Nolwenn Jouvenet Lab
@lab_jouvenet
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Research unit at @institutpasteur . Interested in the interplay between RNA viruses and the innate immune response (in human and reservoir hosts)
Joined December 2020
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Delighted to welcome today three new lab members from three different countries
@SamuelDCarpio
🇪🇸
@Dana_Hawasheen
🇯🇴
And Chloé Delon 🇫🇷
Stronger in cultural diversity
@institutpasteur
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We found 4 vials of
#poliovirus
vaccine candidates sent by A. Sabin to A. Lwoff in 1960 and never opened since !
We managed to sequence 3 of them and isolate 2 of them …we got some surprises… to be followed…
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Our lab is arriving on Twitter ! We are excited to share with you Virology and Innate Immunity news ! Follow us !
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Our work describing the replication of SARS-CoV-2 in several bat cell lines is out
@JVirology
😎 We started from scratch (= a Spanish field trip
@aicher_sophie
and
@jordiserracobo
to collect patagium biopsies)
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Registration is now open! Highly recommended by the lab
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3-year postdoc position. Are you interested in non-coding genes and antiviral immunity? Do you have experience in RNAseq, computational analysis and non-coding gene biology? Join us! Great opportunity to check by yourself that French wines and cheeses are truly amazing 🗼🥐🇫🇷🍷🥖
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Very happy to share our latest study on bat cells and SARS-CoV-2 replication
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We discovered a novel mechanism by which flaviviruses evade interferon response
Congrat's to lab members Ségolène, Vincent
@chazal_maxime
Thanks to
@AdriaSogues
@DecrolyE
and others for precious help
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Cool discovery about 🦇 antibodies: temperature fluctuations regulate antigen binding strength and diversity
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Very cool that the
@nytimes
likes our video of bat cells (expressing hACE2) infected with SARS-CoV-2😍👏🇫🇷 Congrat's to
@aicher_sophie
and
@Delphine_Planas
from
@Virus_Immunity
Watch how the coronavirus nefariously infiltrates the cells of a bat brain in this video, taken by Sophie-Marie Aicher and Delphine Planas, which received an honorable mention in the 2021 Nikon Small World in Motion Competition.
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We discovered a new mechanism by which viruses counteract the IFN response 🤩
Driven by Ségo and Vince, help from
@chazal_maxime
@DecrolyE
@AdriaSogues
and others... 🇫🇷🇪🇸🇧🇪
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Exciting day at lab today: we got the last piece of data to wrap up our first story on tick-borne
#flaviviruses
🥳 Stay tuned !
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First titrations of 🦇 flaviviruses by in-cell Western. Good news, the pan-flavi anti-Env allowed the titration of all bat flaviviruses, even the ones belonging to the ‘no known vector’ group 🥳
@morganecns
@aicher_sophie
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Postdoc position at
@institutpasteur
@PasteurVirology
Join us to study African Zika virus, collaborative project
@LambrechtsLab
, part of the CAZIKANO consortium (whose mascot Leon lives in the garden of one of us)
@agenceANRS
🇳🇱
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It seems like that some of my lab members need a break
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Two happy lab moments : we received a bat virus 🦇(after one year of wait) and a new coffee machine
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Archaeovirology in the lab
sequencing of Polioviruses stored for more than 60 years in a sealed box unlocked some mysteries
DOI: 10.1093/ve/veae063
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Testing an home-made 🐰antibody against TBEV NS5 protein in infected cells
Pretty happy♥️
Thank
@DecrolyE
et al for purifying the protein and
@chazal_maxime
for imaging
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2
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Congratulation Amandine for one of the best poster prize 🏅🦇🦇🦠
@SFV_France
Comparative study of innate immune gene landscape in bat cells
On going work, initiated by
@aicher_sophie
, collaboration with
@sci_questions
@MarcelAMller
@qdinhtran
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Emerging Viruses course in October 2023 at
@institutpasteur
@PasteurEdu
@PasteurVirology
Deadline for registration : June 25th
Join us!
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An artistic representation of our studies on interaction between SARS-CoV-2 and bat cells by
@SaundersNell1
in
@Virus_Immunity
lab
Pretty cool bat-shaped fluorescent multi-nucleated cells 😍😎
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6
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Nice Journal Club discussion today. Intriguing possibility. RIG-I may block SARS-CoV-2 replication in a MAVS-independent manner by displacing the polymerase from the viral genome (and may explain why there is no replication in A549 cells) 🤔🤔
@NatImmunol
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the anti-dsRNA ab (very) commonly used by RNA virologists to identify viral dsRNAs in infected cells probably recognizes cellular dsRNAs too. Some of these are generated from decay of intronic and intergenic transcripts folded as RNA duplexes.
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Happy holidays🎄🎄
(9 y-o Joseph Meister, who was bitten by a rabid dog in 1885, was the first person to be treated for rabies
@institutpasteur
)
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Little revolution in the lab today: we welcomed our new robot and celebrated the end of manual plastic columns-based RNA extraction 🥳😎😍
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Intense Western blotting session to address the reviewers’ comments (our hopefully-soon-to-be-published story on IFN evasion by tick-borne flaviviruses). Go Ségo 💪💪
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Today marks the 10 years anniversary of hiring my first ever team member
@chazal_maxime
So awesome that he is still on board 10 years later 😍🥳😎🥰
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Very happy to receive funding
@AgenceRecherche
to investigate the interplay between chromatin remodeling and antiviral innate immunity, looking forward to collaborate with
@GAlmouzni
. Thank you team member
@chazal_maxime
for exciting preliminary data👏😍🙂 (and CE15 reviewers)
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Sorting SARS-CoV-2 infected cells showed that the NF-κB pathway escapes viral-induced host gene expression shutoff and that CYLD reduces infection by dampening inflammation
@LabMorillon
@_AnvitaBhargava
@chazal_maxime
@beauclair_g
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@AleksDeLab
Indeed! What a treat! A ‘viral time capsule’ from 1960!
@institutpasteur
is full of biological treasures
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Powassan virus just arrived the lab : cool addition to our collection of tick-borne flaviviruses 😍
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Proud of our lab member Ségolène that obtained her master degree in Virology today with the highest possible grade!! VAE (‘validation des acquis de l'expérience’), is a great French process that allows people with sufficient professional experience to obtain diplomas 🥰😍🥳
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Insight into the biological activity of NSP6 of SARS-CoV-2 and of other coronaviruses 🇮🇹
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We have a lab logo ! Designed by
@Virolicious_FS
😍 V2S stands for ‘Virus Sensing and Signaling’ … as for the turkey, it is our mascot – based on a long-lasting lab joke (explanation on demand 😉)
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Submitting a paper is SOOOOO satisfactory!
(even if it may be followed by rejection/resubmission/revisions)
It should be online in a few days as a preprint (spoiler SARS-CoV-2 and bat cells 🦇🦇)
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Getting ready for
#JFV2022
! Very much Looking forward to reconnect with the French Virology community Monday 😍 Visit posters from
@chazal_maxime
@Virolicious_FS
@_AnvitaBhargava
and Ségo.
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Few more days to apply to our 'Emerging viruses' course in Paris at the
@institutpasteur
@PasteurEdu
🇫🇷🥖🥐
List of speakers
@bbrennan83
@mcinerney_gerry
@ASFVacc
@brankahorvat88
@LEnjuanes
, PIs from
@PasteurVirology
and many others
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Team version summer 2023 🇫🇷🇮🇹🇮🇳🇩🇪🇺🇾🇵🇹
The usual crew
@chazal_maxime
@_AnvitaBhargava
@morganecns
, Amandine, Ségo and Vince.
Happy to host for the summer Natalia from
@NicolasSarute
lab and
@margascience
from
@ASP_GPO
Missing
@Virolicious_FS
gone to
@DouamLab
for 4 months
1
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Our collaborative paper with
@cecerelab
'A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection" officially accepted today 😍🙂! Congrat's to co-first authors
@meetalichauhan
@chazal_maxime
👏
Very stimulating and fun collaboration with
@cecerelab
. Discovery of a miRNA encoded by
#SARSCoV2
able to modulate the host antiviral response
@institutpasteur
@PasteurVirology
. Now posted on
@biorxivpreprint
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Beautiful cover
@TrendsImmuno
to illustrate our review
@sci_questions
@BaidKaushal
@BatResearch
Research in bat immunity may lead to translational approaches to improve human health.
Image credit: B and S Fenton.
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Finalizing the program of the Virology Master course of
@InstitutPasteur
@PasteurEdu
Over 90 invited speakers: all the PIs from
@PasteurViro
and many more great virologists
@amara_lab
@DecrolyE
@Margottin11
@ASFVacc
@brennanlab
@mcinerney_gerry
@MammanoFabrizio
(to name a few)
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After a year on Tweeter, it was time to update our team picture (multicultural gender-balanced dream team 🇫🇷🇮🇹🇩🇪🇪🇺🌈🥰)
@Virolicious_FS
@_AnvitaBhargava
@chazal_maxime
, Ségo,
@aicher_sophie
and Vincent
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First day among us for Natalia from
@NicolasSarute
- 3 month visit for a collaborative project 🇫🇷🇺🇾
@PasteurVirology
@institutpasteur
@IPMontevideo
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3 years post-doctoral position in Virology (hijacking of cell signalling by African horse sickness virus) at the Vet school in the close suburb of Paris (fun team directed by Damien Vitour - not yet on Twitter - damien.vitour
@vet
-alfort.fr)
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Thank you
@institutpasteur
@CNRS
@AgenceRecherche
for the support ♥️
Collaboration with
@Env_Alfort
@DecrolyE
@AdriaSogues
and others ♥️
We discovered a mechanism by which Tick-borne flaviviruses evade innate immunity in human cells 🇫🇷🇪🇸🇧🇪
🦠 Flaviviruses are pathogens transmitted by ticks that can cause serious diseases including neurological disorders. A study conducted at the Institut Pasteur by
@lab_jouvenet
reveals how these viruses can slip between the cracks of immunity ↘️
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Well done
@aicher_sophie
! Presenting data this morning during an impressively large audience
#JFV2022
= great practice for your future talk at +strand RNA virus keystone meeting next June 👏👏
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We are looking for a postdoc to study role played by recombination in the evolution of enteroviruses
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Want to know about the fierce battle between interferons and SARS-CoV-2? Read our mini-review
@TrendsImmuno
Fun writing and discussing with
@sci_questions
and
@caro_goujon
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Congrats
@aicher_sophie
👏👏 Thesis manuscript printed today!!
@Lucie_Virevolte
and
@JonathanHeeney
as reviewers 😊
Public defense on dec 6th
@PasteurVirology
😎
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the lab of
@caro_goujon
strikes again 👏😍 Discovery of DDX42 as an intrinsic inhibitor of positive-strand RNA viruses. Glad to have contributed some of the flavivirus and Measles experiments 🙂
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Most beautiful poster session ever 🇮🇹 Annual meeting of the Italian Society for Virology in Brescia
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Two lab members at the
@WSVirology
annual meeting in Riga, Latvia
Ségolène presented today her project on innate immune evasion by tick-borne flaviviruses 😍👏
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Happy Holidays🎄🎄🎄
Glass recycling at
@institutpasteur
Every one of these represent the celebration of a publication or grant 😍👏
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Enjoying the annual meeting
@SFV_France
in Brussels
#JFV2024
posters and talks by
@chazal_maxime
@Virolicious_FS
and other lab members 🇧🇪🇫🇷🇩🇪
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Discovery of host proteins that modulate Zika virus replication in interferon-stimulated human cells (including MTA2, a chromatin remodeling factor). Great collaboration
@NicolasManelLab
.
‘Antiviral immunity’ special issue
@JMolBiol
edited by
@compton_lab
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You thought you knew all about the strategies deployed by SARS-CoV-2 to evade IFN response? Check out our paper 👇👇
Fun and stimulating collaboration with
@cecerelab
! Congrats'
@meetalichauhan
@chazal_maxime
@Pierq
Our
#COVID19
work in
@emboreports
is out! Great collaboration with
@lab_jouvenet
and
@institutpasteur
. We discovered a
#SARSCoV2
-derived
#miRNA
that can potentially target immune response genes.
@meetalichauhan
@chazal_maxime
@Pierq
@cecerelab
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Great defense indeed! Congratulations
@aicher_sophie
😍 Many thanks to the jury
@sci_questions
@Lucie_Virevolte
@JonathanHeeney
, JC Manuguerra, Sylvie Van Der Werf and Meriadeg Ar Gouilh for a great discussion and to Sophie family for a great party 🇩🇪
Congratulations Dr. Sophie-Marie Aicher (
@aicher_sophie
). What a fabulous presentation and PhD defence
@PasteurVirology
. Congratulations to the thesis director,
@lab_jouvenet
. Bravo! 👏🏾
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Discovery of another special feature of 🦇 (Jordan Dimitrov
@DesmazesLacroix
)
Bat antibodies have enhanced recognition for pathogen-derived antigens at flight temperatures
May explain why bats are resistant to many viruses
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Congrats to our PhD student
@aicher_sophie
and
@Delphine_Planas
from
@Virus_Immunity
for their winning video in the 2021 Small World in Motion Competition 👏👏🦇😍
The full story behind the movie is in our preprint 👇
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We are moving to a new building on campus... packing up with care precious items
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Today we celebrated International Women's Day at lab 🇮🇳🇮🇹🇫🇷🇩🇪🇪🇺 4 candles for the 4 Wonder-Women of the lab
@aicher_sophie
@_AnvitaBhargava
+ Ségo (we locked the guys in the cold room… but one managed to escape 😉)
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Such a treat to work on a beautiful campus in the center of Paris 🇫🇷 🌺🌻🌹🌷
@institutpasteur
@PasteurVirology
(thanks to the gardeners)
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Second day of the
@WSVirology
annual meeting in Latvia🇱🇻 Amandine presented her poster on antiviral genes in bat cells 🦇🦇
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Official PhD ceremony
@institutpasteur
@PasteurEdu
Our brand new doctor
@aicher_sophie
caught an endangered bat species
@qdinhtran
🦇🦇👏👏
Thanks
@SaundersNell1
for the bat-shaped syntycium
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Teamwork – harvesting the fruits and veggies from the lab garden
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Continuing celebrating the lab 10 year anniversary with current members
@Virolicious_FS
@chazal_maxime
@_AnvitaBhargava
@aicher_sophie
, former members
@beauclair_g
@couderc_elodie
and adopted members
@m_aguirreb
@AdriaSogues
(+other loved ones not on Twitter)🇫🇷🇩🇪🇮🇹🇮🇳🇵🇱🇪🇸🇨🇴🇺🇸
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Learn a lot about viral RNA sensing in Drosophila 🪰yesterday. Thesis supervised by
@krinMoo
. Great defense (congrats to Claire 👏👏) and discussions with
@LabPfeffer
@Alf_Castello
Icing on the cake, meet there
@Lucie_Virevolte
,
@JayCyPa67
@matteonegroni4
@Dj0gil
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♥️♥️♥️
Don't miss our next seminar THURSDAY 21st by the ever-engaging Nolwenn
@lab_jouvenet
from
@institutpasteur
. Talking about her team's exciting new work showing how
#tick_borne_viruses
suppress
#innate_immunity
. All welcome and please help us with a re-tweet to spread the word.
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Join us in Brittany in Oct 24
@Rafa_Sanjuan_
@MT_Sofonea
@Mark_P_Zwart
@PaulTurnerLab
@willemsen_anouk
@bkoskella
@DirtySci
@anice_lowen
@katrina_lythgoe
@samuel_alizon
@sociovirology
@Lucie_Virevolte
@pilardomingoc
@SantiagoFElena
@_chris_brooke
and more
0
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Check out our new SARS-CoV-2 preprint 👇👇 Congrat's to actual team members
@_AnvitaBhargava
@chazal_maxime
@aicher_sophie
, former team member
@beauclair_g
and collaborators not yet on Tweeter, Morillon lab and
@institutpasteur
Biomics pole 👏👏
Check out our preprint showcasing the massive yet selective transcriptomic shutoff of host genes by SARS-CoV-2. The virus "switches on" only what it needs and it needs... NFkB!
Collaboration between
@lab_jouvenet
and Morillon Lab
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Nice study led by
@neoviral
and A Komarova
@PasteurVirology
identifying cellular RIG-I ligands during viral infection and an HIV-1 VPR mechanism that dampens the ligand immunogenicity. We contributed the
#dengue
virus experiments😎
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Well done Amandine 👏! Best poster award at the
@WSVirology
annual meeting in Latvia🇱🇻
Antiviral responses in bat cells 🦇, project initiated by
@aicher_sophie
, collaborative work with
@sci_questions
@MarcelAMller
@qdinhtran
and others
@PasteurVirology
2
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Nice workshop
@institutpasteur
@TheCrick
... i met some people i hadn't seen in a while (memories of former CSHL Retrovirus meetings)
1
1
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Nice union of a virology lab
@PasteurVirology
with a parasitology lab
@PIV_IP
, triggered by
@Virolicious_FS
and
@m_aguirreb
😍🙂
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Updated team pictures in front of our building (which will be destroyed next month 😞)
@aicher_sophie
@Virolicious_FS
@chazal_maxime
@_AnvitaBhargava
, Vince and ségo
2
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Fun collaboration with
@FerdinandRoesch
,
@VignuzziLab
@SEBNisole
,
@ArhelNathalie
,
@Virus_Immunity
,
@SimonLoriereLab
and
@MollyOhainle
. Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen
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We are looking for a Research Assistant (12-month contract) to support the team in starting up the CAZIKANO project, which brings together eight multidisciplinary teams in France and Australia to assess the risk of Zika virus emergence.
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Still on the move: today moving the 🌿🌱🪴🌵and unpacking in the new place
@_AnvitaBhargava
@chazal_maxime
1
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Latest preprint from the team, fun collaboration with
@NicolasManelLab
; we identified genes modulating flavivirus replication in IFN-stimulated cells using a loss of function strategy.
1
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Very happy to present today our latest data at the retreat of the Infection Department of the
@karolinskainst
, happening at the Yasuragi Japanese spa. Many thanks
@mcinerney_gerry
for the invitation ! A day of great seminars + a spa session = great combo
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Congrat’s to our new post-doc
@_AnvitaBhargava
for the publication of her PhD work
@NicolasManelLab
, enlightening the mechanisms by which SUN proteins restrict HIV replication. Out in
@cellreports
👏👏😍😍
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Our study on the neurotropism of a discontinued Fellow fever live vaccine is out
#NPJVaccines
! It led us to investigate viral cooperation (cool to know that even the tiniest entities do better collectively than individually). Congrats to the team!
2
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The Flaviviridae family (comprising Zika, Dengue, Yellow fever virus and other beasts) is at least 100 million years old. Arthropod-borne flaviviruses evolved from tick-specific viruses
@Paleovirologist
@cggbamford
@wmarciels
@RhysHParry
0
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We found that all Enterovirus A71 genogroups form a unique serotype. Guidance for the development of a novel EV-A71 vaccine
@MicrobioSoc
Thanks to our international team
@PasteurNetwork
@PasteurVirology
🇫🇷🇲🇬🇨🇭🇨🇲🇨🇫🇰🇭🇨🇳🇳🇱🇬🇧
0
7
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Cool use of protein structure prediction to write the evolutionary history of Flaviviridae
I had imagined that the Flaviviridae common ancestor had a segmented genome (Jingmenvirus) - i was wrong
@GroveLab
@SpyrosLytras
@jonathon_mifsud
0
8
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Very stimulating and fun collaboration with
@cecerelab
. Discovery of a miRNA encoded by
#SARSCoV2
able to modulate the host antiviral response
@institutpasteur
@PasteurVirology
. Now posted on
@biorxivpreprint
@cecerelab
is excited to share this collaborative work with
@lab_jouvenet
and
@institutpasteur
born last year during the first pandemic wave. We unexpectedly found a viral-encoded
#miRNAs
produced during
#SARSCoV2
infection which targets the host mRNAs!
6
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Great visit
@IRIM_life
today! Thank you
@Gaudinlab
for the invitation! Nice opportunity to discuss science with
@caro_goujon
@bonazzilab
@KarimMajzoub
@ArhelNathalie
@SEBNisole
@Gaudinlab
@ChauveauLise
@EmmaPartiot
@_JoeMcKellar
@JimZPhD
@elodiebishop
Great seminar by
@lab_jouvenet
today
@IRIM_life
! Impressive amount of very cool data 🤩
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Fun being at
@IPMontevideo
for the course on emerging viruses
#BENV23
organized by
@NicolasSarute
Fantastic group of students from all over Latin America 🇧🇷🇺🇾🇦🇷🇵🇦🇨🇱🇨🇴 thanks
@institutpasteur
and
@PasteurNetwork
for support
0
4
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It was fun brainstorming with
@BaidKaushal
@sci_questions
and
@BatResearch
on translational potential of bat immunity studies
Can we translate research on bat immunity to improve human health? Postdoctoral fellow, Dr. Baid and collaborators, Drs. Irving and Jouvenet weigh in on this emerging topic.
#Bats
#translationalresearch
🦇
@BaidKaushal
@lab_jouvenet
@BatResearch
#LZCI
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Updated preprint of our deep RNAseq analysis of S+ cells showing that SARS-CoV-2 requires the NF-kB pathway for optimal replication.
Collaboration
@LabMorillon
@_AnvitaBhargava
@maxime
@aicher_sophie
@beauclair_g
2
6
30
3 lab members made it to
#ksrnavirus22
to present their work (posters+ talk) on tick-borne
#flaviviruses
and
#SARSCoV2
. Thanks to Boehringer Ingelheim Fonds (BIF) and the organizers for the travel awards to
@Virolicious_FS
and
@aicher_sophie
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Nice story from
@pylozach
,
@BoulantLab
and Co showing the importance of TMPRSS2 for SARS-CoV-2 entry routes
0
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Great time and great science indeed! Merci
@MaringerLab
Always happy to come back to
@Pirbright_Inst
We had a great time hosting
@merkling_lab
,
@ClaudiaRueckert
,
@SalehLabParis
,
@vectorgen
,
@LambrechtsLab
,
@Dickson14Laura
,
@lab_jouvenet
,
@littlebaleine
at
@Pirbright_Inst
back in July for a great two days of science talks all about vectors and arboviruses.
#arbovirus
#mosquito
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Thank you
@ArbovirusS
for promoting arbovirology ♥️
Excited to announce the lineup for the 4th International virtual seminars on
#arbovirus
biology. Investigators will present their research on a range of topics, from differing career stages and perspectives. Help spread the word with a retweet! All welcome!
Starts 19th Oct.
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