Gamaleldin osman
@jamaleldin
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Neurologist, Epileptologist @Mayo Clinic, Rochester, MN. Tweets are my own.
Rochester, MN
Joined September 2009
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Happy to announce that I will be joining Mayo Clinic Neurology department for a staff position in July. Looking forward to working with an amazing team of mentors and colleagues in the epilepsy, neuromodulation, MEG and IONM fields !
@MayoClinicNeuro
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First randomized controlled trial from Australia demonstrating significant electrogarphic seizure reduction with bilateral CM stimulation now published. We finally now have level 1 evidence fo DBS in LGS. Next up : GGE.
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Excellent talk by my great mentor Dr
@Kai_J_Miller
on Laser ablation in Epilepsy
@MayoClinicNeuro
Jacksonville Stereotactic and Functional Neurosurgery course
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Dr
@Kai_J_Miller
presenting fascinating work on the discovery of Rolandic Motor area (RMA) interrupting the traditional motor homunculus at the depth of central sulcus
@AmEpilepsySoc
annual meeting
#AES2023
@MayoClinicNeuro
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Thomas Bleck, a great neurointensivist once said " Treating status epilepticus without cEEG is just like treating cardiac arrhythmias without cardiac monitoring." Great to have more available data supporting that.
If this does not convince you to initiate cEEG monitoring to screen for after convulsive status epilepticus, we do not know what will 😉
@JClinNeurophys
@ACNS_org
@SZehtabchi
@SilbergleitRobert
@UnderwoodEllen
@KapurJaideep
@sunydownstate
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Dr
@Kai_J_Miller
illustrating direct targeting of ANT in hands on workshop at Mayo Clinic epilepsy stimulation therapies course
@MayoClinicNeuro
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Congratulations to my friend and superb co-fellow Dr Benjamin Cox on receiving the AES young investigator award for his work on the impact of subclinical seizures recorded on invasive EEG monitoring on seizure outcome. Well deserved!
#AES2021
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Our recently published review article on SE in older adults
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Drs
@JamieVanGompel
and
@Kai_J_Miller
illustrating posterior extraventricular approach to ANT-DBS
@MayoClinicNeuro
stereotactic and functional neurosurgery course
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Our work on low frequency RNS in patients with refractory focal epilepsy..low frequency stimulation has been safe and may provide additional benefits in patients with suboptimal response to standard parameters' stimulation!
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Highlights from Dr Elackar s talk on precision therapy in Epilepsy at Merritt- Putnam symposium:
-Channelopathies:
SCNA2 and SCN8A: Important to distinguish GOF from LOF mutations. Na channel blockers beneficial in GOF but can worsen LOF cases. IV lidocaine can help in SCN2A 1/2
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Great to connect with mentors,friends and colleagues at my favorite scientific meeting
@ACNS_org
@MayoClinicNeuro
@DrBenjaminCoxMD
@JeffBrittonMD
@LilyWongKisiel
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Our recently published review article on emerging neurostimulation approaches in Epilepsy. Fortunate to have worked with my mentors Drs Lundstrom, Gregg and my friend
@hughdsimpson
on this work summarizing recent advances in epilepsy neuromodulation
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Professor Gregory Worrell presenting updates in AI applications in EEG interpretation
@AmEpilepsySoc
Annual meeting Merritt Putnam symposium
#AES2023
@MayoClinicNeuro
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If you are attending
@ACNS_org
annual meeting and have interest in clinical MEG, check out our poster (T62) during today s poster session on the 1st standardized MEG reporting system!
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Professor Patrick Chauvel discussing important pitfalls in anatomo-electro-clinical correlation with SEEG evaluation
@SEEG
course!
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It is mind-blowing to see how much the field has evolved since I attended my 1st SEEG course in cleveland in fall 2014. Excellent course taught by the world leaders in this field. Thanks to Dr
@imadnajm
and CCF team for keeping this coarse going in such an amazing manner!
Closing remarks from Professor Imad Najm (
@imadmnajm
), for our
#SEEG2023
course on
#Cingulate
#epilepsy
. Always inspiring, as we continue to strive to help patients with
#epilepsy
.
#leadership
#neurology
#epileptology
#neurosurgery
#seeg
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Children are not little adults. In children epilepsy surgery is all about the lesion. In adults it is EEG and semiology first then comes the lesion !
Seizure outcome determinants in children after surgery for single unilateral lesions on MRI: role of preoperative ictal and interictal EEG
#epilepsy
#epilepsyresearch
#EpilepsySurgery
#EEG
#MRI
#lesions
@IlaeWeb
@WileyNeuro
@yesILAE
@epilepsiajourn
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Excellent article by my friend and mentor Dr
@hughdsimpson
providing a wonderful summary of practical considerations in the field of epilepsy neuromodulation.
Practical considerations in epilepsy neurostimulation
#epilepsy
#epilepsyresearch
#Neuromodulation
#VNS
#DBS
#RNS
#brainstimulation
@IlaeWeb
@WileyNeuro
@yesILAE
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Our recent work on validation of our proposed TERSE model for electro-clinical seizure risk stratification in the critically ill. Our model allowed for detection of 95% of patients with ESZ and 97% of patients with ESE, while reducing cEEG duration time by 2/3.
[ICU EEG in press] Cissé et al.: "In a cohort of 407 patients and compared to full CEEG review, the model allowed the detection of 95% of patients with electrographic seizures and 97% of those with electrographic status epilepticus."
#ICU
#ClinicalNeuroph
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Register for the first Mayo Epilepsy neurostimulation course covering both surgical and programming aspects. Special discount available for trainees!
Register today for the Mayo Clinic Stimulation Therapies for
#Epilepsy
Course and learn: the importance of
#neurostimulation
, advanced programming techniques, and advanced surgical techniques for placement of stimulation devices. Register:
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Congratulations to my great mentor. Very well deserved !
Congratulations to my friend, colleague, and mentor
@GregoryWorrell
on the AES clinical science award today. A very well deserved honor, and could not be given to a nicer guy.
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Professor Gregory Worrell presenting history of brain stimulation therapies
@Mayo
Clinic Stimulation therapies in Epilepsy first course
@MayoClinicNeuro
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Dr
@Kai_J_Miller
presenting future stimulation therapies for epilepsy at Mayo Clinic 1st epilepsy stimulation therapies course
@MayoClinicNeuro
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An excellent course covering qEEG principles in the ICU setting !
Is that a flame? No, It’s a (broadband monotonous) forest fire 🔥🔥🔥 ….IYKYK. Join us
#ICUEEG
Course Pt 2
#ACNS2022
to learn all things Quantitative EEG! We’re bringing you the forest and the trees. Thurs Jan 27, 9ET
@EEGTalk
@bensalem_owen
@ACNS_org
@StruckAF
@NeuroLlama
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Congratulations to my superb friend and co-fellow
@shruti_agashe1
for receiving
@ACNS_org
young investigator award. Well deserved !
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Can't agree more. How can you not like or even admire EEG?!
[Real scenario from today]
- PGY-2 this AM: Why do you like EEG so much?
- Me: How can you not? You can tell an entire story from a 10-second snapshot of brain activity! Let me show you, choose any page of any of our overnight studies
- PGY-2: *This one*
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An excellent talk. Time means brain in epilepsies just like with strokes .This message should be spread out. Timely referral matters!
If you want to understand why early surgery is important for cognitive outcomes in drug resistant epilepsy, tune into the Presidential symposium at
#AES2020
NOW!!
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Surgery in eloquent cortex maybe feasible with minimal deficit in certain cases. Superficial corticectomy guided by intraoperative SEEG may guide extent of resection, reports
@AMoosaMD
@AES2019
amazing session on pediatric epilepsy case studies
#AES2019
#CureEpilepsy
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Congratulations Dr Sinha for all the accomplishments during your tenure including the new format for the fall course and to Dr
@bensalem_owen
on the well deserved appointment
@ACNS_org
Congratulations to the new ACNS President, Meriem Bensalem-Owen, MD, FACNS! During the
#ACNS2024
General Session on Friday, March 1, outgoing ACNS President, Saurabh R. Sinha, MD, PhD, FACNS presented her with the ACNS gavel.
Thank you, Dr. Sinha, for your dedication & service!
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Excellent talk by such a brilliant scientist and mentor
@dora_hermes
@MayoClinicNeuro
Exciting talk by
@dora_hermes
on using invasive electrophysiological measures together with tractography to measure conduction speed along childhood development.
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A talk by my mentor and the godfather of the ICU-EEG field. Hard to find a better speaker on qEEG interpretation in ICU EEG world! Can’t recommend enough !
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Announcement: Mayo Clinic Rochester campus is hiring MEG neurodiagnostic technologist to work in the new state of art MEG center to be launched later this year
@MayoClinic
@MayoClinicNeuro
@meetmegin
@ACNS_org
. Details included in the flyer
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Dear All please don’t respond to any twitter messages from a person named Anas Alburrak who identifies himself as an epileptologist from Saudi Arabia. He sent me a message with a suspicious link ended up stealing my WhatsApp account.
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Excellent talk as usual by Dr
@AMoosaMD
. To me, Dr Moosa's talks have always among the most fascinating AES and ACNS talks that I look forward to. What a gifted speaker and mentor he is !
@imadmnajm
@AmEpilepsySoc
Here are the key slides from the talk
@AmEpilepsySoc
@DrHussamShaker
@vumcpedepilepsy
@CalleYamile
@Sebasortizdelar
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A remarkable year for Dravet syndrome patients and providers, hopefully more targeted therapies to come in the upcoming years for Dravet syndrome as well as other genetic epilepsies!
📌 2020 was a very good year for
#Dravet
syndrome, with cannabidiol and fenfluramine now approved in the US and EU and the arrival of the ASO from Stoke to clinical trials.
New updated figures and info at the Dravet syndrome pipeline review 2020 👇
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Meeting of the godfathers of modern Epilepsy Surgery at UH on Monday! Highly recommended!
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Our work investigating accuracy of AI based algorithm for classification of seizures and IIC patterns compared to expert classification has just been published inthe green journal!
Looks like
#AI
algorithms for reading critical care EEG will be coming soon
Development of Expert-Level Classification of Seizures and Rhythmic and Periodic Patterns During EEG Interpretation
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Our work on improving clinician performance in classifying EEG IIC patterns using machine learning !
Original Article: Improving Clinician Performance in Classifying EEG Patterns on the Ictal–Interictal Injury Continuum Using Interpretable Machine Learning
Policy Corner: Ethical Oversight of Data Science Health Research in Africa
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Dr
@DrHussamShaker
giving an excellent talk on how to start an SEEG program starting with the SEEG car plate !
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Congratulations Dr
@LyellJ
. Well deserved!
Congratulations to a most deserving awardee. The Physician Leadership awardee 2024. Lyell Jones
#AANAM
@AANmember
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Excellent discussions with multiple fascinating cases. Thanks for the kind invitation.
@UFEpilepsy
@UFMBI
@MichaelOkun
What does it take to get someone 'seizure free?' Dr. Kalamangalam the Director of the Wilder Center for Epilepsy Research shows a humbling case which included a team of neurologists, neurosurgeons, neuropsychologists, techs, scientists, researchers, advanced imaging, some new
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@omar_danoun
@AmEpilepsySoc
We can give a list of medications to
@hebasrashed
from Mersal foundation and hopefully they can arrange for donations to be sent there
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Dr
@JamieVanGompel
giving an excellent talk on targeting ANT with DBS
@MayoClinicNeuro
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@e_gleich
@DrNicteMejia
@TheNotoriousEEG
@spikewhisperer
@Tracey1milligan
@MonicaDhakar
@AMoosaMD
@drhibahaider
@dfreedman7
@scott_mintzer
GPFA. Tonic seizure. Same pattern can be interictal during sleep but buildup of myogenic artifact suggests ictal nature Associated findings: Slow spike and wave discharges and background slowing. Age of onset: 1-8. But can be seen in older folks.
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@wesleytkerr
@AlanaKinrich
Yes and that is why there is a bone window with CT head that focuses on skull abnormalities.
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3/3: GRIN2A : Mixed results with memantine and dextromethorphan
- STXBP1 and SLC6A1: phenylbuturate potentially helpful.
-GABAR mutations: Mixed results to GABAergic drugs.
-Remember vitamin responsive epilepsies and metabolic treatable epilepsies.
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Deep dive into brain circuits through Deep Brain stimulation!
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Very grateful to work with such an amazing group of residents!
Happy Thank a Resident Day! We are so grateful for everything our residents do, today and every day!
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Excellent case presentation as always by Dr
@AMoosaMD
!
Thank you
@AMoosaMD
for an outstanding, illustrative case
@acns
of cingulate motor epilepsy. I always learn from you !
@CLENeurons
@CleClinicMD
#cingulate
@WPSA1
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Strongly recommended for anyone with interest in neuromodulation field !
Thanks so much to the amazing
@andreashorn_
for having
@Kai_J_Miller
and me on the podcast about brain stimulation!
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Excellent review on stereotactic approaches in epilepsy surgery!
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Largest series so far of neurological complications of COVID! Strokes were the most common followed by encephalopathy which in few cases met CSF or MRI criteria for encephalitis. Neuropsychiatric changes also reported.
Delighted to be involved in this groundbreaking work on
#COVID
-19
#Coronavirus
#Encephalitis
#Neurology
#Psychiatry
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@TheNotoriousEEG
@curedravet
@DrDaniAndrade
@a_brunklaus
@csmetcalf
@BarabanLab
Has been an excellent meeting . Enjoyed all the talks and discussions. Thanks Dr
@TheNotoriousEEG
for organizing
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Excellent review of neurosurgical treatments for psychiatric disorders: past, present and future!
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An excellent talk providing concise yet comprehensive review of DS. Thanks Dr
@TheNotoriousEEG
for organising and for the kind invitation!
Dr. Kelly Knupp of
@ChildrensColo
kicks off the clinical track of
#Dravet
Family and Prof conference with “Dravet 101” - an excellent overview of the condition!
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Amitriptyline, riluzole and mexilitene potentially helpful in SCN8A cases.
KCNQ2: Ezogabine off market but phase 3 clinical trial for KNC2 ongoing
- KCNA2: 4AP (Ampyra) beneficial in GOF cases.
- KCNT1: Mixed results with quinidine.
- GRIN2A: Mixed results with meantime and
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Can’t agree more ! Dr Jones as always hit the nail on the head.
We need a modern taxonomy of practice. The “academic or private” dichotomy doesn’t reflect complexities of what physicians do anymore.
Distribution of effort (clinical, research, education, admin etc) at the person and group level is probably a better framework
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Setting the record straight on the chances of seizure freedom after two medications fail // International League Against Epilepsy
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An excellent review on the available data on 2nd line therapies for SE . None was superior in ESETT tial, but one meta-analysis showed that phenytoin was the poorest of all. Once considered the gold standard therapy, phenytoin seems to be now dying a slow agonizing death!
Second-line treatment for status epilepticus: What’s the latest?
What do the latest data show about second-line treatment effectiveness, and how can research move forward?
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A wonderful review by Josep Dalmau s group on GAD AB related CNs syndromes . No evidence so far that GAD antibodies are pathogenic in any of these syndromes and benefit of immunotherapy remains limited !
Our latest Review is online now: "GAD antibodies in neurological disorders — insights and challenges" by Josep Dalmau and colleagues
#newfromnrneurology
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Excellent talk as always by Dr Rao from UCSF on treatment response bio markers in RNS
@NANS_ION
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@LyellJ
@Dr_Ighodaro
@DeborahSetter
@MarcusVPinto
@daboojeeMD
@RamiAbdelAziz2
@EYemmCoon
@MayoClinicNeuro
@mayoneurores
@MayoPedNeuroRes
Congratulations to such a fabulous group of residents and good luck to all of them in their future careers!
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@AMoosaMD
@MParfyonov
@bowtieneuro
@DesireeMarkant1
@AlinaIvaniuk
@DavidMBEp
@SquigglylinesMD
@Sebasortizdelar
Trasmantle type (type IIB) FCD
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@nabilelhalfawy
يتبع- و رفضته اثيوبيا و هو ما عطل عمل اللجنة الفرنسية في الدراسة و تنص الاتفاقية كذلك على التوصل لتوافق بين البلاد الثلاث قبل بدء ملء الخزان و تنص على عدم الاضرار باي من بلاد المصب. ليس في الاتفاقية اي تنازل عن حقوق مصر المائية خلافا لما يردده الاعلام الاخواني
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@TheNotoriousEEG
@LGS_Foundation
Yes and No. The orphan drug designation allows expedited approval but I do feel the IGE patients are the most under studied in clinical trials and definitely need more attention.
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Take home message : Take care when wandering around rogue camels!
Focal
#epilepsy
may develop due to displacement of the temporomandibular joint into the temporal lobe.
#NeurologyRF
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Update : The post includes 5000$ sign-on bonus for external (non Mayo) candidates only . Here is the updated flyer
@MayoClinic
@MayoClinicNeuro
@ACNS_org
@ABRETEO
@JeffBrittonMD
Announcement: Mayo Clinic Rochester campus is hiring MEG neurodiagnostic technologist to work in the new state of art MEG center to be launched later this year
@MayoClinic
@MayoClinicNeuro
@meetmegin
@ACNS_org
. Details included in the flyer
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@AMahajanMD
@wesleytkerr
Absolutely agree. Plus the study didn't preclude patients from being converted from routine to cEEG if deemed appropriate by the primary team and they excluded patients with RSE requiring cEEG from the start so the focus should be on the effect of delay
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Dr Nicholas Gregg discussing brainsense application in ANT DBS for epilepsy
@MayoClinicNeuro
Mayo Clinic 1st epilepsy stimulation course
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Excellent thread on important pitfalls in DAT-SPECT interpretation. Take away message : DAT-SPECT is very useful in distinguishing Parkinsonism from functional tremors but is less reliable in distinguishing PD from atypical Parkinsonian syndromes or PD mimics.
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#ContinnumCase
A 73 yo 👩🦰 is in the NeuroICU for SDH after a fall.
Reviewing her hx, you note years of “shaking” which was treated as essential tremor.
However, she continued to progress with worsening balance, truncal ataxia, and bradykinesia.
In her chart you see this:
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@nabilelhalfawy
يا فندم الاتفاقية دي هي اللي هتحمي حقوق مصر باذن الله و التوقيع عليها كان خطوة مهمة جدا. الاتفاقية تنص على ان الدول الثلاث ستعين لجنة خبراء لاعداء دراسة بخصوص اضرار السد و هذا ما حدث و لكن اللجنة الهولندية انسحبت و اللجنة الفرنسية اعدت تقريرا استهلاليا قبلته مصر و رفضته -يتبع
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@sineadtaylor
@DGlaucomflecken
He forgot to appreciate recs which coupled with thanking primary services for consults represent the backbone of medicine :)
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Interesting to see the shift in paradigm among US epilepsy surgical centers. Seems like the Europeans were well ahead of the curve!
How do epilepsy centers in the US perform invasive EEG monitoring? Survey published in
@JClinNeurophys
provides interesting data on preferences for invasive monitoring among members of NAEC. Training, volumes and delays in care also addressed.
@ACNS_org
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Epilepsy Comprehensive Update and Board Review | McGovern Medical School
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Excellent thread discussing SESA as a cause of acute symptomatic seizures and encephalopathy!
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#EmoryNCCTweetorials
🚨
The setup: Neuro ICU at
@EmoryNeuroCrit
The pt: John Doe transferred for status epilepticus
You’re told about the pt’s ammonia lvl ➡️ 181 (where's
@Capt_Ammonia
?!). He’s also on 5 different AED’s...
@MedTweetorials
#MedEd
#tweetorial
#neurotwitter
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This can be a game changer for patients with SE!
Congrats to
@MeganRx1
presenting work from our lab at
#AES
showing lack of
#EmergencyMedicine
GCS deterioration after
#ketamine
(blue) except when administered for pre-planned intubation (red). Age <>65 & dose <>1.5mg/kg ➡️ similar GCS trajectory. Consider for
#statusepilepticus
?
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Can’t wait to attend my favorite meeting of all scientific meetings
@ACNS_org
!
So exciting to see one of our fabulous residents, future clinical neurophysiologist, new ACNS member & attendee of
#ACNS2024
featured by the
@ACNS_org
Bravo Dr. Akemokwe ! 🙌🤓🧠
@UKYneuroscience
@NeuroUky
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@neuro_chick
النقطه الثانيه ABCDE program ده معمول لناس موجوده هنا اصلا و في الاغلب خلصوا معادلات و الشروط بخصوص السكورات صعبه لكن في ناس اصلا عندها صعوبه في دفع تكلفه امتحانات المعادله و هنا وجود جمعيه في مصر بدعم من دكاتره هنا ممكن يكون مفيد جدا
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These series are just phenomenal. Whoever has not yet followed
@DGlaucomflecken
is definitely missing a lot!
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@asim_epilepsy
@TheNotoriousEEG
@AMoosaMD
@EliaMPestana
@neelmed
@SalamNasralla
@SLhatoo
@mzkoubeissi
@MOHAMME23267570
We have done a few cases targeting CM in patients with LGS here at Mayo.Dr Alcala recently published the Mayo experience of CM stimulation which included LGS patients among other patient populations
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@wesleytkerr
@TheNotoriousEEG
That is because many times patients that appear to be non-surgical candidates based on semiology, EEG, MRI, etc.. may turn out to be surgical candidates once comprehensive evaluation is performed and vice versa. So the key message is to push for early referral of refractory pts.
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More emerging data on precision therapies in Epilepsy
#AES2022
Really excited to see our work about
#PrecisionMedicine
after epilepsy surgery with d-galactose for the treatment of
#MOGHE
commented by our friend & collaborator
@IngmarBlumcke
at the
#AES2022
😍
We hope the full research paper will be out very soon🧬
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Severe cerebral edema or highly malignant EEG patterns (including severe (<2uV) background suppression, and burst suppression with identical bursts) can predict poor prognosis post-CA regardless of TTM strategy based on a large study from UPMC that included 1319 patients.
This study supports a more personalized approach to
#TTM
after cardiac arrest to help guide temperature targets. Cerebral edema or a malignant EEG portended poor prognosis regardless of temperature.
@JAMANetworkOpen
@SCCM
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Unfortunately couldn’t make it to AES this year but this session has always been one of my favorite AES sessions. Highly recommended !
Join us for the Pediatric Epilepsy Case Discussion SIG tomorrow at 7 am. Level 1, 102A. We will share 2️⃣ cases with some great takeaways.
#AES2022
@AmEpilepsySoc
@VineetPuniaMD
@TheNotoriousEEG
@PostDomRhythm
@Majalzahrany
@jamaleldin
@PESAlliance
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@NaguibSawiris
دول يا فندم مش بيصادوا في المياه العكرة دول بيعكروا المياه الصافية علشان يعرفوا يصطادوا فيها😅😅😅😅
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Congratulations my friend
@fabnascimen
Well deserved !
Congratulations to Fábio Nascimento, MD, (
@fabnascimen
) for his recent appointments: Vice-Chair of the EEG SIG at
@AmEpilepsySoc
and Educational Program Director of the EEG course (focal, diffuse, and epileptiform abnormalities in adults) for the
@AANmember
#AANAM
.
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