Bob the Grumpy Med Chemist @med_chemist profile

Bob the Grumpy Med Chemist

@med_chemist

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Jaded. Let me know when one of you figures out how the human body works.

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Joined May 2021

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Bob the Grumpy Med Chemist

@med_chemist

3 months

@raffcolo @ducholab @KRHornberger Indeed! I've always thought that this must really irk professors who spend a lot of time teaching 1st year chemistry undergrads significant figures, and then turn around to read the literature full of grad students and PhDs constantly butchering the rules

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Bob the Grumpy Med Chemist

@med_chemist

6 months

@BagPhos I'll take his scorecard though!

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Bob the Grumpy Med Chemist

@med_chemist

6 months

@BagPhos Could you please clarify how I obtain the solvent named "obvious to those skilled in the art" :)

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Bob the Grumpy Med Chemist

@med_chemist

6 months

@KRHornberger has several useful past posts on the relevant kinetics here, if helpful.

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Bob the Grumpy Med Chemist

@med_chemist

7 months

I've previously collected similar articles with useful warnings and tips about methods such as scavenger reagents. See them by following the linked threaded tweets

Bob the Grumpy Med Chemist

@med_chemist

3 years

Glad there is room for papers like this to be published. I hope there will be some follow up on the original ACS Med. Chem. Lett. paper on the supposed probe. Some other references on metal impurities linked below, if useful.

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Bob the Grumpy Med Chemist

@med_chemist

9 months

@MoleculesGoHard Just needed to get out and see the world for a bit :)

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Bob the Grumpy Med Chemist

@med_chemist

9 months

@AdamQuic Happy to. @KRHornberger has provided some great resources around PK reporting, such as the thread below Regarding the nature paper, the issues are unfortunately beyond lack of data, and show a misunderstanding of the usual meaning of the parameters.

Keith Hornberger

@KRHornberger

4 years

🧵PSA: we need to chat about pharmacokinetics & pubs. If you plan to publish in vivo PD/efficacy studies, the minimum credible accompanying PK package is an IV leg + an IP/PO leg if that's your eventual route. In the same species, preferably at the planned efficacy dose. 1/

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Bob the Grumpy Med Chemist

@med_chemist

9 months

@BagPhos @KRHornberger Missed the chaos of this twitter thing a bit too

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Bob the Grumpy Med Chemist

@med_chemist

9 months

@jsrosenblum Guilty!

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Bob the Grumpy Med Chemist

@med_chemist

9 months

@KRHornberger Clearly you need to keep spreading the good word on proper PK reporting :)

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Bob the Grumpy Med Chemist

@med_chemist

9 months

@thederzzz @KRHornberger Regarding the paper with the odd PK table in my original post, some of the parameters mentioned do not match their usual definitions.

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Bob the Grumpy Med Chemist

@med_chemist

9 months

On the other hand, the efficacy data for antibiotics does mitigate the risk of mischaracterization a bit. Paws up / paws down is a pretty clear endpoint!

Bob the Grumpy Med Chemist

@med_chemist

3 years

I propose a solution to 2 problems: - Lack of novel antibiotics - Abundance of terrible in vivo efficacy studies Solution: If you publish a bad efficacy study, you must instead work on antibiotics development, where output of animal model is much clearer... paws up / paws down

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Bob the Grumpy Med Chemist

@med_chemist

2 years

@VRBoombatzMDPhD @KRHornberger @D_B_McConnell @agwaterson Right, fair point that it’s definitely a simplification, but at least clarifies that you can’t win the game simply by moving the PK curve higher and higher, and brings the idea of a therapeutic window into focus.

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Bob the Grumpy Med Chemist

@med_chemist

2 years

After good data: "May I die if I were to change places with the Persian king!" After bad data: "You know, maybe leaving behind chemistry in exchange for my own kingdom would be a sensible choice if given the option."

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