🚨Excited to share our latest work, now out in @NatureBiotech ! We introduce SEED-Selection, a powerful method that enables high-efficiency enrichment of T cells edited at multiple loci in a single step 🧵👇 🔗

@jmdubs6 @RahulBanerjeeMD @NEJM @MScordoMD @szusmani @MSKCancerCenter Yeah, It’s been in patients (6 so far) at MSKCC for lymphoma and we are submitting an IND at UCSF for Myeloma. Both autologous product.

@jmdubs6 @RahulBanerjeeMD @NEJM @MScordoMD @szusmani @MSKCancerCenter So I strongly believe that more targeted approach will be necessary in the future. Especially as we move from “vanilla CAR” (like here) to much more potent T cell engineering using gene editing and synBio which enhance signaling/proliferation/persistence.

@DarkMatterDNA Thanks for highlighting our work!

@Ruviunz @NatureBiotech Thanks Pedro! It’s been a good week indeed!

10/ This was an awesome collab with the @brshy Lab and led by @ChrisRChang. A huge shoutout to our amazing teams, collaborators and funders for making this possible! @UCSF @GladstoneInst @parkerici @pewhealth

10/ Excited to see how this tool will help the field of immunology and gene therapy! Ark13 on addgene: 📢Read the full paper here: 💬Questions? Thoughts? Let’s discuss! ⬇️