Dr. Om Lakhani, MD, DNB (ENDO)
@omlakhani
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Endocrinologist & Technocrinologist. The Medical IndieHacker. Creator of Notes in Endocrinology, https://t.co/QdCZDCgj4b and many many more to come
Ahmedabad, India
Joined October 2009
Hello everyone For those who missed the Part 2 of the LIPAGLYN MASLD PRO 2025 here is the link to the video: These are the topics we discussed : 1. How does a patient with MASLD present to you in clinical practice ? 2. Should you actively screen or search for MASLD ? 3. The interpretation of liver function tests in MASLD. 4. My patient has MASLD , what are the next steps ? (Deep dive into non-invasive biomarkers like Fib-4 score for MASLD). We have shared some useful tools which you can use in your clinical practice like the AASLD Diagnostic tool, Fib-4 calculator, FAST score calculator, etc. If not done already, please also sign up on our platform to get access to all the previous lectures, notes on the current lectures, and tools and applications : Part 3 is coming up next week Thanks and regards, Dr. Om J Lakhani
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What Causes Gestational Diabetes During Pregnancy? Author: Dr. Om J Lakhani Date Created: February 2025 🎥 Video Lecture: Watch to Learn More: 🤰 Understanding Gestational Diabetes What is Gestational Diabetes? A type of diabetes that develops during pregnancy in women without prior diabetes. Caused by the body's inability to produce enough insulin to meet pregnancy's increased demands. Why Does Pregnancy Affect Blood Sugar? Pregnancy naturally increases insulin resistance to fuel the baby. The pancreas typically compensates by producing more insulin. When this compensation fails, gestational diabetes develops. 🔬 What Happens in Your Body During Pregnancy? Increased Insulin Resistance: Body becomes 2–3 times more resistant to insulin. Higher Glucose Production: Pancreas produces about 30% more glucose. Hormonal Changes: Hormones like human placental lactogen (HPL) increase insulin resistance. 👩‍⚕️ Who is More Likely to Develop It? Women with poor pancreatic beta cell reserve. Those who are obese before pregnancy. Individuals with a family history of diabetes. Why Do Some Women Develop It While Others Don’t? Pregnancy acts as a "stress test" for the pancreas. Women with limited insulin-producing capacity before pregnancy are more likely to develop gestational diabetes. 📉 Short-Term Effects of Gestational Diabetes For the Mother: High blood sugar levels. Increased risk of complications like preeclampsia. Need for blood sugar monitoring and management. For the Baby: Risk of growing larger than normal (macrosomia). Higher chances of delivery complications. Elevated insulin levels in the baby's blood. 🩺 Long-Term Implications For the Mother: Increased risk of type 2 diabetes later in life. Necessity for regular diabetes screening post-pregnancy. For the Baby: Higher risk of childhood obesity. Increased likelihood of developing type 2 diabetes in adulthood. ✅ Key Takeaways Gestational diabetes occurs when your body can't produce enough insulin during pregnancy. It acts as a "stress test" for your pancreas, revealing pre-existing limitations in insulin production. While it resolves after pregnancy, it signals a higher risk of future diabetes for both mother and child. Regular monitoring and proper management are essential during and after pregnancy. 👩‍⚕️ What Can You Do? Attend all prenatal check-ups and screenings. Get tested for gestational diabetes between 24–28 weeks of pregnancy. Follow your doctor’s advice if diagnosed. Maintain a healthy lifestyle during pregnancy. Monitor your diabetes risk post-pregnancy with regular check-ups. Remember, gestational diabetes is manageable with proper care and understanding!
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Good morning everyone. A gentle reminder to join us for the Part 2 of the LIPAGLYN MASLD PRO 2025 at 8:30 p.m. tonight (11-February-25). These are the topics we will be discussing tonight : 1. How does a patient with MASLD present to you in clinical practice ? 2. Should you actively screen or search for MASLD ? 2. The interpretation of liver function tests in MASLD. 3. My patient has MASLD , what are the next steps ? (Deep dive into non-invasive biomarkers like Fib-4 score for MASLD). Along with this, we will be sharing useful tools which you can use in your clinical practice like the AASLD Diagnostic tool, Fib-4 calculator, FAST score calculator, etc. Please join for the lecture at 8:30 p.m . If you have signed up for the first lecture, you will receive the link automatically from Zoom. If not, you can view the lecture on our Endocrinology India YouTube channel: If not done already, please also sign up on our platform to get access to all the previous lectures, notes on the current lectures, and tools and applications : Thanks and regards, Dr. Om J Lakhani
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Excellent post
#MedTwitter
#anatest For doctors confused on Ana testing 👇 ANA Testing in Rheumatology: Methods & Interpretation (case based) 1/ 📢 Let’s demystify ANA (anti-nuclear antibody) testing in rheumatology! A positive ANA test doesn’t always mean you have an autoimmune disease, and a negative result doesn’t always rule one out. Context is everything. 🩺💡 2/ Case 1: •34 y/o male, chronic back pain, HLA-B27 negative. •ANA 3+ positive (IFA), dense fine speckled (DFS) pattern. •ANA Blot: DFS+++ & Ku++. •Diagnosis? No CTD (connective tissue disease). Pain management, exercises, and mindfulness helped. 3/ Case 2: •24 y/o female, fever, rash, weight loss, oral ulcers, severe hair loss. •Initial ANA negative. •Strong SLE suspicion. Repeat ANA positive, low C3/C4, severe myositis. •Final diagnosis: SLE, even though ANA blot/profile was negative! 4/ 🔬 ANA Testing Methods: •ELISA: Not standardized. May miss nuclear antigens. Not recommended. •Immunofluorescence (IFA): Gold standard! Measures intensity (1+, 2+, 3+, 4+) and titer (e.g., 1:160). 5/ 💡 ANA pattern matters! Examples: •Homogeneous: Think SLE or drug-induced lupus. •Speckled: Common in Sjögren’s, SLE, or dermatomyositis. •Centromere: Strongly linked to systemic sclerosis. But patterns are observer-dependent and not always diagnostic. 6/ 🤔 What about ANA blot/ENA profile? •Detects antibodies to specific nuclear antigens (e.g., Ro, Sm, dsDNA). •Important for SLE and other CTDs. •But a patient can have a positive ANA and negative ENA or blot, or vice versa! 7/ Key Lessons: •Positive ANA ≠disease. 30% of healthy people can have positive results. •Negative ANA doesn’t rule out all CTDs (e.g., Sjögren’s, myositis). •Always correlate clinically: Look for multiple signs (rash, ulcers, serology). 8/ Clinical tips: •Avoid over-relying on ANA alone. Combine with ESR, CRP, LFTs, CBC, urinalysis, etc. •Use IFA, not ELISA, for ANA testing. •ANA positivity often guides, but doesn’t confirm, the diagnosis. 9/ 🚨 Remember: Rheumatology doesn’t have rigid diagnostic criteria, just classification criteria. Clinical judgment is key. Consult a specialist when in doubt! 10/ Wrapping up: ANA is a surrogate marker. It’s a tool, not the answer. A holistic approach, combining history, physical exams, and labs, is crucial. 🩺✨ Thoughts? Questions? Drop them below! 👇 #Rheumatology #ANA #AutoimmuneDisease
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It was a weekend well spent learning something new from the best in the business (@IIMAhmedabad ), and making new friends, and connections.
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Good morning everyone, We are launching the first Chapter of the LIPAGLYN MASLD PRO 2025 starting at 8.30 pm tonight (4th Feb 2024). Happy to say that we have more than 2000 registrations (2336 to be exact) ! The people who have registered will receive an email from Zoom regarding instructions to join the zoom webinar with a link for the same. It is recommended that you join early. If you have not registered this will be the time to do so We are anticipating more people than we had originally expected; some of you may not be able to join via the Zoom webinar. If you are not able to join the Zoom webinar, the talk will be live-streamed on our YouTube channel Endocrinology India. Here is the link to the channel: In case you miss the lecture entirely, it will be uploaded in a day or two on the same channel as well as uploaded on the course page. This reminds me, if you have not done so already, this will be a good time also to join the system. All the notes, mini-applications, quiz, presentations and videos will be available on the system: We have already uploaded the content for the first chapter and you can review it ASAP. Looking forward to seeing you at 8.30 pm tonight. Regards, Dr. Om J Lakhani
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@realDonaldTrump has completely crazy THIS is the time for India to be a superpower He is concentrating on picking a fight with Canada, Europe, Mexico and China We have gone under his radar. If we play our cards right, this is a great opportunity for us to rapidly ascend in the global economy
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For example if you are govt employee and your salary is 12.75 lakhs pa - zero tax (75k is std deduction) If you are a practicing lawyer and earn 11.9 lakhs pa as professional fees- you pay 10 percent tax
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Take charge of your health! 🌟 On Jan 30, join us for a series of #TOIMedithon expert sessions on how to live well with #diabetes. #diabetescare Know more:
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RT @CMEINDIA1: @omlakhani The much-awaited lecture, notes, presentation & mini-app on Diabetes Remission (it is not "Diabetes reversal").…
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Corrected link
4. Mini-App & Tool:
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