Chancellor's Fellow & Assoc Prof at UC Irvine. Brain circuit mechanisms of memory, olfaction and Alzheimer's Disease. PhD at UTokyo, postdoc in Norway.
Where in the brain is abstract map generated?
It is the lateral entorhinal cortex (LEC) and the medial prefrontal cortex (mPFC), working together!!
Here is our new finding published in
@Nature
Prefrontal and lateral entorhinal neurons
co-dependently learn item–outcome rules
Our paper finally out in Nature!!!
@Nature
We found that dopamine facilitates associative memory encoding of fan cells in the lateral entorhinal cortex.
5yr-work by
@jasonyensunlee
,
@jun_heechul
, Shogo Soma & Tom Nakazono!
Our new paper is out in Neuron
@NeuroCellPress
We found that "remapping" of hippocampus place cells is disrupted in Alzheimer's disease model, suggesting a circuit mechanism causing spatial memory impairment in AD. 3yr-work by Heechul Jun
@jun_heechul
!
論文をNature誌に発表しました!
Prefrontal and lateral entorhinal neurons
co-dependently learn item–outcome rules
Heechul Jun†, Jason Y. Lee†, Nicholas R. Bleza, Ayana Ichii, Jordan D. Donohue & Kei M. Igarashi
Nature (2024)
I wrote a review in Trends in Neurosciences:
"Entorhinal Cortex Dysfunction in Alzheimer's Disease"
Cell Press gives a 50-day free access link - if you are interested, please download within this period!
Gordon Conference でNat Neurosciのeditorと話していたら、日本からのreviewerを増やしたいのに、日本人研究者は英語のwebsiteが少なく、誰に頼んだら良いのか分からず困っているとの事でした。
日本の研究者の皆さん、英語のプロフィールサイトを充実させましょう!!
We wrote an opinion minireview on knowledge representations in Curr Opin Neurobio.
"Reconciling neuronal representations of schema, abstract task structure, and categorization under cognitive maps in the entorhinal-hippocampal-frontal circuits"
日本学士院から奨励賞を頂けることになりました。一緒に研究を進めてくれたラボのみなさんに感謝したいです。
Honored to receive Japan Academy Medal from Japanese Academy of Sciences - I would like to thank all my lab members!
Kei Igarashi, Associate Professor of Anatomy & Neurobiology at UC Irvine, was elected as a recipient of the 19th Japan Academy Medal.
This prize is The Japan Academy’s highest honor that annually recognizes outstanding researchers under the age of 45.
February 2023 issue of
@TrendsNeuro
:
Free featured content & more:
On the cover:
‘Entorhinal cortex dysfunction in Alzheimer's disease’
by &
@Kei_M_Igarashi
Our
@jun_heechul
's Neuron paper on Disrupted Place Cell Remapping in Alzheimer's Disease is out on the current issue of Neuron
@NeuroCellPress
. Please enjoy while the paper is free:
Great preview by
@inna_slutsky
is also there:
Our protocol paper on In Vivo E-phys Recording of Place cell/Grid cell Remapping is out in STAR Protocols
@STARProtocols
by
@jun_heechul
et al
We deposited place/grid cell spike data and Matlab code!
(Codes credit to
@EdvardMoser
&
@MayBrittMoser
lab)
Had a great time visiting UCLA in-person after 1.5 yr break. Thanks Weizhe
@TheHongLab
and Peyman
@pgolshani
for inviting!! And congrats Weizhe for the Nature paper just coming up this week!!!
Heechul Jun
@jun_heechul
, my first PhD student from 2017, now gets his PhD. Three (3x) his first author paper mugs from the lab. Congratulations Heechul, and we are looking forward to seeing your next scientific adventures!!
YouTubeに昨年の公開講座が出ました。「伝えたい 脳科学の達人たちの教え」ということで、研究者をめざす若い方に向けて私がこれまで教えられたことを盛り込んだつもりです。
Here’s my lay talk in JNS meeting 2023: “What I learned from superstar neuroscientists”
Congrats to Heechul Jun
@jun_heechul
, my first and superstar MD-PhD student, for being matched with NYU
@nyugrossman
@NYULH_Neuro
physician-scientist psychiatry residency!
#Match2024
Matched at my top choice - NYU Psychiatry Research Career Accelerated Track! Thanks to my amazing family, colleagues and mentor. So grateful and excited for the new journey and adventures! :)
The Igarashi lab at UC Irvine is recruiting postdocs.
We investigate neural circuit mechanisms for "what" memory (item memory) and how these circuits impair in Alzheimer's disease.
There are so many open questions left in our research - pls msg me for potential projects!
6 yrs ago today my family entered the US. Exciting but tough 6 years for newcomers, but hard work was always rewarded in this country. I am thankful to this country that always provides opportunities to develop my science, and to our friends who are always generous to strangers.
Our lab is being highlighted in
@UCIrvine
‘s Great Mind branding campaign - here’s
@YutianZhang27
being filmed in the lab. Stay tuned for final movies!
Please RT:
Several Postdoc/grad student positions available in our lab at UC Irvine. In vivo e-phys and opotogenetics to investigate memory mechanisms in the entorhinal-hippocampal circuit and Alzheimer models. Come over to our SfN poster on Wed 23 AM!
Now in Alzheimer’s + spatial navigation meeting in Magdeburg.
Had great discussions on how we can translate findings from Alzheimer’s research to early detection of people with AD risks.
With Moto Yoshida, Thomas Wolbers, Dennis Chan,
@vschinazi
@HasselmoMichael
As a program committee member
@SfNtweets
, I highly recommend today’s Meet-the-expert session
by one and only
@MayBrittMoser
!!
She will be surely your role model.
Room 103 from 3:30pm
The Igarashi lab at UC Irvine is looking for a Postdoc. We investigate circuit mechanisms for Associative Memory and how these circuits impair in Alzheimer's Disease. There are many open questions in this field - pls msg me for ongoing projects!
Great turnaround in Day 1 of SfN program committee, even with a time for drinking afterwards.
Looking forward to Day 2 with our best chair
@ColginLab
!
Had a session on reward representation in EC-HPC circuit w/
@ChaBoccara
@lisa_giocomo
and
@attila_losonczy
in
@jnsorg
annual meeting in Okinawa.
I just wish Japan had less restriction for foreign travelers so they could join in-person and enjoy gorgeous beaches w/ their family..
After getting swiped last minute on the first attempt for *not having candidacy yet*, I have convinced the NIA to throw some bucks at our project on AD memory circuit dysfunction.
#F31
#NRSA
I will give talks in three sessions in Japan Neuroscience Meeting next week.
1) "Brain network dysfunction in Alzheimer's disease: a new potential target for future therapy"
Speakers: Jorge Palop (UCSF), Annabelle Singer (Georgia Tech), Abid Hussaini (Columbia) and Igarashi
WE ARE THRILLED to announce that Det of Anat&Neurobio
@UCIrvine
is hiring a AS/AS/F PROF IN NEUROSCIENCE, broadly defined. The focus will be, but not limited to, studies in epilepsy and brain disorders. Apply early, search will be continued until filled.
Grad school reunion at Univ Tokyo. These professors were my superheroes when I was there. After 12 yrs, they are still active and still my role models!
From Left, Drs. Tadatsugu Taniguchi, Yasushi Miyashita, Takao Shimizu, Yasushi Okada, Kohei Miyazono, Tomoyuki Takahashi.
1st day of SfN program committee meeting - we discussed lecture speakers. Starting at 4pm, discussion over dinner and wines(!), concluding at 11:45pm. Will resume the meeting from 7:30am tomorrow!
The Department of Anatomy and Neurobiology at UC Irvine
@UCIMedSchool
invites applications for a tenure track/tenured Assistant or Associate Professor, broadly on neuronal circuit function at the cellular to systems level.
Please apply here:
Today we had the one and only Weizhe
@TheHongLab
from UCLA for
@UCI_NeurCircuit
seminar! Thanks for the tour de force lecture on social brain circuits!!
Enjoyed a session on the Lateral Entorhinal Cortex in
#SpringHipp
#HippTaormina
in Sicily with
@JamieAinge
@brivandrey
Kaori Takehara & Eirik Nilssen . Will definitely come back here for another LEC session next time in 2021!
We had Laura Colgin
@ColginLab
, who is also an
@AnatomyNeurobio
alumnus, for
@ucicnlm
seminar speaker. Welcome home, Laura, and thank you for the inspiring talk!!
Great evening with my friends and colleagues at my place - I am really happy being connected with you all!! Thanks for coming all over to UC Irvine - we'll have you again here!
#76
Getting Out of the Comfort Zone
UC Irvineの五十嵐啓さん(
@kei_m_igarashi
)再登場。
転職活動振り返り、次に出る論文のSneak peek 、R01グラント審査の実際&それを踏まえたライティング戦略講座、この時期の留学について
#NeuroRadio
#神経科学 #ポッドキャスト
Success of trainees is always the biggest reward. Congrats
@TatsukiNakagawa
on the AARF!
ポスドクの中川さんがAlzheimer’s Association の二千万円/3年のフェローシップを獲得しました。PI冥利に尽きますね。
Super happy that I'm awarded Alzheimer's Association Research Fellowship.
Thanks to
@alzassociation
for supporting our research. And of course, I'm grateful to
@kei_m_igarashi
for your mentorship.
Pls RT: The Igarashi lab at UC Irvine is looking for a postdoc with expertise in electrophysiology. If you are interested or know someone who may be interested, please let me know!
And here is my symposium at
#LEARNMEM2018
with Peyman Goshani
@pgolshani
, Ueli Rutishauser and Alex Mably! It is very rewarding to hear people say it was a great session!!