Christian Landry
@landrychristian
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Scientifique, karatéka et curieux working on non-Artificial Intelligence. Mes opinions sont my own.
Québec
Joined March 2011
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This week is my lab’s anniversary. I started 10 years ago as a
#newPI
. Someone asked me recently advice based on my experience. Here are some modest thoughts
#NotSoNewPI
1/15
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Thinking about a Python programming for biochemists/biologists bootcamp (2-3 days) for newcomers (interns, grad students and postdocs) for my lab in early summer. Has anyone developed a successful curriculum for this? Thanks!
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What if being a PI just means being more efficient at googling stuff?
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Sabbatical project: putting together a course on molecular evolution for biochemists. (Not a biochemist and never had a class on molecular evolution; should be fun)
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We can celebrate when we receive proofs of articles even if we celebrated acceptance already, right?
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The cheaper DNA sequencing gets, the more money we spend on it.
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I am impressed with how
@theJagmeetSingh
has gained debating skills in French since the last election. Wow!
#Elxn44
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Excellent news for our graduate students with fellowships. Hopefully for all others funding will increase as well. The researchers who can offer these $ as stipends are very few. A PhD fellowship is now more than the average NSERC DG!
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Happy to share the work of
@DianaIAscencio
who measured the fitness effects of individual gene duplications and examined whether some duplications were deleterious because they altered the assembly of protein complexes. See the paper here for the details:
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This is such an honour! Thank you!
This is the result of teamwork with past and current lab members
2024 Gairdner Award recipients paved way for revolutions in cancer treatment, genomics, and global health
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Our latest work on yeast genome editing is out: using a base editor to assess the functional importance of thousands of amino acids genome-wide in a single flask experiment. By
@PhilDespres
in coll with
@nzmyachie
at
@NatureComms
#systemsbiology
#synbio
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Happy to be the awardee of one of these new Canada Research Chairs! This gives us research momentum for the next 7 years
@ibis_laval
@FSGulaval
@universitelaval
@CRDM_UL
Congratulations to the 259 new and renewed Canada Research Chairs from 47 institutions across 🇨🇦!
#CRC20in2020
#CdnPSE
@SSHRC_CRSH
@NSERC_CRSNG
@CIHR_IRSC
@InnovationCA
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When you are preparing a talk on your recent, exciting work on hybridization in fungi and you find this old paper you never saw before that shows they knew everything before you were born...
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The government found a way to keep people at home and stop viral transmission.
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Having a Zoom interview today with a student from Colombia. Should I avoid to show her this?
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“Accepted in principle” deserves a celebration right?
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Please RT. —My lab has a
#postdoc
position available to work on why natural selection can or cannot optimize cellular networks and functions. It is funded by an international and interdisciplinary HFSP grant—
#systemsbiology
#evolution
#syntheticbiology
#genomics
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Hard to believe I have my portrait there with
@twittkopp
@3rdreviewer
@toni_gabaldon
and
@stepheniwright
, all people whose work I admire! Thanks to
@SMBE
and past and current members of my lab!
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My group will be looking for two postdocs soon to work on the genomic prediction of antifungal resistance in fungal clinical samples. One experimental (DMS/Experimental evolution/Whole-genome sequencing) and one computational (ML/AI). Get in touch! Please RT.
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#Postdoc
position in our group to study
#ProteinEvolution
and
#FitnessLandscapes
in the context of
#GeneDuplication
. Please RT.
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Happy to join the Editorial Board of Genetics, in the Genome and Systems Biology section alongside many scientists who have inspired me during my career. I remember how proud I was to publish my first Ph.D. paper in this journal 15 years ago.
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We are in a terrible crisis that we hope science can help us solve. Let's put 250 bn $ in the economy but cancel the current
@CIHR_IRSC
biomedical grant competition...which is worth pennies compared to that. Research that will help save lives in the long term. I do not get it.
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When nobody shows up at the most prestigious plenary speaker’s talk because it is the morning after the conference’s party with free drinks.
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@ProfRachelGaN
I’ve worked maybe 3-5 weekends since I got my position more than 10 years ago. The more you do, the more people will ask from you. I set my working hours and do as much as I can and as good as I can within this time frame.
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Tonight would have been the
#SMBE2020
banquet. We are having a Québec drink and I am wearing my t-shirt for the event! Thanks to those who were coming! We’ll try to host you at some other time in the future.
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I remember as a MSc student I was wondering a lot about how every graduate student around me could speak English and I did not. It was hard to imagine for me how I could ever learn English and become fluent enough to continue. I gave my first conference talk by reading my text.
MY PAPER on
@ScienceMagazine
! SO PROUD 💚🖤! "These results add to a small yet growing body of work providing concrete evidence of how language barriers affect nonnative English speakers and hinder diversity in science" Thanks
@rpocisv
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Preprint by
@PhilDespres
: how many mutations are needed to turn an obligate homodimer into an obligate heterodimer by gene duplication? One/gene is enough.
See our story on how deleterious mutations can construct more complex molecular machines.
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Very proud to be among the laureates of this
@universitelaval
Teaching and Mentoring Excellence Award for graduate students! This is the result of team work with all lab members.
L’Université Laval dévoile les lauréates et les lauréats des Prix d’excellence en
#enseignement
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This little man is now an adult and
@NSERC_CRSNG
funding has not changed since this picture was taken. Graduate scholarships are the same, discovery grants are about the same and Canada Research Chairs are the same. Time for something big
@JustinTrudeau
#SupportOurScience
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Amazed by the work of the other laureates and inspired by the fact that, often, the most critical developments in
#genomics
research are enabled by curiosity-driven investigations. Including our beloved next-gen sequencing technologies.
Congratulations to the 2024 Canada Gairdner Award laureates! This year’s laureates represent some of the world’s most significant biomedical and global health research & discoveries.
Find more about these incredible scientists and their award-winning research here:
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I am getting paid to ask questions about the world around us and discuss and hang out with some of the most brilliant brains in the world. What more could I ask for!
#NotSoNewPI
15/15
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Heading to the Gordon Conference on Ecological and Evolutionary Genomics this weekend in Manchester NH. I was at this same conference 16 years ago as a young PhD student (photo) with
@naubinhorth
. I will be the Chair of the conference this year :-) . Different kind of stress.
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Publishing in "high-profile" open access journals costs about 20% of the average annual
@NSERC_CRSNG
discovery grant project. Just saying.
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Happy to share the work of Guillaume C,
@marsit_m
,
@mathieu_henault
and
@LenouMartin
on the neutral evolution of
#hybrid
lineages and their recovery from
#sterility
. Amazing amount of work that led to very exciting results! See the story at
@NatureComms
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Happy to share Damien's work in which he tested if swapping mitochondria among yeast strains would affect the paths of adaptive evolution. Massive work with awesome collaborators,
@SophieBreton16
's and
@Heather_Fiumera
's groups
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Thanks to
@InnovationCA
, this new lab space will be transformed into ALFRED, the Advanced Laboratory For Fungal Resistance Evolutionary Dynamics (I know, this is pompous but hey, we needed a nice acronym).
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It is now official! Our training program on the
#evolution
of
#fungal
#pathogens
has been funded by
@NSERC_CRSNG
! Please follow
@evofunpath
for details!
@universitelaval
@ibis_laval
@FSGulaval
@ProteoQuebec
@FRQ_NT
@FRQS1
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I have not started a talk (slides) from scratch in a while. The trick is to start and spend an hour or two on the colour scheme right?
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I sometimes like to complain that my lab members do not use books anymore. I guess this is not true.
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I hope there is a place in heaven for all these sentences in manuscripts that we carefully crafted and that we later removed, especially for those written in a language that is not your maternal one.
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Je tiens à remercier les Fonds de recherche du Québec
@FRQ_NT
de soutenir ma carrière en recherche. Comme moi, joignez votre voix à celle de la
#communaut
éFRQ et affichez votre soutien à la recherche !
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I just canceled two seminar visits that were going to take place in the next two weeks. They were going to take place in cities where there is no crisis, but if we want to keep them safe, we need to act BEFORE things go bad. Anything that is not abs. necessary can wait.
#COVID19
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Happy to share
@AngelFCC119
and Isabelle's paper on how promoter activity shapes the effect of protein coding mutations. If you like this type of work and are looking for a
#PhD
or a
#postdoc
position, get in touch!
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“Textbooks are not written from papers published in Science”
What's the catchphrase from your PhD supervisor that stuck with you and you hold it in as a lemma?
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Happy to share Samuel Plante’s work on
#yeast
spores’ exit of dormancy. Their cytoplasm is highly transformed during activation, leading to changes in solubility for several proteins.
#Hsp42
and its
#phosphorylation
are key players in this transformation.
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Hybridization repeats itself in wild yeast populations. Our latest work by C Eberlein,
@mathieu_henault
,
@afijarczyk
, M Bouvier, G Charron and our collaborators J Anderson and L kohn on the subject just published online:
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Very happy to share
@DianaIAscencio
's work. Diana measured the distribution of fitness effects of single gene duplications and tested the dosage balance hypothesis as a mechanism for duplication deleteriousness. Coll. with
@deluna_lab
. See details here:
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The mRNA-based vaccines would probably do just fine outside without dry ice today.
#meanwhileInQuebec
#nearAbsoluteZero
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For those in ecological and evolutionary genomics who are already planning their meetings for 2019: Mark you calendars for this one
#genomics
#evolution
#ecology
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You want to know what leaders in the field of yeast molecular evolution and genomics have found the most exciting in the past few years? See the set of reviews Gianni
@liti_nice
and I had the pleasure to edit over the past year
#OA
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Raising funds to organize a conference: difficult and demanding. Returning that money because the conference is canceled: sooo depressing.
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Co-first authors! :) What a competition and a nice lesson at the same time! these guys where spectacular.
#Athletics
#coGold
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more than 8, 000 petris dishes
about 170 L of culture media
more than 600 hours of streaking colonies
more than 200 hours of tetrad dissection
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My Department (Université Laval) has two tenure track positions seeking for candidates: one in viral ecology and one in microbial functional genomics. Get in touch if interested. It requires teaching in French but comes with a learning period.
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A fifth trainee from my lab just got a Faculty position. Makes my day (week and month).
#proud_PI
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We have been seeing a lot of pubs about Canada's investment in research in the last few days. All I have seen is a decline in investment since I started graduate school 20 years ago, but increased bragging about it. A cynical mind could see some sort of compensation.
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When one of your lab members qualifies a 1997 paper as very old and another says he was not even born!
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I think there is worse than brain drain. There is no brain power development at all. Many brilliant students will just not go into science rather than go study abroad.
Members of the Parliamentary Standing Committee on Science and Research in Canada warn that insufficient federal funding for research grants and graduate scholarships could lead to a brain drain.
We urge Finance Minister
@cafreeland
to increase funding in the Fall Economic
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Thank you/Merci
@GairdnerAwards
!
Meet Prof. Christian Landry, 2024 Canada Gairdner Momentum Award Winner
From Cap-Chat, Gaspésie, Québec to becoming a pioneering figure in systems biology and synthetic biology, Prof. Landry's journey is as inspiring as his research. He's reshaping our understanding of gene
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Doing fundamental research and keeping a well funded lab in Canada
Name something that 𝙞𝙨𝙣'𝙩 an Olympic sport, but 𝙛𝙚𝙚𝙡𝙨 like an Olympic sport 🤔
9K
729
14K
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We torture yeast and bacteria during the week in the lab, we spoil them at home on the weekends
#sourdough
#ainsivalavie
#wildyeast
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Interested in knowing about
#SMBE2020
? Go see
@naubinhorth
at the back of the large room. You’ll get some maple candies :)
#SMBE2019
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Starting on June 1st I will be Full Professor of Biology. I guess I can no longer blame it on being a young professor
#TimeFlies
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Just learned how to dissect tetrads thanks to
@gregoryianlang
(also photo credit to him). I am in a better position now to appreciate the amount of talent that went into our paper here: 200 hours of dissection by the lead author Guillaume.
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I am happy to share our latest preprint in which
@CamilleBed17
identified 100s of resistance mutations in fungal pathogens' most crucial drug target (Erg11/Cyp51). Bottom line: rampant cross-resistance and very little fitness cost
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If you think buying lab equipment is expensive, try fixing broken lab equipment.
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Our first paper on de novo gene birth is out in Genome Research. Yeast pops explore a large protein sequence space. Great coll with
@namyolivier
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We will host the SMBE meeting in Quebec City in 2020! Looking forward to having you all in Quebec
#smbe17
@universitelaval
@FSGulaval
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A postdoc who receives a prestigious fellowship award this morning and another with an accepted paper. Do I qualify for a day off?
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I have written a few grant proposals recently in which I had to talk about EDI. I would trust Institutions and funding agencies about their EDI ambitions if they put hard measures in place that make sure all graduate students have incomes above poverty lines. 1/3
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Hang out with undergraduate scientists whenever you can. Their view of science is idealistic as it should be and it makes you forget all obstacles you face with funding, admin etc.
#NotSoNewPI
14/15
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The latest preprint from our lab by
@dbradley534
in collaboration with
@juditvr
. We examine how costly spurious phosphorylation is using yeast and human protein kinases
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Wherever you are my friend
@LouBernatchez
I hope you can see your paper is out. You pretty much pioneered this whole field!
Genomics for monitoring and understanding species responses to global climate change
#Review
by
@LouBernatchez
,
@AL_Ferchaud
,
@Chloe_Berger05
,
@ClareVenney
&
@AmandaXuereb23
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Our latest work on protein networks in hybrids is now on bioRxiv. Chimeric complexes are common but some things go wrong in hybrids, particularly in complexes related to protein homeostasis (synthesis and degradation). Collab with
@lenjf
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I just had a chat with a german student in my office, with a french postdoc at the coffee machine, with a spanish student in the hall, I crossed a polish postdoc on my way to the water fountain and took the elevator with an intern from Uruguay.
#being_a_scientist_is_awesome
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We had a fun day at our annual lab retreat. We talked about many things, from watery North American coffee to species de-extinction and how to generate networks using fractal-inspired matrix approaches
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Setting up my recording studio for my cell biology lectures. Let’s see how it goes. The coronavirus won’t win, students won’t miss a thing. Cell cycle regulation today
#lectureDistancing
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One accepted paper, one desk rejected. Does that count as a neutral Friday?
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Introducing an invited speaker at a symposium who is your former PhD student
#GreyHairAchievement
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I never with few exceptions gave up family time for work time. That is what kept me mentally healthy (kind of). Weekends are off my work calendar.
#NotSoNewPI
7/15
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Thanks to potential reviewers who decline reviews request BUT suggest the names of other reviewers. This is particularly useful to find early career people one may not know about !
#editorsLife
#PeerReview
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What are the odds? I am giving a seminar at the same place as my postdoc advisor within a week. Posters are back to back on the same glass door.
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My
@NSERC_CRSNG
Discovery grant proposal is submitted! I wish there were more opportunities like that for fundamental science funding in Canada! Trying to understand how the world works is so much fun and motivating!
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From 2022 onward, I will only Tweet about food, sports and sometimes science. Here is one about Québécois having fun on their lakes. Surprisingly, our lakes are enjoyed by a few in the Summer and many in the Winter.
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For my Biology of the Cell class this year I conducted interviews with researchers, early career and established. I used these short interviews to introduce the topics and show students that the subjects we talk about are being investigated as we speak!
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Snow bike season has officially started! What a wonderful Monday morning. I forgot my N+1 deadlines for about 20 minutes.
@universitelaval
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My F1 was born the year I was trying to wrap up my last PhD experiments. He is now finishing high school and playing in the rock band. Wow! What a ride!
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