadelScandal
are keeping cancer treatment from people like this and they are doing it ILLEGALLY. See the current litigation where the illegal spoofing is not even denied by the defendants.
@SECGov
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#dcvax
#allsolidtumors
$nwbo
#gbm
#TissueAgnostic
#PrecisionMedicine
Excellent post by Chiugray
@ATLnsider
, That is a great DD find!
A DCVax-L approval in stage 3 malignant gliomas would double the market size over GBM alone.
And we are talking about the new SOC therapy.
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#dcvax
#allsolidtumors
$nwbo
#gbm
Another Merck 'KEYTRUDA' phase 3 fails.
It is becoming very clear what KEYTRUDA needs to enhance efficacy and safety..... DCVax®
Note- Head and neck squamous cell carcinoma (HNSCC) is a type of solid tumor
DCVax®-L is designed to cover all
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#dcvax
#allsolidtumors
$nwbo
#gbm
Linda Liau presenting on the following times/dates:-
Friday, February 2, 2024
10:50 a.m. – 11:20 a.m.
'Immunotherapy for the Treatment of Glioblastoma'
Linda M. Liau, MD
11:20 a.m. – 11:30 a.m.
Q&A
Linda M. Liau, MD
Saturday, February
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#dcvax
#allsolidtumors
#nwbo
Interesting choice of language... "Awaiting FDA approval" would suggest approval request already submitted ??
"Northwest Bio, which has a proven, groundbreaking cancer vaccine awaiting FDA approval" - Laura Posner
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#dcvax
#allsolidtumors
$nwbo
#gbm
Therapeutic cancer vaccines: advancements, challenges, and prospect
13 December 2023
"These results from the phase 3 clinical trial offer a newfound sense of hope for the treatment of patients with glioblastoma"
In a recent phase 3 clinical
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