NefzgerLab 🦋 @nefzgerlab.bsky.social
@nefzgerc
Followers
387
Following
722
Statuses
77
Cell identity/transcription factors/Aging/Maturation - Group Leader @IMBatUQ at the University of Queensland.
Brisbane, QLD, Australia
Joined October 2011
Our new @Cell_Metabolism study proposes a mechanistic connection between molecular remodelling in development & aging. We uncovered a common transcription factor pattern linked to chromatin remodelling in organismal maturation & aging. Link Thread 🧵👇1/10
7
44
113
RT @SamStehbens: Say whaaat!?? 👇👇👇ever wanted to visit Australia & see great science?? ‘We are excited to announce that the next Hunter Me…
0
12
0
🙏 to Manuel Serrano for writing a preview 👉 for our study NOW IN PRINT @Cell_Metabolism. We introduce the "Stimulus-Induced Programming Hijacks Ontogeny" (SIPHON) model for chromatin & transcriptome remodeling in organismal maturation & aging We provide compelling data that “cell identity loss” in aging represents the hijacking of a developmental mechanism via epigenetic de-repression of AP-1 rich regulatory elements through stress/stimulus processes. The resulting predictable transcription factor network changes may drive many aging phenotypes. Link to our study 👉 It was an absolute pleasure to work with @Cell_Metabolism & @AmberMuellerPhD The project spanned 15 labs and was led by talented co-first authors @rjPatrick19 & @MarinaNaval, with crucial contributions from @nikkideshpande, Yifei Huang @Jason836452, Jingyu Zhang @IAMorlandozhang, Xiaoli Chen, Ying Yang @haokandeyy, @Mohammad_E1990, Kanupriya Tiwari, Minh Tran, @AMohamed85, Binxu Wang, Di Xia, Jun Ma, Jacqueline Bayliss, Kahlia Wong, Michael Hun, @Sallyxsun, Benjamin Cao, Denny Cottle, Tara Catterall, Hila Barzilai-Tutsch, @robinleetroskie, @ZhianAnthony, Andrea F. Wise, Ye Mon Soe, Snehlata Kumari @Sne_K, @TheSweetGroup, Helen Thomas, Ian Smyth, Anne Fletcher @ImmunologyMelb, Konstantin Knoblich, @MattWattUnimelb, Majid Alhomrani, @WalaaAlsanie, @DrQuinn4realz, @Tobias_Merson, Ann Chidgey, @SharonRicardo1, @YUmmunology, @JardeThierry, @SethCheetham, Christophe Marcelle, Susan Nilsson, @Quan_Nguyen_UQ & @MelanieDWhite
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
3
19
42
RT @agingdoc1: The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening ht…
0
2
0
0
0
1
@jpsenescence @prof_horvath @Cell_Metabolism @StemCellsAus @AusStemCell @IMBatUQ @ARMI_Labs @AEpiA @ANZSCDB @reNEW_Global @AgingBiology @humanageing @CellPressNews Thanks for the kind words, João :)
0
0
1
RT @LongevityTech: Master controller of aging and development uncovered New insights into transcription factors and chromatin remodeling re…
0
5
0
RT @jpsenescence: Very cool multi-omic analysis of development and aging across >45 mouse and human cell types. They find a transcription…
0
18
0
The study was big collaborative effort LED BY talented co-first authors @rjPatrick19 & @MarinaNaval, with CRUCIAL CONTRIBUTIONS from @nikkideshpande, Yifei Huang @Jason836452, Jingyu Zhang @IAMorlandozhang, Xiaoli Chen, Ying Yang @haokandeyy, @Mohammad_E1990, Kanupriya Tiwari, Minh Tran, @AMohamed85, Binxu Wang, @dixia2018, Jun Ma, Jacqueline Bayliss, Kahlia Wong, Michael Hun, @Sallyxsun, Benjamin Cao, Denny Cottle, Tara Catterall, Hila Barzilai-Tutsch, @robinleetroskie @ZhianAnthony, Andrea F. Wise, Ye Mon Soe, Snehlata Kumari @Sne_K, @TheSweetGroup, Helen Thomas, Ian Smyth, Anne Fletcher @ImmunologyMelb, Konstantin Knoblich @MattWattUnimelb, Majid Alhomrani, @WalaaAlsanie, @DrQuinn4realz, @Tobias_Merson, Ann Chidgey, @SharonRicardo1, @YUmmunology, @JardeThierry, @SethCheetham, Christophe Marcelle, Susan Nilsson, @Quan_Nguyen_UQ & @MelanieDWhite
0
4
15
@Quan_Nguyen_UQ @MarinaNaval Thanks a lot Quan for your help and contributions to the project :)
0
0
1