Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation. Published today in @Nature thanks to the work of many!

RT @MinetoOta: Thank you Jonathan for the elegant explanation of our recent work! We dove into how we can model the gene regulatory archit…

@BowTiedBiotech Yes! We believe that some of the regulators we identified could be utilized to selectively alter Treg or Teff sensitivity to IL-2

RT @ImmunoSketch: Think of a conductor guiding an orchestra—scientists discovered how T cells fine-tune their responses to keep the immune…

RT @GladstoneInst: A team of scientists uncovered how one protein controls the behavior of immune cells, which could have applications for…

Comprehensively, this work revealed dynamic regulatory mechanisms that enable state-specific gene expression in T cells. This story was made possible by members of the Marson lab as well as exciting collaborations with @KroganLab @Satpathology and @jkpritch !

RT @J__Stock: Thrilled to share our work on inferring gene networks in T cells using CRISPR perturbations. We show how to build these netwo…