Jess Cardin
@jess_cardin
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Systems neuroscientist / Cortical circuits researcher / Associate Prof in Neuroscience at Yale School of Medicine
New Haven, CT USA
Joined August 2017
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Tenured! Very grateful to have been privileged to collaborate with so many colleagues inside and outside my lab here at Yale. I have been fortunate to have a series of truly fantastic people bring their creativity and expertise to the lab over the last 10 years!
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NIH grant applications should have an acknowledgements section. "The PI thanks her parents for help with last-minute childcare, without which this grant would not have been possible."
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Officially promoted to full Professor! I guess that means I'm supposed to be an adult now?
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Success! Simultaneous widefield imaging and Neuropixels recordings by our amazing students at
@NSB_MBL
! Amazing data, only possible with support from
@zeiss_micro
and
@HamamatsuPhoton
🔬🐭🧠
@MBLScience
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New work with
@mjhigley
lab is out! Spearheaded by postdocs
@SweytaLohani
and Andrew Moberly, in collaboration with
@HBenisty
and
@yulonglilab
. 2-color imaging of the relationship between ACh and neural activity across states in the awake cortex in 🐭.
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Feeling deeply irked at the editor who sent me a (non-automated) reminder email early this morning. On Sunday morning I am busy playing with my kids and drinking tea. Requests for unpaid effort can wait for Monday morning, when I am wearing my other hat.
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Just yelled at the nth person I've encountered in med school campus buildings recently without a mask. Idiots jeopardizing the health and careers of my students and postdocs doing experiments and staff working to keep things moving. I don't care if you don't like the mf mask!
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Now online in final form, work by
@kt_ferguson
on the role of cortical VIP interneurons in visual processing and perception!
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New review on cortical circuit flexibility is online. This one was really fun to write, it's a topic we think about a lot in the lab!
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Choose your opsins wisely!
Short new paper from the lab now on bioRxiv:
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Applications are open for the 2021-2022 Yale SYNAPSES postdoc seminar series. If you're a senior postdoc doing awesome science, please apply! Deadline September 7th.
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Little tired of looking around and suddenly realizing I’m the only female in the room for committees and other meetings.
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So happy for two of my postdocs,
@kt_ferguson
and Garrett Neske, who were both just awarded k99/R00 grants! Well deserved, after much hard work by them. Look for them to be out on the job market in a year or two...
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Two exciting new papers from the lab both out on
@biorxiv_neursci
today! Everything from development to neuromodulation, single-neuron reconstructions to whole-cortex imaging, huge efforts from our amazing team of colleagues. I declare that it will now be the weekend 😎
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We're recruiting
@YaleNeuro
this year! Got questions about the department, the broader Yale community, or the application process? Please ask, happy to chat.
📢 Faculty job
@YaleNeuro
📢 We are hiring tenure track faculty members! Seeking candidates in neuroscience at large who will join a richly collaborative community that strives to foster an inclusive research environment. Deadline Oct. 15. Please share!
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Do you have a background in neuroscience and engineering? The Neurotechnology Core at Yale is looking for a new neuroengineer. Come solve problems with us, we have all the cool toys!
Are you interested in developing engineering solutions to expand
#neuroscience
research capabilities? We are looking for a neuro-engineer to work with our Neurotechnology Core Director at Yale. Apply here:
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What's the most important change/idea you think would help to retain more women and minority scientists in academia?
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Updated version of new work by
@kt_ferguson
and several other lab folks! Cortical VIP cells aren't just for disinhibition or state-dependent modulation, they also regulate size tuning and have a context-dependent role in visual perception. 🔬🐭🧠
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Our department
@YaleNeuro
is hiring again this year! Come join a diverse, vibrant community of scientists, now housed in a new building with gorgeous spaces. Happy to answer questions about the search and the environment anytime.
📢 Faculty job 📢 We
@YaleNeuro
are hiring tenure-track faculty members! We seek candidates in
#neuroscience
at large who will join a richly collaborative community that strives to foster an inclusive research environment. Deadline Oct. 15. Please share!
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The Cardin lab is looking for a postbac student to work on a new project using wide-field imaging to study longitudinal cortical changes in models of Alzheimer's disease! 2-year project in a great environment with lots of resources and career dev opportunities 🔬🧠🐁
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Now we just need more female chairs, more female faculty in other leadership positions! And more female faculty in general. Maybe more support for childcare costs, so that fewer of Yale's amazing female students and postdocs feel a need to leave science.
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Now out in preprint form, work from
@garrett_neske
on the unique contributions of a transthalamic pathway in mouse cortex. This epic saga pitted man vs mouse, spanned the pandemic, and required heroics with thalamic causal manipulations, but turned out to be beautiful!
Transthalamic input to higher-order cortex selectively conveys state information
#biorxiv_neursci
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Very happy that this review with
@kt_ferguson
on gain regulation in the cortex is now out online!
What are the mechanisms that modulate gain in the
#cortex
? Check out this latest Review by
@kt_ferguson
and
@jess_cardin
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Really looking forward to working on this project, an offshoot of our recent work on Alzheimer's Disease models! Even better, it also includes a fun collaboration with Carla Rothlin and Sourav Ghosh here at Yale 😎
Congratulations 🙌 to our own
@jess_cardin
who was named a Novartis Global Scholar 🌎(
@Novartis
)! This is a highly competitive program funding groundbreaking science. Learn More Here 👇
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Huge congratulations to postdoc
@SweytaLohani
, who was just awarded a Narsad grant from
@BBRFoundation
to continue working on cholinergic signals in the cortex!
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I have officially run out of swear words (first time for everything). Kids' school is going back to fully remote learning. Older kid utterly hates remote learning and was deeply miserable last spring. Younger kid too young to have attention span. Fml.
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Now on bioRxiv, a long-term collaboration between
@AlexWang955
and
@kt_ferguson
on somatostatin interneuron development, with gorgeous synaptic data from
@mjhigley
and Jyoti Gupta. SST cells in 🐭V1 have a unique developmental window right after 👁️opening!
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Loving the fact that my lab is really humming with activity this summer, all projects seem to suddenly have momentum. Nice to remember that science is also fun and exciting when it works, it's not all endless drudgery and evil reviewers.
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New work from a collaboration between the Cardin and Higley labs! With
@mjhigley
,
@SweytaLohani
,
@yulonglilab
, and the twitterless (?) Andrew Moberly, Hadas Benisty, and Boris Landa. Dual color wide-field imaging of ACh release and neural activity across the cortex in mice.
Dual color mesoscopic imaging reveals spatiotemporally heterogeneous coordination of cholinergic and neocortical activity.
#biorxiv_neursci
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Life as a scientist certainly has interesting variations from moment to moment! One grant triaged this week, one grant awarded (both collaborations with
@mjhigley
). I think I will take our 50% hit rate for the week and call it a solid win.
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Setting up for cycle 3 of
@NSB_MBL
in Woods Hole! This year we're doing wide-field imaging of the 🧠 in a virtual reality environment.
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Running a two-day quantitative skills bootcamp for our 23 (!) incoming neuro grad students. Lots of coffee and Matlab coding!
@YaleNeuro
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Deadline for applying to the faculty search at
@YaleNeuro
is coming up in a couple of weeks (October 15th)! DM if you have questions about the search, want to chat about being a PI in the
@YaleMed
environment, need recs for New Haven pizza, etc.
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Finishing up 2 fantastic weeks with our mouse V1 2p imaging crew at
@NSB_MBL
! Lobster rolls & fried clams to celebrate 😎 We got amazing data, with huge support from teams at
@CoherentInc
and Sutter Instruments. And then we did a ton of data analysis spearheaded by
@kt_ferguson
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@schoppik
Grad school and postdoc are protected time--hoard it, exploit it while your only responsibility is awesome science on someone else's dime.
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Made it through the week with only one 'naked child in zoom mtg' moment!
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Little worn down by grinding out endless grants from home. 5 grants in 5 months, 2 big ones with
@mjhigley
. Quarantine is very productive when you share a home office with your best collaborator! But wow, I could use a break, maybe record some damn neurons for a change.
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Yale Engineering has an open rank faculty search for a neuroengineer! Do you work on cool engineering ideas for BMI, neurotech, systems neuro, or signal processing? Come be part of a vibrant and growing interdisciplinary community. Deadline 11/29.
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New review with
@mjhigley
and
@MCrair
on mesoscopic imaging and cortical networks! Think this is the first review
@mjhigley
and I have written together 🙂
Widefield “mesoscopic” imaging is rapidly becoming a key method for investigating large-scale network dynamics. With
@jess_cardin
and
@MCrair
, we’ve summarized the ins and outs of this powerful approach and highlighted some cool recent findings!
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Looking for a postdoc spot? The Wu Tsai Institute at Yale has open spots: $60k starting postdoc salary, at least 3 years of guaranteed $$, new facilities, and career development support. Also, opportunities for cutting-edge interdisciplinary neuroscience!
Interested in neuroscience from an interdisciplinary approach? Our
#WuTsaiPostdocFellowships
offer competitive stipends, training funds, professional development, & an inclusive community. Deadline Aug 15
#BlackInNeuroCareers
@NeuroBoricuas
@sacnas
@BlackinPsych
@LatinxInNeuro
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Gave a lecture last week for
@NSB_MBL
. Halfway through I realized why I was having so much fun--first in-person talk in ~15 months! Nice to feel some energy in the room, instead of staring at a screen, and lots of great questions from the NS&B students.
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Very excited to welcome our incoming class of neuroscience grad students
@Yale_INP
for our annual coding Bootcamp! This year we added sessions on data analysis and statistics from
@ifat_levy
@mjhigley
and Nick Turk-Browne 😎
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The Yale neuroscience graduate program is having an open house! If you're thinking about getting a PhD in neuro, please drop by and say hello 🙂 Awesome research, amazing peers, collaborative interdisciplinary projects, and resources for career development. Ask us anything!
Interested in applying to the Yale Interdepartmental Neuroscience Program? Sign up for our zoom open house on 11/18/21, 6-8 PM east coast time to hear about the program from faculty and current students. Please register here:
#neuroscience
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Science during quarantine: Spent a good chunk of my week looking over one of our old datasets for a paper and thousands lines of old, mostly uncommented analysis code written for it by someone else. Now in need of several stiff drinks and a vacation to recover my sanity.
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My department is hiring this year! Lots of great colleagues, an intellectually lively environment, tons of technology development, amazing trainees. Dept is moving to brand new space next year along with psych and data science folks. Got questions about the search? Just ask!
📢Job alert!📢 We are hiring *multiple* tenure track faculty members at
@YaleNeuro
. Seeking candidates in neuroscience at large who will join a richly collaborative community that strives to foster an inclusive research environment. Please RT!
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Bit sad to leave Woods Hole this week! Between teaching in
@NSB_MBL
and then hanging out to write some stuff, it was a good way to spend part of the summer. Good to be back in New Haven in time for peak tomato season 😉
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So happy to be back at the MBL for the NS&B course! Gonna do some 2p imaging in awake behaving mice. But first, a stroll around the pond...
@NSB_MBL
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Bit sad to be finishing up an awesome 6-week stretch of teaching at
@MBLScience
in the
@NSB_MBL
and
@MblNeuro
courses with
@mjhigley
and Andrew Moberly and some amazing students. Even got to catch up with
@WeAreTheCrabLab
and
@MelColemanLab
!
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@bita137
Have had several postdocs with babies. We put in a nursing corner at one point, many preps run with kids snoozing in lab (mine too). Have noticed minimal detriment to productivity--productive people just keep on going, non-productive people keep on being non-productive.
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So happy to see this study out on biorxiv! This was a huge, multi-year undertaking by
@QuentinPerreno1
, together with
@aho_fonseca
and with stellar assistance from
@AustinAirhart
, Rong Mao, and James Bonanno. /1
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Good week for the lab! Very happy for
@hmbatchelor
, who got her NOA for her NRSA today 😎 to do some super cool mesoscale imaging and visual behavior in mice.
@YaleNeuro
@YaleMDPhD
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Tomorrow we kick off the 2020
@Yale
Interdepartmental Neuroscience Program quantitative skills Bootcamp with our new INP students! It took a big team to go virtual this year, very appreciative of our awesome TAs. Two days of coding with mouse, fly, and genomics data.
@YaleNeuro
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Clear that the field as a whole has several different working definitions of 'E/I balance'. Given how complex E/I interactions really are, I'm not sure whether this remains a useful concept to motivate autism research. But it was a good discussion!
SFARI workshop earlier this year revisited the excitation/inhibition (E/I) hypothesis of
#autism
in light of current knowledge of autism pathophysiology. Read a summary here:
@blsabatini
@jess_cardin
@DanFeldmanPhD
@cian_neuro
@SachaNelsonLab
@OferYizhar
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Lunch at the clam shack with our awesome crew of
@NSB_MBL
students! They came up with super creative projects for cycle 3, and TAs
@QuentinPerreno1
and Clayton Barnes pulled off some incredible feats of experimental wizardry.
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New work with
@BatistaBritoLab
,
@martin_a_vinck
,
@AntaraMajumdar
, and the twitterless Alejandro Nuno! Early but not late loss of ErbB4 in PV interneurons perturbs state-dependent cortical circuit activity patterns, impairs pyramidal dendrites & spines.
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Are you a skeptic? A believer? Come listen to a friendly debate on gamma rhythms in the brain, bring your pointed questions and drive the discussion! Based on past evidence, this should really have been scheduled at 10pm in a pub, but
@sohallab
and I are up for the challenge!
New at
#SfN18
:
@sohallab
@UCSF
&
@jess_cardin
@YaleMed
discuss views on whether gamma oscillations contribute to
#brain
function in our Dual Perspectives session moderated by Matthew Shapiro
@IcahnMountSinai
, November 5. Don't miss the vibrant debate:
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So happy this one is out🥳 This was a heroic project with a great team. Turns out, early postnatal PV cells sculpt functional and morphological properties of local cortical pyramidal cells, even before PV cell maturity. That process depends on Nrg1/ErbB4 signaling in PV cells.
New paper out studying the postnatal development of PV interneurons in a truly collaborative project. Thanks to
@jess_cardin
@martin_a_vinck
@heyclaireward
@AntaraMajumdar
@bonafide_kasra
for the great work and team spirit!
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Leaving SFN? Or didn't go and feeling like you miss neuroscience conferences? Time to work on your abstract for
@CosyneMeeting
! Deadline for COSYNE abstract submission is next week, Nov 23rd. Submission link at
#cosyne2023
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#COSYNE2023
preliminary program for next month is up on the website! Looking forward to an awesome slate of talks
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Deadline rapidly approaching! Open rank faculty positions at Yale's Wu Tsai Institute for candidates bridging disciplines across neuroscience, biology, psychology, cognitive science, data science, computer science, and engineering.
Job openings at all levels at Wu Tsai Institute at Yale University
@WuTsaiYale
. Application deadline in October 15. 👉
@BlackInNeuro
@BlackinPsych
@BlackInBME
@LatinxinSTEM
@LatinxinSTEM
@LGBTSTEM
@DisabledStem
#womeninSTEM
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Had so much fun writing a preview with
@QuentinPerreno1
on the elegant new work from
@Jule_Veit
,
@BrentDoiron
, Hillel Adesnik, and coauthors! Still much to learn about the functional roles of cortical GABAergic interneurons.
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Rolled into Woods Hole this morning for cycle 3 of
@NSB_MBL
! So excited to set up, this year we’re doing an imaging + Neuropixels prep 😎
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New review with my favorite collaborator!
New review out with
@jess_cardin
- we discuss the complementary benefits of electrophysiology and mesoscopic imaging for investigating network dynamics!
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This year recruiting for new faculty for our department and students for our PhD program are going on almost simultaneously. The diversity of people/ideas and the enthusiasm at both levels makes me seriously nostalgic for new beginnings, starting PhD/postdoc/lab.
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One of my favorite little things on the
@YaleMed
campus, this geranium has been growing beside a parking lot for years. It blooms all year round, even in snow, kept alive by the warm air from a nearby vent. Gets run over once in a while, just keeps blooming.
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Briefly alone in the
@NSB_MBL
rig room with a 2p microscope and a working prep...trying to resist the urge to keep tinkering with the students' experiment. Gorgeous responses in visual cortex neurons!
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New work from
@QuentinPerreno1
on the complex and often surprising relationship between neural processes and power spectra!
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Huge congratulations to Dr. Alex Wang, who just defended his thesis this Friday! Very proud of everything Alex has accomplished 😎Preprint of his paper coming shortly, a deep dive into interneuron maturation!
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Heading to CSHL tomorrow to teach in the Computational Vision course co-run by
@jpillowtime
. Wondering if I have too many or too few slides...from Berger 1924 to various 2018 papers in 3 hours?
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Kindergarten outreach day with
@mjhigley
! Off to do the 5 senses, talk about the brain, and do the jellybean experiment with 5-year-olds.
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One of the best ways to combat 2020 stress if you live in CT, lovely evenings on the (sparsely populated) beach.
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Round two! Another day of seven awesome jobs talks by impressive candidates. And four more women, so 8 of 14 total this year are female.
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I ran off to the lab and did some experiments for grant data. Amazingly, entropy hasn't quite set in after 5 months and the rig still works, preps were beautiful. As punishment, my inbox instantaneously filled with requests for meetings and reviews, problems, & complaints.
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@neuroecology
Deeply disagree. I did two postdocs and loved all of it (6.5years). The protected time was key for figuring out what I was going to do in my own research program. Not just about training to be a PI, it's about independence without crappy, distracting responsibilities.
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Out for a (much needed) mental health break yesterday evening, on the Mill River here in New Haven. Lots of birds, turtles, and a surprising number of large fish.
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Fantastically successful Lunch for Equality and Diversity at COSYNE today! Wonderful to see so many people hang out and discuss not only problems but also potential solutions and plans. Cheers to
@neimarkgeffen
and Stephanie Palmer!
#cosyne18
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Had a really wonderful day today
@UCSanDiego
. Always an honor to be invited by students to come give a talk! Had a series of impressive conversations with the grad students here about their work and their plans for the future.
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Headed to NYC to spend tomorrow discussing E-I balance in autism with Simons/SFARI folks. Not sure I believe in E-I balance, should be fun.
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Seriously impressed by my lab and
@mjhigley
's lab! They're awesome under normal conditions, but even more so at the moment. Everyone is staying sane and healthy, working from home, and still cheery over zoom. We might even (slowly) catch up to our data analysis backlog.
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Congratulations to our amazing junior faculty
@emiliafavuzzi
and
@tgeiller
!!!
📣Not one but TWO
@YaleNeuro
junior faculty awarded the Peter and Patricia Gruber International Research Award in Neuroscience!!! Congratulations to
@emiliafavuzzi
, assistant prof, and
@tgeiller
, incoming assistant prof. Congratulations!!!🥳
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Despite everything, it's still looking like spring in New Haven.
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Power outage at med school, backup power down too, -80 slowly defrosting, servers down, blots interrupted mid-run, mouse room dark. Well played, 2020.
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Been a bit fried by stress and travel lately. So, we ran away from home for a week! A few more days and I may be almost human again.
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Currently at the Synapsy mtg in Geneva on the Neurobio of Mental Health. Amazing science, nice that ~50% of invited speakers are female 😁
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The idea of big team science has come up a lot lately. The issue of trainee credit assignment for contributions to papers seems like a key unsolved sticking point to me. There's a tradeoff between being small and nimble versus large and comprehensive. Other thoughts?
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Trying hard to work on a grant, but the 5 year old in the next room has discovered how to make 'Sabotage' play on repeat on the AppleTV. My inner angry 90's teenager approves.
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New posting for Swartz Theoretical Neuroscience postdoctoral fellowships here at Yale! Are you a theorist who wants to collaborate with experimentalists as a postdoc? Please think about applying to this cross-campus fellowship program!
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Getting ready for a huge day of interviewing for the Yale neuroscience graduate program tomorrow. Always hoping for a few candidates who get excited and draw all over my whiteboard to tell me about their current project!
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Went out sledding at 8am, in a very quiet, snowy New Haven. Bit cold, but good for subduing the 2020 stress.
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Gordon was the most generous and gracious colleague one could have. He was incredibly welcoming when I arrived at Yale, and a wonderful neighbor. We will miss his thoughtful presence at the weekly joint lab meetings with the
@mjhigley
lab.
A remembrance of Gordon Shepherd from Charlie Greer
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Very happy for (twitterless) grad student Alex Wang, who just received his NOA for an NRSA!
@Yale_INP
@YaleNeuro
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@NSB_MBL
end of 3rd cycle lunch, with our fabulous teams of students and TAs
@ODubanet
and Peng Xu! Two weeks later, we have an avalanche of data. Many thanks to
@MBLScience
,
@zeiss_micro
for an AxioZoom scope,
@HamamatsuPhoton
for an Orca Fire camera, and Charles Felts at RPI.
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Nicely laid out argument for using stats that account for within- and across- subject variance for experiments with inherently nested design.
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